Abstract
Allergic hypersensitivity reactions (IgE and cell-mediated type) were described soon after the market introduction of antiacid drugs, with a large number of severe reactions as anaphylaxis or severe cutaneous adverse drug reactions (SCARs), including Stevens-Johnson syndrome and toxic epidermal necrolysis.
In this review, we aim to summarize what has been published about clinical manifestation and pathogenetic mechanisms of adverse reactions induced by PPIs and H2-blockers, focusing on accuracy of diagnostic procedures (in vivo and in vitro test) and management of possible cross-reactivity.
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References
Fock KM, Ang TL, Bee LC, et al. Proton pump inhibitors: do differences in pharmacokinetics translate into differences in clinical outcomes? Clin Pharmacokinet. 2008;47:1–6.
Nehra AK, Alexander JA, Loftus CG, et al. Proton pump inhibitors: review of emerging concerns. Mayo Clin Proc. 2018;93:240–6. This review on the safety of long term therapy with PPIs focuses on 3 possible concerns: interaction with clopidogrel therapy, the risk of spontaneous fractures and of hypomagnesemia
Lombardo C, Bonadonna P. Hypersensitivity reactions to proton pump inhibitors. Curr Treat Opt Allerg. 2015;2:110–23. This review provides a comprehensive overview of allergic and nonallergic hypersensitivity reactions to PPIs
Kepil Özdemir S, Erkekol FO, Unal D, et al. Management of hypersensitivity reactions to proton pump inhibitors: a retrospective experience. Int Arch Allergy Immunol. 2016;172:54–60.
Lin CY, Wang C-W, Hui C-YR, et al. Delayed type hypersensitivity by proton pump inhibitors: a clinical and in vitro T-cell reactivity study. Allergy. 2018;73:221–9. This paper is the largest case case series about severe delayed reactions to PPIs with a study of cross-reactivity
Park KH, Pai J, Song DJ, et al. Ranitidine-induced anaphylaxis: clinical features, cross-reactivity, and skin testing. Clin Exp Allerg. 2016;46:631–9.
Bonadonna P, Lombardo C, Bortolami O, et al. Hypersensitivity to proton pump inhibitors: diagnostic accuracy of skin tests compared to oral provocation test. J Allergy Clin Immunol. 2012;130:547–9.
Kepil Özdemir S, Yılmaz I, Aydin Ö, et al. Immediate-type hypersensitivity reactions to proton pump inhibitors: usefulness of skin tests in the diagnosis and assessment of cross-reactivity. Allergy. 2013;68:1008–14.
Watts TJ, Haque R. DRESS syndrome induced by ranitidine. J Allergy Clin Immunol Pract. 2018;6:1030–1.
Cho HJ, Yoo HS, Park SJ, et al. A case of cimetidine-induced immediate hypersensitivity. JACI. 2012;22:216–8.
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Bonadonna, P., Lombardo, C. (2022). Antiacid drugs: Proton Pump Inhibitors and H2 Receptor Antagonists. In: Bircher, A.J., Maibach, H.I., Brockow, K., Barbaud, A. (eds) Cutaneous Drug Hypersensitivity. Springer, Cham. https://doi.org/10.1007/978-3-030-82743-4_30
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DOI: https://doi.org/10.1007/978-3-030-82743-4_30
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