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Towards Molecular Mechanism in Long Non-coding RNAs: Linking Structure and Function

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Long Noncoding RNA

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1363))

Abstract

While long non-coding RNAs play key roles in disease and development, few structural studies have been performed to date for this emerging class of RNAs. Here, we provide a brief review of functional studies of long non-coding RNAs, followed by a review of previous structural studies of long non-coding RNAs. We then describe structural studies of other classes of RNAs using chemical probing, nuclear magnetic resonance, small angle X-ray scattering, X-ray crystallography and cryogenic electron microscopy (cryo-EM). Next, we describe the way forward for the structural biology of long non-coding RNAs in terms of cryo-EM. Finally, we discuss of the roles of long non-coding RNAs in the cell and how structure-function relationships might be used to elucidate further understanding.

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Acknowledgements

The author acknowledges generous support by the LANL LDRD program.

Author information

Authors and Affiliations

  1. Los Alamos National Laboratory, Los Alamos, NM, USA

    Karissa Sanbonmatsu

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  1. Karissa Sanbonmatsu
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Correspondence to Karissa Sanbonmatsu .

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  1. Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA

    Susan Carpenter

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Sanbonmatsu, K. (2022). Towards Molecular Mechanism in Long Non-coding RNAs: Linking Structure and Function. In: Carpenter, S. (eds) Long Noncoding RNA. Advances in Experimental Medicine and Biology, vol 1363. Springer, Cham. https://doi.org/10.1007/978-3-030-92034-0_3

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