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Interferometric Biosensing

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Single Molecule Sensing Beyond Fluorescence

Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

Interferometric biosensors characterise biological specimens via the effects they have on the interference between two optical fields. Generally, one field is arranged to interact with the specimen, perhaps propagating through it and incurring a phase shift, or scattering from it. Interference with the second field can both allow phase shifts to be resolved, and amplify weak scattering signals to measurable levels. While widely used in biological imaging, recent experiments have shown that interferometric sensors are also capable of probing the size and dynamics of single protein molecules. This chapter reviews this recent progress, outlines the concepts and techniques involved, and discusses areas in which such single-molecule interferometric biosensors have been applied.

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Notes

  1. 1.

    This is the state of a laser free of technical noise and without any quantum correlations between photons.

  2. 2.

    \(Var[X](f)=\int _{f-\mathrm{RBW}/2}^{f+\mathrm{RBW}/2}|X(f')|^2df'\) whith RBW the resolution bandwidth.

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Authors and Affiliations

  1. School of Mathematics and Physics, The University of Queensland, Brisbane, Australia

    Nicolas P. Mauranyapin, Larnii Booth, Igor Marinkovic & Warwick P. Bowen

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  1. Nicolas P. Mauranyapin
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  2. Larnii Booth
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  3. Igor Marinkovic
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  4. Warwick P. Bowen
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Correspondence to Nicolas P. Mauranyapin .

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Editors and Affiliations

  1. School of Mathematics and Physics, University of Queensland, Brisbane, QLD, Australia

    Warwick Bowen

  2. Department of Physics and Astronomy, University of Exeter, Exeter, UK

    Frank Vollmer

  3. Department of Computer and Electrical Engineering, University of Victoria, Victoria, BC, Canada

    Reuven Gordon

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Mauranyapin, N.P., Booth, L., Marinkovic, I., Bowen, W.P. (2022). Interferometric Biosensing. In: Bowen, W., Vollmer, F., Gordon, R. (eds) Single Molecule Sensing Beyond Fluorescence . Nanostructure Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-90339-8_1

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