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Acquired Pathology

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Hybrid PET/MR Neuroimaging

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Abstract

Temporal lobe epilepsy (TLE) is one of the most common forms of intractable epilepsy, with the frontal lobe the most common extratemporal site of seizure origin. Temporal lobe epilepsy can be further characterized as mesial temporal lobe epilepsy (mTLE) if there is an involvement of the amygdala, hippocampus, and/or entorhinal cortex. Of these, hippocampal or mesial temporal sclerosis (MTS) is one of the most common treatable causes of TLE. Sommer first characterized hippocampal sclerosis in 1880 [1], but the ability to diagnose this entity improved with noninvasive neuroimaging. This hardening or sclerosis of the hippocampus is the most commonly reported lesion in surgical and autopsy reports of temporal lobe epilepsy (TLE), occurring in up to 50% of cases of temporal lobe epilepsy. MTS is pathologically characterized by neuronal loss of pyramidal cells in the cornu ammonis, as well as dentate hilar neuronal loss. Patients may have a prior history of infection, trauma, or infantile febrile seizures.

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  1. Stanford University, Department of Radiology, Stanford, CA, USA

    Andrew Chiu & Michael Zeineh

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  1. Andrew Chiu
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  2. Michael Zeineh
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Correspondence to Michael Zeineh .

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  1. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, The Feinstein Institutes for Medical Research, Manhasset, NY, USA

    Ana M. Franceschi

  2. Stony Brook University Hospital, Stony Brook, NY, USA

    Dinko Franceschi

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Chiu, A., Zeineh, M. (2022). Acquired Pathology . In: Franceschi, A.M., Franceschi, D. (eds) Hybrid PET/MR Neuroimaging. Springer, Cham. https://doi.org/10.1007/978-3-030-82367-2_43

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  • DOI: https://doi.org/10.1007/978-3-030-82367-2_43

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