Abstract
Bacillus Calmette–Guérin (BCG) immunotherapy has shown significant success for bladder cancer treatment, but due to the lack of personalization, it does not fulfill its full promise as the interaction between immunity and cancer varies significantly between patients and results in extremely different clinical outcomes. As personalized treatment developed, it is important to take into consideration the geometrical configuration of the bladder in order to get realistic results using spatio-temporal treatment models.
We present an extension to the model proposed by Lazebnik et al. [9] by improving the approximation of the bladder’s geometry from sphere-ring to ellipsoid-ring [8]. We show the differences between the models on the clinical results and their influence on the optimal treatment protocol.
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References
Bhattacharya, S., Sah, P.P., Banerjee, A., Ray, S.: Structural impact due to PPQEE deletion in multiple cancer associated protein - integrin V: an in silico exploration. Biosystems 98, 104216 (2020)
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L., Jemal, A.: Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Cling. 68(2), 394–424 (2018)
Eylert, M., et al.: Falling bladder cancer incidence from 1990 to 2009 is not producing universal mortality improvements. J. Clin. Urol. 7(2), 90–98 (2014)
Fridman, A., Kao, C.: Mathematical modeling of biological processs. Lecture Notes on Mathematical Modeling in the Life Sciences (2014)
Fullstone, G., Wood, J., Holcombe, M., Battaglia, G.: Modelling the transport of nanoparticles under blood flow using an agent-based approach. Sci. Rep. 5, 10649 (2015)
Guzev, E., Halachmi, S., Bunimovich-Mendrazitsky, S.: Additional extension of the mathematical model for BCG immunotherapy of bladder cancer and its validation by auxiliary tools. Int. J. Nonlinear Sci. Num.l Simul. 20, 675–689 (2019)
Herr, H.W., et al.: Bacillus calmette-Guérin therapy alters the progression of superficial bladder cancer. J. Clin. Oncol. 6, 1450–1455 (1988)
Kristiansen, N.K., Ringgaard, S., Nygaard, H., Djurhuus, J.C.: Effect of bladder volume, gender and body position on the shape and position of the urinary bladder. Scand. J. Urol. Nephrol. 38, 462–468 (2004)
Lazebnik, T., Bunimovich-Mendrazitsky, S., Haroni, N.: PDE based geometry model for BCG immunotherapy of bladder cancer. Biosystems 200, 104319 (2021)
Lazebnik, T., Yanetz, S., Bunimovich-Mendrazitsky, S., Haroni, N.: Treatment of bladder cancer using BCG immunotherapy: PDE modeling. Partial Diff. Equ. 26, 203–219 (2020)
Morales, A., Eidinger, D., Bruce, A.: Intracavity Bacillus Calmette-Guérin in the treatment of superficial bladder tumors. J. Urol. 116, 180–183 (1976)
Paterson, D., Patel, A.: Bactillus Calmette-Guerin (BCG) immunotherapy for bladder cancer: review of complications and their treatment. Aust. NZJ Surg. 68, 340–344 (1998)
Schöneberg, J., Ullrich, A., Noé, F.: Simulation tools for particle-based reaction-diffusion dynamics in continuous space. BMC Biophys 7(11) (2014)
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Lazebnik, T., Bunimovich-Mendrazitsky, S. (2021). Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model. In: Bebis, G., Gaasterland, T., Kato, M., Kohandel, M., Wilkie, K. (eds) Mathematical and Computational Oncology. ISMCO 2021. Lecture Notes in Computer Science(), vol 13060. Springer, Cham. https://doi.org/10.1007/978-3-030-91241-3_6
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DOI: https://doi.org/10.1007/978-3-030-91241-3_6
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