Abstract
Crohn’s disease is a segmental inflammatory disease of the gastrointestinal tract. Formerly, a disease of Western societies, it is now a worldwide condition. Presentation is commonly with abdominal pain, often accompanies by growth failure and occasionally symptoms of colitis. Fecal calprotectin is the most useful screening test, but diagnosis rests on ileal biopsy. Modern therapy is directed at mucosal healing with surgery reserved for specific indications. The nature of surgery has altered since the introduction of anti-TNF therapy.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
By contrast—cigarette smoke appears to protect against the development of ulcerative colitis.
- 2.
Seton—derived from Latin seta—a stiff hair or bristle.
Further Reading
Abdelaal K, Jaffray B. Colonic disease site and perioperative complications predict need for later intestinal interventions following intestinal resection in pediatric Crohn’s disease. J Pediatr Surg. 2016;51:272–6.
Dilillo D, Zuccotti GV, Galli E, Meneghin F, Dell’Era A, Penagini F, et al. Noninvasive testing in the management of children with suspected inflammatory bowel disease. Scand J Gastroenterol. 2019;54:586–91.
Kapasi R, Glatter J, Lamb CA, Acheson AG, Andrews C, Arnott ID, et al. Consensus standards of healthcare for adults and children with inflammatory bowel disease in the UK. Frontline Gastroenterol. 2020;11(3):178–87.
Murthy SK, Begum J, Benchimol EI, et al. Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study. Gut. 2020;69(2):274–82.
Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769–78.
Rutgeerts P, Vermeire S, Van Assche G. biological therapies for inflammatory bowel diseases. Gastroenterology. 2009;136:1182–97.
van Rheenen PF, Van de Vijver E, Fidler V. Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis. Br Med J. 2010;341:11.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Jaffray, B. (2022). Crohn’s Disease. In: Sinha, C.K., Davenport, M. (eds) Handbook of Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-84467-7_55
Download citation
DOI: https://doi.org/10.1007/978-3-030-84467-7_55
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-84466-0
Online ISBN: 978-3-030-84467-7
eBook Packages: MedicineMedicine (R0)