Tumor: Stroma Interaction and Cancer

Rogers, Michael P.; Mi, Zhiyong; Li, Neill Y.; Wai, Philip Y.; Kuo, Paul C.

doi:10.1007/978-3-030-91311-3_2

Michael P. Rogers³,
Zhiyong Mi³,
Neill Y. Li³,
Philip Y. Wai³ &
…
Paul C. Kuo³

Part of the book series: Experientia Supplementum ((EXS,volume 113))

1267 Accesses
1 Citations

Abstract

The understanding of how normal cells transform into tumor cells and progress to invasive cancer and metastases continues to evolve. The tumor mass is comprised of a heterogeneous population of cells that include recruited host immune cells, stromal cells, matrix components, and endothelial cells. This tumor microenvironment plays a fundamental role in the acquisition of hallmark traits, and has been the intense focus of current research. A key regulatory mechanism triggered by these tumor–stroma interactions includes processes that resemble epithelial–mesenchymal transition, a physiologic program that allows a polarized epithelial cell to undergo biochemical and cellular changes and adopt mesenchymal cell characteristics. These cellular adaptations facilitate enhanced migratory capacity, invasiveness, elevated resistance to apoptosis, and greatly increased production of ECM components. Indeed, it has been postulated that cancer cells undergo epithelial–mesenchymal transition to invade and metastasize.

In the following discussion, the physiology of chronic inflammation, wound healing, fibrosis, and tumor invasion will be explored. The key regulatory cytokines, transforming growth factor β and osteopontin, and their roles in cancer metastasis will be highlighted.

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Abbreviations

bFGF:: Basic fibroblast growth factor
BM:: Basement membrane
BSP:: Bone sialoprotein
CAF:: Cancer-associated fibroblasts
CDE:: Cancer-associated fibroblast-derived exosome
CSC:: Cancer stem cell
CSF-1:: Colony-stimulating factor
DMP1:: Dentin matrix protein 1
DSPP:: Dentin sialoprotein
ECM:: Extracellular matrix
EGF:: Epidermal growth factor
EMT:: Epithelial–mesenchymal transition
GAG:: Glycosaminoglycan
GM-CSF:: Granulocyte–macrophage colony-stimulating factor
HCC:: Hepatocellular carcinoma
HCV:: Hepatitis C virus
Hh:: Hedgehog
HSC:: Hepatic stellate cells
IFN:: Interferon
IL:: Interleukin
LEF:: Lymphoid enhancer factor
LLC:: Large latency complex
LOX:: Lysyl oxidase
LPS:: Lipopolysaccharide
MAPK:: Mitogen-activated protein kinase
MDCK:: Madin–Darby canine kidney
MDSC:: Myeloid-derived suppressor cell
MEPE:: Matrix extracellular phosphoglycoprotein
MET:: Mesenchymal–epithelial transition
MHC:: Major histocompatibility complex
MIF:: Macrophage migration inhibitory factor
miR:: microRNA
MSC:: Mesenchymal stem cell
NK:: Natural killer
OPN:: Osteopontin
PDGF:: Platelet-derived growth factor
PMA:: Phorbol 12-myristate 13-acetate
SIBLING:: Small integrin-binding ligand N-linked glycoprotein
TAM:: Tumor-associated macrophages
TGF-β:: Transforming growth factor
TME:: Tumor microenvironment
TNF:: Tumor necrosis factor
UUO:: Unilateral ureteral obstruction
VEGF:: Vascular endothelial growth factor

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Department of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Michael P. Rogers, Zhiyong Mi, Neill Y. Li, Philip Y. Wai & Paul C. Kuo

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Neill Y. Li
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Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
Magdalena Klink
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Izabela Szulc-Kielbik

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Rogers, M.P., Mi, Z., Li, N.Y., Wai, P.Y., Kuo, P.C. (2022). Tumor: Stroma Interaction and Cancer. In: Klink, M., Szulc-Kielbik, I. (eds) Interaction of Immune and Cancer Cells. Experientia Supplementum, vol 113. Springer, Cham. https://doi.org/10.1007/978-3-030-91311-3_2

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