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Arterial Stimulation Venous Sampling for Pancreatic Endocrine Tumors

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Diagnosis and Management of Endocrine Disorders in Interventional Radiology
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Abstract

Arterial stimulation venous sampling (ASVS) is a minimally invasive technique to diagnose and localize functional pancreatic endocrine tumors. This test is most commonly used to identify insulinomas in patients for whom noninvasive imaging fails to localize the lesion. The test is performed by injecting a stimulating agent (calcium or secretin) in arteries that supply discrete regions of the pancreas while simultaneously obtaining venous samples from the hepatic veins. While this test has been shown in several studies to have high sensitivity and specificity, it does require a thorough knowledge of pancreatic arterial anatomy and potential anatomic variants in order to maximize the usefulness of this study.

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References

  1. Imamura M, Takahashi K, Adachi H, Minematsu S, Shimada Y, Naito M, et al. Usefulness of selective arterial secretin injection test for localization of gastrinoma in the Zollinger-Ellison syndrome. Ann Surg. 1987;205(3):230–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Doppman JL, Miller DL, Chang R, Maton PN, London JF, Gardner JD, et al. Gastrinomas: localization by means of selective intraarterial injection of secretin. Radiology. 1990;174(1):25–9.

    Article  CAS  PubMed  Google Scholar 

  3. Norton JA, Doppman JL, Jensen RT. Curative resection in Zollinger-Ellison syndrome. Results of a 10-year prospective study. Ann Surg. 1992;215(1):8–18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Doppman JL, Miller DL, Chang R, Shawker TH, Gorden P, Norton JA. Insulinomas: localization with selective intraarterial injection of calcium. Radiology. 1991;178(1):237–41.

    Article  CAS  PubMed  Google Scholar 

  5. Pereira PL, Roche AJ, Maier GW, Huppert PE, Dammann F, Farnsworth CT, et al. Insulinoma and islet cell hyperplasia: value of the calcium intraarterial stimulation test when findings of other preoperative studies are negative. Radiology. 1998;206(3):703–9.

    Article  CAS  PubMed  Google Scholar 

  6. Roche A, Raisonnier A, Gillon-Savouret MC. Pancreatic venous sampling and arteriography in localizing insulinomas and gastrinomas: procedure and results in 55 cases. Radiology. 1982;145(3):621–7.

    Article  CAS  PubMed  Google Scholar 

  7. Gaeke RF, Kaplan EL, Rubenstein A, Starr J, Burke G. Insulin and proinsulin release during calcium infusion in a patient with islet-cell tumor. Metabolism. 1975;24(9):1029–34.

    Article  CAS  PubMed  Google Scholar 

  8. Liu Y, Song Q, Jin HT, Lin XZ, Chen KM. The value of multidetector-row CT in the preoperative detection of pancreatic insulinomas. Radiol Med. 2009;114(8):1232–8.

    Article  CAS  PubMed  Google Scholar 

  9. Gouya H, Vignaux O, Augui J, Dousset B, Palazzo L, Louvel A, et al. CT, endoscopic sonography, and a combined protocol for preoperative evaluation of pancreatic insulinomas. AJR Am J Roentgenol. 2003;181(4):987–92.

    Article  PubMed  Google Scholar 

  10. Lin XZ, Wu ZY, Tao R, Guo Y, Li JY, Zhang J, et al. Dual energy spectral CT imaging of insulinoma-value in preoperative diagnosis compared with conventional multi-detector CT. Eur J Radiol. 2012;81(10):2487–94.

    Article  PubMed  Google Scholar 

  11. Stark DD, Moss AA, Goldberg HI, Deveney CW. CT of pancreatic islet cell tumors. Radiology. 1984;150(2):491–4.

    Article  CAS  PubMed  Google Scholar 

  12. Rossi P, Baert A, Passariello R, Simonetti G, Pavone P, Tempesta P. CT of functioning tumors of the pancreas. AJR Am J Roentgenol. 1985;144(1):57–60.

    Article  CAS  PubMed  Google Scholar 

  13. Günther RW, Klose KJ, Rückert K, Kuhn FP, Beyer J, Klotter HJ, et al. Islet-cell tumors: detection of small lesions with computed tomography and ultrasound. Radiology. 1983;148(2):485–8.

    Article  PubMed  Google Scholar 

  14. Günther RW, Klose KJ, Rückert K, Beyer J, Kuhn FP, Klotter HJ. Localization of small islet-cell tumors. Preoperative and intraoperative ultrasound, computed tomography, arteriography, digital subtraction angiography, and pancreatic venous sampling. Gastrointest Radiol. 1985;10(2):145–52.

    Article  PubMed  Google Scholar 

  15. Kann PH, Rothmund M, Zielke A. Endoscopic ultrasound imaging of insulinomas: limitations and clinical relevance. Exp Clin Endocrinol Diabetes. 2005;113(8):471–4.

    Article  CAS  PubMed  Google Scholar 

  16. Kann PH, Moll R, Bartsch D, Pfützner A, Forst T, Tamagno G, et al. Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) in insulinomas: indications and clinical relevance in a single investigator cohort of 47 patients. Endocrine. 2017;56(1):158–63.

    Article  CAS  PubMed  Google Scholar 

  17. Wang H, Ba Y, Xing Q, Du JL. Diagnostic value of endoscopic ultrasound for insulinoma localization: a systematic review and meta-analysis. PLoS One. 2018;13(10):e0206099.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Kunz PL, Reidy-Lagunes D, Anthony LB, Bertino EM, Brendtro K, Chan JA, et al. Consensus guidelines for the management and treatment of neuroendocrine tumors. Pancreas. 2013;42(4):557–77.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Morganstein DL, Lewis DH, Jackson J, Isla A, Lynn J, Devendra D, et al. The role of arterial stimulation and simultaneous venous sampling in addition to cross-sectional imaging for localisation of biochemically proven insulinoma. Eur Radiol. 2009;19(10):2467–73.

    Article  CAS  PubMed  Google Scholar 

  20. Lau JH, Drake W, Matson M. The current role of venous sampling in the localization of endocrine disease. Cardiovasc Intervent Radiol. 2007;30(4):555–70.

    Article  PubMed  Google Scholar 

  21. Monroe EJ, Carney BW, Ingraham CR, Johnson GE, Valji K. An interventionist’s guide to endocrine consultations. Radiographics. 2017;37(4):1246–67.

    Article  PubMed  Google Scholar 

  22. Harness JK, Geelhoed GW, Thompson NW, Nishiyama RH, Fajans SS, Kraft RO, et al. Nesidioblastosis in adults. A surgical dilemma. Arch Surg. 1981;116(5):575–80.

    Article  CAS  PubMed  Google Scholar 

  23. Laidlaw GF. Nesidioblastoma, the islet tumor of the pancreas. Am J Pathol. 1938;14(2):125–34.5.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Jabri AL, Bayard C. Nesidioblastosis associated with hyperinsulinemic hypoglycemia in adults: review of the literature. Eur J Intern Med. 2004;15(7):407–10.

    Article  CAS  PubMed  Google Scholar 

  25. Service GJ, Thompson GB, Service FJ, Andrews JC, Collazo-Clavell ML, Lloyd RV. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med. 2005;353(3):249–54.

    Article  CAS  PubMed  Google Scholar 

  26. Maeda Y, Yokoyama K, Takeda K, Takada J, Hamada H, Hujioka Y, et al. Adult-onset diffuse nesidioblastosis causing hypoglycemia. Clin J Gastroenterol. 2013;6(1):50–4.

    Article  PubMed  Google Scholar 

  27. Toyomasu Y, Fukuchi M, Yoshida T, Tajima K, Osawa H, Motegi M, et al. Treatment of hyperinsulinemic hypoglycemia due to diffuse nesidioblastosis in adults: a case report. Am Surg. 2009;75(4):331–4.

    Article  PubMed  Google Scholar 

  28. Kenney B, Tormey CA, Qin L, Sosa JA, Jain D, Neto A. Adult nesidioblastosis. Clinicopathologic correlation between pre-operative selective arterial calcium stimulation studies and post-operative pathologic findings. JOP. 2008;9(4):504–11.

    PubMed  Google Scholar 

  29. Malik S, Mitchell JE, Steffen K, Engel S, Wiisanen R, Garcia L, et al. Recognition and management of hyperinsulinemic hypoglycemia after bariatric surgery. Obes Res Clin Pract. 2016;10(1):1–14.

    Article  PubMed  Google Scholar 

  30. Cui Y, Elahi D, Andersen DK. Advances in the etiology and management of hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass. J Gastrointest Surg. 2011;15(10):1879–88.

    Article  PubMed  Google Scholar 

  31. Okauchi Y, Nammo T, Iwahashi H, Kizu T, Hayashi I, Okita K, et al. Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS). Intern Med. 2009;48(12):1025–30.

    Article  PubMed  Google Scholar 

  32. Eguchi H, Tanemura M, Marubashi S, Kobayashi S, Wada H, Okita K, et al. Arterial stimulation and venous sampling for glucagonomas of the pancreas. Hepato-Gastroenterology. 2012;59(113):276–9.

    CAS  PubMed  Google Scholar 

  33. Bertelli E, Di Gregorio F, Bertelli L, Mosca S. The arterial blood supply of the pancreas: a review. I. The superior pancreaticoduodenal and the anterior superior pancreaticoduodenal arteries. An anatomical and radiological study. Surg Radiol Anat. 1995;17(2):97–106, 1–3.

    Article  CAS  PubMed  Google Scholar 

  34. Bertelli E, Di Gregorio F, Bertelli L, Civeli L, Mosca S. The arterial blood supply of the pancreas: a review. II. The posterior superior pancreaticoduodenal artery. An anatomical and radiological study. Surg Radiol Anat. 1996;18(1):1–9.

    Article  CAS  PubMed  Google Scholar 

  35. Bertelli E, Di Gregorio F, Bertelli L, Civeli L, Mosca S. The arterial blood supply of the pancreas: a review. III. The inferior pancreaticoduodenal artery. An anatomical review and a radiological study. Surg Radiol Anat. 1996;18(2):67–74.

    Article  CAS  PubMed  Google Scholar 

  36. Bertelli E, Di Gregorio F, Bertelli L, Orazioli D, Bastianini A. The arterial blood supply of the pancreas: a review. IV. The anterior inferior and posterior pancreaticoduodenal aa., and minor sources of blood supply for the head of the pancreas. An anatomical review and radiologic study. Surg Radiol Anat. 1997;19(4):203–12.

    CAS  PubMed  Google Scholar 

  37. Bertelli E, Di Gregorio F, Mosca S, Bastianini A. The arterial blood supply of the pancreas: a review. V. The dorsal pancreatic artery. An anatomic review and a radiologic study. Surg Radiol Anat. 1998;20(6):445–52.

    Article  CAS  PubMed  Google Scholar 

  38. Uflacker R. Atlas of vascular anatomy: an angiographic approach. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2007. xiv, 905 p.

    Google Scholar 

  39. Sakuhara Y, Kodama Y, Abo D, Hasegawa Y, Shimizu T, Omatsu T, et al. Evaluation of the vascular supply to regions of the pancreas on CT during arteriography. Abdom Imaging. 2008;33(5):563–70.

    Article  PubMed  Google Scholar 

  40. Wiesli P, Brändle M, Schmid C, Krähenbühl L, Furrer J, Keller U, et al. Selective arterial calcium stimulation and hepatic venous sampling in the evaluation of hyperinsulinemic hypoglycemia: potential and limitations. J Vasc Interv Radiol. 2004;15(11):1251–6.

    Article  PubMed  Google Scholar 

  41. Guettier JM, Kam A, Chang R, Skarulis MC, Cochran C, Alexander HR, et al. Localization of insulinomas to regions of the pancreas by intraarterial calcium stimulation: the NIH experience. J Clin Endocrinol Metab. 2009;94(4):1074–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Thompson SM, Vella A, Service FJ, Grant CS, Thompson GB, Andrews JC. Impact of variant pancreatic arterial anatomy and overlap in regional perfusion on the interpretation of selective arterial calcium stimulation with hepatic venous sampling for preoperative localization of occult insulinoma. Surgery. 2015;158(1):162–72.

    Article  PubMed  Google Scholar 

  43. Tseng LM, Chen JY, Won JG, Tseng HS, Yang AH, Wang SE, et al. The role of intra-arterial calcium stimulation test with hepatic venous sampling (IACS) in the management of occult insulinomas. Ann Surg Oncol. 2007;14(7):2121–7.

    Article  PubMed  Google Scholar 

  44. Defreyne L, König K, Lerch MM, Hesse UJ, Rottiers R, Feifel G, et al. Modified intra-arterial calcium stimulation with venous sampling test for preoperative localization of insulinomas. Abdom Imaging. 1998;23(3):322–31.

    Article  CAS  PubMed  Google Scholar 

  45. Kajiwara K, Yamagami T, Toyota N, Kakizawa H, Urashima M, Hieda M, et al. New diagnostic criteria for the localization of insulinomas with the selective arterial calcium injection test: decision tree analysis. J Vasc Interv Radiol. 2018;29(12):1749–53.

    Article  PubMed  Google Scholar 

  46. Wang H, Ba Y, Xing Q, Cai RC. Diagnostic value of ASVS for insulinoma localization: a systematic review and meta-analysis. PLoS One. 2019;14(11):e0224928.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Thompson SM, Vella A, Thompson GB, Rumilla KM, Service FJ, Grant CS, et al. Selective arterial calcium stimulation with hepatic venous sampling differentiates insulinoma from nesidioblastosis. J Clin Endocrinol Metab. 2015;100(11):4189–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Spanakis E, Gragnoli C. Successful medical management of status post-Roux-en-Y-gastric-bypass hyperinsulinemic hypoglycemia. Obes Surg. 2009;19(9):1333–4.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Øhrstrøm CC, Worm D, Hansen DL. Postprandial hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass: an update. Surg Obes Relat Dis. 2017;13(2):345–51.

    Article  PubMed  Google Scholar 

  50. Thom AK, Norton JA, Doppman JL, Miller DL, Chang R, Jensen RT. Prospective study of the use of intraarterial secretin injection and portal venous sampling to localize duodenal gastrinomas. Surgery. 1992;112(6):1002–8; discussion 8–9.

    CAS  PubMed  Google Scholar 

  51. Jackson JE. Angiography and arterial stimulation venous sampling in the localization of pancreatic neuroendocrine tumours. Best Pract Res Clin Endocrinol Metab. 2005;19(2):229–39.

    Article  PubMed  Google Scholar 

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Burke, C.T. (2022). Arterial Stimulation Venous Sampling for Pancreatic Endocrine Tumors. In: Yu, H., Burke, C.T., Commander, C.W. (eds) Diagnosis and Management of Endocrine Disorders in Interventional Radiology. Springer, Cham. https://doi.org/10.1007/978-3-030-87189-5_10

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  • DOI: https://doi.org/10.1007/978-3-030-87189-5_10

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