Abstract
Lifestyle factors are of major determinants of environmental exposures. Endocrine signaling pathways can be disrupted by environmental chemicals. Endocrine function is established in early life and any endocrine disorders with adverse consequences can develop later in life. Evidence has shown that endocrine disrupting chemicals (EDCs) with hormone like activity have adverse health consequences in both genders. EDCs may act as obesogens and affect appetite, weight and energy balance, regulation of metabolism as well as the development of adipose tissue. In addition, EDCs may interfere in pubertal development, time of puberty and influence on pubertal height growth. It is documented that exposure to EDCs is associated with short femur length. One of the phenotypes of overweight and obesity is elevated body mass index with normal weight in presence of short stature. This type of excess weight can be considered as one of the health concern for the pediatric age group. EDCs can disturb the normal function of estrogen receptors and endogenous androgen action. They change transcription and release of growth hormone, insulin like growth factor-I (IGF-I) concentration, and in turn they would affect the normal growth of height and weight. Such growth disorders might have long-term impact on the development of chronic diseases in adulthood. Understanding the effect of EDCs on hormone functions and growth development can be important for primordial prevention of non-communicable diseases related to obesity. Following a healthy lifestyle can reduce the exposure to EDCs and their adverse effects. This chapter aims to summarize the current literature on the effect of EDCs on excess weight related to short stature and growth hormone.
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References
Muralikrishna I, Manickam V (2017) Environmental management. In: Analytical methods for monitoring environmental pollution. Elsevier, Butterworth Heinemann, p 495570
Chowdhary P et al (2020) Microorganisms for sustainable environment and health, in 21-Environmental pollution: causes, effects, and the remedies. Elsevier, Joseph Hayton
Khan K, Shah A, Khan J (2016) Electricity consumption patterns: comparative evidence from Pakistan’s public and private sectors. Lahore J Econ 21:99–122
Pradip PK et al (2018) Environmental impact of urban consumption patterns: drivers and focus points Resour Conserv Recycl 137:260–269
Withrow D, Alter DA (2011) The economic burden of obesity worldwide: a systematic review of the direct costs of obesity. Obes Rev 12:131–141
Bouret S, Levin BE, Ozanne SE (2015) Gene-Environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiol Rev 95:47–82
Gore AC et al (2015) EDC-2: the endocrine Society’s second scientific statement on endocrine-disrupting chemicals. Endocr Rev 36:E1-150
Liu G et al (2018) Perfluoroalkyl substances and changes in body weight and resting metabolic rate in response to weight-loss diets: a prospective study. PLoS Med 15:e1002502
Chamorro-Garcia R, Diaz-Castillo C, Shoucri BM (2012) Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice. Nat Commun
Danilovich N et al (2000) Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice. Endocrinology 141:4295–4308
Murata Y et al (2002) Effect of estrogen deficiency in the male: the ArKO mouse model. Mol Cell Endocrinol 193(1–2):7–12
Naville D et al (2015) Metabolic outcome of female mice exposed to a mixture of low-dose pollutants in a diet-induced obesity model. PLoS One 10:e0124015
Stojanoska MM et al (2015) Do diethyl phthalate (DEP) and di-2-ethylhexyl phthalate (DEHP) influence the metabolic syndrome parameters? Pilot Study Environ Monit Assess 187:526
Somm E et al (2009) Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect 117:1549–1555
Miyawaki J et al (2007) Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice. J Atheroscler Thromb 14:245–252
Hurst CH, Waxman DJ (2003) Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci 74:297–308
Stahlhut RW et al (2007) Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect 115:876–882
Heuvel JPV et al (2006) Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. Toxicol Sci 92:476–489
Ma X et al (2011) Environmental inhibitors of 11beta-hydroxysteroid dehydrogenase type 2. Toxicology 285:83–89
Silva MJ et al (2004) Urinary levels of seven phthalate metabolites in the U.S. population from the national health and nutrition examination survey (NHANES) 1999–2000. Environ Health Perspect 112:331–338
Becker K et al (2009) GerES IV: phthalate metabolites and bisphenol a in urine of German children. Int J Hyg Environ Health 212:685–692
Caserta DA et al (2013) Heavy metals and placental fetal-maternal barrier: a mini-review on the major concerns. Eur Rev Med Pharmacol Sci 17:2198–2206
Edwards SC et al (2010) Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children’s intelligence at 5 years of age in a prospective cohort study in Poland. Environ Health Perspect 118:1326–1331
Gardner RM et al (2013) Environmental exposure to metals and children’s growth to age 5 years: a prospective cohort study. Am J Epidemiol 177:1356–1367
Dhooge W et al (2011) Internal exposure to pollutants and sex hormone levels in Flemish male adolescents in a cross-sectional study: associations and dose–response relationships. J Eposure Sci Environ Epidemiol 21:106–113
Zawatski W, Lee MM (2013) Male pubertal development: are endocrine-disrupting compounds shifting the norms? J Endocrinol 218:R1-12
Lin H et al (2008) Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero. Proc Natl Acad Sci USA 105:7218–7222
Iglesias P, Diez JJ (2009) Thyroid dysfunction and kidney disease. Eur J Endocrinol 160:503–515
Adibi JJ et al (2009) Maternal urinary metabolites of di-(2-ethylhexyl) phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study. Am J Epidemiol 169:1015–1024
Wittassek M, Angerer J (2008) Phthalates: metabolism and exposure. Int J Androl 31:131–138
Peretz J et al (2014) Bisphenol a and reproductive health: update of experimental and human evidence, 2007–2013. Environ Health Perspect 122:775–786
Wang Z et al (2017) Urine bisphenol a and pubertal development in boys. Int J Hyg Environ Health 220:43–50
Miao M et al (2017) Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study. Environ Health A Glob Access Sci Source 16:80
Wells EM, Jackson LW, Koontz MB (2014) Association between bisphenol a and waist-to-height ratio among children: national health and nutrition examination survey, 2003–2010. Ann Epidemiol 24:165–167
Harley KG et al (2013) Prenatal and postnatal bisphenol a exposure and body mass index in childhood in the CHAMACOS cohort. Environ Health Perspect 121:514–520
Wilson ME, Westberry ME, Trout AL (2011) Estrogen receptor-alpha gene expression in the cortex: sex differences during development and in adulthood. Horm Behav Modif 59:353–357
Bhandari R, Xiao J, Shankar A (2013) Urinary bisphenol A and obesity in U.S. children. Am J Epidemiol 177:1263–1270
Li D-K et al (2013) Urine bisphenol-A level in relation to obesity and overweight in school-age children. PLoS One 8:e65399
Wolff MS et al (2008) Prenatal phenol and phthalate exposures and birth outcomes. Environ Health Perspect 116:1092–1097
Rönn M et al (2014) Bisphenol a is related to circulating levels of adiponectin, leptin and ghrelin, but not to fat mass or fat distribution in humans. Chemosphere 112:42–48
Buser MC, Murray HE, Scinicariello F (2014) Age and sex differences in childhood and adulthood obesity association with phthalates: analyses of NHANES 2007–2010. Int J Hyg Environ Health 217:687–694
Wang H et al (2013) Urinary phthalate metabolites are associated with body mass index and waist circumference in Chinese school children. PLOS One 8:e56800
Mason C, Craig CL, Katzmarzyk PT (2008) Influence of central and extremity circumferences on all-cause mortality in men and women. Obesity (Silver Spring) 16:2690–2695
Trasande L et al (2013) Race/ethnicity-specific associations of urinary phthalates with childhood body mass in a nationally representative sample. Environ Health Perspect 121:501–506
Teitelbaum SL et al (2012) Associations between phthalate metabolite urinary concentrations and body size measures in New York City children. Environ Res 112:186–193
Hatch EE et al (2008) Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999–2002. Environ Health 7:1–15
Boas M et al (2010) Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth. Environ Health Perspect 118:1458–1464
Desvergne B, Feige JN, Casals-Casas C (2009) PPAR-mediated activity of phthalates: a link to the obesity epidemic? Mol Cell Endocrinol 304:43–48
Deierlein AL et al (2016) Longitudinal associations of phthalate exposures during childhood and body size measurements in young girls. Epidemiology 27:492–499
Jedrychowski WA et al (2015) Depressed height gain of children associated with intrauterine exposure to polycyclic aromatic hydrocarbons (PAH) and heavy metals: the cohort prospective study. Environ Res 136:141–147
Meeker JD (2012) Exposure to environmental endocrine disruptors and child development. Arch Pediatr Adolesc Med 166:952–958
Kumar M et al (2020) Environmental endocrine-disrupting chemical exposure: role in non-communicable diseases. Front Publ Health 8:553850
Velmurugan G et al (2017) Gut microbiota, endocrine-disrupting chemicals, and the diabetes epidemic. Trends Endocrinol Metab 28:612–625
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Hemati, Z., Heidari-Beni, M., Kelishadi, R. (2022). Exposure to Endocrine Disrupting Chemicals, Part of Lifestyle Factors Related to Growth Disorders in Childhood and Chronic Diseases in Adulthood. In: Kelishadi, R. (eds) Healthy Lifestyle. Integrated Science, vol 3. Springer, Cham. https://doi.org/10.1007/978-3-030-85357-0_14
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DOI: https://doi.org/10.1007/978-3-030-85357-0_14
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