Abstract
Registration of hepatic dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) series remains challenging, due to variable uptakes of the agent on different tissues or even the same tissues in the liver. The differences reflect on the intensity variations, which typically makes traditional intensity-based deformable registration methods fail to align small anatomical structures in liver such as vessels. Although deep-learning-based registration methods have become popular because of their superior efficiency for several years, registration of DCE-MRI series with dynamic intensity change is still under tackle. To solve this challenge, we present a two-stage registration network, in which the first stage aligns the whole liver and the second stage focuses on the registration of anatomical structures like vessels and tumors. Furthermore, we adopt a recurrent registration strategy for the deformation refinement. To evaluate our proposed method, we used clinical DCE-MRI series of 60 patients, and registered the arterial phase and the portal venous phase images onto the pre-contrast phases. Experimental results showed that the proposed method achieved a better registration performance than the traditional method (i.e., SyN) and the deep-learning-based method (i.e., VoxelMorph), especially in aligning anatomical structures such as vessel branches in liver.
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References
Aronhime, S., et al.: DCE-MRI of the liver: effect of linear and nonlinear conversions on hepatic perfusion quantification and reproducibility. J. Magn. Reson. Imaging 40(1), 90–98 (2014)
Avants, B.B., Epstein, C.L., Grossman, M., Gee, J.C.: Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Med. Image Anal. 12(1), 26–41 (2008)
Avants, B.B., Tustison, N.J., Song, G., Cook, P.A., Klein, A., Gee, J.C.: A reproducible evaluation of ants similarity metric performance in brain image registration. Neuroimage 54(3), 2033–2044 (2011)
Balakrishnan, G., Zhao, A., Sabuncu, M.R., Guttag, J., Dalca, A.V.: An unsupervised learning model for deformable medical image registration. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 9252–9260 (2018)
Cao, X., et al.: Deformable image registration based on similarity-steered CNN regression. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D., Duchesne, S. (eds.) Medical Image Computing and Computer Assisted Intervention, vol. 10433, pp. 300–308. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66182-7_35
Chen, L., et al.: Semantic hierarchy guided registration networks for intra-subject pulmonary CT image alignment. In: Martel, A.L. et al. (eds.) Medical Image Computing and Computer Assisted Intervention, vol. 12263, pp. 181–189. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-59716-0_18
Çiçek, Ö., Abdulkadir, A., Lienkamp, S.S., Brox, T., Ronneberger, O.: 3D U-Net: learning dense volumetric segmentation from sparse annotation. In: Ourselin, S., Joskowicz, L., Sabuncu, M., Unal, G., Wells, W. (eds.) Medical Image Computing and Computer-Assisted Intervention, vol. 9901, pp. 424–432. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46723-8_49
Guo, C.K.: Multi-modal image registration with unsupervised deep learning. Ph.D. Thesis, Massachusetts Institute of Technology (2019)
Haskins, G., Kruger, U., Yan, P.: Deep learning in medical image registration: a survey. Mach. Vis. Appl. 31(1), 1–18 (2020). https://doi.org/10.1007/s00138-020-01060-x
Jaderberg, M., Simonyan, K., Zisserman, A., Kavukcuoglu, K.: Spatial transformer networks. arXiv preprint arXiv:1506.02025 (2015)
Newatia, A., Khatri, G., Friedman, B., Hines, J.: Subtraction imaging: applications for nonvascular abdominal MRI. Am. J. Roentgenol. 188(4), 1018–1025 (2007)
Rohé, M.M., Datar, M., Heimann, T., Sermesant, M., Pennec, X.: SVF-Net: learning deformable image registration using shape matching. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D., Duchesne, S. (eds.) Medical Image Computing and Computer Assisted Intervention, vol. 10433, pp. 266–274. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66182-7_31
Vercauteren, T., Pennec, X., Perchant, A., Ayache, N.: Diffeomorphic demons: efficient non-parametric image registration. NeuroImage 45(1), S61–S72 (2009)
Wei, D., et al.: An auto-context deformable registration network for infant brain MRI. arXiv preprint arXiv:2005.09230 (2020)
Wollny, G., Kellman, P., Santos, A., Ledesma-Carbayo, M.J.: Automatic motion compensation of free breathing acquired myocardial perfusion data by using independent component analysis. Med. Image Anal. 16(5), 1015–1028 (2012)
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This study has received funding by the National Natural Science Foundation of China (No. 91859107).
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Shen, W. et al. (2021). A Recurrent Two-Stage Anatomy-Guided Network for Registration of Liver DCE-MRI. In: Lian, C., Cao, X., Rekik, I., Xu, X., Yan, P. (eds) Machine Learning in Medical Imaging. MLMI 2021. Lecture Notes in Computer Science(), vol 12966. Springer, Cham. https://doi.org/10.1007/978-3-030-87589-3_23
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DOI: https://doi.org/10.1007/978-3-030-87589-3_23
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