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Single-Molecule Ionic and Optical Sensing with Nanoapertures

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Single Molecule Sensing Beyond Fluorescence

Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

Solid-state nanoapertures (nanometer sized holes within a membrane) allow for the interrogation of single molecules by probing them within their nanoscale volume through which molecules pass in a single-file manner. Molecules are probed using two main techniques: ionic sensing where a salt solution and applied voltage is used to produce an ionic current through the nanopore, and optical sensing through a shift in the resonance wavelength of the plasmonic nanoaperture. Here, we briefly review the basic principles, applications, and challenges in sensing with solid-state nanoapertures, as well as some strategies for further improvements. We compare the complimentary features of the two approaches and highlight recent attempts to combine them into new sensing platforms.

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Acknowledgements

We would like to thank Alessio Fragasso, Xin Shi and Sonja Schmid for fruitful discussions. C.D would like to acknowledge funding from ERC grant SynDiv 669598 and the Netherlands Organization for Scientific Research (NWO/OCW) as part of the Frontiers of Nanoscience and Basyc programs.

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  1. Kavli Institute of Nanoscience, Delft University of Technology, Delft, The Netherlands

    Wayne Yang & Cees Dekker

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  1. Wayne Yang
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Correspondence to Cees Dekker .

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  1. School of Mathematics and Physics, University of Queensland, Brisbane, QLD, Australia

    Warwick Bowen

  2. Department of Physics and Astronomy, University of Exeter, Exeter, UK

    Frank Vollmer

  3. Department of Computer and Electrical Engineering, University of Victoria, Victoria, BC, Canada

    Reuven Gordon

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Yang, W., Dekker, C. (2022). Single-Molecule Ionic and Optical Sensing with Nanoapertures. In: Bowen, W., Vollmer, F., Gordon, R. (eds) Single Molecule Sensing Beyond Fluorescence . Nanostructure Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-90339-8_12

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