Abstract
By many parameters, chemistry is a central science that interfaces several disciplines with overlapping borders to a different extension to each one of them. On the other hand, systems biology became a new concept to a holistic approach to understanding life. One of the overlapping borders between chemistry and biology is bioanalytical chemistry that could be considered the analytical tools and methods to provide the data necessary in systems biology. In this chapter, we will explore further this concept of analytical chemistry for life sciences to the point that we could consider as bioanalytical systems! We will also make a brief introduction to the critical elements of this exciting field, such as the omics sciences and high-resolution, high-throughput instrumentation, keeping in mind that other chapters in this book will go deeper into the analytical techniques and methods.
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References
Ahmad S (2008) Plant metabolomics: techniques, applications, trends, and challenges. In: Barh D, Zambare V, Azevedo V (eds) OMICS applications in biomedical, agricultural, and environmental sciences, 1st edn. CRC Press, Boca Raton
Aizat W, Hassan M (2018) Proteomics in systems biology. In: Aizat W, Goh H, Baharum SNS, Azizan KA (eds) Omics applications for systems biology, 1st edn. Springer, Gewerbestrasse
Amiri-Dashatan N, Koushki M, Abbaszadeh H, Rostami-Nejad M (2018) Iran J Pharm Res 17:1523–1536
Aslam B, Basit M, Nisar MA, Khurshid M, Rasool MH (2017) J Chromatogr Sci 55:182–196
Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linderd T, Wawroscha C, Uhrine P, Temmlf V, Wanga L, Schwaigerb S, Heissa EH, Rollingera JM, Schusterf D, Breusse JM, Bochkovg V, Mihovilovicd MD, Koppa B, Bauerc R, Dirscha VM, Stuppner H (2015) Biotechnol Adv 33:1–18
Auroux PA, Iossifidis D, Reyes DR, Manz A (2002) Anal Chem 74:2637–2652
Bedia C (2018) Experimental approaches in omic sciences. In: Jaumot J, Bedia C, Tauler R (eds) Data analysis for omic sciences: methods and applications, 1st edn. Elsevier, Amsterdam
Boggio KJ, Obasuyi E, Sugino K, Nelson SB, Agar NYR, Agar JN (2011) Expert Rev Proteomics 8:591–604
Bounab Y, Eyer K, Dixneuf S, Rybczynska M, Chauvel C, Mistretta M, Tran T, Aymerich N, Chenon G, Llitjos J-F, Venet F, Monneret G, Gillespie IA, Cortez P, Moucadel V, Pachot A, Troesch A, Leissner P, Textoris J, Bibette J, Guyard C, Baudry J, Griffiths AD, Védrine C (2020) Nat Protoc 15:2920–2955
Bravo-Merodio L, Williams JA, Gkoutos GV, Acharjee A (2019) J Transl Med 17:1–10
Campa C, Coslovi A, Flamigni A, Rossi M (2006) Electrophoresis 27:2027–2050
Carrasco-Ramiro F, Peiró-Pastor R, Aguado B (2017) Gene Ther 24:551–561
Carrilho E (2000) Electrophoresis 21:55–65
Chandrasekhar K, Dileep A, Lebonah DE, Kumari JP (2014) Int Lett Nat Sci 17:77–84
Chen X, Wang Y, Ma N, Tian J, Shao Y, Zhu B, Wong YK, Liang Z, Zou C, Wang J (2020) Signal Transduct Target Ther 5:1–13
Chipuk JE, Bouchier-Hayes L, Green DR (2006) Cell Death Differ 13:1396–1402
Clark KD, Zhang C, Anderson JL (2016) Anal Chem 88:11262–11270
Datta LP, Manchineella S, Govindaraju T (2020) Biomaterials 230:119633
Davis SL, Eckhardt SG, Tentler JJ, Diamond JR (2014) Ther Adv Med Oncol 6:88–100
de Anda-Jáuregui G, Hernández-Lemus E (2020) Front Oncol 10:1–21
de Oliveira GCM, de Souza Carvalho JH, Brazaca LC, Vieira NCS, Janegitz BC (2020) Biosens Bioelectron 152:112016
de Zawadzki A, Arrivetti LOR, Vidal MP, Catai JR, Nassu RT, Tullio RR, Berndt A, Oliveira CR, Ferreira AG, Neves-Junior LF, Colnago LA, Skibsted LH, Cardoso DR (2017) Food Res Int 99:336–347
Dewey FE, Pan S, Wheeler MT, Quake SR, Ashley EA (2013) Circulation 125:931–944
Duarte GRM, Coltro WKT, Borba JC, Price CW, Landers JP, Carrilho E (2012) Analyst 137:2692–2698
Duportet X, Aggio RBM, Carneiro S, Villas-Bôas SG (2012) Metabolomics 8:410–421
Eberl HC, Werner T, Reinhard FB, Lehmann S, Thomson D, Chen P, Zhang C, Rau C, Muelbaier M, Drewes G, Drewry D, Bantscheff M (2019) Sci Rep 9:1–14
Edman P, Begg G (1967) Eur J Biochem 1:80–91
Emmert-Streib F, Dehmer M, Yli-Harja O (2017) Front Genet 8:184–186
Enot DP, Haas B, Weinberger KM (2011) Bioinformatics for mass spectrometry-based metabolomics. In: Mayer B (ed) Bioinformatics for omics data, methods and protocols, 1st edn. Humana Press, London
Fekete A, Schmitt-Kopplin P (2007) Capillary electrophoresis. In: Picó Y (ed) Food toxicants analysis, 1st edn. Elsevier, Amsterdam
Ferreira VG, Leme GM, Cavalheiro AJ, Funari CS (2016) Anal Chem 88:8421–8427
Fiehn O (2002) Metabolomics – the link between genotypes and phenotypes. In: Town CD (ed) Functional genomics, 1st edn. Springer, Dordrecht
França LTC, Carrilho E, Kist TBL (2002) Q Rev Biophys 35:169–200
Funari CS, Castro-Gamboa I, Cavalheiro AJ, Bolzani VS (2013) Quim Nova 36:1605–1609
Galderisi U, Jori FP, Giordano A (2003) Oncogene 22:5208–5219
Gault VA, McClenaghan NH (2009) Introduction to biomolecules. In: Gault VA, McClenaghan NH (eds) Understanding bioanalytical chemistry, 1st edn. Wiley-Blackwell, Chichester
Gibbs RA (2020) Nat Rev Genet 21:575–576
Glad M, Larsson PO (1991) Curr Opin Biotechnol 2:413–418
Gomes KFB, Santos AS, Semzezem C, Correia MR, Brito LA, Ruiz MO, Fukui RT, Matioli SR, Passos-Bueno MR, da Silva MER (2017) Sci Rep 7:1–10
Gomez FA (2010) Bioanalysis 2:1661–1662
Hellhammer DH, Wüst S, Kudielka BM (2009) Psychoneuroendocrinology 34:163–171
Hersel U, Dahmen C, Kessler H (2003) Biomaterials 24:4385–4415
Hodge C, Bousse L, Knapp M (2001) Microfluidic analysis, screening, and synthesis. In: Sucholeiki I (ed) High throughput synthesis, 1st edn. Marcel Dekker, New York
Horvai G, Worsfold P, Karlberg B, Andersen JET (2011) Trends Anal Chem 30:422–424
Humphery-Smith I (2015) Proteomics 15:1773–1776
Imamura AH, Segato TP, de Oliveira LJM, Hassan A, Crespilho FN, Carrilho E (2020) Microchim Acta 187:1–8
Ingber DE (2018) Development 145:10–13
Jorge TF, Mata AT, António C (2016) Philos Trans R Soc A Math Phys Eng Sci 374:20150370
Joyce AR, Palsson B (2006) Nat Rev Mol Cell Biol 7:198–210
Kanehisa M (2019) Protein Sci 28:1947–1951
Karczewski KJ, Snyder MP (2018) Nat Rev Genet 19:299–310
Kim HK, Verpoorte R (2010) Phytochem Anal 21:4–13
Kim M-S, Pinto SM, Getnet D, Nirujogi RS, Manda SS, Chaerkady R, Madugundu AK, Kelkar DS, Isserlin R, Jain S, Thomas JK, Muthusamy B, Leal-Rojas P, Kumar P, Sahasrabuddhe NA, Balakrishnan L, Advani J, George B, Renuse S, Selvan LDN, Patil AH, Nanjappa V, Radhakrishnan A, Prasad S, Subbannayya T, Raju R, Kumar M, Sreenivasamurthy SK, Marimuthu A, Sathe GJ, Chavan S, Datta KK, Subbannayya Y, Sahu A, Yelamanchi SD, Jayaram S, Rajagopalan P, Sharma J, Murthy KR, Syed N, Goel R, Khan AA, Ahmad S, Dey G, Mudgal K, Chatterjee A, Huang T-C, Zhong J, Wu X, Shaw PG, Freed D, Zahari MS, Mukherjee KK, Shankar S, Mahadevan A, Lam H, Mitchell CJ, Shankar SK, Satishchandra P, Schroeder JT, Sirdeshmukh R, Maitra A, Leach SD, Drake CG, Halushka MK, Prasad TSK, Hruban RH, Kerr CL, Bader GD, Iacobuzio-Donahue CA, Gowda H, Pandey A (2014) Nature 509:575–581
Kogikoski S, Paschoalino WJ, Kubota LT (2018) Trends Anal Chem 108:88–97
Kubinyi H (2002) J Braz Chem Soc 13:717–726
LaBaer J, Ramachandran N (2005) Curr Opin Chem Biol 9:14–19
Labuda J, Bowater RP, Fojta M, Gauglitz G, Glatz Z, Hapala I, Havliš J, Kilar F, Kilar A, Malinovská L, Sirén HMM, Skládal P, Torta F, Valachovič M, Wimmerová M, Zdráhal Z, Hibbert DB (2018) Pure Appl Chem 90:1121–1198
Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, Fitzhugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, Levine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Hong ML, Dubois J, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, De La Bastide M, Dedhia N, Blöcker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JGR, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AFA, Stupka E, Szustakowki J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Patrinos A, Morgan MJ (2001) Nature 409:860–921
Laue TM, Stafford WF (1999) Annu Rev Biophys Biomol Struct 28:75–100
Lechner A, Wolff P, Leize-Wagner E, François Y-N (2020) Anal Chem 92:7363–7370
Li PCH (2010) Introduction. In: Li PCH (ed) Fundamentals of microfluidics and lab on a chip for biological analysis and discovery, 1st edn. CRC Press, Boca Raton
Li JR, Sun CH, Li W, Chao RF, Huang CC, Zhou XJ, Liu CC (2016) Nucleic Acids Res 44:D944–D951
Lindahl A, Heuchel R, Forshed J, Lehtiö J, Löhr M, Nordström A (2017) Metabolomics 13:1–10
Lottspeich F, Engels JW (2018) Protein purification. In: Lottspeich F, Engels JW (eds) Bioanalytics—analytical methods in biochemistry and molecular biology, 1st edn. Wiley, Weinheim
Mamanova L, Coffey AJ, Scott CE, Kozarewa I, Turner EH, Kumar A, Howard E, Shendure J, Turner DJ (2010) Nat Methods 7:111–118
Manz A, Harrison DJ, Verpoorte EMJ, Fettinger JC, Paulus A, Lüdi H, Widmer HM (1992) J Chromatogr A 593:253–258
Manz A, Pamme N, Lossifidis D (2004) Biomolecules. In: Manz A, Pamme N, Lossifidis D (eds) Bioanalytical chemistry, 1st edn. Imperial College Press, London
Martínez-Jiménez F, Muiños F, Sentís I, Deu-Pons J, Reyes-Salazar I, Arnedo-Pac C, Mularoni L, Pich O, Bonet J, Kranas H, Gonzalez-Perez A, Lopez-Bigas N (2020) Nat Rev Cancer 20:555–572
Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Anal Chem 75:3019–3030
Medvedev P, Stanciu M, Brudno M (2009) Nat Methods 6:S13–S20
Mesquita FS, Alexandri FLD, Scolari SC, Membrive CMB, Papa PC, Cardoso D (2012) Anim Reprod 9:713–722
Mikkelsen SR, Cortón E (2016) Principles of electrophoresis. In: Mikkelsen SR, Cortón E (eds) Bioanalytical chemistry, 2nd edn. Wiley, Hoboken
Narod SA, Foulkes WD (2004) Nat Rev Cancer 4:665–676
Nordström A, O’Maille G, Qin C, Siuzdak G (2006) Anal Chem 78:3289–3295
O’Connor C, Adams JU (2010) Cyclin-dependent kinases regulate progression through the cell cycle. In: O’Connor C, Adams JU (eds) Essentials of cell biology, 1st edn. NPG Education, Cambridge
Ozaki T, Nakagawara A (2011) Cancer 3:994–1013
Paganelli MO, Grossi AB, Dores-Silva PR, Borges JC, Cardoso DR, Skibsted LH (2016) Food Chem 210:491–499
Parry-Smith DJ (2019) Bioinformatics and its applications in genomics. In: Ramesh V (ed) Biomolecular and bioanalytical techniques, 1st edn. Wiley, Chichester
Pollard TD, Earnshaw WC, Lippincott-Schawartz J, Johnson GT (2004) Introduction to cell cycle. In: Pollard TD, Earnshaw WC, Lippincott-Schawartz J, Johnson GT (eds) An introduction to cell biology, 3th edn. Elsevier, Philadelphia
Poole C, Mester Z, Miró M, Pedersen-Bjergaard S, Pawliszyn J (2016) Pure Appl Chem 88:649–687
Pross A, Pascal R (2013) Open Biol 3:120–190
Qiao B, de la Cruz MO (2020) ACS Nano 14:10616–10623
Rahman J, Rahman S (2018) Lancet 391:2560–2574
Raja K, Patrick M, Gao Y, Madu D, Yang Y, Tsoi LC (2017) Int J Genomics 2017:6213474
Razzaq A, Sadia B, Raza A, Hameed MK, Saleem F (2019) Metabolites 9:303–339
Reyes DR, Iossifidis D, Auroux P, Manz A (2002) Anal Chem 74:2623–2636
Roat-Malone RM (2007) Biochemistry fundamentals. In: Roat-Malone RM (ed) Bioinorganic chemistry, 2nd edn. Wiley, Hoboken
Roman GT, Kennedy RT (2007) J Chromatogr A 1168:170–188
Rotroff DM (2020) Chest 158:S113–S123
Sali A, Glaeser R, Earnest T, Baumeister W (2003) Nature 422:216–225
Sandberg R (2014) Nat Methods 11:22–24
Schuster SC (2008) Nat Methods 5:16–18
Selzer PM, Marhöfer RJ, Koch O (2018) The biological foundations of bioinformatics. In: Selzer PM, Marhöfer RJ, Koch O (eds) Applied bioinformatics, 2nd edn. Springer, Berlin
Shamas-Din A, Kale J, Leber B, Andrews DW (2013) Cold Spring Harb Perspect Biol 5:a008714
Spratlin JL, Serkova NJ, Eckhardt SG (2009) Clin Cancer Res 15:431–440
Srikoti M, Bolgar MS, Kazakevich Y (2020) J Chromatogr B Anal Technol Biomed Life Sci 1140:121984
Sutandy FXR, Qian J, Chen CS, Zhu H (2013) Curr Protoc Protein Sci 72:1–16
Terry SC, Herman JH, Angell JB (1979) IEEE Trans Electron Devices 26:1880–1886
Triba MN, Le Moyec L, Amathieu R, Goossens C, Bouchemal N, Nahon P, Rutledge DN, Savarin P (2015) Mol BioSyst 11:13–19
Varshney RK, Kudapa H, Pazhamala L, Chitikineni A, Thudi M, Bohra A, Gaur PM, Janila P, Fikre A, Kimurto P, Ellis N (2015) Crit Rev Plant Sci 34:169–194
Vaz C, Tanavde V (2019) Proteomics. In: Arivaradarajan P, Misra G (eds) Omics approaches, technologies and applications: integrative approaches for understanding OMICS data, 1st edn. Springer, Singapore
Vernon ST, Hansen T, Kott KA, Yang JY, O’Sullivan JF, Figtree GA (2019) Microcirculation 26:e12488
Villas-Bôas SG, Gombert AK (2006) Biotecnologia Ciência e Desenvolvimento 36:59–69
Wake MH (2008) Bioscience 58:349–353
Wang X (2012) Clin Transl Med 1:1–3
Whibley C, Pharoah PDP, Hollstein M (2009) Nat Rev Cancer 9:95–107
Wishart DS (2007) Brief Bioinform 8:279–293
Woolfson MM (2018) Phys Scr 93:032501
Yan-Do R, Macdonald PE (2017) Endocrinology 158:1064–1073
Yates JR, Ruse CI, Nakorchevsky A (2009) Annu Rev Biomed Eng 11:49–79
Yoon D, Choi BR, Kim YC, Oh SM, Kim HG, Kim JU, Baek NI, Kim S, Lee DY (2019) Biomol Ther 9:424–439
Zawadzki A, Alloo C, Grossi AB, do Nascimento ESP, Almeida LC, Junior SB, Skibsted LH, Cardoso DR (2018) Food Res Int 105:210–220
Zeng W, Musson DG, Fisher AL, Chen L, Schwartz MS, Woolf EJ, Wang AQ (2008) J Pharm Biomed Anal 46:534–542
Zhang J, Rector J, Lin JQ, Young JH, Sans M, Katta N, Giese N, Yu W, Nagi C, Suliburk J, Liu J, Bensussan A, Dehoog RJ, Garza KY, Ludolph B, Sorace AG, Syed A, Zahedivash A, Milner TE, Eberlin LS (2017) Sci Transl Med 9:eaan3968
Zhang B, Korolj A, Lai BFL, Radisic M (2018) Nat Rev Mater 3:257–278
Zubritsky E (2002) Anal Chem 74:22A–26A
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Ferreira, V.G., Feitor, J.F., Almeida, M.B., Cardoso, D.R., Carrilho, E. (2022). What Is Bioanalytical Chemistry? Scientific Opportunities with Immediate Impact. In: Kubota, L.T., da Silva, J.A.F., Sena, M.M., Alves, W.A. (eds) Tools and Trends in Bioanalytical Chemistry. Springer, Cham. https://doi.org/10.1007/978-3-030-82381-8_1
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