Abstract
A non-steroidal anti-inflammatory drug ketoprofen (2-(3-benzoylphenyl)propanoic acid) is one of the most commonly found pharmaceuticals in the environment. The ability of Rhodococcus erythropolis IEGM 746 to decompose 100 mg/L ketoprofen was revealed. The strain IEGM 746 co-metabolized 38% of the initial ketoprofen level for 14 days in the presence of 0.1% n-hexadecane. The metabolic activity of rhodococci during KTP bioconversion was evaluated. The toxicity of ketoprofen towards rhodococci was manifested in the increased number of dead cells and in a change in cell size and reduction in the cell–ketoprofen contact area. R. erythropolis IEGM 746 might be a good biocatalyst for the innovative bioremediation of wastewater containing pharmaceutical residues.
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Acknowledgments
The study was fulfilled under the State Assignment (AAAA-A19-119112290008-4, AAAA-A19-119031890083-9) and supported by the Russian Science Foundation grant (21-14-00132) and the scholarship of the President of the Russian Federation. The authors thank Grigory G. Glebov, a Ph.D. student, Perm Federal Research Center Ural Branch Russian Academy of Sciences (PFRC UB RAS), for his assistance in providing the AFM/CLSM data. The work was carried out using the equipment of The Core Facilities Center “Research of materials and matter” at PFRC UB RAS.
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Bazhutin, G.A., Polygalov, M.A., Tyumina, E.A., Tyan, S.M., Ivshina, I.B. (2022). Cometabolic Bioconversion of Ketoprofen by Rhodococcus erythropolis IEGM 746. In: Rocha, A., Isaeva, E. (eds) Science and Global Challenges of the 21st Century - Science and Technology. Perm Forum 2021. Lecture Notes in Networks and Systems, vol 342. Springer, Cham. https://doi.org/10.1007/978-3-030-89477-1_40
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