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Molecular Mechanisms Driving Bone Metastasis of Cancers

  • Living reference work entry
  • First Online:
Handbook of Cancer and Immunology

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Abstract

Bone metastasis of cancer is a common process that destroys the balance between osteoclast and osteoblast, causing skeletal-related events. Cancer bone metastasis is a complex and orderly process, including pre-metastasis niche, escape and home, colonization and dormancy, reactivation and growth. The extracellular matrix, blood vessels, various cells including immune cells and osteocytes, different factors like cytokines, growth factors, chemokines form the bone microenvironment, some of them make the tumor more prone to metastasis. In addition, primary tumors metastasize to bone through different signaling pathways. Understanding the mechanism of bone metastasis is very significant for exploring more effective treatment methods. This section introduces the mechanism of bone metastasis in different cancers.

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Acknowledgments

This section is supported by the Natural Science Foundation Council of China (82172386, 81700780 and 81922081), the Department of Education of Guangdong Province (2021KTSCX104), the Guangdong Basic and Applied Basic Research Foundation (2022A1515012164), and the Science, Technology and Innovation Commission of Shenzhen (JCYJ20210324104201005).

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Authors and Affiliations

  1. Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China

    Fang Qiu, Jie Huang, Xuekun Fu & Chao Liang

  2. Institute of Integrated Bioinfomedicine and Translational Science (IBTS), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China

    Chao Liang

  3. State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China

    Chao Liang

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  1. Fang Qiu
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  2. Jie Huang
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  3. Xuekun Fu
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Correspondence to Xuekun Fu or Chao Liang .

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  1. Division of Clinical Immunology, Karolinska University Hospital, Huddinge, Sweden

    Nima Rezaei

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Qiu, F., Huang, J., Fu, X., Liang, C. (2023). Molecular Mechanisms Driving Bone Metastasis of Cancers. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_80-1

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