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Trichinella and Trichinellosis: From Wildlife to the Human Beings

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Zoonoses: Infections Affecting Humans and Animals

Abstract

Trichinellosis is a cosmopolitan infection transmitted to humans through the consumption of raw or undercooked meat of domestic and wild pigs, horses, and carnivorous animals infected by nematode larvae of the genus Trichinella. These parasites are maintained in nature by a sylvatic cycle. Spillover from wild animals to domesticated animals can occur when there is improper management in segregating livestock and wildlife. The symptoms associated with trichinellosis vary with the number of infecting larvae ingested, the time after infection, and the Trichinella species. Progression of the disease follows the biological development of these nematodes. Most of the clinical features of trichinellosis are immunopathological in origin and are related to the capacity of these parasites to induce allergic responses.

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References

  • Akkoc N, Kuruuzum Z, Akar S, Yuce A, Onen F, Yapar N, Ozgenc O, Turk M, Ozdemir D, Avci M, Guruz Y, Oral AM, Pozio E, Izmir Trichinellosis Outbreak Study Group (2009) A large-scale outbreak of trichinellosis caused by Trichinella britovi in Turkey. Zoonoses Public Health 56:65–70

    Article  CAS  PubMed  Google Scholar 

  • Ancelle T, Dupouy-Camet J, Bougnoux ME, Fourestie V, Petit H, Mougeot G, Nozais JP, Lapierre J (1988) Two outbreaks of trichinosis caused by horsemeat in France in 1985. Am J Epidemiol 127:1302–1311

    Article  CAS  PubMed  Google Scholar 

  • Blaga R, Durand B, Antoniu S, Gherman C, Cretu CM, Cozma V, Boireau P (2007) A dramatic increase in the incidence of human trichinellosis in Romania over the past 25 years: impact of political changes and regional food habits. Am J Trop Med Hyg 76:983–986

    Article  PubMed  Google Scholar 

  • Boireau P, Vallee I, Roman T, Perret C, Mingyuan L, Gamble HR, Gajadhar A (2000) Trichinella in horses: a low frequency infection with high human risk. Vet Parasitol 93:309–320

    Article  CAS  PubMed  Google Scholar 

  • Bruschi F, Brunetti E, Pozio E (2013) Neurotrichinellosis. Handb Clin Neurol 114:243–249

    Article  PubMed  Google Scholar 

  • Bruschi F, Gómez-Morales MA, Hill DE (2019) International Commission on Trichinellosis: recommendations on the use of serological tests for the detection of Trichinella infection in animals and humans. Food Waterborne Parasitol 12:e00032

    Article  Google Scholar 

  • Compton SJ, Celum CL, Lee C, Thompson D, Sumi SM, Fritsche TR, Coombs RW (1993) Trichinosis with ventilatory failure and persistent myocarditis. Clin Infect Dis 16:500–504

    Article  CAS  PubMed  Google Scholar 

  • Despommier DD (1998) How does Trichinella spiralis make itself at home? Parasitol Today 14:318–323

    Article  CAS  PubMed  Google Scholar 

  • Dupouy-Camet J, Ancelle T, Fourestie V, Boireau P, Soule C (1998) Trichinelloses. In: Maladies infectieuses Encycl Méd Chir (Ed.). Elsevier, Paris, p 8-517-A-10

    Google Scholar 

  • Dupouy-Camet J, Kociecka W, Bruschi F, Bolas-Fernandez F, Pozio E (2002) Opinion on the diagnosis and treatment of human trichinellosis. Expert Opin Pharmacother 3:1117–1130

    Article  PubMed  Google Scholar 

  • Ellrodt A, Halfon P, Le Bras P, Halimi P, Bourée P, Dési M, Caquet R (1987) Multifocal central nervous system lesions in three patients with trichinosis. Arch Neurol 44:432–434

    Article  CAS  PubMed  Google Scholar 

  • European Commission (2015) Commission implementing regulation (EU) 2015/1375 of 10 August 2015 laying down specific rules on official controls for Trichinella in meat. Off J Eur Union L212:7–34

    Google Scholar 

  • European Commission (2018) Commission Implementing Decision (EU) 2018/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions. Off J Eur Union L170:1–74

    Google Scholar 

  • European Food Safety Agency (2021) The European Union One Health 2019 Zoonoses Report. EFSA J 19(2):6406

    Google Scholar 

  • Feydy A, Touze E, Miaux Y, Bolgert F, Martin-Duverneuil N, Laplane D, Chiras J (1996) MRI in a case of neurotrichinosis. Neuroradiology 38(S1):S80–S82

    Article  PubMed  Google Scholar 

  • Fourestie V, Douceron H, Brugieres P, Ancelle T, Lejonc JL, Gherardi RK (1993) Neurotrichinosis. A cerebrovascular disease associated with myocardial injury and hypereosinophilia. Brain 116:603–616

    Article  PubMed  Google Scholar 

  • Gaeta R, Bruschi F (2021) History of the parasite and disease. In: Bruschi F (ed) Trichinella and Trichinellosis. Academic Press. (in press)

    Google Scholar 

  • Gajadhar AA, Pozio E, Gamble HR, Nöckler K, Maddox-Hyttel C, Forbes LB, Vallée I, Rossi P, Marinculić A, Boireau P (2009) Trichinella diagnostics and control: mandatory and best practices for ensuring food safety. Vet Parasitol 159:197–205

    Article  PubMed  Google Scholar 

  • Gallardo MT, Mateos L, Artieda J, Wesslen L, Ruiz C, García MA, Galmés-Truyols A, Martin A, Hernández-Pezzi G, Andersson Y, Gárate T, Christensson D (2007) Outbreak of trichinellosis in Spain and Sweden due to consumption of wild boar meat contaminated with Trichinella britovi. Euro Surveill 12:E070315.1

    CAS  PubMed  Google Scholar 

  • Gamble HR, Pozio E, Bruschi F, Nöckler K, Kapel CM, Gajadhar AA (2004) International Commission on Trichinellosis: recommendations on the use of serological tests for the detection of Trichinella infection in animals and man. Parasite 11:3–13

    Article  CAS  PubMed  Google Scholar 

  • Gari-Toussaint M, Tieulié N, Baldin J, Dupouy-Camet J, Delaunay P, Fuzibet JG, Le Fichoux Y, Pozio E, Marty P (2005) Human trichinellosis due to Trichinella britovi in southern France after consumption of frozen wild boar meat. Euro Surveill 10:117–118

    Article  CAS  PubMed  Google Scholar 

  • Gómez-Morales MA, Ludovisi A, Amati M, Blaga R, Zivojinovic M, Ribicich M, Pozio E (2012) A distinctive Western blot pattern to recognize Trichinella infections in humans and pigs. Int J Parasitol 42:1017–1023

    Article  PubMed  Google Scholar 

  • Gottstein B, Pozio E, Nöckler K (2009) Epidemiology, diagnosis, treatment, and control of trichinellosis. Clin Microbiol Rev 22:127–145

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Houzé S, Ancelle T, Matra R, Boceno C, Carlier Y, Gajadhar AA, Dupouy-Camet J (2009) Trichinellosis acquired in Nunavut, Canada in September 2009: meat from grizzly bear suspected. Euro Surveill 14:19383

    Article  PubMed  Google Scholar 

  • Kociecka W (2000) Trichinellosis: human disease, diagnosis and treatment. Vet Parasitol 93:365–383

    Article  CAS  PubMed  Google Scholar 

  • Lacour SA, Heckmann A, Macé P, Grasset-Chevillot A, Zanella G, Vallée I, Kapel CM, Boireau P (2013) Freeze-tolerance of Trichinella muscle larvae in experimentally infected wild boars. Vet Parasitol 194:175–178

    Article  PubMed  Google Scholar 

  • Lazarević AM, Nesković AN, Goronja M, Golubovic S, Komić J, Bojić M, Popović AD (1999) Low incidence of cardiac abnormalities in treated trichinosis: a prospective study of 62 patients from a single-source outbreak. Am J Med 107:18–23

    Article  PubMed  Google Scholar 

  • Messiaen P, Forier A, Vanderschueren S, Theunissen C, Nijs J, Van Esbroeck M, Bottieau E, De Schrijver K, Gyssens IC, Cartuyvels R, Dorny P, van der Hilst J, Blockmans D (2016) Outbreak of trichinellosis related to eating imported wild boar meat, Belgium, 2014. Euro Surveill 21:30341

    Article  PubMed  PubMed Central  Google Scholar 

  • Murrell KD, Pozio E (2011) Worldwide occurrence and impact of human trichinellosis, 1986–2009. Emerg Infect Dis 17:2194–2202

    Article  PubMed  PubMed Central  Google Scholar 

  • Neghina R, Neghina AM, Marincu I, Iacobiciu I (2010) Cardiac involvement in patients with trichinosis hospitalized in western Romania. Foodborne Pathog Dis 7:1235–1238

    Article  PubMed  Google Scholar 

  • Office International des Epizoties (2013) Chapter 8.14, Infection with Trichinella spp. In: Terrestrial animal health code, pp 1–4

    Google Scholar 

  • Porto-Fett AC, Call JE, Shoyer BE, Hill DE, Pshebniski C, Cocoma GJ, Luchansky JB (2010) Evaluation of fermentation, drying, and/or high pressure processing on viability of Listeria monocytogenes, Escherichia coli O157:H7, Salmonella spp., and Trichinella spiralis in raw pork and Genoa salami. Int J Food Microbiol 140:61–75

    Article  CAS  PubMed  Google Scholar 

  • Pozio E (2007) World distribution of Trichinella spp. infections in animals and humans. Vet Parasitol 149:3–21

    Article  PubMed  Google Scholar 

  • Pozio E (2014) Searching for Trichinella: not all pigs are created equal. Trends Parasitol 30:4–11

    Article  PubMed  Google Scholar 

  • Pozio E (2015) Trichinella spp. imported with live animals and meat. Vet Parasitol 213:46–55

    Article  PubMed  Google Scholar 

  • Pozio E (2021a) Scientific achievements of the last 60 years: from a single to a multispecies concept of the genus Trichinella. Vet Parasitol 297:109042

    Article  CAS  PubMed  Google Scholar 

  • Pozio E (2021b) Epidemiology. In: Bruschi F (ed) Trichinella and Trichinellosis. Academic Press, pp 185–263

    Chapter  Google Scholar 

  • Pozio E, Gomez Morales MA, Dupouy-Camet J (2003) Clinical aspects, diagnosis and treatment of trichinellosis. Expert Rev Anti-Infect Ther 1:471–482

    Article  CAS  PubMed  Google Scholar 

  • Pozio E, La Rosa G (2010) Trichinella. In: Liu D (ed) Molecular detection of foodborne pathogens. CRC Press, Boca Raton, pp 851–863

    Google Scholar 

  • Pozio E, Ludovisi A, Pezzotti P, Bruschi F, Gómez-Morales MÁ (2019) Retrospective analysis of hospital discharge records for cases of trichinellosis does not allow evaluation of disease burden in Italy. Parasite 26:42

    Article  PubMed  PubMed Central  Google Scholar 

  • Pozio E, Marucci G (2003) Trichinella-infected pork products: a dangerous gift. Trends Parasitol 19:338

    Article  PubMed  Google Scholar 

  • Pozio E, Merialdi G, Licata E, Della Casa G, Fabiani M, Amati M, Cherchi S, Ramini M, Faeti V, Interisano M, Ludovisi A, Rugna G, Marucci G, Tonanzi D, Gómez-Morales MA (2020) Differences in larval survival and IgG response patterns in long-lasting infections by Trichinella spiralis, Trichinella britovi and Trichinella pseudospiralis in pigs. Parasit Vectors 16:520

    Article  Google Scholar 

  • Pozio E, Murrell KD (2006) Systematics and epidemiology of Trichinella. Adv Parasitol 63:367–439

    Article  PubMed  Google Scholar 

  • Pozio E, Sacchini D, Sacchi L, Tamburrini A, Alberici F (2001) Failure of mebendazole in the treatment of humans with Trichinella spiralis infection at the stage of encapsulating larvae. Clin Infect Dis 32:638–642

    Article  CAS  PubMed  Google Scholar 

  • Pozio E, Zarlenga DS (2013) New pieces of the Trichinella puzzle. Int J Parasitol 43:983–997

    Article  PubMed  Google Scholar 

  • Pozio E, Zarlenga DS (2021) Taxonomy of the Trichinella genus. In: Bruschi F (ed) Trichinella and Trichinellosis. Academic Press, pp 35–76

    Chapter  Google Scholar 

  • Puljiz I, Beus A, Kuzman I, Seiwerth S (2005) Electrocardiographic changes and myocarditis in trichinellosis: a retrospective study of 154 patients. Ann Trop Med Parasitol 99:403–411

    Article  CAS  PubMed  Google Scholar 

  • Ribicich M, Gamble HR, Rosa A, Sommerfelt I, Marquez A, Mira G, Cardillo N, Cattaneo ML, Falzoni E, Franco A (2007) Clinical, haematological, biochemical and economic impacts of Trichinella spiralis infection in pigs. Vet Parasitol 147:265–270

    Article  CAS  PubMed  Google Scholar 

  • Rostami A, Gamble HR, Dupouy-Camet J, Khazan H, Bruschi F (2017) Meat sources of infection for outbreaks of human trichinellosis. Food Microbiol 64:65–71

    Article  PubMed  Google Scholar 

  • Sharma R, Thompson P, Hoberg EP, Scandrett WB, Konecsni K, Harms NJ, Kukka PM, Jung TS, Elkin B, Mulders R, Larter NC, Branigan M, Pongracz J, Wagner B, Kafle P, Lobanov VA, Rosentha BM, Jenkins EJ (2020) Hiding in plain sight: discovery and phylogeography of a cryptic species of Trichinella (Nematoda: Trichinellidae) in wolverine (Gulo gulo). Int J Parasitol 50:277–287

    Article  CAS  PubMed  Google Scholar 

  • Soule C, Dupouy-Camet J, Georges P, Ancelle T, Gillet JP, Vaissaire J, Delvigne A, Plateau E (1989) Experimental trichinellosis in horses: biological and parasitological evaluation. Vet Parasitol 31:19–36

    Article  CAS  PubMed  Google Scholar 

  • Stensvold CR, Nielsen HV, Mølbak K (2007) A case of trichinellosis in Denmark, imported from Poland, June 2007. Euro Surveill 12:E070809.3

    CAS  PubMed  Google Scholar 

  • Zarlenga D, Thompson P, Pozio E (2020) Trichinella species and genotypes. Res Vet Sci 133:289–296

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Edoardo Pozio .

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Pozio, E., Gomez Morales, M.Á. (2023). Trichinella and Trichinellosis: From Wildlife to the Human Beings. In: Sing, A. (eds) Zoonoses: Infections Affecting Humans and Animals. Springer, Cham. https://doi.org/10.1007/978-3-030-85877-3_58-1

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  • DOI: https://doi.org/10.1007/978-3-030-85877-3_58-1

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