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Orthotic and Robotic Substitution Devices for Central Nervous System Rehabilitation and Beyond

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Engineering Biomaterials for Neural Applications

Abstract

During the last decade, the scientific community has enormously advanced in the development of innovative wearable devices, orthoses, and robotic exoskeletons that are revolutionizing rehabilitation in patients who suffer any kind of neurological, neuromuscular, or orthopedical disorder. In this context, different materials and manufacturing design processes are being under investigation with the aim of enhancing the recovery outcomes and the level of functional independence of the patients. In this chapter, current progress in materials applied to the development of orthotics, robotics, and other wearable devices is reviewed, as well as their manufacturing design processes, with a major attention in the rehabilitation of central nervous system disorders. Specifically, orthoses and exoskeleton devices will be classified according to their manufacturing materials. We will later discuss how material and manufacturing choices affect the features of the resulting devices, indicating both associated advantages and disadvantages, and then condition their clinical applicability along the rehabilitation process and patient recovery. Final considerations and future research directions will be proposed in an attempt to improve the usability of these devices, both during the clinical practice and, even more importantly, in the patients’ daily life.

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References

  1. Herr H (2009) Exoskeletons and orthoses: classification, design challenges and future directions. J Neuroeng Rehabil 6:21

    Article  Google Scholar 

  2. Garavaglia L, Pagliano E, Baranello G, Pittaccio S (2018) Why orthotic devices could be of help in the management of movement disorders in the young. J Neuroeng Rehabil 15:118

    Article  Google Scholar 

  3. Garavaglia L, Pagliano E, Arnoldi MT et al (2017) Two single cases treated by a new pseudoelastic upper-limb orthosis for secondary dystonia of the young. 2017 International Conference on Rehabilitation Robotics (ICORR), 1260–1265

    Article  Google Scholar 

  4. Matthews MJ, Payne C, Watson M (2011) The use of a dynamic elastomeric fabric orthosis to manage painful shoulder subluxation: A case study. J Prosthet Orthot 23:155–158

    Article  Google Scholar 

  5. Yang K, Isaia B, Brown LJE, Beeby S (2019) E-textiles for healthy ageing. Sensors 19:4463

    Article  Google Scholar 

  6. Zhao S, Liu J, Gong Z et al (2020) Wearable physiological monitoring system based on electrocardiography and electromyography for upper limb rehabilitation training. Sensors 20:4861

    Article  Google Scholar 

  7. Hesse S, Waldner A, Tomelleri C (2010) Innovative gait robot for the repetitive practice of floor walking and stair climbing up and down in stroke patients. J Neuroeng Rehabil 7:30

    Article  Google Scholar 

  8. Krebs HI, Hogan N, Aisen ML, Volpe BT (1998) Robot aided neurorehabilitation. IEEE Trans Rehabil Eng 6:75–87

    Article  CAS  Google Scholar 

  9. Krebs HI, Conroy SS, Bever CT, Hogan N (2012) Forging mens et manus: The MIT experience in upper extremity robotic therapy. In Dietz V, Nef T, Zev Rymer W (eds) Neurorehabilitation Technology (pp 125–140). Springer, London

    Google Scholar 

  10. Colombo G, Joerg M, Schreier R, Dietz V (2000) Treadmill training of paraplegic patients using a robotic orthosis. J Rehab Res Dev 37:693–700

    CAS  Google Scholar 

  11. Mantone J (2006) Getting a leg up? Rehab patients get an assist from devices such as Health South’s AutoAmbulator, but the robot’s clinical benefits are still in doubt. Mod Healthc 36:58–60

    PubMed  Google Scholar 

  12. Fleerkotte BM, Koopman B, Buurke JH et al (2014) The effect of impedance-controlled robotic gait training on walking ability and quality in individuals with chronic incomplete spinal cord injury: an explorative study. J Neuroeng Rehabil 11:26

    Article  Google Scholar 

  13. Nam KY, Kim HJ, Kwon BS et al (2017) Robot-assisted gait training (Lokomat) improves walking function and activity in people with spinal cord injury: a systematic review. J Neuroeng Rehabil 14:24

    Article  Google Scholar 

  14. Esquenazi A, Talaty M, Packel A, Saulino M (2012) The ReWalk powered exoskeleton to restore ambulatory function to individuals with thoracic-level motor-complete spinal cord injury. Am J Phys Med Rehabil 91:911–921

    Article  Google Scholar 

  15. Contreras-Vidal JL, Bhagat NA, Brantley J et al (2016) Powered exoskeletons for bipedal locomotion after spinal cord injury. J Neural Eng 13:031001

    Article  Google Scholar 

  16. Sánchez-Villamañan MC, Gonzalez-Vargas J, Torricelli D et al (2019). Compliant lower limb exoskeletons: a comprehensive review on mechanical design principles. J Neuroeng Rehabil 16:55

    Article  Google Scholar 

  17. Chen Y, Tan X, Yan D et al (2020) A composite fabric-based soft rehabilitation glove with soft joint for dementia in Parkinson’s disease. IEEE J Transl Eng Health Med 8:1400110

    PubMed  Google Scholar 

  18. Kumar B, Noor N, Thakur S et al (2019) Shape memory polyurethane-based smart polymer substrates for physiologically responsive, dynamic pressure (re)distribution. ACS Omega 4:15348–15358

    Article  CAS  Google Scholar 

  19. Nematollahi M, Baghbaderani KS, Amerinatanzi A et al (2019) Application of NiTi in assistive and rehabilitation devices: A review. Bioengineering 6:37

    Article  Google Scholar 

  20. Chaudhari R, Vora JJ, Patel V et al (2020) Surface analysis of wire-electrical-discharge-machining-processed shape-memory alloys. Materials 13:530

    Article  CAS  Google Scholar 

  21. Attard J, Rithalia S (2010) Physiological effects of LycraⓇ pressure garments on children with cerebral palsy. In: Anand SC, Kennedy JF, Miraftab M, Rajendran S (ed) Woodhead publishing series in textiles, medical and healthcare textiles. Woodhead Publishing, Sawston, pp 300–308

    Chapter  Google Scholar 

  22. Attfield SF, Nicholson J, Morton RE (2009) Evaluation of stability of Lycra soft orthoses using 3D kinematic analysis. Orthopädie Technik, edition IV 1–7

    Google Scholar 

  23. Matthews MJ, Watson M, Richardson B (2009) Effects of dynamic elastomeric fabric orthoses on children with cerebral palsy. Prosthet Orthot Int 33:339–347

    Article  Google Scholar 

  24. Inoue M, Tange A, Niwa M (2013) Theoretical analysis of biaxial tensile properties of power net. Text Res J 83:1319–1324

    Article  CAS  Google Scholar 

  25. Matthews M, Blandford S, Marsden J, Freeman J (2016) The use of dynamic elastomeric fabric orthosis suits as an orthotic intervention in the management of children with neuropathic onset scoliosis: A retrospective audit of routine clinical case notes. Scoliosis Spinal Disord 11:14

    Article  Google Scholar 

  26. García-Dominguez A, Claver J, Sebastián MA (2020) Integration of additive manufacturing, parametric design, and optimization of parts obtained by fused deposition modeling (FDM). A methodological approach. Polymers 12:1993

    Google Scholar 

  27. Telfer S, Pallari J, Munguia J et al (2012) Embracing additive manufacture: implications for foot and ankle orthosis design. BMC Musculoskeletal Disord 13:84

    Article  Google Scholar 

  28. Barrios-Muriel J, Romero-Sánchez F, Alonso-Sánchez FJ, Salgado DR (2020) Advances in orthotic and prosthetic manufacturing: A technology review. Materials 13:295

    Article  CAS  Google Scholar 

  29. Portnova AA, Mukherjee G, Peters KM et al (2018) Design of a 3D-printed, open-source wrist-driven orthosis for individuals with spinal cord injury. PloS One 13:e0193106

    Article  Google Scholar 

  30. Yoo HJ, Lee S, Kim J et al (2019) Development of 3D-printed myoelectric hand orthosis for patients with spinal cord injury. J Neuroeng Rehabil 16:162

    Article  Google Scholar 

  31. Parker DJ, Nuttall GH, Bray N et al (2019) A randomised controlled trial and cost-consequence analysis of traditional and digital foot orthoses supply chains in a National Health Service setting: application to feet at risk of diabetic plantar ulceration. J Foot Ankle Res 12:2

    Article  CAS  Google Scholar 

  32. Zuniga JM, Cortes A (2020) The role of additive manufacturing and antimicrobial polymers in the COVID-19 pandemic. Expert Rev Med Devices 17:477–481

    Article  CAS  Google Scholar 

  33. Li K, Xia C, Qiao Y, Liu X (2019) Dose-response relationships between copper and its biocompatibility/antibacterial activities. J Trace Elem Med Biol 55:127–135

    Article  CAS  Google Scholar 

  34. Song J, Jin P, Li M et al (2019) Antibacterial properties and biocompatibility in vivo and vitro of composite coating of pure magnesium ultrasonic micro-arc oxidation phytic acid copper loaded. J Mater Sci Mater Med 30:49

    Article  Google Scholar 

  35. Cao Q, Li J, Wang E (2019) Recent advances in the synthesis and application of copper nanomaterials based on various DNA scaffolds. Biosens Bioelectron 132:333–342

    Article  CAS  Google Scholar 

  36. Ahmedova A, Todorov B, Burdzhiev N, Goze C (2018) Copper radiopharmaceuticals for theranostic applications. Eur J Med Chem 157:1406–1425

    Article  CAS  Google Scholar 

  37. Anitha A, Iswariya K, Karunya S (2016) A survey on next generation in revolution—Leap Motion. Int J Trend Res Develop 3:275–276

    Google Scholar 

  38. Wang TX, Renata C, Chen HM, Huang WM (2017) Elastic shape memory hybrids programmable at around body-temperature for comfort fitting. Polymers 9:674

    Article  Google Scholar 

  39. Mahon ST, Roberts JO, Sayed ME et al (2018) Capability by stacking: the current design heuristic for soft robots. Biomimetics 3:16

    Article  Google Scholar 

  40. Abels C, Mastronardi VM, Guido F et al (2017) Nitride-based materials for flexible MEMS tactile and flow sensors in robotics. Sensors 17:1080

    Article  Google Scholar 

  41. Gil-Agudo A, Ama-Espinosa AJ, Lozano-Berrio V et al (2020) Terapia robótica con el exoesqueleto H2 en la rehabilitación de la marcha en pacientes con lesión medular incompleta. Una experiencia clínica. Rehabilitación 54:87–95

    CAS  Google Scholar 

  42. Robotic exoskeleton Exo-H2 (2021). Technaid. https://www.technaid.com/products/robotic-exoskeleton-exo-exoesqueleto/. Cited 30 Sep 2021

  43. Robotic exoskeleton Exo-H3 (2021). Technaid. https://www.technaid.com/products/robotic-exoskeleton-exo-exoesqueleto-h3/. Cited 30 Sep 2021

  44. Soft exosuits for lower extremity mobility (2021). Wyss Institute and Harvard University. https://wyss.harvard.edu/technology/soft-exosuits-for-lower-extremity-mobility/. Cited 30 Sep 2021

  45. Exoskeleton Report: Carbonhand. https://exoskeletonreport.com/product/carbonhand/. Cited 30 Sep 2021

  46. Soft exosuit for post-stroke gait re-training. https://wyss.harvard.edu/media-post/soft-exosuit-for-post-stroke-gait-re-training/. Cited 30 Sep 2021

  47. Awad LN, Esquenazi A, Francisco GE, et al (2020) The ReWalk ReStoreTM soft robotic exosuit: a multi-site clinical trial of the safety, reliability, and feasibility of exosuit-augmented post-stroke gait rehabilitation. J Neuroeng Rehabil 17:80

    Article  Google Scholar 

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Acknowledgements

Authors would like to thank Professor Ismael Payo (Department of Electrical Engineering, School of Electrical, Electronic and Aeronautical Engineering, University of Castilla-La Mancha, Spain) for the critical review of the chapter.

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Correspondence to Ángel Gil-Agudo or Elisa López-Dolado .

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Madroñero-Mariscal, R., Guzmán, A.d.l.R., Veiga, J.M., Contreras, A.B., Gil-Agudo, Á., López-Dolado, E. (2022). Orthotic and Robotic Substitution Devices for Central Nervous System Rehabilitation and Beyond. In: López-Dolado, E., Concepción Serrano, M. (eds) Engineering Biomaterials for Neural Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-81400-7_9

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