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Anxiety Disorders

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Key Topics in Perinatal Mental Health

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Abstract

Perinatal mental illness is a major complication that occurs during pregnancy and the postpartum period and can affect approximately 20% of women. Among the various mental illnesses, anxiety disorders (generalized anxiety disorder, panic disorder, social anxiety disorder, or specific phobias) are the most common but are often undiagnosed, as anxiety during pregnancy and childbirth is generally considered a normal phenomenon. However, during recent years, researchers have found that an undiagnosed and untreated anxiety disorder during pregnancy or the postpartum period can affect both the mother and newborn. Early identification of risk factors, prompt diagnosis using valid screening tools, and rapid intervention with personalized treatment all remain a challenge for both researchers and perinatal psychiatrists to prevent short- and long-term consequences of mental health disorders for both the mother and child.

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References

  1. Çalıkoğlu EO, Bedir B, Aydın A, Yılmaz S. An investigation of the prevalence of depression and related factors in pregnant women living in the province of Erzurum. Eur Res J. 2018;4(4):381–9.

    Google Scholar 

  2. Bhat NA, Hassan R, Shafiq M, Sheikh S. Sociodemographic factors: a major predictor of anxiety and depression among pregnant women. Delhi Psychiatry J. 2015;18(1)

    Google Scholar 

  3. O’Hara MW, Wisner KL. Perinatal mental illness: definition, description and aetiology. Best Pract Res Clin Obstet Gynaecol. 2014;28(1):3–12. https://linkinghub.elsevier.com/retrieve/pii/S1521693413001338

    PubMed  Google Scholar 

  4. de la Fe Rodríguez-Muñoz M, Le H-N, de la Cruz IV, Crespo MEO, Méndez NI. Feasibility of screening and prevalence of prenatal depression in an obstetric setting in Spain. Eur J Obstet Gynecol Reprod Biol. 2017;215:101–5. https://linkinghub.elsevier.com/retrieve/pii/S030121151730283X

    PubMed  Google Scholar 

  5. Gentile S, Fusco ML. Untreated perinatal paternal depression: effects on offspring. Psychiatry Res. 2017;252:325–32. https://linkinghub.elsevier.com/retrieve/pii/S0165178116309283

    PubMed  Google Scholar 

  6. Austin M-P, Tully L, Parker G. Examining the relationship between antenatal anxiety and postnatal depression. J Affect Disord. 2007;101(1–3):169–74. https://linkinghub.elsevier.com/retrieve/pii/S0165032706004976

    PubMed  Google Scholar 

  7. Vesga-López O, Blanco C, Keyes K, Olfson M, Grant BF, Hasin DS. Psychiatric disorders in pregnant and postpartum women in the United States. Arch Gen Psychiatry. 2008;65(7):805. http://archpsyc.jamanetwork.com/article.aspx?doi=10.1001/archpsyc.65.7.805

    PubMed  PubMed Central  Google Scholar 

  8. Paschetta E, Berrisford G, Coccia F, Whitmore J, Wood AG, Pretlove S, et al. Perinatal psychiatric disorders: an overview. Am J Obstet Gynecol. 2014;210(6):501–509.e6. https://linkinghub.elsevier.com/retrieve/pii/S0002937813010478

    PubMed  Google Scholar 

  9. Nillni YI, Mehralizade A, Mayer L, Milanovic S. Treatment of depression, anxiety, and trauma-related disorders during the perinatal period: a systematic review. Clin Psychol Rev. 2018;66:136–48. https://linkinghub.elsevier.com/retrieve/pii/S0272735817304075

    PubMed  PubMed Central  Google Scholar 

  10. Oates M. Perinatal psychiatric disorders: a leading cause of maternal morbidity and mortality. Br Med Bull. 2003;67(1):219–29. https://academic.oup.com/bmb/article/67/1/219/330390

    PubMed  Google Scholar 

  11. Dennis CL, Falah-Hassani K, Shiri R. Prevalence of antenatal and postnatal anxiety: systematic review and meta-analysis. Br J Psychiatry. 2017;210:315–23.

    Google Scholar 

  12. Fawcett EJ, Fairbrother N, Cox ML, White IR, Fawcett JM. The prevalence of anxiety disorders during pregnancy and the postpartum period. J Clin Psychiatry. 2019;80(4):18r12527. https://pubmed.ncbi.nlm.nih.gov/31347796

    PubMed  PubMed Central  Google Scholar 

  13. Goodman JH, Watson GR, Stubbs B. Anxiety disorders in postpartum women: a systematic review and meta-analysis. J Affect Disord. 2016;203

    Google Scholar 

  14. Grigoriadis S, Graves L, Peer M, Mamisashvili L, Tomlinson G, Vigod SN, et al. Maternal anxiety during pregnancy and the association with adverse perinatal outcomes. J Clin Psychiatry. 2018;79(5):11–2. https://www.psychiatrist.com/JCP/article/Pages/2018/v79/17r12011.aspx

    Google Scholar 

  15. Misri S, Abizadeh J, Sanders S, Swift E. Perinatal generalized anxiety disorder: assessment and treatment. J Women’s Heal. 2015;24(9):762–70. http://www.liebertpub.com/doi/10.1089/jwh.2014.5150

    Google Scholar 

  16. Martini J, Petzoldt J, Einsle F, Beesdo-Baum K, Höfler M, Wittchen H-U. Risk factors and course patterns of anxiety and depressive disorders during pregnancy and after delivery: a prospective-longitudinal study. J Affect Disord. 2015;175:385–95. https://linkinghub.elsevier.com/retrieve/pii/S0165032715000166

    PubMed  Google Scholar 

  17. Fairbrother N, Young AH, Zhang A, Janssen P, Antony MM. The prevalence and incidence of perinatal anxiety disorders among women experiencing a medically complicated pregnancy. Arch Womens Ment Health. 2017;20(2):311–9. http://link.springer.com/10.1007/s00737-016-0704-7

    PubMed  Google Scholar 

  18. Hutchens BF, Kearney J. Risk factors for postpartum depression: an umbrella review. J Midwifery Womens Health. 2020;65(1):96–108.

    PubMed  Google Scholar 

  19. American Psychiatric Association, editor. Diagnostic and statistical manual of mental disorders fifth edition. American Psychiatric Association, editor. Arlington, VA: American Psychiatric Association; 2013.

    Google Scholar 

  20. Sharma V, Mazmanian D. The DSM-5 peripartum specifier: prospects and pitfalls. Arch Womens Ment Health. 2014;17(2):171–3. http://link.springer.com/10.1007/s00737-013-0406-3

    PubMed  Google Scholar 

  21. Kane JB. Marriage advantages in perinatal health: evidence of marriage selection or marriage protection? J Marriage Fam. 2016;78(1):212–29. https://doi.org/10.1111/jomf.12257.

    Article  PubMed  Google Scholar 

  22. Lener MS, Charney DS, Feder A. Anxiety disorders. In: Simon AB, New AS, Goodman WK, editors. Psychiatry. New York: Wiley Blackwell; 2017. p. 88–102. (Mount Sinai expert guides). http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2017-19219-012&site=ehost-live.

    Google Scholar 

  23. Faisal-Cury A, Rossi MP. Prevalence of anxiety and depression during pregnancy in a private setting sample. Arch Womens Ment Health. 2007;10(1):25–32. https://doi.org/10.1007/s00737-006-0164-6.

    Article  CAS  PubMed  Google Scholar 

  24. Glazier R, Elgar F, Goel V, Holzapfel S. Stress, social support, and emotional distress in a community sample of pregnant women. J Psychosom Obstet Gynecol. 2004;25(3–4):247–55. http://www.tandfonline.com/doi/full/10.1080/01674820400024406

    CAS  Google Scholar 

  25. Dunkel Schetter C, Niles AN, Guardino CM, Khaled M, Kramer MS. Demographic, medical, and psychosocial predictors of pregnancy anxiety. Paediatr Perinat Epidemiol. 2016;30(5):421–9. https://doi.org/10.1111/ppe.12300.

    Article  PubMed  Google Scholar 

  26. Barcelona de Mendoza V, Harville E, Theall K, Buekens P, Chasan-Taber L. Effects of acculturation on prenatal anxiety among Latina women. Arch Womens Ment Health. 2016;19(4):635–44. http://link.springer.com/10.1007/s00737-016-0605-9

    PubMed  Google Scholar 

  27. Bödecs T, Szilágyi E, Cholnoky P, Sándor J, Gonda X, Rihmer Z, et al. Prevalence and psychosocial background of anxiety and depression emerging during the first trimester of pregnancy: data from a Hungarian population-based sample. Psychiatr Danub. 2013;25(4):352–8. http://www.ncbi.nlm.nih.gov/pubmed/24247046

    PubMed  Google Scholar 

  28. Giardinelli L, Innocenti A, Benni L, Stefanini MC, Lino G, Lunardi C, et al. Depression and anxiety in perinatal period: prevalence and risk factors in an Italian sample. Arch Womens Ment Health. 2012;15(1):21–30. https://doi.org/10.1007/s00737-011-0249-8.

    Article  CAS  PubMed  Google Scholar 

  29. Rubertsson C, Hellström J, Cross M, Sydsjö G. Anxiety in early pregnancy: prevalence and contributing factors. Arch Womens Ment Health. 2014;17(3):221–8. https://doi.org/10.1007/s00737-013-0409-0.

    Article  CAS  PubMed  Google Scholar 

  30. Bayrampour H, McDonald S, Tough S. Risk factors of transient and persistent anxiety during pregnancy. Midwifery. 2015;31(6):582–9. https://linkinghub.elsevier.com/retrieve/pii/S0266613815000662

    PubMed  Google Scholar 

  31. Bellantuono C, Vargas M, Mandarelli G, Nardi B, Martini MG. The safety of serotonin-noradrenaline reuptake inhibitors (SNRIs) in pregnancy and breastfeeding: a comprehensive review. Hum Psychopharmacol. 2015;30(3):143–51.

    CAS  PubMed  Google Scholar 

  32. Lee AM, Lam SK, Sze Mun Lau SM, Chong CSY, Chui HW, Fong DYT. Prevalence, course, and risk factors for antenatal anxiety and depression. Obstet Gynecol. 2007;110(5):1102–12. https://journals.lww.com/00006250-200711000-00024

    PubMed  Google Scholar 

  33. Marcus SM, Flynn HA, Blow FC, Barry KL. Depressive symptoms among pregnant women screened in obstetrics settings. J Women’s Heal. 2003;12(4):373–80. http://www.liebertpub.com/doi/10.1089/154099903765448880

    Google Scholar 

  34. Marchesi C, Ampollini P, Paraggio C, Giaracuni G, Ossola P, De Panfilis C, et al. Risk factors for panic disorder in pregnancy: a cohort study. J Affect Disord. 2014;156:134–8. https://www.sciencedirect.com/science/article/pii/S0165032713008422

    PubMed  Google Scholar 

  35. Groves AK, Kagee A, Maman S, Moodley D, Rouse P. Associations between intimate partner violence and emotional distress among pregnant women in Durban. South Africa J Interpers Violence. 2012;27(7):1341–56. http://journals.sagepub.com/doi/10.1177/0886260511425247

    PubMed  Google Scholar 

  36. Choi KW, Sikkema KJ. Childhood maltreatment and perinatal mood and anxiety disorders. Trauma Violence Abuse. 2016;17(5):427–53. http://journals.sagepub.com/doi/10.1177/1524838015584369

    PubMed  Google Scholar 

  37. Atzl VM, Grande LA, Davis EP, Narayan AJ. Perinatal promotive and protective factors for women with histories of childhood abuse and neglect. Child Abuse Negl. 2019;91:63–77. https://pubmed.ncbi.nlm.nih.gov/30831534

    PubMed  PubMed Central  Google Scholar 

  38. Bayrampour H, Tomfohr L, Tough S. Trajectories of perinatal depressive and anxiety symptoms in a community cohort. J Clin Psychiatry. 2016;77(11):e1467–73.

    PubMed  Google Scholar 

  39. Blackmore ER, Côté-Arsenault D, Tang W, Glover V, Evans J, Golding J, et al. Previous prenatal loss as a predictor of perinatal depression and anxiety. Br J Psychiatry. 2011;198(5):373–8. https://www.cambridge.org/core/product/identifier/S0007125000255116/type/journal_article

    PubMed  PubMed Central  Google Scholar 

  40. Glover V, O’Connor TG, O’Donnell K. Prenatal stress and the programming of the HPA axis. Neurosci Biobehav Rev. 2010;35(1):17–22. https://linkinghub.elsevier.com/retrieve/pii/S0149763409001742

    CAS  PubMed  Google Scholar 

  41. Tyano S, Keren M, Herrman H, Cox J. Parenthood and mental health: a bridge between infant and adult psychiatry; 2010.

    Google Scholar 

  42. Grant K-A, Bautovich A, McMahon C, Reilly N, Leader L, Austin M-P. Parental care and control during childhood: associations with maternal perinatal mood disturbance and parenting stress. Arch Womens Ment Health. 2012;15(4):297–305. https://doi.org/10.1007/s00737-012-0292-0.

    Article  PubMed  Google Scholar 

  43. Jeong H-G, Lim J-S, Lee M-S, Kim S-H, Jung I-K, Joe S-H. The association of psychosocial factors and obstetric history with depression in pregnant women: focus on the role of emotional support. Gen Hosp Psychiatry. 2013;35(4):354–8. https://www.sciencedirect.com/science/article/pii/S0163834313000613

    PubMed  Google Scholar 

  44. Lanzi RG, Bert SC, Jacobs BK. Depression among a sample of first-time adolescent and adult mothers. J Child Adolesc Psychiatr Nurs. 2009;22(4):194–202. https://doi.org/10.1111/j.1744-6171.2009.00199.x.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Redshaw M, Henderson J. From antenatal to postnatal depression: associated factors and mitigating influences. J Women’s Heal. 2013;22(6):518–25. https://doi.org/10.1089/jwh.2012.4152.

    Article  Google Scholar 

  46. Ali NS, Azam IS, Ali BS, Tabbusum G, Moin SS. Frequency and associated factors for anxiety and depression in pregnant women: a hospital-based cross-sectional study. Sci World J. 2012;2012:1–9. http://www.hindawi.com/journals/tswj/2012/653098/

    Google Scholar 

  47. Gong X, Hao J, Tao F, Zhang J, Wang H, Xu R. Pregnancy loss and anxiety and depression during subsequent pregnancies: data from the C-ABC study. Eur J Obstet Gynecol Reprod Biol. 2013;166(1):30–6. https://linkinghub.elsevier.com/retrieve/pii/S0301211512004472

    PubMed  Google Scholar 

  48. Waqas A, Raza N, Lodhi HW, Muhammad Z, Jamal M, Rehman A. Psychosocial factors of antenatal anxiety and depression in Pakistan: is social support a mediator? Fischer G, editor. PLoS One. 2015;10(1):e0116510. https://doi.org/10.1371/journal.pone.0116510.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Bergner A, Beyer R, Klapp BF, Rauchfuss M. Pregnancy after early pregnancy loss: a prospective study of anxiety, depressive symptomatology and coping. J Psychosom Obstet Gynecol. 2008;29(2):105–13. http://www.tandfonline.com/doi/full/10.1080/01674820701687521

    Google Scholar 

  50. Glover V. Prenatal stress and its effects on the fetus and the child: possible underlying biological mechanisms. 2015. Adv Neurobiol 10:p. 269–283. http://link.springer.com/10.1007/978-1-4939-1372-5_13

  51. Kroll-Desrosiers AR, Nephew BC, Babb JA, Guilarte-Walker Y, Moore Simas TA, Deligiannidis KM. Association of peripartum synthetic oxytocin administration and depressive and anxiety disorders within the first postpartum year. Depress Anxiety. 2017;34(2):137–46. https://onlinelibrary.wiley.com/doi/abs/10.1002/da.22599

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Stonawski V, Frey S, Golub Y, Moll GH, Heinrich H, Eichler A. Af ektive Belastungen der Mutter in der Schwangerschaft und assoziierte epigenetische Veränderungen beim Kind: Eine Übersicht. Vol. 46, Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie. Verlag Hans Huber AG; 2018 [cited 2021 Mar 18]. p. 155–67. https://pubmed.ncbi.nlm.nih.gov/28256157/

  53. Glover V, O’Connor TG, Heron J, Golding J. Antenatal maternal anxiety is linked with atypical handedness in the child. Early Hum Dev. 2004;79(2):107–18. https://pubmed.ncbi.nlm.nih.gov/15324991/

    PubMed  Google Scholar 

  54. Glover V. Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done. Best Pract Res Clin Obstet Gynaecol. 2014;28(1):25–35. https://pubmed.ncbi.nlm.nih.gov/24090740/

    PubMed  Google Scholar 

  55. Zappas MP, Becker K, Walton-Moss B. Postpartum anxiety. J Nurse Pract. 2021;17(1):60–4.

    Google Scholar 

  56. Cena L, Palumbo G, Mirabella F, Gigantesco A, Stefana A, Trainini A, et al. Perspectives on early screening and prompt intervention to identify and treat maternal perinatal mental health. Protocol for a prospective multicenter study in Italy. Front Psychol. 2020;11. https://www.frontiersin.org/article/10.3389/fpsyg.2020.00365/full

  57. Yeaton-Massey A, Herrero T. Recognizing maternal mental health disorders: beyond postpartum depression. Curr Opin Obstet Gynecol. 2019;31(2) https://journals.lww.com/co-obgyn/Fulltext/2019/04000/Recognizing_maternal_mental_health_disorders_.6.aspx

  58. NICE. Antenatal and postnatal mental health: clinical management and service guidance Clinical guideline [CG192] - Published date: 17 December 2014 - Last updated: 11 February 2020; 2020. https://www.nice.org.uk/guidance/cg192

  59. Löwe B, Decker O, Müller S, Brähler E, Schellberg D, Herzog W, et al. Validation and standardization of the generalized anxiety disorder screener (GAD-7) in the general population. Med Care. 2008;46(3):266–74. https://journals.lww.com/00005650-200803000-00006

    PubMed  Google Scholar 

  60. Spitzer RL, Kroenke K, Williams JBW, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006;166(10)

    Google Scholar 

  61. Sapra A, Bhandari P, Sharma S, Chanpura T, Lopp L. Using generalized anxiety disorder-2 (GAD-2) and GAD-7 in a primary care setting. Cureus; 2020.

    Google Scholar 

  62. Spielberger C, Gorsuch R, Lushene R, Vagg PR, Jacobs G. Manual for the State-Trait Anxiety Inventory (Form Y1 – Y2), vol. 4. Palo Alto, CA: Consulting Psychologists Press; 1983.

    Google Scholar 

  63. Grant K-A, McMahon C, Austin M-P. Maternal anxiety during the transition to parenthood: a prospective study. J Affect Disord. 2008;108(1–2):101–11. https://linkinghub.elsevier.com/retrieve/pii/S016503270700345X

    PubMed  Google Scholar 

  64. Skouteris H, Wertheim EH, Rallis S, Milgrom J, Paxton SJ. Depression and anxiety through pregnancy and the early postpartum: an examination of prospective relationships. J Affect Disord. 2009;113(3):303–8. https://linkinghub.elsevier.com/retrieve/pii/S0165032708002401

    PubMed  Google Scholar 

  65. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56(6):893–7. http://doi.apa.org/getdoi.cfm?doi=10.1037/0022-006X.56.6.893

    CAS  PubMed  Google Scholar 

  66. Matthey S, Ross-Hamid C. Repeat testing on the Edinburgh depression scale and the HADS-A in pregnancy: differentiating between transient and enduring distress. J Affect Disord. 2012;141(2–3):213–21. https://linkinghub.elsevier.com/retrieve/pii/S0165032712001516

    PubMed  Google Scholar 

  67. Gladstone GL, Parker GB, Mitchell PB, Malhi GS, Wilhelm KA, Austin M-P. A brief measure of worry severity (BMWS): personality and clinical correlates of severe worriers. J Anxiety Disord. 2005;19(8):877–92. https://linkinghub.elsevier.com/retrieve/pii/S0887618504001288

    PubMed  Google Scholar 

  68. Meyer TJ, Miller ML, Metzger RL, Borkovec TD. Development and validation of the Penn state worry questionnaire. Behav Res Ther. 1990;28(6):487–95. https://linkinghub.elsevier.com/retrieve/pii/0005796790901356

    CAS  PubMed  Google Scholar 

  69. Murray L, Cooper P, Creswell C, Schofield E, Sack C. The effects of maternal social phobia on mother–infant interactions and infant social responsiveness. J Child Psychol Psychiatry. 2007;48(1):45–52. https://doi.org/10.1111/j.1469-7610.2006.01657.x.

    Article  PubMed  Google Scholar 

  70. Huizink AC, Mulder EJH, Robles de Medina PG, Visser GHA, Buitelaar JK. Is pregnancy anxiety a distinctive syndrome? Early Hum Dev. 2004;79(2):81–91. https://linkinghub.elsevier.com/retrieve/pii/S037837820400074X

    PubMed  Google Scholar 

  71. Buss C, Davis EP, Hobel CJ, Sandman CA. Maternal pregnancy-specific anxiety is associated with child executive function at 6–9 years age. Stress. 2011;14(6):665–76. http://www.tandfonline.com/doi/full/10.3109/10253890.2011.623250

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Van den Bergh BRH, Mulder EJH, Mennes M, Glover V. Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review. Neurosci Biobehav Rev. 2005;29(2):237–58. https://linkinghub.elsevier.com/retrieve/pii/S0149763404001307

    PubMed  Google Scholar 

  73. Rini CK, Dunkel-Schetter C, Wadhwa PD, Sandman CA. Psychological adaptation and birth outcomes: the role of personal resources, stress, and sociocultural context in pregnancy. Health Psychol. 1999;18(4):333–45. http://doi.apa.org/getdoi.cfm?doi=10.1037/0278-6133.18.4.333

    CAS  PubMed  Google Scholar 

  74. Davis EP, Sandman CA. The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development. Child Dev. 2010;81(1):131–48. https://doi.org/10.1111/j.1467-8624.2009.01385.x.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Henrichs J, Schenk JJ, Roza SJ, van den Berg MP, Schmidt HG, Steegers EAP, et al. Maternal psychological distress and fetal growth trajectories: the generation R study. Psychol Med. 2010;40(4):633–43. https://www.cambridge.org/core/product/identifier/S0033291709990894/type/journal_article

    CAS  PubMed  Google Scholar 

  76. Somerville S, Dedman K, Hagan R, Oxnam E, Wettinger M, Byrne S, et al. The perinatal anxiety screening scale: development and preliminary validation. Arch Womens Ment Health. 2014;17(5):443–54. http://link.springer.com/10.1007/s00737-014-0425-8

    PubMed  Google Scholar 

  77. Fairbrother N, Corbyn B, Thordarson DS, Ma A, Surm D. Screening for perinatal anxiety disorders: room to grow. J Affect Disord. 2019;250:363–70. https://www.sciencedirect.com/science/article/pii/S0165032718323395

    PubMed  Google Scholar 

  78. Ali E. Women’s experiences with postpartum anxiety disorders: a narrative literature review. Int J Women’s Health. 2018;10:237–49. https://www.dovepress.com/womens-experiences-with-postpartum-anxiety-disorders-a-narrative-liter-peer-reviewed-article-IJWH

    Google Scholar 

  79. Abbasi MA, Malik S, Ali K. Smoking cessation after counselling in patients presenting with acute coronary syndrome. J Ayub Med Coll Abbottabad. 2018;30(2):223–9.

    Google Scholar 

  80. Anniverno R, Bramante A, Mencacci C, Durbano F. Anxiety disorders in pregnancy and the postpartum period. New insights into anxiety disorders. In Tech; 2013. http://www.intechopen.com/books/new-insights-into-anxiety-disorders/anxiety-disorders-in-pregnancy-and-the-postpartum-period

  81. Aris-Meijer J, Bockting C, Stolk R, Verbeek T, Beijers C, van Pampus M, et al. What if pregnancy is not seventh heaven? The influence of specific life events during pregnancy and delivery on the transition of antenatal into postpartum anxiety and depression. Int J Environ Res Public Health. 2019;16(16):2851. https://www.mdpi.com/1660-4601/16/16/2851

    PubMed Central  Google Scholar 

  82. Agrati D, Browne D, Jonas W, Meaney M, Atkinson L, Steiner M, et al. Maternal anxiety from pregnancy to 2 years postpartum: transactional patterns of maternal early adversity and child temperament. Arch Womens Ment Health. 2015;18(5):693–705. http://link.springer.com/10.1007/s00737-014-0491-y

    PubMed  Google Scholar 

  83. Brockington IF, Macdonald E, Wainscott G. Anxiety, obsessions and morbid preoccupations in pregnancy and the puerperium. Arch Womens Ment Health. 2006;9(5):253–63.

    CAS  PubMed  Google Scholar 

  84. Pleshette N, Asch S, Chase J. A study of anxieties during pregnancy, labor, the early and late puerperium. Bull N Y Acad Med. 1956;32(6):436–55.

    CAS  PubMed  PubMed Central  Google Scholar 

  85. Levin JS. The factor structure of the pregnancy anxiety scale. J Health Soc Behav. 1991;32(4):368–81.

    CAS  PubMed  Google Scholar 

  86. Standley K, Soule B, Copans SA. Dimensions of prenatal anxiety and their influence on pregnancy outcome. Am J Obstet Gynecol. 1979;135(1):22–6.

    CAS  PubMed  Google Scholar 

  87. Blackmore ER, Gustafsson H, Gilchrist M, Wyman C, O’Connor G, T. Pregnancy-related anxiety: evidence of distinct clinical significance from a prospective longitudinal study. J Affect Disord. 2016;197:251–8. https://pubmed.ncbi.nlm.nih.gov/26999549

    PubMed  PubMed Central  Google Scholar 

  88. Williams KE, Koleva H. Identification and treatment of peripartum anxiety disorders. Obstet Gynecol Clin N Am. 2018;45(3):469–81. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=med15&NEWS=N&AN=30092922

    Google Scholar 

  89. Mudra S, Göbel A, Barkmann C, Goletzke J, Hecher K, Schulte-Markwort M, et al. The longitudinal course of pregnancy-related anxiety in parous and nulliparous women and its association with symptoms of social and generalized anxiety. J Affect Disord. 2019;2020(260):111–8. https://doi.org/10.1016/j.jad.2019.08.033.

    Article  Google Scholar 

  90. Perna G, Barone Y, Alciati A. Anxiety disorders. In: Perinatal psychopharmacology. Cham: Springer; 2019. p. 287–95. http://link.springer.com/10.1007/978-3-319-92919-4_17.

  91. Perna G, Barone Y, Miceli W. I disturbi d’ansia in gravidanza e nel postpartum. In: Giovanni Fioriti Editore s.r.l., editor. Manuale di psichiatria perinatale; 2021.

    Google Scholar 

  92. Arch JJ. Cognitive behavioral therapy and pharmacotherapy for anxiety: treatment preferences and credibility among pregnant and non-pregnant women. Behav Res Ther. 2014;52(1):53–60.

    PubMed  Google Scholar 

  93. Fordham B, Sugavanam T, Edwards K, Hemming K, Howick J, Copsey B, et al. Cognitive–behavioural therapy for a variety of conditions: an overview of systematic reviews and panoramic meta-analysis. Health Technol Assess (Rockv). 2021;25(9):1–378. https://www.journalslibrary.nihr.ac.uk/hta/hta25090

    Google Scholar 

  94. Maguire PN, Clark GI, Wootton BM. The efficacy of cognitive behavior therapy for the treatment of perinatal anxiety symptoms: a preliminary meta-analysis. J Anxiety Disord. 2018;60:26–34.

    Google Scholar 

  95. Li C, Sun X, Li Q, Sun Q, Wu B, Duan D. Role of psychotherapy on antenatal depression, anxiety, and maternal quality of life. Medicine (Baltimore). 2020;99(27):e20947. https://journals.lww.com/10.1097/MD.0000000000020947

    Google Scholar 

  96. Han Q, Guo M, Ren F, Duan D, Xu X. Role of midwife-supported psychotherapy on antenatal depression, anxiety and maternal health: a meta-analysis and literature review. Exp Ther Med. 2020;20(3):2599–610. http://www.spandidos-publications.com/10.3892/etm.2020.9011

    PubMed  PubMed Central  Google Scholar 

  97. Bright KS, Charrois EM, Mughal MK, Wajid A, McNeil D, Stuart S, et al. Interpersonal psychotherapy to reduce psychological distress in perinatal women: a systematic review. Int J Environ Res Public Health. 2020;17(22):8421. https://www.mdpi.com/1660-4601/17/22/8421

    PubMed Central  Google Scholar 

  98. Viuff A-CF, Pedersen LH, Kyng K, Staunstrup NH, Børglum A, Henriksen TB. Antidepressant medication during pregnancy and epigenetic changes in umbilical cord blood: a systematic review. Clin. Epigenetics. 2016;8(1):94. http://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-016-0262-x

    Google Scholar 

  99. Grigoriadis S, VonderPorten EH, Mamisashvili L, Eady A, Tomlinson G, Dennis C-L, et al. The effect of prenatal antidepressant exposure on neonatal adaptation: a systematic review and meta-analysis. J Clin Psychiatry. 2013;74(4):e309–20.

    PubMed  Google Scholar 

  100. Grigoriadis S, Graves L, Peer M, Mamisashvili L, Dennis C-L, Vigod SN, et al. Benzodiazepine use during pregnancy alone or in combination with an antidepressant and congenital malformations: systematic review and meta-analysis. J Clin Psychiatry. 2019;80(4)

    Google Scholar 

  101. Meltzer-Brody S. New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum. Dialogues Clin Neurosci. 2011;13(1):89–100.

    PubMed  PubMed Central  Google Scholar 

  102. Viswasam K, Eslick GD, Starcevic V. Prevalence, onset and course of anxiety disorders during pregnancy: a systematic review and meta analysis. J Affect Disord. 2019;255:27–40. http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2019-36156-006&site=ehost-live

    PubMed  Google Scholar 

  103. Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci. 2015;17(3):327–35.

    PubMed  PubMed Central  Google Scholar 

  104. Wenzel A, Haugen EN, Jackson LC, Brendle JR. Anxiety symptoms and disorders at eight weeks postpartum. J Anxiety Disord. 2005;19(3):295–311.

    PubMed  Google Scholar 

  105. Wenzel A, Haugen EN, Jackson LC, Robinson K. Prevalence of generalized anxiety at eight weeks postpartum. Arch Womens Ment Health. 2003;6(1):43–9.

    CAS  PubMed  Google Scholar 

  106. Uguz F, Yakut E, Aydogan S, Bayman MG, Gezginc K. Prevalence of mood and anxiety disorders during pregnancy: a case-control study with a large sample size. Psychiatry Res. 2019;272:316–8. http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2019-11442-047&site=ehost-live

    PubMed  Google Scholar 

  107. Uguz F, Gezginc K, Yazici F. Are major depression and generalized anxiety disorder associated with intrauterine growth restriction in pregnant women? A case-control study. Gen Hosp Psychiatry. 2011;33(6):640.e7–9. https://pubmed.ncbi.nlm.nih.gov/21749842/

    Google Scholar 

  108. Uguz F, Sonmez EO, Sahingoz M, Gokmen Z, Basaran M, Gezginc K, et al. Maternal generalized anxiety disorder during pregnancy and fetal brain development: a comparative study on cord blood brain-derived neurotrophic factor levels. J Psychosom Res. 2013;75(4):346–50. https://pubmed.ncbi.nlm.nih.gov/24119941/

    PubMed  Google Scholar 

  109. Coates R, Ayers S, de Visser R. Women’s experiences of postnatal distress: a qualitative study. BMC Pregnancy Childbirth. 2014;14(1):359. https://doi.org/10.1186/1471-2393-14-359.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Highet N, Stevenson AL, Purtell C, Coo S. Qualitative insights into women’s personal experiences of perinatal depression and anxiety. Women Birth. 2014;27(3):179–84.

    PubMed  Google Scholar 

  111. Britton JR. Maternal anxiety: course and antecedents during the early postpartum period. Depress Anxiety. 2008;25(9)

    Google Scholar 

  112. Green SM, Haber E, Frey BN, McCabe RE. Cognitive-behavioral group treatment for perinatal anxiety: a pilot study. Arch Womens Ment Health. 2015;18(4):631–8.

    PubMed  Google Scholar 

  113. Goodman JH, Guarino A, Chenausky K, Klein L, Prager J, Petersen R, et al. CALM pregnancy: results of a pilot study of mindfulness-based cognitive therapy for perinatal anxiety. Arch Womens Ment Health. 2014;17(5):373–87.

    PubMed  PubMed Central  Google Scholar 

  114. Uguz F, Ak M. Cognitive-behavioral therapy in pregnant women with generalized anxiety disorder: a retrospective cohort study on therapeutic efficacy, gestational age and birth weight. Brazilian. J Psychiatry. 2021;43(1):61–4. https://pubmed.ncbi.nlm.nih.gov/32756804/

    Google Scholar 

  115. Bérard A, Iessa N, Chaabane S, Muanda FT, Boukhris T, Zhao J-P. The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis. Br J Clin Pharmacol. 2016;81(4):589–604.

    PubMed  PubMed Central  Google Scholar 

  116. Gentile S. SSRIs in pregnancy and lactation: emphasis on neurodevelopmental outcome. CNS Drugs. 2005;19(7):623–33.

    CAS  PubMed  Google Scholar 

  117. Orsolini L, Bellantuono C. Serotonin reuptake inhibitors and breastfeeding: a systematic review. Hum Psychopharmacol. 2015;30(1):4–20.

    CAS  PubMed  Google Scholar 

  118. Drugs and Lactation Database (LactMed). Venlafaxine [Updated 2021 Feb 15]. National Library of Medicine (US); 2006 [cited 2021 Mar 20]. https://www.ncbi.nlm.nih.gov/books/NBK501192/

  119. Martini J, Beesdo-Baum K, Garthus-Niegel S, Wittchen H-U. The course of panic disorder during the peripartum period and the risk for adverse child development: a prospective-longitudinal study. J Affect Disord. 2020;266:722–30. http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2020-22174-094&site=ehost-live

    PubMed  Google Scholar 

  120. Fairbrother N, Janssen P, Antony MM, Tucker E, Young AH. Perinatal anxiety disorder prevalence and incidence. J Affect Disord. 2016;200:148–55. http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2016-28385-021&site=ehost-live

    PubMed  Google Scholar 

  121. Hertzberg T, Wahlbeck K. The impact of pregnancy and puerperium on panic disorder: a review. J Psychosom Obstet Gynaecol. 1999;20(2):59–64.

    CAS  PubMed  Google Scholar 

  122. Guler O, Koken GN, Emul M, Ozbulut O, Gecici O, Uguz F, et al. Course of panic disorder during the early postpartum period: a prospective analysis. Compr Psychiatry. 2008;49(1):30–4.

    PubMed  Google Scholar 

  123. Aydogan S, Uguz F, Yakut E, Bayman MG, Gezginc K. The course and clinical correlates of panic disorder during the postpartum period: a naturalistic observational study. Braz J Psychiatry. 2020;43:6–11. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462020005035203&tlng=en

    PubMed  PubMed Central  Google Scholar 

  124. Grassi M, Caldirola D, Di Chiaro NV, Riva A, Daccò S, Pompili M, et al. Are respiratory abnormalities specific for panic disorder? A meta-analysis. Neuropsychobiology. 2014;70(1):52–60. https://www.karger.com/Article/FullText/364830

    PubMed  Google Scholar 

  125. Grassi M, Caldirola D, Vanni G, Guerriero G, Piccinni M, Valchera A, et al. Baseline respiratory parameters in panic disorder: a meta-analysis. J Affect Disord. 2013;146(2):158–73. https://linkinghub.elsevier.com/retrieve/pii/S0165032712006052

    PubMed  Google Scholar 

  126. Caldirola D, Perna G. Toward a personalized therapy for panic disorder: preliminary considerations from a work in progress. Neuropsychiatr Dis Treat. 2019;15:1957–70. https://www.dovepress.com/toward-a-personalized-therapy-for-panic-disorder-preliminary-considera-peer-reviewed-article-NDT

    CAS  PubMed  PubMed Central  Google Scholar 

  127. Perna G, Caldirola D. Is panic disorder a disorder of physical fitness? A heuristic proposal. F1000Research. 2018;7:294. https://pubmed.ncbi.nlm.nih.gov/29623195

    PubMed  PubMed Central  Google Scholar 

  128. Kazma JM, van den Anker J, Allegaert K, Dallmann A, Ahmadzia HK. Anatomical and physiological alterations of pregnancy. J Pharmacokinet Pharmacodyn. 2020;47(4):271–85. http://link.springer.com/10.1007/s10928-020-09677-1

    PubMed  PubMed Central  Google Scholar 

  129. Hegewald MJ, Crapo RO. Respiratory physiology in pregnancy. Clin Chest Med. 2011;32(1):1–13. https://linkinghub.elsevier.com/retrieve/pii/S0272523110001322

    PubMed  Google Scholar 

  130. LoMauro A, Aliverti A. Respiratory physiology of pregnancy. Breathe. 2015;11(4):297–301. http://breathe.ersjournals.com/lookup/doi/10.1183/20734735.008615

    PubMed  PubMed Central  Google Scholar 

  131. Wenzel A, Gorman LL, O’Hara MW, Stuart S. The occurrence of panic and obsessive compulsive symptoms in women with postpartum dysphoria: a prospective study. Arch Womens Ment Health. 2001;4(1):5–12. https://doi.org/10.1007/s007370170002.

    Article  Google Scholar 

  132. Uguz F, Sahingoz M, Sonmez EO, Karsidag C, Yuksel G, Annagur BB, et al. The effects of maternal major depression, generalized anxiety disorder, and panic disorder on birth weight and gestational age: a comparative study. J Psychosom Res. 2013;75(1):87–9.

    PubMed  Google Scholar 

  133. Matthey S, Barnett B, Howie P, Kavanagh DJ. Diagnosing postpartum depression in mothers and fathers: whatever happened to anxiety? J Affect Disord. 2003;74(2):139–47. https://linkinghub.elsevier.com/retrieve/pii/S0165032702000125

    PubMed  Google Scholar 

  134. Robinson L, Walker JR, Anderson D. Cognitive-behavioural treatment of panic disorder during pregnancy and lactation. Can J Psychiatr. 1992;37(9):623–6.

    CAS  Google Scholar 

  135. Matsumoto K, Sato K, Hamatani S, Shirayama Y, Shimizu E. Cognitive behavioral therapy for postpartum panic disorder: a case series. BMC Psychol. 2019;7(1):53. https://pubmed.ncbi.nlm.nih.gov/31439043

    PubMed  PubMed Central  Google Scholar 

  136. Uguz F. Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases. J Matern Neonatal Med. 2013;26(11):1066–8. http://www.tandfonline.com/doi/full/10.3109/14767058.2013.766697

    CAS  Google Scholar 

  137. Gentile S. Use of escitalopram during pregnancy navigating towards international guidelines and the real world. Clin Drug Investig. 2008;28(11):735–9. https://doi.org/10.2165/00044011-200828110-00006.

    Article  CAS  PubMed  Google Scholar 

  138. Nascimento I, Lopes FL, Valença AM, Mezzasalma MA, Nardi AE. Transtorno do pânico e gravidez. Rev Bras Psiquiatr. 2004;26(3):211–2. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462004000300013&lng=pt&tlng=pt

    PubMed  Google Scholar 

  139. Uguz F, Akman C, Kaya N, Sahingoz M, Cilli AS. One year follow-up of postpartum-onset obsessive–compulsive disorder: a case series. Prog Neuro-Psychopharmacol Biol Psychiatry. 2008;32(4):1091–2. https://linkinghub.elsevier.com/retrieve/pii/S0278584608000808

    Google Scholar 

  140. Ware MR, DeVane CL. Imipramine treatment of panic disorder during pregnancy. J Clin Psychiatry. 1990;51(11):482–4.

    CAS  PubMed  Google Scholar 

  141. Goodman JH, Chenausky KL, Freeman MP. Anxiety disorders during pregnancy: a systematic review. J Clin Psychiatry. 2014;75:e1153–84. https://pubmed.ncbi.nlm.nih.gov/25373126/

    PubMed  Google Scholar 

  142. Nath S, Busuulwa P, Ryan EG, Challacombe FL, Howard LM. The characteristics and prevalence of phobias in pregnancy. Midwifery. 2020;82:102590. https://doi.org/10.1016/j.midw.2019.102590.

    Article  PubMed  Google Scholar 

  143. Patel RR, Hollins K. Clinical report: the joint obstetric and psychiatric management of phobic anxiety disorders in pregnancy. J Psychosom Obstet Gynecol. 2015;36(1):10–4. http://www.tandfonline.com/doi/full/10.3109/0167482X.2014.993312

    Google Scholar 

  144. Demšar K, Svetina M, Verdenik I, Tul N, Blickstein I, Velikonja VG. Tokophobia (fear of childbirth): prevalence and risk factors. J Perinat Med. 2018;46(2):151–4.

    PubMed  Google Scholar 

  145. Hofberg K, Ward MR. Fear of childbirth, tocophobia, and mental health in mothers: the obstetric–psychiatric interface. Clin Obstet Gynecol. 2004;47(3):527–34. http://journals.lww.com/00003081-200409000-00006

    PubMed  Google Scholar 

  146. Goodman JH, Chenausky KL, Freeman MP. Anxiety disorders during pregnancy. J Clin Psychiatry. 2014;75(10):e1153–84. http://www.psychiatrist.com/jcp/article/pages/2014/v75n10/v75n1018.aspx

    PubMed  Google Scholar 

  147. Lilliecreutz C, Sydsjö G, Josefsson A. Obstetric and perinatal outcomes among women with blood- and injection phobia during pregnancy. J Affect Disord. 2011;129(1–3):289–95. https://linkinghub.elsevier.com/retrieve/pii/S0165032710005471

    PubMed  Google Scholar 

  148. Lilliecreutz C, Josefsson A, Sydsjö G. An open trial with cognitive behavioral therapy for blood- and injection phobia in pregnant women - a group intervention program. Arch Womens Ment Health. 2010;13(3):259–65. https://pubmed.ncbi.nlm.nih.gov/19859788/

    PubMed  Google Scholar 

  149. Stoll K, Swift EM, Fairbrother N, Nethery E, Janssen P. A systematic review of nonpharmacological prenatal interventions for pregnancy-specific anxiety and fear of childbirth. Birth. 2018;45(1):7–18. https://doi.org/10.1111/birt.12316.

    Article  PubMed  Google Scholar 

  150. Rose GM, Tadi P. Social anxiety disorder. StatPearls. 2021. http://www.ncbi.nlm.nih.gov/pubmed/32310350

  151. Viswasam K, Berle D, Milicevic D, Starcevic V. Prevalence and onset of anxiety and related disorders throughout pregnancy: a prospective study in an Australian sample. Psychiatry Res. 2020;2021(297):113721. https://doi.org/10.1016/j.psychres.2021.113721.

    Article  Google Scholar 

  152. Mauri M, Oppo A, Montagnani MS, Borri C, Banti S, Camilleri V, et al. Beyond “postpartum depressions”: specific anxiety diagnoses during pregnancy predict different outcomes. J Affect Disord. 2010;127(1–3):177–84. https://doi.org/10.1016/j.jad.2010.05.015.

    Article  PubMed  Google Scholar 

  153. Coelho HF, Murray L, Royal-Lawson M, Cooper PJ. Antenatal anxiety disorder as a predictor of postnatal depression: a longitudinal study. J Affect Disord. 2011;129(1–3):348–53. https://doi.org/10.1016/j.jad.2010.08.002.

    Article  PubMed  Google Scholar 

  154. Staneva A, Bogossian F, Pritchard M, Wittkowski A. The effects of maternal depression, anxiety, and perceived stress during pregnancy on preterm birth: a systematic review. Women Birth. 2015;28(3):179–93. https://linkinghub.elsevier.com/retrieve/pii/S187151921500030X

    PubMed  Google Scholar 

  155. Avraham L, Tamar W, Eyal S, Gali P. Perinatal outcomes and offspring long-term neuropsychiatric hospitalizations of mothers with anxiety disorder. Arch Womens Ment Health. 2020;23(5):681–8. http://link.springer.com/10.1007/s00737-020-01018-y

    PubMed  Google Scholar 

  156. Martini J, Knappe S, Beesdo-Baum K, Lieb R, Wittchen H-U. Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes. Early Hum Dev. 2010;86(5):305–10.

    PubMed  Google Scholar 

  157. Chen Y-H, Lin H-C, Lee H-C. Pregnancy outcomes among women with panic disorder — do panic attacks during pregnancy matter? J Affect Disord. 2010;120(1–3):258–62. https://linkinghub.elsevier.com/retrieve/pii/S0165032709001797

    PubMed  Google Scholar 

  158. Kendig S, Keats JP, Hoffman MC, Kay LB, Miller ES, Moore Simas TA, et al. Consensus bundle on maternal mental health. Obstet Gynecol. 2017;129(3):422–30. https://journals.lww.com/00006250-201703000-00004

    PubMed  PubMed Central  Google Scholar 

  159. Stein A, Craske MG, Lehtonen A, Harvey A, Savage-McGlynn E, Davies B, et al. Maternal cognitions and mother–infant interaction in postnatal depression and generalized anxiety disorder. Vol. 121, Journal of Abnormal Psychology. Stein, Alan: Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom, OX3 7JX, : American Psychological Association; 2012. p. 795–809.

    Google Scholar 

  160. Tietz A, Zietlow A-L, Reck C. Maternal bonding in mothers with postpartum anxiety disorder: the crucial role of subclinical depressive symptoms and maternal avoidance behaviour. Arch Womens Ment Health. 2014;17(5):433–42. https://doi.org/10.1007/s00737-014-0423-x.

    Article  CAS  PubMed  Google Scholar 

  161. Dagla M, Mrvoljak-Theodoropoulou I, Karagianni D, Dagla C, Sotiropoulou D, Kontiza E, et al. Women’s mental health as a factor associated with exclusive breastfeeding and breastfeeding duration: data from a longitudinal study in Greece. Children. 2021;8(2):150. https://www.mdpi.com/2227-9067/8/2/150

    PubMed  PubMed Central  Google Scholar 

  162. Coo S, García MI, Mira A, Valdés V. The role of perinatal anxiety and depression in breastfeeding practices. Breastfeed Med. 2020;15(8):495–500. https://www.liebertpub.com/doi/10.1089/bfm.2020.0091

    PubMed  Google Scholar 

  163. Field T. Postnatal anxiety prevalence, predictors and effects on development: a narrative review. Infant Behav Dev. 2018;51:24–32. https://linkinghub.elsevier.com/retrieve/pii/S0163638317302357

    PubMed  Google Scholar 

  164. Fallon V, Groves R, Halford JCG, Bennett KM, Harrold JA. Postpartum anxiety and infant-feeding outcomes. J Hum Lact. 2016;32(4):740–58. http://journals.sagepub.com/doi/10.1177/0890334416662241

    PubMed  Google Scholar 

  165. Teissedre F, Chabol H. Postnatal depression: a study of the predictive effects of postnatal anxiety. Ir J Psychol Med. 2003;20(4):111–4. https://www.cambridge.org/core/product/identifier/S0790966700007898/type/journal_article

    PubMed  Google Scholar 

  166. Farias DR, Pinto TDJP, Teofilo MMA, Vilela AAF, dos Santos Vaz J, Nardi AE, et al. Prevalence of psychiatric disorders in the first trimester of pregnancy and factors associated with current suicide risk. Psychiatry Res. 2013;210(3):962–8. https://linkinghub.elsevier.com/retrieve/pii/S0165178113005131

    PubMed  Google Scholar 

  167. Andersson NW, Hansen MV, Larsen AD, Hougaard KS, Kolstad HA, Schlünssen V. Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies. Allergy. 2016;71(1):15–26. https://onlinelibrary.wiley.com/doi/10.1111/all.12762

    CAS  PubMed  Google Scholar 

  168. Gilles M, Otto H, Wolf IAC, Scharnholz B, Peus V, Schredl M, et al. Maternal hypothalamus-pituitary-adrenal (HPA) system activity and stress during pregnancy: effects on gestational age and infant’s anthropometric measures at birth. Psychoneuroendocrinology. 2018;94:152–61. https://linkinghub.elsevier.com/retrieve/pii/S0306453017313070

    CAS  PubMed  Google Scholar 

  169. Reck C, Müller M, Tietz A, Möhler E. Infant distress to novelty is associated with maternal anxiety disorder and especially with maternal avoidance behavior. J Anxiety Disord. 2013;27(4):404–12. https://www.sciencedirect.com/science/article/pii/S0887618513000558

    PubMed  Google Scholar 

  170. Jover M, Colomer J, Carot JM, Larsson C, Bobes MT, Ivorra JL, et al. Maternal anxiety following delivery, early infant temperament and mother’s confidence in caregiving. Span J Psychol. 2014;17

    Google Scholar 

  171. Field CD. A short walk through some Chinese mangroves. Wetl Aust. 2010;5(1):1. https://wetlandsaustralia.com/article/10.31646/wa.203/

    Google Scholar 

  172. Ali NS, Mahmud S, Khan A, Ali BS. Impact of postpartum anxiety and depression on child’s mental development from two peri-urban communities of Karachi, Pakistan: a quasi-experimental study. BMC Psychiatry. 2013;13(1):274. https://doi.org/10.1186/1471-244X-13-274.

    Article  PubMed  PubMed Central  Google Scholar 

  173. Barker ED, Jaffee SR, Uher R, Maughan B. The contribution of prenatal and postnatal maternal anxiety and depression to child maladjustment. Depress Anxiety. 2011;28(8):696–702. https://onlinelibrary.wiley.com/doi/abs/10.1002/da.20856

    PubMed  Google Scholar 

  174. Clout D, Brown R. Sociodemographic, pregnancy, obstetric, and postnatal predictors of postpartum stress, anxiety and depression in new mothers. J Affect Disord. 2015;188:60–7. https://www.sciencedirect.com/science/article/pii/S0165032715305966

    PubMed  Google Scholar 

  175. Grizenko N, Shayan YR, Polotskaia A, Ter-Stepanian M, Joober R. Relation of maternal stress during pregnancy to symptom severity and response to treatment in children with ADHD. J Psychiatry Neurosci. 2008;33(1):10–6. https://pubmed.ncbi.nlm.nih.gov/18197267

    PubMed  PubMed Central  Google Scholar 

  176. Grizenko N, Fortier M-E, Zadorozny C, Thakur G, Schmitz N, Duval R, et al. Maternal stress during pregnancy, ADHD symptomatology in children and genotype: gene-environment interaction. J Can Acad Child Adolesc Psychiatry. 2012;21(1):9–15. https://pubmed.ncbi.nlm.nih.gov/22299010

    PubMed  PubMed Central  Google Scholar 

  177. Mughal MK, Giallo R, Arnold P, Benzies K, Kehler H, Bright K, et al. Trajectories of maternal stress and anxiety from pregnancy to three years and child development at 3 years of age: findings from the all our families (AOF) pregnancy cohort. J Affect Disord. 2018;234:318–26.

    PubMed  Google Scholar 

  178. Kingston D, Kehler H, Austin M-P, Mughal MK, Wajid A, Vermeyden L, et al. Trajectories of maternal depressive symptoms during pregnancy and the first 12 months postpartum and child externalizing and internalizing behavior at three years. PLoS One. 2018;13(4):e0195365. https://pubmed.ncbi.nlm.nih.gov/29652937

    PubMed  PubMed Central  Google Scholar 

  179. O’Connor TG, Heron J, Glover V. Antenatal anxiety predicts child behavioral/emotional problems independently of postnatal depression. J Am Acad Child Adolesc Psychiatry. 2002;41(12):1470–7. https://pubmed.ncbi.nlm.nih.gov/12447034/

    PubMed  Google Scholar 

  180. Dugan AM, Parrott JM, Redus L, Hensler JG, O’Connor JC. Low-level stress induces production of neuroprotective factors in wild-type but not BDNF +/− mice: interleukin-10 and kynurenic acid. Int J Neuropsychopharmacol. 2016;19(3):pyv089. https://academic.oup.com/ijnp/article-lookup/doi/10.1093/ijnp/pyv089

    Google Scholar 

  181. Adamson B, Letourneau N, Lebel C. Prenatal maternal anxiety and children’s brain structure and function: a systematic review of neuroimaging studies. J Affect Disord. 2018;241:117–26. https://linkinghub.elsevier.com/retrieve/pii/S0165032718311340

    PubMed  Google Scholar 

  182. Alder J, Fink N, Bitzer J, Hösli I, Holzgreve W. Depression and anxiety during pregnancy: a risk factor for obstetric, fetal and neonatal outcome? A critical review of the literature. J Matern Neonatal Med. 2007;20(3):189–209. https://doi.org/10.1080/14767050701209560.

    Article  Google Scholar 

  183. Ruiz-Padial E, Sollers JJ, Vila J, Thayer JF. The rhythm of the heart in the blink of an eye: emotion-modulated startle magnitude covaries with heart rate variability. Psychophysiology. 2003;40(2):306–13. https://doi.org/10.1111/1469-8986.00032.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neuroscience and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Ylenia Barone

  2. Department of Biological Sciences, Humanitas University, Milan, Italy

    Francesco Cuniberti & Giampaolo Perna

  3. Department of Clinical Neurosciences, Villa San Benedetto Menni, Hermanas Hospitalarias, Como, Italy

    Francesco Cuniberti & Giampaolo Perna

  4. Personalized Medicine Center for Anxiety and Panic Disorders, Humanitas SanPio X, Milan, Italy

    Francesco Cuniberti & Giampaolo Perna

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  1. Ylenia Barone
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  3. Giampaolo Perna
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Editors and Affiliations

  1. Department of Mental Health and Addiction Services, Niguarda Hospital, Milan, Italy

    Mauro Percudani

  2. Policentro Donna Ambulatory, Italian Marcé Society, Milan, Italy

    Alessandra Bramante

  3. Department of Mental Health and Addiction Services, Niguarda Hospital, Italian Marcé Society, Milan, Italy

    Valeria Brenna

  4. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

    Carmine Pariante

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Barone, Y., Cuniberti, F., Perna, G. (2022). Anxiety Disorders. In: Percudani, M., Bramante, A., Brenna, V., Pariante, C. (eds) Key Topics in Perinatal Mental Health. Springer, Cham. https://doi.org/10.1007/978-3-030-91832-3_4

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