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Angiogenesis and the Tumor Microenvironment

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Handbook of Cancer and Immunology

Abstract

Tumorigenesis is a complex and multistep process involving genetic and epigenetic changes within the tumor cell, as well as supportive conditions within the tumor microenvironment (TME). The TME is widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer. Moreover, nonmalignant cells in the TME play essential roles in all stages of carcinogenesis by stimulating and facilitating uncontrolled cell proliferation. A key contributory condition is angiogenesis, blood vessel growth, which plays a critical role in the growth of cancer as solid tumors require a blood supply to grow past a few millimeters in size. Tumors promote this blood supply to form by releasing chemical signals that stimulate angiogenesis. Angiogenesis is a major point of biomedical research that has led to the clinical approval of several antiangiogenic agents resulting in new treatment strategies. This chapter outlines some of the most important aspects of the interrelationship between tumor cells and its microenvironment leading to tumor progression. The focus is on angiogenesis and incorporates novel antiangiogenic strategies and therapies.

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Authors and Affiliations

  1. immunePCS LLC, Greater Boston Area, MA, USA

    Joseph F. Murphy

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  1. Joseph F. Murphy
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Correspondence to Joseph F. Murphy .

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Editors and Affiliations

  1. Division of Clinical Immunology, Karolinska University Hospital, Huddinge, Sweden

    Nima Rezaei

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Murphy, J.F. (2022). Angiogenesis and the Tumor Microenvironment. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_87-1

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  • DOI: https://doi.org/10.1007/978-3-030-80962-1_87-1

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  • Print ISBN: 978-3-030-80962-1

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