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Inflammatory Environment and Cartilage Repair

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Joint Function Preservation

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Abstract

Articular cartilage has become the focus of early reparative treatments and the object of joint preservation just in the last decades.

Osteoarthritis represents one of the most debilitating diseases with important physical, psychological, and socioeconomic severe burdens. Recently OA has been identified as an inflammation-associated multifactorial disorder, characterized by a chronic, comparatively low-grade inflammation. The body reacts to the initial damage by the activation of several molecular, immune and mechanical pathways, transducing joint trauma, chronic injury, or overuse damage into inflammatory processes. These inflammatory processes determine the modifications of cartilage metabolism that lead to osteochondral unit breakdown and degeneration. These new understandings of OA pathophysiology have opened the way to the development of new, specific molecular drugs and various orthobiologic components that may intervene not just on symptoms, but be able to establish new treatment paradigms that may modify the disease development and progression.

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Authors and Affiliations

  1. Clinica Nostra Signora della Mercede, Rome, Italy

    Fabio Valerio Sciarretta

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  1. Fabio Valerio Sciarretta
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Editors and Affiliations

  1. O.A.S.I. Bioresearch Foundation Gobbi NPO, Milan, Italy

    Alberto Gobbi

  2. Musculoskeletal and Joint Research Foundation, San Diego, CA, USA

    John G. Lane

  3. Orthopaedics and Traumatology Unit, University Campus Biomedico, Roma, Italy

    Umile Giuseppe Longo

  4. OASI Bioresearch Foundation Gobbi NPO, Milan, Italy

    Ignacio Dallo

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Sciarretta, F.V. (2022). Inflammatory Environment and Cartilage Repair. In: Gobbi, A., Lane, J.G., Longo, U.G., Dallo, I. (eds) Joint Function Preservation. Springer, Cham. https://doi.org/10.1007/978-3-030-82958-2_22

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