Abstract
The challenge of treating glenohumeral arthritis in the young patient often leads to a pause in the consideration of surgical management. As such, various injection options are often offered as a first or even second level of treatment for symptomatic patients. Various options for injections exist with the most traditional of options being corticosteroid injections. More recent options include hyaluronic acid as a form of viscosupplementation or even the still developing options of platelet-rich plasma or stem cell injections. Regardless of the choice, patients must be aware that these options are helpful in treating symptoms but do not alter the development of further arthritis in the shoulder. In addition, these injection options often have the law of diminishing returns with their use becoming less effective over time. Good clinical and patient-reported outcomes have been demonstrated in the literature in young patients, as well as in patients with more severe forms of glenohumeral arthritis. Patients often report decreased pain and, subsequently, greater function. However, the science of these newer injections continues to evolve, and further large randomized trials remain necessary to determine their long-term effectiveness.
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References
Barlow JD, Abboud J. Surgical options for the young patient with glenohumeral arthritis. Int J Shoulder Surg. 2016;10(1):28–36.
Denard PJ, Wirth MA, Orfaly RM. Management of glenohumeral arthritis in the young adult. J Bone Joint Surg Am. 2011;93(9):885–92.
Ansok CB, Muh SJ. Optimal management of glenohumeral osteoarthritis. Orthop Res Rev. 2018;10:9–18.
Strauss EJ, Hart JA, Miller MD, Altman RD, Rosen JE. Hyaluronic acid viscosupplementation and osteoarthritis: current uses and future directions. Am J Sports Med. 2009;37(8):1636–44.
Gross C, Dhawan A, Harwood D, Gochanour E, Romeo A. Glenohumeral joint injections: a review. Sports Health. 2013;5(2):153–9.
van der Meijden OA, Gaskill TR, Millett PJ. Glenohumeral joint preservation: a review of management options for young, active patients with osteoarthritis. Adv Orthop. 2012;2012:160923.
Izquierdo R, Voloshin I, Edwards S, Freehill MQ, Stanwood W, Michael Wiater J, et al. Treatment of glenohumeral osteoarthritis. J Am Acad Orthop Surg. 2010;18(6):375–82.
Buchbinder R, Green S, Youd JM. Corticosteroid injections for shoulder pain. Cochrane Database Syst Rev. 2003;2003(1):CD004016.
Merolla G, Sperling JW, Paladini P, Porcellini G. Efficacy of Hylan G-F 20 versus 6-methylprednisolone acetate in painful shoulder osteoarthritis: a retrospective controlled trial. Musculoskelet Surg. 2011;95(3):215–24.
Bellamy N, Campbell J, Welch V, Gee TL, Bourne R, Wells GA. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006;(2):CD005328.
Wernecke C, Braun HJ, Dragoo JL. The effect of intra-articular corticosteroids on articular cartilage: a systematic review. Orthop J Sports Med. 2015;3(5):2325967115581163.
Dragoo JL, Danial CM, Braun HJ, Pouliot MA, Kim HJ. The chondrotoxicity of single-dose corticosteroids. Knee Surg Sports Traumatol Arthrosc. 2012;20(9):1809–14.
Braun HJ, Wilcox-Fogel N, Kim HJ, Pouliot MA, Harris AHS, Dragoo JL. The effect of local anesthetic and corticosteroid combinations on chondrocyte viability. Knee Surg Sports Traumatol Arthrosc. 2012;20(9):1689–95.
Brockmeier SF, Shaffer BS. Viscosupplementation therapy for osteoarthritis. Sports Med Arthrosc Rev. 2006;14(3):155–62.
Conduah AH, Baker CL, Baker CL. Managing joint pain in osteoarthritis: safety and efficacy of hylan G-F 20. J Pain Res. 2009;2:87–98.
Moreland LW. Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther. 2003;5(2):54–67.
Zhang B, Thayaparan A, Horner N, Bedi A, Alolabi B, Khan M. Outcomes of hyaluronic acid injections for glenohumeral osteoarthritis: a systematic review and meta-analysis. J Shoulder Elb Surg. 2019;28(3):596–606.
Abate M, Pulcini D, Iorio A, Schiavone C. Viscosupplementation with intra-articular hyaluronic acid for treatment of osteoarthritis in the elderly. Curr Pharm Des. 2010;16(6):631–40.
Peyron JG, Balazs EA. Preliminary clinical assessment of Na-hyaluronate injection into human arthritic joints. Pathol Biol. 1974;22(8):731–6.
Watterson JR, Esdaile JM. Viscosupplementation: therapeutic mechanisms and clinical potential in osteoarthritis of the knee. J Am Acad Orthop Surg. 2000;8(5):277–84.
Silverstein E, Leger R, Shea KP. The use of intra-articular hylan G-F 20 in the treatment of symptomatic osteoarthritis of the shoulder: a preliminary study. Am J Sports Med. 2007;35(6):979–85.
Bowman S, Awad ME, Hamrick MW, Hunter M, Fulzele S. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin Transl Med. 2018;7:6.
Weick JW, Bawa HS, Dirschl DR. Hyaluronic acid injections for treatment of advanced osteoarthritis of the knee: utilization and cost in a national population sample. J Bone Joint Surg (Am Vol). 2016;98(17):1429–35.
Sánchez M, Anitua E, Azofra J, Aguirre JJ, Andia I. Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol. 2008;26(5):910–3.
McArthur BA, Dy CJ, Fabricant PD, Gonzalez Della Valle A. Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee. Patient Prefer Adherence. 2012;6:905–10.
Cole BJ, Karas V, Hussey K, Pilz K, Fortier LA. Hyaluronic acid versus platelet-rich plasma. Am J Sports Med. 2017;47(2):347–54.
Freitag J. The effect of photoactivated platelet-rich plasma injections in the novel treatment of shoulder osteoarthritis. Int J Case Rep Images. 2014;5(8):546.
Patel S, Dhillon MS, Aggarwal S, Marwaha N, Jain A. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis. Am J Sports Med. 2013;41(2):356–64.
Dai WL, Zhou AG, Zhang H, Zhang J. Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials. Arthroscopy. 2017;33(3):659–70.
Shen L, Yuan T, Chen S, Xie X, Zhang C. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res. 2017;12:16.
Pas HI, Winters M, Haisma HJ, Koenis MJ, Tol JL, Moen MH. Stem cell injections in knee osteoarthritis: a systematic review of the literature. Br J Sports Med. 2017;51(15):1125–33.
Jo CH, Chai JW, Jeong EC, Oh S, Kim PS, Yoon JY, et al. Intratendinous injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of rotator cuff disease: a first-in-human trial. Stem Cells. 2018;36(9):1441–50.
Jones IA, Chen X, Evseenko D, Vangsness CT. Nomenclature inconsistency and selective outcome reporting hinder understanding of stem cell therapy for the knee. J Bone Joint Surg Am. 2019;101(2):186–95.
Carr JB, Rodeo SA. The role of biologic agents in the management of common shoulder pathologies: current state and future directions. J Shoulder Elb Surg. 2019;28(11):2041–52.
Centeno CJ, Al-Sayegh H, Bashir J, Goodyear SH, Freeman D, M. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. J Pain Res. 2015;8:269–76.
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Horneff, J.G., Lu, J. (2022). Injection Therapies for Glenohumeral Osteoarthritis in the Young Patient. In: Grawe, B.M., Horneff III, J.G., Abboud, J.A. (eds) Glenohumeral Osteoarthritis in the Young Patient. Springer, Cham. https://doi.org/10.1007/978-3-030-91190-4_5
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DOI: https://doi.org/10.1007/978-3-030-91190-4_5
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