Overview
- Represents the most comprehensive discussion of the entire respiratory microbiome and associated key diseases
- Provides information on designing and interpreting studies and how they can be applied in clinical treatment
- Includes issues specific to the upper and lower respiratory tract
Part of the book series: Respiratory Medicine (RM)
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Table of contents (11 chapters)
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Front Matter
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Principles and Tools of Respiratory Microbiome Investigation
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Front Matter
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Applications: Role of the Microbiome in Respiratory Disease
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Front Matter
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Back Matter
Keywords
About this book
The book is organized into two main sections. Part I, Principles and Tools, covers conceptual modeling of the respiratory microbiome, experimental methodology with a focus on a priori considerations in study design and sampling, laboratory and computational methods for analysis of respiratory microbiome data, and minimizing interpretive pitfalls. Part II, Applications, discusses the evidence from specific studies that have shed novel insights into the influence of respiratory microbiota on mechanisms or outcomes in specific diseases. Based on current best evidence, disease-specific chapters include chronic rhinosinusitis, asthma (pediatric and adult studies), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), bronchiectasis not due to CF, idiopathic pulmonary fibrosis, and lung transplant.
This is an ideal reference for forward-thinking practitioners with interest in novel developments in precision medicine applications in lung disease, as well as translational scientists in the field of microbiology, immunology and lung biology.
Editors and Affiliations
About the editors
Dr. Huang is Assistant Professor in the Division of Pulmonary/Critical Care Medicine at the University of Michigan. She has directed numerous respiratory microbiome investigations of asthma and COPD, including NIH multi-center studies. Her research laboratory utilizes interdisciplinary approaches to understand how the compositional structure and functions of airway and gut microbiota affect airway disease phenotype. Dr. Huang has served on numerous panels and committees regarding microbiome science and respiratory disease, including for the National Academy of Science, Engineering and Medicine.
Dr. Garantziotis is Staff Clinician, Principal Investigator and Medical Director of the Clinical Research Unit at the National Institute of Environmental Health Sciences. His research focuses on gene-environment interactions in the pathogenesis of lung disease. He is leading a number of studies on the role of the microbiome in lung injury and is the Chairperson ofthe working group “Microbiome in Lung Disease” of the American Thoracic Society, Allergy, Immunology and Inflammation Assembly.
Bibliographic Information
Book Title: The Microbiome in Respiratory Disease
Book Subtitle: Principles, Tools and Applications
Editors: Yvonne J. Huang, Stavros Garantziotis
Series Title: Respiratory Medicine
DOI: https://doi.org/10.1007/978-3-030-87104-8
Publisher: Humana Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022
Hardcover ISBN: 978-3-030-87103-1Published: 16 December 2021
Softcover ISBN: 978-3-030-87106-2Published: 17 December 2022
eBook ISBN: 978-3-030-87104-8Published: 01 January 2022
Series ISSN: 2197-7372
Series E-ISSN: 2197-7380
Edition Number: 1
Number of Pages: XI, 305
Number of Illustrations: 16 illustrations in colour