Skip to main content

Complementary and Alternative Therapies

  • Chapter
  • First Online:
Handbook of Autism and Pervasive Developmental Disorder

Part of the book series: Autism and Child Psychopathology Series ((ACPS))

  • 2954 Accesses

Abstract

In recent years, complementary and alternative medicine has gained significant popularity among people with autism spectrum disorders and their families. However, information concerning the use of unconventional therapies is often not disclosed to physicians, thus, preventing shared and educated decision-making concerning treatment options. While many complementary and alternative therapies seem to have a good safety profile, evidence regarding their efficacy is often missing. In this chapter, we review current knowledge of complementary and alternative therapies that are most used in autism spectrum disorders, including nutritional interventions, acupuncture, massage therapy, and mind-body interventions. Results and methodologies from recent studies, systematic reviews and meta-analyses are presented and discussed in the light of a Western scientific framework. While no conclusive evidence currently supports the use of complementary and alternative medicine in autism, we encourage practitioners to discuss with families the opportunity to implement practices that are safe, available and accessible in addition to standard treatment, as these could improve therapeutic response and care satisfaction.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aalbers, S., Fusar-Poli, L., Freeman, R. E., Spreen, M., Ket, J. C., Vink, A. C., … Gold, C. (2017). Music therapy for depression. Cochrane Database of Systematic Reviews, 11.

    Google Scholar 

  • Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011). Gastrointestinal flora and gastrointestinal status in children with autism–comparisons to typical children and correlation with autism severity. BMC Gastroenterology, 11(1), 1–13.

    Google Scholar 

  • Ahn, A. C., Colbert, A. P., Anderson, B. J., Martinsen, Ø. G., Hammerschlag, R., Cina, S., Wayne, P. M., & Langevin, H. M. (2008). Electrical properties of acupuncture points and meridians: A systematic review. Bioelectromagnetics: Journal of the Bioelectromagnetics Society, The Society for Physical Regulation in Biology and Medicine, The European Bioelectromagnetics Association, 29(4), 245–256.

    Google Scholar 

  • Al-Ayadhi, L. Y., & Elamin, N. E. (2013). Camel milk as a potential therapy as an antioxidant in autism spectrum disorder (ASD). Evidence-based Complementary and Alternative Medicine, 2013, 602834.

    PubMed  PubMed Central  Google Scholar 

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub.

    Google Scholar 

  • Anderson, G. M., Scahill, L., McCracken, J. T., McDougle, C. J., Aman, M. G., Tierney, E., Arnold, L. E., Martin, A., Katsovich, L., & Posey, D. J. (2007). Effects of short-and long-term risperidone treatment on prolactin levels in children with autism. Biological Psychiatry, 61(4), 545–550.

    PubMed  Google Scholar 

  • Aourell, M., Skoog, M., & Carleson, J. (2005). Effects of Swedish massage on blood pressure. Complementary Therapies in Clinical Practice, 11(4), 242–246.

    PubMed  Google Scholar 

  • Arezina, C. H. (2011). The effect of interactive music therapy on joint attention skills in preschool children with autism spectrum disorder. University of Kansas,

    Google Scholar 

  • Astin, J. A., Pelletier, K. R., Marie, A., & Haskell, W. L. (2000). Complementary and alternative medicine use among elderly persons: One-year analysis. Journal of Gerontology Medical Science, 55, M4–M9.

    Google Scholar 

  • Barbeau, W. E. (2017). Neonatal and regressive forms of autism: Diseases with similar symptoms but a different etiology. Medical Hypotheses, 109, 46–52.

    PubMed  Google Scholar 

  • Barnes, P. M., Bloom, B., & Nahin, R. L. (2008). Complementary and alternative medicine use among adults and children; United States, 2007.

    Google Scholar 

  • Barnes, P. M., Powell-Griner, E., McFann, K., & Nahin, R. L. (2004). Complementary and alternative medicine use among adults: United States, 2002. In Seminars in integrative medicine (Vol. 2, pp. 54–71). Elsevier.

    Google Scholar 

  • Bashir, S., & Al-Ayadhi, L. Y. (2014). Effect of camel milk on thymus and activation-regulated chemokine in autistic children: Double-blind study. Pediatric Research, 75(4), 559–563.

    PubMed  Google Scholar 

  • Becker, R. O., Reichmanis, M., Marino, A. A., & Spadaro, J. A. (1976). Electrophysiological correlates of acupuncture points and meridians. Psychoenergetic Systems, 1(106), 195–212.

    Google Scholar 

  • Belardo, A., Gevi, F., & Zolla, L. (2019). The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children. The Journal of Nutritional Biochemistry, 70, 38–46.

    PubMed  Google Scholar 

  • Bent, S., Bertoglio, K., Ashwood, P., Bostrom, A., & Hendren, R. L. (2011). A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder. Journal of Autism and Developmental Disorders, 41(5), 545–554.

    PubMed  Google Scholar 

  • Bent, S., Hendren, R. L., Zandi, T., Law, K., Choi, J.-E., Widjaja, F., Kalb, L., Nestle, J., & Law, P. (2014). Internet based, randomized, controlled trial of omega-3 fatty acids for hyperactivity in autism. Journal of the American Academy of Child & Adolescent Psychiatry, 53(6), 658–666.

    Google Scholar 

  • Bertoglio, K., Jill James, S., Deprey, L., Brule, N., & Hendren, R. L. (2010). Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism. The Journal of Alternative and Complementary Medicine, 16(5), 555–560.

    PubMed  Google Scholar 

  • Birch, S. (2003). Trigger point–acupuncture point correlations revisited. The Journal of Alternative & Complementary Medicine, 9(1), 91–103.

    Google Scholar 

  • Birch, S. (2008). On the impossibility of trigger point–acupoint equivalence: A commentary on Peter Dorsher’s analysis. The Journal of Alternative and Complementary Medicine, 14(4), 343–345.

    Google Scholar 

  • Bogels, S., Hoogstad, B., van Dun, L., de Schutter, S., & Restifo, K. (2008). Mindfulness training for adolescents with externalizing disorders and their parents. Behavioural and Cognitive Psychotherapy, 36(2), 193.

    Google Scholar 

  • Bölte, S., Girdler, S., & Marschik, P. B. (2019). The contribution of environmental exposure to the etiology of autism spectrum disorder. Cellular and Molecular Life Sciences, 76(7), 1275–1297.

    PubMed  Google Scholar 

  • Boso, M., Politi, P., Barale, F., & Emanuele, E. (2006). Neurophysiology and neurobiology of the musical experience. Functional Neurology, 21(4), 187.

    PubMed  Google Scholar 

  • Brondino, N., Fusar-Poli, L., Rocchetti, M., Provenzani, U., Barale, F., & Politi, P. (2015). Complementary and alternative therapies for autism spectrum disorder. Evidence-Based Complementary and Alternative Medicine, 2015, 258589.

    PubMed  PubMed Central  Google Scholar 

  • Brownell, M. D. (2002). Musically adapted social stories to modify behaviors in students with autism: Four case studies. Journal of Music Therapy, 39(2), 117–144.

    PubMed  Google Scholar 

  • Buday, E. M. (1995). The effects of signed and spoken words taught with music on sign and speech imitation by children with autism. Journal of Music Therapy, 32(3), 189–202.

    Google Scholar 

  • Cabýoglu, M. T., Ergene, N., & Tan, U. (2006). The mechanism of acupuncture and clinical applications. International Journal of Neuroscience, 116(2), 115–125.

    PubMed  Google Scholar 

  • Chan, A. S., Han, Y. M., Sze, S. L., & Lau, E. M. (2015). Neuroenhancement of memory for children with autism by a mind–body exercise. Frontiers in Psychology, 6, 1893.

    PubMed  PubMed Central  Google Scholar 

  • Chan, A. S., Sze, S. L., Han, Y. M., & Cheung, M.-C. (2012, 2012). A Chan dietary intervention enhances executive functions and anterior cingulate activity in autism spectrum disorders: A randomized controlled trial. Evidence-Based Complementary and Alternative Medicine, 262136.

    Google Scholar 

  • Chan, A. S., Sze, S. L., Siu, N. Y., Lau, E. M., & Cheung, M.-C. (2013). A Chinese mind-body exercise improves self-control of children with autism: A randomized controlled trial. PLoS One, 8(7), e68184.

    PubMed  PubMed Central  Google Scholar 

  • Chen, W.-X., Wu-Li, L., & Wong, V. C. (2008). Electroacupuncture for children with autism spectrum disorder: Pilot study of 2 cases. The Journal of Alternative and Complementary Medicine, 14(8), 1057–1065.

    PubMed  Google Scholar 

  • Cho, S. H., & Chun, S. I. (1994). The basal electrical skin resistance of acupuncture points in normal subjects. Yonsei Medical Journal, 35(4), 464–474.

    PubMed  Google Scholar 

  • Cignolini, A. (2002). An original Qigong massage methodology to treat autism, Asperger syndrome and autistic spectrum disorders in children. The Newsletter of Cignolini Education Association and Chinese Acupuncture for Physicians, 2, 2–4.

    Google Scholar 

  • Clarke, T. C., Black, L. I., Stussman, B. J., Barnes, P. M., & Nahin, R. L. (2015). Trends in the use of complementary health approaches among adults: United States, 2002–2012. National Health Statistics Reports, 79, 1.

    Google Scholar 

  • Coelho, H., Boddy, K., & Ernst, E. (2008). Massage therapy for the treatment of depression: A systematic review. International Journal of Clinical Practice, 62(2), 325–333.

    PubMed  Google Scholar 

  • Cullen-Powell, L. A., Barlow, J. H., & Cushway, D. (2005). Exploring a massage intervention for parents and their children with autism: The implications for bonding and attachment. Journal of Child Health Care, 9(4), 245–255.

    PubMed  Google Scholar 

  • Davis, T. N., O’Reilly, M., Kang, S., Lang, R., Rispoli, M., Sigafoos, J., Lancioni, G., Copeland, D., Attai, S., & Mulloy, A. (2013). Chelation treatment for autism spectrum disorders: A systematic review. Research in Autism Spectrum Disorders, 7(1), 49–55.

    Google Scholar 

  • de Bruin, E. I., Blom, R., Smit, F. M., van Steensel, F. J., & Bögels, S. M. (2015). MYmind: Mindfulness training for youngsters with autism spectrum disorders and their parents. Autism, 19(8), 906–914.

    PubMed  Google Scholar 

  • De Magistris, L., Picardi, A., Siniscalco, D., Riccio, M. P., Sapone, A., Cariello, R., Abbadessa, S., Medici, N., Lammers, K. M., & Schiraldi, C. (2013). Antibodies against food antigens in patients with autistic spectrum disorders. BioMed Research International, 2013, 729349.

    PubMed  PubMed Central  Google Scholar 

  • Diego, M. A., Field, T., Hernandez-Reif, M., Deeds, O., Ascencio, A., & Begert, G. (2007). Preterm infant massage elicits consistent increases in vagal activity and gastric motility that are associated with greater weight gain. Acta Paediatrica, 96(11), 1588–1591.

    PubMed  Google Scholar 

  • Diego, M. A., Field, T., Hernandez-Reif, M., Shaw, K., Friedman, L., & Ironson, G. (2001). HIV adolescents show improved immune function following massage therapy. International Journal of Neuroscience, 106(1–2), 35–45.

    PubMed  Google Scholar 

  • Dorsher, P. T. (2008a). Can classical acupuncture points and trigger points be compared in the treatment of pain disorders? Birch’s analysis revisited. The Journal of Alternative and Complementary Medicine, 14(4), 353–359.

    PubMed  Google Scholar 

  • Dorsher, P. T. (2008b). On the probability of trigger point–acupuncture point correspondences: An evidence-based rebuttal of Stephen Birch’s commentary. The Journal of Alternative and Complementary Medicine, 14(10), 1183–1184.

    PubMed  Google Scholar 

  • Dovrolis, N., Kolios, G., Spyrou, G. M., & Maroulakou, I. (2019). Computational profiling of the gut–brain axis: Microflora dysbiosis insights to neurological disorders. Briefings in Bioinformatics, 20(3), 825–841.

    PubMed  Google Scholar 

  • Eisenberg, D. M., Davis, R. B., Ettner, S. L., Appel, S., Wilkey, S., Van Rompay, M., & Kessler, R. C. (1998). Trends in alternative medicine use in the United States, 1990-1997: Results of a follow-up national survey. JAMA, 280(18), 1569–1575.

    PubMed  Google Scholar 

  • Eisenberg, D. M., Kaptchuk, T. J., Laine, C., & Davidoff, F. (2001). Complementary and alternative medicine— an annals series. Annals of Internal Medicine., 135(3), 208.

    PubMed  Google Scholar 

  • Eisenberg, D. M., Kessler, R. C., Foster, C., Norlock, F. E., Calkins, D. R., & Delbanco, T. L. (1993). Unconventional medicine in the United States – prevalence, costs, and patterns of use. New England Journal of Medicine, 328(4), 246–252.

    PubMed  Google Scholar 

  • Elder, J. H., Shankar, M., Shuster, J., Theriaque, D., Burns, S., & Sherrill, L. (2006). The gluten-free, casein-free diet in autism: Results of a preliminary double blind clinical trial. Journal of Autism and Developmental Disorders, 36(3), 413–420.

    PubMed  Google Scholar 

  • Eldevik, S., Hastings, R. P., Hughes, J. C., Jahr, E., Eikeseth, S., & Cross, S. (2009). Meta-analysis of early intensive behavioral intervention for children with autism. Journal of Clinical Child & Adolescent Psychology, 38(3), 439–450.

    Google Scholar 

  • Elsabbagh, M., Divan, G., Koh, Y. J., Kim, Y. S., Kauchali, S., Marcín, C., Montiel-Nava, C., Patel, V., Paula, C. S., & Wang, C. (2012). Global prevalence of autism and other pervasive developmental disorders. Autism Research, 5(3), 160–179.

    PubMed  PubMed Central  Google Scholar 

  • Emanuele, E., Orsi, P., Boso, M., Broglia, D., Brondino, N., Barale, F., di Nemi, S. U., & Politi, P. (2010). Low grade endotoxemia in patients with severe autism. Neuroscience Letters, 471(3), 162–165.

    PubMed  Google Scholar 

  • Ernst, E., Resch, K., Mills, S., Hill, R., Mitchell, A., Willoughby, M., & White, A. (1995). Complementary medicine—a definition. The British Journal of General Practice, 45(398), 506.

    PubMed Central  Google Scholar 

  • Escalona, A., Field, T., Singer-Strunck, R., Cullen, C., & Hartshorn, K. (2001). Brief report: Improvements in the behavior of children with autism following massage therapy. Journal of Autism and Developmental Disorders, 31(5), 513–516.

    PubMed  Google Scholar 

  • Esposito, D., Belli, A., Ferri, R., & Bruni, O. (2020). Sleeping without prescription: Management of sleep disorders in children with autism with non-pharmacological interventions and over-the counter treatments. Brain Sciences, 10(7), 441.

    PubMed  PubMed Central  Google Scholar 

  • Evangeliou, A., Vlachonikolis, I., Mihailidou, H., Spilioti, M., Skarpalezou, A., Makaronas, N., Prokopiou, A., Christodoulou, P., Liapi-Adamidou, G., & Helidonis, E. (2003). Application of a ketogenic diet in children with autistic behavior: Pilot study. Journal of Child Neurology, 18(2), 113–118.

    PubMed  Google Scholar 

  • Ezzo, J., Moerman, D., Hadhazy, V., Bausell, B., & Berman, B. (2002). Reviewing the reviews: How strong is the evidence? How clear are the conclusions? International Journal of Technology Assessment in Health Care, 18(1), 158–158. (vol 17, pg 457, 2001).

    Google Scholar 

  • Fahmy, S. F., El-hamamsy, M. H., Zaki, O. K., & Badary, O. A. (2013). L-Carnitine supplementation improves the behavioral symptoms in autistic children. Research in Autism Spectrum Disorder, 7(1), 159–166.

    Google Scholar 

  • Farmer, K. J. (2003). Effect of music vs. nonmusic paired with gestures on spontaneous verbal and nonverbal communication skills of children with autism between the ages; pp. 1–5.

    Google Scholar 

  • Field, T. (2014). Massage therapy research review. Complementary Therapies in Clinical Practice, 20(4), 224–229.

    PubMed  PubMed Central  Google Scholar 

  • Field, T., Diego, M., & Hernandez-Reif, M. (2007). Massage therapy research. Developmental Review, 27(1), 75–89.

    Google Scholar 

  • Field, T., Lasko, D., Mundy, P., Henteleff, T., Kabat, S., Talpins, S., & Dowling, M. (1997). Brief report: Autistic children’s attentiveness and responsivity improve after touch therapy. Journal of Autism and Developmental Disorders, 27(3), 333–338.

    PubMed  Google Scholar 

  • Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M.-L., Bolte, E., McTeague, M., Sandler, R., Wexler, H., & Marlowe, E. M. (2002). Gastrointestinal microflora studies in late-onset autism. Clinical Infectious Diseases, 35(Supplement_1), S6–S16.

    PubMed  Google Scholar 

  • Fjær, E. L., Landet, E. R., McNamara, C. L., & Eikemo, T. A. (2020). The use of complementary and alternative medicine (CAM) in Europe. BMC Complementary Medicine and Therapies, 20, 1–9.

    Google Scholar 

  • Frass, M., Strassl, R. P., Friehs, H., Müllner, M., Kundi, M., & Kaye, A. D. (2012). Use and acceptance of complementary and alternative medicine among the general population and medical personnel: A systematic review. Ochsner Journal, 12(1), 45–56.

    PubMed  PubMed Central  Google Scholar 

  • Fusar-Poli, L., & Guiot, C. (2020). Cardiovascular and emotional effects of music. Brain and Heart Dynamics, 891–911.

    Google Scholar 

  • Gattino, G. S., Riesgo, R. S., Longo, D., Leite, J. C. L., & Faccini, L. S. (2011). Effects of relational music therapy on communication of children with autism: A randomized controlled study. Nordic Journal of Music Therapy, 20(2), 142–154.

    Google Scholar 

  • Geier, D. A., Kern, J. K., Davis, G., King, P. G., Adams, J. B., Young, J. L., & Geier, M. R. (2011). A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 17(6), PI15.

    PubMed  Google Scholar 

  • Geretsegger, M., Elefant, C., Mössler, K. A., & Gold, C. (2014). Music therapy for people with autism spectrum disorder. Cochrane Database of Systematic Reviews, 2014(6), CD004381.

    PubMed  PubMed Central  Google Scholar 

  • Geretsegger, M., Mössler, K. A., Bieleninik, Ł., Chen, X. J., Heldal, T. O., & Gold, C. (2017). Music therapy for people with schizophrenia and schizophrenia-like disorders. Cochrane Database of Systematic Reviews, 5(5), CD004025.

    PubMed  Google Scholar 

  • Gevitz, N. (1988). Other healers: Unorthodox medicine in America. Johns Hopkins University Press.

    Google Scholar 

  • Ghalichi, F., Ghaemmaghami, J., Malek, A., & Ostadrahimi, A. (2016). Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: A randomized clinical trial. World Journal of Pediatrics, 12(4), 436–442.

    PubMed  Google Scholar 

  • Gotink, R. A., Chu, P., Busschbach, J. J., Benson, H., Fricchione, G. L., & Hunink, M. M. (2015). Standardised mindfulness-based interventions in healthcare: An overview of systematic reviews and meta analyses of RCTs. PLoS One, 10(4), e0124344.

    PubMed  PubMed Central  Google Scholar 

  • Goyal, M., Singh, S., Sibinga, E. M., Gould, N. F., Rowland-Seymour, A., Sharma, R., Berger, Z., Sleicher, D., Maron, D. D., & Shihab, H. M. (2014). Meditation programs for psychological stress and well-being: A systematic review and meta-analysis. JAMA Internal Medicine, 174(3), 357–368.

    PubMed  PubMed Central  Google Scholar 

  • Grandin, T. (1992). An inside view of autism. In High-functioning individuals with autism (pp. 105–126). Springer.

    Google Scholar 

  • Haase, U. (2012). Thoughts on WFMT’s definition of music therapy. Nordic Journal of Music Therapy, 21(2), 194–195.

    Google Scholar 

  • Hanson, E., Kalish, L. A., Bunce, E., Curtis, C., McDaniel, S., Ware, J., & Petry, J. (2007). Use of complementary and alternative medicine among children diagnosed with autism spectrum disorder. Journal of Autism and Developmental Disorders, 37(4), 628–636.

    PubMed  Google Scholar 

  • Harrington, J. W., Rosen, L., Garnecho, A., & Patrick, P. A. (2006). Parental perceptions and use of complementary and alternative medicine practices for children with autistic spectrum disorders in private practice. Journal of Developmental & Behavioral Pediatrics, 27(2), S156–S161.

    Google Scholar 

  • Harris, P. E., Cooper, K., Relton, C., & Thomas, K. (2012). Prevalence of complementary and alternative medicine (CAM) use by the general population: A systematic review and update. International Journal of Clinical Practice, 66(10), 924–939.

    PubMed  Google Scholar 

  • Hendren, R. L., James, S. J., Widjaja, F., Lawton, B., Rosenblatt, A., & Bent, S. (2016). Randomized, placebo controlled trial of methyl B12 for children with autism. Journal of Child and Adolescent Psychopharmacology, 26(9), 774–783.

    PubMed  Google Scholar 

  • Höfer, J., Hoffmann, F., Kamp-Becker, I., Küpper, C., Poustka, L., Roepke, S., Roessner, V., Stroth, S., Wolff, N., & Bachmann, C. J. (2019). Complementary and alternative medicine use in adults with autism spectrum disorder in Germany: Results from a multi-center survey. BMC Psychiatry, 19(1), 1–8.

    Google Scholar 

  • Hong, E. R., Neely, L., Rispoli, M. J., Trepinski, T. M., Gregori, E., & Davis, T. (2015). A comparison of general and explicit delay cues to reinforcement for tangible-maintained challenging behaviour. Developmental Neurorehabilitation, 18(6), 395–401.

    PubMed  Google Scholar 

  • Horvath, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C., & Tildon, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. The Journal of Pediatrics, 135(5), 559–563.

    PubMed  Google Scholar 

  • Hourston, S., & Atchley, R. (2017). Autism and mind–body therapies: A systematic review. The Journal of Alternative and Complementary Medicine, 23(5), 331–339.

    PubMed  PubMed Central  Google Scholar 

  • Hufford, D. J. (2002). CAM and cultural diversity: Ethics and epistemology converge. The role of complementary and alternative medicine: Accommodating pluralism; pp. 15–35.

    Google Scholar 

  • Hui, K. K., Liu, J., Makris, N., Gollub, R. L., Chen, A. J. I., Moore, C., Kennedy, D. N., Rosen, B. R., & Kwong, K. K. (2000). Acupuncture modulates the limbic system and subcortical gray structures of the human brain: Evidence from fMRI studies in normal subjects. Human Brain Mapping, 9(1), 13–25.

    PubMed  PubMed Central  Google Scholar 

  • Hui, K. K., Liu, J., Marina, O., Napadow, V., Haselgrove, C., Kwong, K. K., Kennedy, D. N., & Makris, N. (2005). The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. NeuroImage, 27(3), 479–496.

    PubMed  Google Scholar 

  • Hwang, Y.-S., Kearney, P., Klieve, H., Lang, W., & Roberts, J. (2015). Cultivating mind: Mindfulness interventions for children with autism spectrum disorder and problem behaviours, and their mothers. Journal of Child and Family Studies, 24(10), 3093–3106.

    Google Scholar 

  • Hyman, S. L., Stewart, P. A., Foley, J., Peck, R., Morris, D. D., Wang, H., & Smith, T. (2016). The gluten free/casein-free diet: A double-blind challenge trial in children with autism. Journal of Autism and Developmental Disorders, 46(1), 205–220.

    PubMed  Google Scholar 

  • James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American Journal of Clinical Nutrition, 80(6), 1611–1617.

    PubMed  Google Scholar 

  • Johnson, C. R., Handen, B. L., Zimmer, M., Sacco, K., & Turner, K. (2011). Effects of gluten free/casein free diet in young children with autism: A pilot study. Journal of Developmental and Physical Disabilities, 23(3), 213–225.

    Google Scholar 

  • Jonas, W. B. (2002). Policy, the public, and priorities in alternative medicine research. The Annals of the American Academy of Political and Social Science, 583(1), 29–43.

    Google Scholar 

  • Jyonouchi, H. (2010). Autism spectrum disorders and allergy: Observation from a pediatric allergy/immunology clinic. Expert Review of Clinical Immunology, 6(3), 397–411.

    PubMed  Google Scholar 

  • Karhu, E., Zukerman, R., Eshraghi, R. S., Mittal, J., Deth, R. C., Castejon, A. M., Trivedi, M., Mittal, R., & Eshraghi, A. A. (2020). Nutritional interventions for autism spectrum disorder. Nutrition Reviews, 78(7), 515–531.

    PubMed  Google Scholar 

  • Karkelis, S., Papadaki-Papandreou, O., Lykogeorgou, M., Papandreou, T., Lianou, L., & Chrousos, G. (2010). 786 elemental formula diet in autistic children. Pediatric Research, 68(1), 397–397.

    Google Scholar 

  • Kemppainen, L. M., Kemppainen, T. T., Reippainen, J. A., Salmenniemi, S. T., & Vuolanto, P. H. (2018). Use of complementary and alternative medicine in Europe: Health-related and sociodemographic determinants. Scandinavian Journal of Public Health, 46(4), 448–455.

    PubMed  Google Scholar 

  • Kessler, R. C., Davis, R. B., Foster, D. F., Van Rompay, M. I., Walters, E. E., Wilkey, S. A., Kaptchuk, T. J., & Eisenberg, D. M. (2001). Long-term trends in the use of complementary and alternative medical therapies in the United States. Annals of Internal Medicine, 135(4), 262–268.

    PubMed  Google Scholar 

  • Kientz, M. A., & Dunn, W. (1997). A comparison of the performance of children with and without autism on the Sensory Profile. American Journal of Occupational Therapy, 51(7), 530–537.

    Google Scholar 

  • Kiep, M., Spek, A. A., & Hoeben, L. (2015). Mindfulness-based therapy in adults with an autism spectrum disorder: Do treatment effects last? Mindfulness, 6(3), 637–644.

    Google Scholar 

  • Kim, J., Wigram, T., & Gold, C. (2008). The effects of improvisational music therapy on joint attention behaviors in autistic children: A randomized controlled study. Journal of Autism and Developmental Disorders, 38(9), 1758.

    PubMed  Google Scholar 

  • Knivsberg, A., Reichelt, K., Høien, T., & Nødland, M. (2002). A randomised, controlled study of dietary intervention in autistic syndromes. Nutritional Neuroscience, 5(4), 251–261.

    PubMed  Google Scholar 

  • Knivsberg, A.-M., Reichelt, K.-L., Høien, T., & Nødland, M. (2003). Effect of a dietary intervention on autistic behavior. Focus on Autism and Other Developmental Disabilities, 18(4), 248–257.

    Google Scholar 

  • Koenig, K. P., Buckley-Reen, A., & Garg, S. (2012). Efficacy of the Get Ready to Learn yoga program among children with autism spectrum disorders: A pretest–posttest control group design. American Journal of Occupational Therapy, 66(5), 538–546.

    Google Scholar 

  • Kopelman, L. M. (2002). The role of science in assessing conventional, complementary, and alternative medicines. The role of complementary and alternative medicine Accommodating pluralism; pp. 36–53.

    Google Scholar 

  • Lahbib, S., Trabelsi, M., Dallali, H., Sakka, R., Bourourou, R., Kefi, R., Mrad, R., Abdelhak, S., & Gaddour, N. (2019). Novel MED12 variant in a multiplex Fragile X syndrome family: Dual molecular etiology of two X-linked intellectual disabilities with autism in the same family. Molecular Biology Reports, 46(4), 4185–4193.

    PubMed  Google Scholar 

  • Lange, K. W., Hauser, J., & Reissmann, A. (2015). Gluten-free and casein-free diets in the therapy of autism. Current Opinion in Clinical Nutrition & Metabolic Care, 18(6), 572–575.

    Google Scholar 

  • Lau, N. M., Green, P. H., Taylor, A. K., Hellberg, D., Ajamian, M., Tan, C. Z., Kosofsky, B. E., Higgins, J. J., Rajadhyaksha, A. M., & Alaedini, A. (2013). Markers of celiac disease and gluten sensitivity in children with autism. PLoS One, 8(6), e66155.

    PubMed  PubMed Central  Google Scholar 

  • Lázaro, C. P., Pondé, M. P., & Rodrigues, L. E. (2016). Opioid peptides and gastrointestinal symptoms in autism spectrum disorders. Brazilian Journal of Psychiatry, 38(3), 243–246.

    PubMed  PubMed Central  Google Scholar 

  • Lee, H.-K. (2008). Effects of massage and attachment promotion program on social maturity, child autism and attachment of children with autism and their mothers. Child Health Nursing Research, 14(1), 14–21.

    Google Scholar 

  • Lee, M. S., Kim, J.-I., & Ernst, E. (2010). Massage therapy for children with autism spectrum disorders: A systematic review. The Journal of Clinical Psychiatry, 72(3), 406–411.

    PubMed  Google Scholar 

  • Lee, B., Lee, J., Cheon, J.-H., Sung, H.-K., Cho, S.-H., & Chang, G. T. (2018, 2018). The efficacy and safety of acupuncture for the treatment of children with autism spectrum disorder: A systematic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine, 1057539.

    Google Scholar 

  • Lee, G.-J., Yin, C. S., Choi, S.-K., Choi, S., Yang, J.-S., Lee, H., & Park, H.-K. (2010). Acupuncture attenuates extracellular glutamate level in global ischemia model of rat. Neurological Research, 32(sup1), 79–83.

    PubMed  Google Scholar 

  • Levy, R. G., Cooper, P. N., Giri, P., & Weston, J. (2012). Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database of Systematic Reviews, 3.

    Google Scholar 

  • Levy, S. E., & Hyman, S. L. (2008). Complementary and alternative medicine treatments for children with autism spectrum disorders. Child and Adolescent Psychiatric Clinics of North America, 17(4), 803–820.

    PubMed  PubMed Central  Google Scholar 

  • Levy, S. E., Mandell, D. S., Merhar, S., Ittenbach, R. F., & Pinto-Martin, J. A. (2003). Use of complementary and alternative medicine among children recently diagnosed with autistic spectrum disorder. Journal of Developmental & Behavioral Pediatrics, 24(6), 418–423.

    Google Scholar 

  • Li, L.-Y., Jiang, N., & Zhao, Y. (2014). Could acupuncture have a role in the treatment of autism spectrum disorder via modulation of BDNF expression and activation? Acupuncture in Medicine, 32(6), 503–505.

    PubMed  Google Scholar 

  • Li, P., Pitsillides, K. F., Rendig, S. V., Pan, H. L., & Longhurst, J. C. (1998). Reversal of reflex-induced myocardial ischemia by median nerve stimulation: A feline model of electroacupuncture. Circulation, 97, 1186–1194.

    PubMed  Google Scholar 

  • Li, P., Tjen-A-Looi, S. C., & Longhurst, J. C. (2006). Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes. American Journal of Physiology-Heart and Circulatory Physiology, 290(6), H2535–H2542.

    PubMed  Google Scholar 

  • Lim, H. A. (2010). Effect of “developmental speech and language training through music” on speech production in children with autism spectrum disorders. Journal of Music Therapy, 47(1), 2–26.

    PubMed  Google Scholar 

  • Lim, H. A., & Draper, E. (2011). The effects of music therapy incorporated with applied behavior analysis verbal behavior approach for children with autism spectrum disorders. Journal of Music Therapy, 48(4), 532–550.

    PubMed  Google Scholar 

  • Liu, Z., Guan, L., Wang, Y., Xie, C.-L., Lin, X.-M., & Zheng, G.-Q. (2012). History and mechanism for treatment of intracerebral hemorrhage with scalp acupuncture. Evidence-Based Complementary and Alternative Medicine, 2012, 895032.

    PubMed  PubMed Central  Google Scholar 

  • Liu, C., Li, T., Wang, Z., Zhou, R., & Zhuang, L. (2019). Scalp acupuncture treatment for children’s autism spectrum disorders: A systematic review and meta-analysis. Medicine, 98(13).

    Google Scholar 

  • Longhurst, J. C. (2010). Defining meridians: A modern basis of understanding. Journal of Acupuncture and Meridian Studies, 3(2), 67–74.

    PubMed  Google Scholar 

  • Maenner, M. J., Shaw, K. A., & Baio, J. (2020). Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2016. MMWR Surveillance Summaries, 69(4), 1.

    PubMed Central  Google Scholar 

  • Mankad, D., Dupuis, A., Smile, S., Roberts, W., Brian, J., Lui, T., Genore, L., Zaghloul, D., Iaboni, A., & Marcon, P. M. A. (2015). A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism. Molecular autism, 6(1), 1–11.

    Google Scholar 

  • Masi, A., DeMayo, M. M., Glozier, N., & Guastella, A. J. (2017). An overview of autism spectrum disorder, heterogeneity and treatment options. Neuroscience Bulletin, 33(2), 183–193.

    PubMed  PubMed Central  Google Scholar 

  • McLay, L. L., & France, K. (2016). Empirical research evaluating non-traditional approaches to managing sleep problems in children with autism. Developmental Neurorehabilitation, 19(2), 123–134.

    PubMed  Google Scholar 

  • McPheeters, M. L., Warren, Z., Sathe, N., Bruzek, J. L., Krishnaswami, S., Jerome, R. N., & Veenstra VanderWeele, J. (2011). A systematic review of medical treatments for children with autism spectrum disorders. Pediatrics, 127(5), e1312–e1321.

    PubMed  Google Scholar 

  • Meguid, N. A., Dardir, A. A., Abdel-Raouf, E. R., & Hashish, A. (2011). Evaluation of oxidative stress in autism: Defective antioxidant enzymes and increased lipid peroxidation. Biological Trace Element Research, 143(1), 58–65.

    PubMed  Google Scholar 

  • Melzack, R., Stillwell, D. M., & Fox, E. J. (1977). Trigger points and acupuncture points for pain: Correlations and implications. Pain, 3(1), 3–23.

    PubMed  Google Scholar 

  • Melzack, R., & Wall, P. D. (1984). Acupuncture and transcutaneous electrical nerve stimulation. Postgraduate Medical Journal, 60(710), 893.

    PubMed  PubMed Central  Google Scholar 

  • Ming, X., Chen, X., Wang, X. T., Zhang, Z., Kang, V., & Zimmerman-Bier, B. (2012). Acupuncture for treatment of autism spectrum disorders. Evidence-Based Complementary and Alternative Medicine, 2012, 679845.

    PubMed  Google Scholar 

  • Mitchell, A., & Cormack, M. A. (1998). The therapeutic relationship in complementary health care. John Wiley & Sons.

    Google Scholar 

  • Moody, L., Chen, H., & Pan, Y.-X. (2017). Early-life nutritional programming of cognition—the fundamental role of epigenetic mechanisms in mediating the relation between early-life environment and learning and memory process. Advances in Nutrition, 8(2), 337–350.

    PubMed  PubMed Central  Google Scholar 

  • Munasinghe, S. A., Oliff, C., Finn, J., & Wray, J. A. (2010). Digestive enzyme supplementation for autism spectrum disorders: A double-blind randomized controlled trial. Journal of Autism and Developmental Disorders, 40(9), 1131–1138.

    PubMed  Google Scholar 

  • Navarro, F., Pearson, D. A., Fatheree, N., Mansour, R., Hashmi, S. S., & Rhoads, J. M. (2015). Are ‘leaky gut’ and behavior associated with gluten and dairy containing diet in children with autism spectrum disorders? Nutritional Neuroscience, 18(4), 177–185.

    PubMed  Google Scholar 

  • Neece, C. L. (2014). Mindfulness-based stress reduction for parents of young children with developmental delays: Implications for parental mental health and child behavior problems. Journal of Applied Research in Intellectual Disabilities, 27(2), 174–186.

    PubMed  Google Scholar 

  • Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., Mandell, D. S., Miller, L. A., Pinto-Martin, J., & Reaven, J. (2007). The epidemiology of autism spectrum disorders. Annual Review of Public Health, 28, 235–258.

    PubMed  Google Scholar 

  • O’Connor, B. B., Calabrese, C., Cardeña, E., Eisenberg, D. M., Fincher, J., Hufford, D. J., Jonas, W. B., Kaptchuk, T., Martin, S. C., & Scott, A. W. (1997). Defining and describing complementary and alternative medicine. Alternative Therapies in Health and Medicine, 3(2), 49–57.

    Google Scholar 

  • Orefice, L. L. (2019). Outside-in: Rethinking the etiology of autism spectrum disorders. Science, 366(6461), 45–46.

    PubMed  Google Scholar 

  • Ornitz, E. M., Guthrie, D., & Farley, A. H. (1977). The early development of autistic children. Journal of Autism and Childhood Schizophrenia, 7(3), 207–229.

    PubMed  Google Scholar 

  • Ouchi, Y., Kanno, T., Okada, H., Yoshikawa, E., Shinke, T., Nagasawa, S., Minoda, K., & Doi, H. (2006). Changes in cerebral blood flow under the prone condition with and without massage. Neuroscience Letters, 407(2), 131–135.

    PubMed  Google Scholar 

  • Owen-Smith, A. A., Bent, S., Lynch, F. L., Coleman, K. J., Yau, V. M., Pearson, K. A., Massolo, M. L., Quinn, V., & Croen, L. A. (2015). Prevalence and predictors of complementary and alternative medicine use in a large insured sample of children with autism spectrum disorders. Research in Autism Spectrum Disorders, 17, 40–51.

    PubMed  PubMed Central  Google Scholar 

  • Pahnke, J., Lundgren, T., Hursti, T., & Hirvikoski, T. (2014). Outcomes of an acceptance and commitment therapy-based skills training group for students with high-functioning autism spectrum disorder: A quasi-experimental pilot study. Autism, 18(8), 953–964.

    PubMed  Google Scholar 

  • Pain, O., Pocklington, A. J., Holmans, P. A., Bray, N. J., O’Brien, H. E., Hall, L. S., Pardiñas, A. F., O’Donovan, M. C., Owen, M. J., & Anney, R. (2019). Novel insight into the etiology of autism spectrum disorder gained by integrating expression data with genome-wide association statistics. Biological Psychiatry, 86(4), 265–273.

    PubMed  PubMed Central  Google Scholar 

  • Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005). Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. Journal of Medical Microbiology, 54(10), 987–991.

    PubMed  Google Scholar 

  • Pedersen, L., Parlar, S., Kvist, K., Whiteley, P., & Shattock, P. (2014). Data mining the ScanBrit study of a gluten-and casein-free dietary intervention for children with autism spectrum disorders: Behavioural and psychometric measures of dietary response. Nutritional Neuroscience, 17(5), 207–213.

    PubMed  Google Scholar 

  • Perrin, J. M., Coury, D. L., Hyman, S. L., Cole, L., Reynolds, A. M., & Clemons, T. (2012). Complementary and alternative medicine use in a large pediatric autism sample. Pediatrics, 130(Supplement 2), S77–S82.

    PubMed  Google Scholar 

  • Piravej, K., Tangtrongchitr, P., Chandarasiri, P., Paothong, L., & Sukprasong, S. (2009). Effects of Thai traditional massage on autistic children’s behavior. The Journal of Alternative and Complementary Medicine, 15(12), 1355–1361.

    PubMed  Google Scholar 

  • Pledger, J. (2014). A feasibility study of acupuncture for the treatment of children with autism spectrum disorder. European Journal of Oriental Medicine, 7, 5.

    Google Scholar 

  • Porkert, M. (1974). The theoretical foundations of Chinese medicine: Systems of correspondence (Vol. 3). MIT Press.

    Google Scholar 

  • Provenzani, U., Fusar-Poli, L., Brondino, N., Damiani, S., Vercesi, M., Meyer, N., Rocchetti, M., & Politi, P. (2020). What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials. Autism, 24(2), 274–284.

    PubMed  Google Scholar 

  • Pusponegoro, H. D., Ismael, S., Firmansyah, A., Sastroasmoro, S., & Vandenplas, Y. (2015). Gluten and casein supplementation does not increase symptoms in children with autism spectrum disorder. Acta Paediatrica, 104(11), e500–e505.

    PubMed  Google Scholar 

  • Radhakrishna, S. (2010). Application of integrated yoga therapy to increase imitation skills in children with autism spectrum disorder. International Journal of Yoga, 3(1), 26.

    PubMed  PubMed Central  Google Scholar 

  • Radhakrishna, S., Nagarathna, R., & Nagendra, H. (2010). Integrated approach to yoga therapy and autism spectrum disorders. Journal of Ayurveda and Integrative Medicine, 1(2), 120.

    PubMed  PubMed Central  Google Scholar 

  • Raymond, L. J., Deth, R. C., & Ralston, N. V. (2014). Potential role of selenoenzymes and antioxidant metabolism in relation to autism etiology and pathology. Autism Research and Treatment, 2014.

    Google Scholar 

  • Reichelt, K. L., Tveiten Bioengineer, D., Knivsberg, A.-M., & Brønstad, G. (2012). Peptides’ role in autism with emphasis on exorphins. Microbial Ecology in Health and Disease, 23(1), 18958.

    Google Scholar 

  • Riskowski, J. L., & Almeheyawi, R. (2019). Effects of tai chi and qigong in children and adolescents: A systematic review of trials. Adolescent Research Review, 4(1), 73–91.

    Google Scholar 

  • Robb, A. S., Andersson, C., Bellocchio, E. E., Manos, G., Rojas-Fernandez, C., Mathew, S., Marcus, R., Owen, R., & Mankoski, R. (2011). Safety and tolerability of aripiprazole in the treatment of irritability associated with autistic disorder in pediatric subjects (6–17 years old): Results from a pooled analysis of 2 studies. The Primary Care Companion to CNS Disorders, 13(1). https://doi.org/10.4088/PCC.10m01008gry

  • Rodrigues, J. M., Mestre, M., & Fredes, L. I. (2019). Qigong in the treatment of children with autism spectrum disorder: A systematic review. Journal of Integrative Medicine, 17(4), 250–260.

    PubMed  Google Scholar 

  • Rodrigues, J. M. S., Mestre, M. I. C., Matos, L. C., & Machado, J. P. (2019). Effects of taijiquan and qigong practice over behavioural disorders in school-age children: A pilot study. Journal of Bodywork and Movement Therapies, 23(1), 11–15.

    PubMed  Google Scholar 

  • Rosenblatt, L. E., Gorantla, S., Torres, J. A., Yarmush, R. S., Rao, S., Park, E. R., Denninger, J. W., Benson, H., Fricchione, G. L., & Bernstein, B. (2011). Relaxation response–based yoga improves functioning in young children with autism: A pilot study. The Journal of Alternative and Complementary Medicine, 17(11), 1029–1035.

    PubMed  PubMed Central  Google Scholar 

  • Rudzki, L., & Szulc, A. (2018). “Immune gate” of psychopathology—the role of gut derived immune activation in major psychiatric disorders. Frontiers in Psychiatry, 9, 205.

    PubMed  PubMed Central  Google Scholar 

  • Saad, K., Eltayeb, A. A., Mohamad, I. L., Al-Atram, A. A., Elserogy, Y., Bjørklund, G., El-Houfey, A. A., & Nicholson, B. (2015). A randomized, placebo-controlled trial of digestive enzymes in children with autism spectrum disorders. Clinical Psychopharmacology and Neuroscience, 13(2), 188.

    PubMed  PubMed Central  Google Scholar 

  • Sathe, N., Andrews, J. C., McPheeters, M. L., & Warren, Z. E. (2017). Nutritional and dietary interventions for autism spectrum disorder: A systematic review. Pediatrics, 139(6).

    Google Scholar 

  • Sato, A., Sato, Y., & Uchida, S. (2002). Reflex modulation of visceral functions by acupuncture-like stimulation in anesthetized rats. In International Congress Series (pp. 111–123). Elsevier.

    Google Scholar 

  • Seung, H., Rogalski, Y., Shankar, M., & Elder, J. (2007). The gluten-and casein-free diet and autism: Communication outcomes from a preliminary double-blind clinical trial. Journal of Medical Speech Language Pathology, 15(4), 337.

    Google Scholar 

  • Siegel, M., & Beaulieu, A. A. (2012). Psychotropic medications in children with autism spectrum disorders: A systematic review and synthesis for evidence-based practice. Journal of Autism and Developmental Disorders, 42(8), 1592–1605.

    PubMed  Google Scholar 

  • Silva, L. M., Ayres, R., & Schalock, M. (2008). Outcomes of a pilot training program in a qigong massage intervention for young children with autism. American Journal of Occupational Therapy, 62(5), 538–546.

    Google Scholar 

  • Silva, L. M., Cignolini, A., Warren, R., Budden, S., & Skowron-Gooch, A. (2007). Improvement in sensory impairment and social interaction in young children with autism following treatment with an original Qigong massage methodology. The American Journal of Chinese Medicine, 35(03), 393–406.

    PubMed  Google Scholar 

  • Silva, L., & Schalock, M. (2013). Treatment of tactile impairment in young children with autism: Results with qigong massage. International Journal of Therapeutic Massage & Bodywork, 6(4), 12.

    Google Scholar 

  • Silva, L. M., Schalock, M., Ayres, R., Bunse, C., & Budden, S. (2009). Qigong massage treatment for sensory and self-regulation problems in young children with autism: A randomized controlled trial. American Journal of Occupational Therapy, 63(4), 423–432.

    Google Scholar 

  • Silva, L. M., Schalock, M., & Gabrielsen, K. (2011). Early intervention for autism with a parent-delivered qigong massage program: A randomized controlled trial. American Journal of Occupational Therapy, 65(5), 550–559.

    Google Scholar 

  • Silva, L. M., Schalock, M., Gabrielsen, K. R., Budden, S. S., Buenrostro, M., & Horton, G. (2015). Early intervention with a parent-delivered massage protocol directed at tactile abnormalities decreases severity of autism and improves child-to-parent interactions: A replication study. Autism Research and Treatment, 2015, 904585.

    PubMed  PubMed Central  Google Scholar 

  • Silva, L. M., Schalock, M., Gabrielsen, K. R., & Gretchen, H. (2016). One-and two-year outcomes of treating preschool children with autism with a qigong massage protocol: An observational follow along study. Alternative & Integrative Medicine, 5, 1–10.

    Google Scholar 

  • Singh, N. N., Lancioni, G. E., Manikam, R., Winton, A. S., Singh, A. N., Singh, J., & Singh, A. D. (2011). A mindfulness-based strategy for self-management of aggressive behavior in adolescents with autism. Research in Autism Spectrum Disorders, 5(3), 1153–1158.

    Google Scholar 

  • Singh, N. N., Lancioni, G. E., Singh, A. D., Winton, A. S., Singh, A. N., & Singh, J. (2011). Adolescents with Asperger syndrome can use a mindfulness-based strategy to control their aggressive behavior. Research in Autism Spectrum Disorders, 5(3), 1103–1109.

    Google Scholar 

  • Singh, N. N., Lancioni, G. E., Winton, A. S., Fisher, B. C., Wahler, R. G., Mcaleavey, K., Singh, J., & Sabaawi, M. (2006). Mindful parenting decreases aggression, noncompliance, and self-injury in children with autism. Journal of Emotional and Behavioral Disorders, 14(3), 169–177.

    Google Scholar 

  • Singh, N. N., Lancioni, G. E., Winton, A. S., Karazsia, B. T., Myers, R. E., Latham, L. L., & Singh, J. (2014). Mindfulness-based positive behavior support (MBPBS) for mothers of adolescents with autism spectrum disorder: Effects on adolescents’ behavior and parental stress. Mindfulness, 5(6), 646–657.

    Google Scholar 

  • Sirois, F. M., & Gick, M. L. (2002). An investigation of the health beliefs and motivations of complementary medicine clients. Social Science & Medicine, 55(6), 1025–1037.

    Google Scholar 

  • Song, Y., Liu, C., & Finegold, S. M. (2004). Real-time PCR quantitation of clostridia in feces of autistic children. Applied and Environmental Microbiology, 70(11), 6459–6465.

    PubMed  PubMed Central  Google Scholar 

  • Spek, A. A., Van Ham, N. C., & Nyklíček, I. (2013). Mindfulness-based therapy in adults with an autism spectrum disorder: A randomized controlled trial. Research in Developmental Disabilities, 34(1), 246–253.

    PubMed  Google Scholar 

  • Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., & Calabrò, A. (2017). New evidences on the altered gut microbiota in autism spectrum disorders. Microbiome, 5(1), 1–11.

    Google Scholar 

  • Tager-Flusberg, H. (2010). The origins of social impairments in autism spectrum disorder: Studies of infants at risk. Neural Networks, 23(8–9), 1072–1076.

    PubMed  PubMed Central  Google Scholar 

  • Thomas, A., Hunter, B. (2003). The effect of music therapy on communication skills of children ages 2-3 with autism: A pilot study. Proceedings of the American Music Therapy Association Conference; Minneapolis (MN).

    Google Scholar 

  • Thompson, G. (2012). Making a connection: Randomised controlled trial of family centred music therapy for young children with autism spectrum disorder.

    Google Scholar 

  • Tick, B., Bolton, P., Happé, F., Rutter, M., & Rijsdijk, F. (2016). Heritability of autism spectrum disorders: A meta-analysis of twin studies. Journal of Child Psychology and Psychiatry, 57(5), 585–595.

    PubMed  Google Scholar 

  • Tindle, H. A., Davis, R. B., Phillips, R. S., & Eisenberg, D. M. (2005). Trends in use of complementary and alternative medicine by US adults: 1997-2002. Alternative Therapies in Health and Medicine, 11(1), 42.

    PubMed  Google Scholar 

  • Tjen-A-Looi, S. C., Fu, L.-W., Syuu, Z., & Longhurst, J. C. (2005). Role of unmyelinated fibers in electroacupuncture cardiovascular responses. Autonomic Neuroscience, 118(1–2), 43–50.

    PubMed  Google Scholar 

  • Tjen-A-Looi, S. C., Li, P., & Longhurst, J. C. (2003). Prolonged inhibition of rostral ventral lateral medullary premotor sympathetic neurons by electroacupuncture in cats. Autonomic Neuroscience, 106(2), 119–131.

    PubMed  Google Scholar 

  • Tjen-A-Looi, S. C., Li, P., & Longhurst, J. C. (2004). Medullary substrate and differential cardiovascular responses during stimulation of specific acupoints. American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 287(4), R852–R862.

    PubMed  Google Scholar 

  • Toma, C., Hervás, A., Balmaña, N., Salgado, M., Maristany, M., Vilella, E., Aguilera, F., Orejuela, C., Cuscó, I., & Gallastegui, F. (2013). Neurotransmitter systems and neurotrophic factors in autism: Association study of 37 genes suggests involvement of DDC. The World Journal of Biological Psychiatry, 14(7), 516–527.

    PubMed  Google Scholar 

  • Tsuji, S., Yuhi, T., Furuhara, K., Ohta, S., Shimizu, Y., & Higashida, H. (2015). Salivary oxytocin concentrations in seven boys with autism spectrum disorder received massage from their mothers: A pilot study. Frontiers in Psychiatry, 6, 58.

    PubMed  PubMed Central  Google Scholar 

  • Unschuld, P. U. (1985). Medicine in China: A history of ideas. University of California.

    Google Scholar 

  • Valicenti-McDermott, M., McVICAR, K., Rapin, I., Wershil, B. K., Cohen, H., & Shinnar, S. (2006). Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. Journal of Developmental & Behavioral Pediatrics, 27(2), S128–S136.

    Google Scholar 

  • van De Sande, M. M., van Buul, V. J., & Brouns, F. J. (2014). Autism and nutrition: The role of the gut–brain axis. Nutrition Research Reviews, 27(2), 199–214.

    PubMed  Google Scholar 

  • Ventola, C. L. (2010). Current issues regarding complementary and alternative medicine (CAM) in the United States: Part 1: The widespread use of CAM and the need for better-informed health care professionals to provide patient counseling. Pharmacy and Therapeutics, 35(8), 461.

    PubMed  PubMed Central  Google Scholar 

  • Voigt, R. G., Mellon, M. W., Katusic, S. K., Weaver, A. L., Matern, D., Mellon, B., Jensen, C. L., & Barbaresi, W. J. (2014). Dietary docosahexaenoic acid supplementation in children with autism. Journal of Pediatric Gastroenterology and Nutrition, 58(6), 715–722.

    PubMed  Google Scholar 

  • Volkmar, F. R., Cohen, D. J., & Paul, R. (1986). An evaluation of DSM-III criteria for infantile autism. Journal of the American Academy of Child Psychiatry, 25(2), 190–197.

    PubMed  Google Scholar 

  • Vuong, H. E., & Hsiao, E. Y. (2017). Emerging roles for the gut microbiome in autism spectrum disorder. Biological Psychiatry, 81(5), 411–423.

    PubMed  Google Scholar 

  • Warren, Z., Veenstra-VanderWeele, J., Stone, W., Vanderbilt Evidence-based Practice Center, et al. (2011). Therapies for children with autism spectrum disorders. Comparative Effectiveness Review No. 26. AHRQ Publication No. 11-EHC029-EF. Available at: http://www.effectivehealthcare.ahrq.gov/search-for-guides-reviewsandreports/?pageaction=displayproduct & productid=651. Accessed January 25, 2020.

  • Weitlauf, A. S., Sathe, N. A., McPheeters, M. L., & Warren, Z. (2017). Interventions targeting sensory challenges in children with autism spectrum disorder—an update.

    Google Scholar 

  • Whiteley, P., Haracopos, D., Knivsberg, A.-M., Reichelt, K. L., Parlar, S., Jacobsen, J., Seim, A., Pedersen, L., Schondel, M., & Shattock, P. (2010). The ScanBrit randomised, controlled, single-blind study of a gluten-and casein-free dietary intervention for children with autism spectrum disorders. Nutritional Neuroscience, 13(2), 87–100.

    PubMed  Google Scholar 

  • Whiteley, P., & Shattock, P. (2002). Biochemical aspects in autism spectrum disorders: Updating the opioid-excess theory and presenting new opportunities for biomedical intervention. Expert Opinion on Therapeutic Targets, 6(2), 175–183.

    PubMed  Google Scholar 

  • Wieland, L. S., Manheimer, E., & Berman, B. M. (2011). Development and classification of an operational definition of complementary and alternative medicine for the Cochrane collaboration. Alternative Therapies in Health and Medicine, 17(2), 50.

    PubMed  PubMed Central  Google Scholar 

  • Williams, J. G., Higgins, J. P., & Brayne, C. E. (2006). Systematic review of prevalence studies of autism spectrum disorders. Archives of Disease in Childhood, 91(1), 8–15.

    PubMed  Google Scholar 

  • Wong, V. (2009). Use of complementary and alternative medicine (CAM) in autism spectrum disorder (ASD): Comparison of Chinese and western culture (Part A). Journal of Autism and Developmental Disorders, 39(3), 454–463.

    PubMed  Google Scholar 

  • Wong, H. H., & Smith, R. G. (2006). Patterns of complementary and alternative medical therapy use in children diagnosed with autism spectrum disorders. Journal of Autism and Developmental Disorders, 36(7), 901–909.

    PubMed  Google Scholar 

  • Wu, W.-w., Kwong, E., X-y, L., & X-y, J. (2015). The effect of a meditative movement intervention on quality of sleep in the elderly: A systematic review and meta-analysis. The Journal of Alternative and Complementary Medicine, 21(9), 509–519.

    PubMed  Google Scholar 

  • Wu, Z., Yuan, Q., Wang, R., & Zhang, C. (2009). Analysis of therapeutic effects of Jin’s Three-Needles acupuncture in children with autism of different age groups. Journal Chongqing Medicine, 38, 2685–2687.

    Google Scholar 

  • Xiang, L., Wang, H., & Li, Z. (1996). TCD observation on cerebral blood flow dynamics inference of cerebral palsy with scalp therapy. Zhen ci yan jiu = Acupuncture Research, 21(4), 7–9.

    PubMed  Google Scholar 

  • Xu, Q., Yang, J.-W., Cao, Y., Zhang, L.-W., Zeng, X.-H., Li, F., Du, S.-Q., Wang, L.-P., & Liu, C.-Z. (2015). Acupuncture improves locomotor function by enhancing GABA receptor expression in transient focal cerebral ischemia rats. Neuroscience Letters, 588, 88–94.

    PubMed  Google Scholar 

  • Yi, H., Han, Y., Li, M., Wang, J., & Yang, L. (2020). Scalp acupuncture for Autism spectrum disorder: A systematic review. In IOP Conference Series: Earth and Environmental Science (Vol. 4, p. 042094). IOP Publishing.

    Google Scholar 

  • Yuan, Q., Wang, R., Wu, Z., Zhao, Y., Bao, X., & Jin, R. (2009). Observation on clinical therapeutic effect of Jin’s 3-needling therapy on severe autism. Zhongguo zhen jiu = Chinese Acupuncture & Moxibustion, 29(3), 177–180.

    Google Scholar 

  • Yuan, Q., Wu, Z., Wang, R., Liu, G., Bao, X., & Lang, J. (2009). Analysis of the effect of Jin’s three needle acupuncture in the treatment of childhood autism of Chinese Medicine syndromes. Journal Guangzhou University Traditional Chinese Medicine, 26, 241–244.

    Google Scholar 

  • Yuan, Q., Wu, Z., Wang, R., Zhao, Y., & Lang, J. (2009). Effect of acupuncture in autistic children with clinical syndromes. Modern Chinese Medicine, 41, 83–85.

    Google Scholar 

  • Zhang, Y., Cai, J., An, L., Hui, F., Ren, T., Ma, H., & Zhao, Q. (2017). Does music therapy enhance behavioral and cognitive function in elderly dementia patients? A systematic review and meta-analysis. Ageing Research Reviews, 35, 1–11.

    PubMed  Google Scholar 

  • Zhang, R., Jia, M.-X., Zhang, J.-S., Xu, X.-J., Shou, X.-J., Zhang, X.-T., Li, L., Li, N., Han, S.-P., & Han, J.-S. (2012). Transcutaneous electrical acupoint stimulation in children with autism and its impact on plasma levels of arginine-vasopressin and oxytocin: A prospective single-blinded controlled study. Research in Developmental Disabilities, 33(4), 1136–1146.

    PubMed  Google Scholar 

  • Zhou, W., Fu, L.-W., Tjen-A-Looi, S. C., Li, P., & Longhurst, J. C. (2005). Afferent mechanisms underlying stimulation modality-related modulation of acupuncture-related cardiovascular responses. Journal of Applied Physiology, 98(3), 872–880.

    PubMed  Google Scholar 

  • Zhou, H., & Zhang, P. (2008). The effect of language therapy combined with point massage on communion disability in autism children. China Practical Medicine, 3(23), 24–26.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Matteo Rocchetti .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Guiot, C., Grasso, F., Rocchetti, M., Brondino, N. (2022). Complementary and Alternative Therapies. In: Matson, J.L., Sturmey, P. (eds) Handbook of Autism and Pervasive Developmental Disorder. Autism and Child Psychopathology Series. Springer, Cham. https://doi.org/10.1007/978-3-030-88538-0_64

Download citation

Publish with us

Policies and ethics