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Transcriptomics to Dissect the Immune System

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Transcriptomics in Health and Disease

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Abstract

The immune system functions to protect the host from diverse pathogenic microorganisms as well as cancers, where transcriptional regulations in various immune cells are stringently controlled to ensure the appropriate activities of the system. Therefore, the transcriptional landscapes in different types of immune cells are distinctive to achieve respective roles in the immune system. The transcriptome analysis in bulk or a population of cells provides essential information which promotes a better understanding of gene regulations and molecular mechanisms shaping respective cell types. Furthermore, given the substantial heterogeneity in immune cells, transcriptome analysis at a single cell resolution would be contributive for identifying disease-relevant cells and genes, which facilitate us to understand the underlying mechanisms of immune disorders. In this chapter, we discuss the relevance of transcriptional profiling of immune cells including single-cell transcriptomes which have great potential to dissect the function of the immune system.

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Authors and Affiliations

  1. YCI Laboratory for Immunological Transcriptomics, RIKEN Center for Integrative Medical Science, Yokohama, Japan

    Hideyuki Yoshida

  2. Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima, Japan

    Mitsuru Matsumoto & Minoru Matsumoto

  3. Department of Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan

    Minoru Matsumoto

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  1. Hideyuki Yoshida
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  2. Mitsuru Matsumoto
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  3. Minoru Matsumoto
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Correspondence to Hideyuki Yoshida .

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  1. Molecular Immunogenetics Group, Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Geraldo A. Passos

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Yoshida, H., Matsumoto, M., Matsumoto, M. (2022). Transcriptomics to Dissect the Immune System. In: Passos, G.A. (eds) Transcriptomics in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-87821-4_10

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