Abstract
Imaging techniques in gastrointestinal surgery are white light endoscopy, and increasingly fluorescence dye imaging (FI) (ICG). Endoluminal ultrasound (US), optical coherence tomography (OCT), confocal microscopy, Raman spectroscopy imaging, near-infrared (NIR) fluorescence, laser speckle contrast imaging (LSCI), narrowband imaging (NBI), and, more recently, photoacoustic imaging (PA) have shown some potential of improving local tissue discrimination and will be introduced. Hyperspectral imaging (HSI) and multispectral imaging (MSI) are relatively new and deliver unique information on a much larger variety of tissue characteristics. This chapter presents the principles, preclinical and clinical applications of HSI/MSI, novel endoscopic systems, and computer-assisted artificial intelligence (AI) tools for analysis of tissue perfusion, oxygenation, water content, identification of risk structures, and tumor margins. Clinical studies and technical improvements are required to support the establishment of HSI in gastrointestinal (GI) surgery. This includes a comparison of HSI with standard methods, integration with robotic systems, further improvements of data analysis tools by artificial intelligence, and clinical approval of the devices.
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References
Alekseev M, Rybakov E, Shelygin Y, Chernyshov S, Zarodnyuk I. A study investigating the perfusion of colorectal anastomoses using fluorescence angiography: results of the FLAG randomized trial. Color Dis. 2020;81:1224.
Arens C, Piazza C, Andrea M, Dikkers FG, Tjon Pian Gi REA, Voigt-Zimmermann S, et al. Proposal for a descriptive guideline of vascular changes in lesions of the vocal folds by the committee on endoscopic laryngeal imaging of the European Laryngological Society. Eur Arch Otorhinolaryngol. 2016;273(5):1207–14.
Ashok PC, Praveen BB, Rube M, Cox B, Melzer A, Dholakia K. In: Vo-Dinh T, Mahadevan-Jansen A, Grundfest WS, editors. Development of a fiber based Raman probe compatible with interventional magnetic resonance imaging. San Francisco: SPIE; 2014. p. 2014.
Attia ABE, Balasundaram G, Moothanchery M, Dinish US, Bi R, Ntziachristos V, et al. A review of clinical photoacoustic imaging: current and future trends. Photo-Dermatology. 2019;16:100144.
Baltussen EJM, Kok END, Brouwer de Koning SG, Sanders J, AGJ A, NFM K, et al. Hyperspectral imaging for tissue classification, a way toward smart laparoscopic colorectal surgery. J Biomed Opt. 2019;24(1):1–9.
Barbeiro S, Libânio D, Castro R, Dinis-Ribeiro M, Pimentel-Nunes P. Narrow-band imaging: clinical application in gastrointestinal endoscopy. GE Port J Gastroenterol. 2018;26(1):40–53.
Barberio M, Longo F, Fiorillo C, Seeliger B, Mascagni P, Agnus V, et al. HYPerspectral enhanced reality (HYPER): a physiology-based surgical guidance tool. Surg Endosc. 2020;34(4):1736–44.
Barberio M, Maktabi M, Gockel I, Rayes N, Jansen-Winkeln B, Köhler H, et al. Hyperspectral based discrimination of thyroid and parathyroid during surgery. Curr Dir Biomed Eng. 2018;4(1):399–402.
Bernard V, Staffa E, Čan V, Farkašová M, Pokorná J, Mitáš L, et al. Semi-quantitative comparison of infrared thermography with Indocyanine green imaging in porcine intestinal resection. IRBM. 2019;40(6):307–12.
Blanco-Colino R, Espin-Basany E. Intraoperative use of ICG fluorescence imaging to reduce the risk of anastomotic leakage in colorectal surgery: a systematic review and meta-analysis. Tech Coloproctol. 2018;22(1):15–23.
Chen Y-M, Lai K-L, Chen H-H, Huang W-N, Lin C-T, Chao W-C, et al. Hyperspectral imaging for skin assessment in systemic sclerosis: A pilot study. Rheumatology (Oxford, England). 2020.
Clancy NT, Jones G, Maier-Hein L, Elson DS, Stoyanov D. Surgical spectral imaging. Med Image Anal. 2020;63:101699.
Cooney GS, Barberio M, Diana M, Sucher R, Chalopin C, Köhler H. Comparison of spectral characteristics in human and pig biliary system with hyperspectral imaging (HSI). Curr Dir Biomed Eng. 2020;6(1):617.
Degett TH, Andersen HS, Gögenur I. Indocyanine green fluorescence angiography for intraoperative assessment of gastrointestinal anastomotic perfusion: a systematic review of clinical trials. Langenbeck's Arch Surg. 2016;401(6):767–75.
Diana M, Agnus V, Halvax P, Liu Y-Y, Dallemagne B, Schlagowski A-I, et al. Intraoperative fluorescence-based enhanced reality laparoscopic real-time imaging to assess bowel perfusion at the anastomotic site in an experimental model. Br J Surg. 2015;102(2):e169–76.
Dietrich M, Marx S, Bruckner T, Nickel F, Müller-Stich BP, Hackert T, et al. Bedside hyperspectral imaging for the evaluation of microcirculatory alterations in perioperative intensive care medicine: a study protocol for an observational clinical pilot study (HySpI-ICU). BMJ Open. 2020;10(9):e035742.
Guo J, Liu Z, Sun S, Wang S, Ge N, Liu X, et al. Endosonography-assisted diagnosis and therapy of gastrointestinal submucosal tumors. Endosc Ultrasound. 2013;2(3):125–33.
Halicek M, Fabelo H, Ortega S, Callico GM, Fei B. In-vivo and ex-vivo tissue analysis through hyperspectral imaging techniques: revealing the invisible features of cancer. Cancers. 2019;11(6):756.
Handgraaf HJM, Boonstra MC, van Erkel AR, Bonsing BA, Putter H, van de Velde CJH, et al. Current and future intraoperative imaging strategies to increase radical resection rates in pancreatic cancer surgery. Biomed Res Int. 2014;2014:890230.
Heeman W, Steenbergen W, van Dam G, Boerma EC. Clinical applications of laser speckle contrast imaging: a review. J Biomed Opt. 2019;24(8):1–11.
Holmer A, Homberger C, Wild T, Siemers F. Hyperspectral imaging of the degradation of meat and comparison with necrotic tissue in human wounds. J Spectral Imaging. 2019.
Holmer A, Marotz J, Wahl P, Dau M, Kämmerer PW. Hyperspectral imaging in perfusion and wound diagnostics - methods and algorithms for the determination of tissue parameters. Biomedizinische Technik. Biomed Eng. 2018;63(5):547–56.
Hu S, Wang LV. Photoacoustic imaging and characterization of the microvasculature. J Biomed Opt. 2010;15(1):11101.
Jafari MD, Wexner SD, Martz JE, McLemore EC, Margolin DA, Sherwinter DA, et al. Perfusion assessment in laparoscopic left-sided/anterior resection (PILLAR II): A Multi-Institutional Study. J Am Coll Surg. 2015;220(1):82–92.e1.
Jansen-Winkeln B, Germann I, Köhler H, Mehdorn M, Maktabi M, Sucher R, et al. Comparison of hyperspectral imaging and fluorescence angiography for the determination of the transection margin in colorectal resections-a comparative setudy. Int J Color Dis. 2020.
Jansen-Winkeln B, Holfert N, Köhler H, Moulla Y, Takoh JP, Rabe SM, et al. Determination of the transection margin during colorectal resection with hyperspectral imaging (HSI). Int J Color Dis. 2019;34(4):731–9.
Köhler H, Jansen-Winkeln B, Maktabi M, Barberio M, Takoh J, Holfert N, et al. Evaluation of hyperspectral imaging (HSI) for the measurement of ischemic conditioning effects of the gastric conduit during esophagectomy. Surg Endosc. 2019;33(11):3775–82.
Köhler H, Kulcke A, Maktabi M, Moulla Y, Jansen-Winkeln B, Barberio M, et al. Laparoscopic system for simultaneous high-resolution video and rapid hyperspectral imaging in the visible and near-infrared spectral range. J Biomed Opt. 2020;25(8):086004.
Kojima S, Sakamoto T, Nagai Y, Matsui Y, Nambu K, Masamune K. Laser speckle contrast imaging for intraoperative quantitative assessment of intestinal blood perfusion during colorectal surgery: a prospective pilot study. Surg Innov. 2019;26(3):293–301.
Kossack B, Wisotzky EL, Hilsmann A, Eisert P, Hänsch R. Local blood flow analysis and visualization from RGB-video sequences. Curr Dir Biomed Eng. 2019;5(1):373–5.
Kumar M, Suliburk JW, Veeraraghavan A, Sabharwal A. PulseCam: a camera-based, motion-robust and highly sensitive blood perfusion imaging modality. Sci Rep. 2020;10(1):4825.
Liang K, Ahsen OO, Wang Z, Lee H-C, Liang W, Potsaid BM, et al. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source. Opt Lett. 2017;42(16):3193–6.
Lu G, Fei B. Medical hyperspectral imaging: a review. J Biomed Opt. 2014;19(1):10901.
Maktabi M, Köhler H, Ivanova M, Jansen-Winkeln B, Takoh J, Niebisch S, et al. Tissue classification of oncologic esophageal resectates based on hyperspectral data. Int J Comput Assist Radiol Surg. 2019;14(10):1651–61.
Maktabi M, Köhler H, Ivanova M, Neumuth T, Rayes N, Seidemann L, et al. Classification of hyperspectral endocrine tissue images using support vector machines. Int J Med Robot. 2020;16:1–10.
Mehdorn M, Köhler H, Rabe SM, Niebisch S, Lyros O, Chalopin C, et al. Hyperspectral imaging (HSI) in acute mesenteric ischemia to detect intestinal perfusion deficits. J Surg Res. 2020;254:7–15.
Mekky MA, Abbas WA. Endoscopic ultrasound in gastroenterology: from diagnosis to therapeutic implications. World J Gastroenterol. 2014;20(24):7801–7.
Nouri D, Lucas Y, Treuillet S. Hyperspectral interventional imaging for enhanced tissue visualization and discrimination combining band selection methods. Int J Comput Assist Radiol Surg. 2016;11(12):2185–97.
Ortega S, Fabelo H, Iakovidis DK, Koulaouzidis A, Callico GM. Use of hyperspectral/multispectral imaging in gastroenterology. shedding some−different−light into the dark. J Clin Med. 2019;8(1):36.
Ortega S, Halicek M, Fabelo H, Callico GM, Fei B. Hyperspectral and multispectral imaging in digital and computational pathology: a systematic review invited. Biomed Opt Express. 2020;11(6):3195–233.
Pokorná J, Staffa E, Čan V, Bernard V, Mornstein V, Farkašová M, et al. Intestinal resection of a porcine model under thermographic monitoring. Physiol Meas. 2019;40(1):14003.
Samel NS, Mashimo H. Application of OCT in the gastrointestinal tract. Appl Sci. 2019;9(15):2991.
Sarri B, Canonge R, Audier X, Simon E, Wojak J, Caillol F, et al. Fast stimulated Raman and second harmonic generation imaging for intraoperative gastro-intestinal cancer detection. Sci Rep. 2019;9(1):10052.
Schols RM, Alic L, Beets GL, Breukink SO, Wieringa FP, Stassen LPS. Automated spectroscopic tissue classification in colorectal surgery. Surg Innov. 2015;22(6):557–67.
Schols RM, Bouvy ND, van Dam RM, Stassen LPS. Advanced intraoperative imaging methods for laparoscopic anatomy navigation: an overview. Surg Endosc. 2013;27(6):1851–9.
Schols RM, Dunias P, Wieringa FP, Stassen LPS. Multispectral characterization of tissues encountered during laparoscopic colorectal surgery. Med Eng Phys. 2013;35(7):1044–50.
Schols RM, ter Laan M, Stassen LPS, Bouvy ND, Amelink A, Wieringa FP, et al. Differentiation between nerve and adipose tissue using wide-band (350-1,830 nm) in vivo diffuse reflectance spectroscopy. Lasers Surg Med. 2014;46(7):538–45.
Shapey J, Xie Y, Nabavi E, Bradford R, Saeed SR, Ourselin S, et al. Intraoperative multispectral and hyperspectral label-free imaging: a systematic review of in vivo clinical studies. J Biophotonics. 2019;12(9):e201800455.
Sucher R, Athanasios A, Köhler H, Wagner T, Brunotte M, Lederer A, et al. Hyperspectral imaging (HSI) in anatomic left liver resection. Int J Surg Case Rep. 2019;62:108–11.
Tsai T-H, Leggett CL, Trindade AJ, Sethi A, Swager A-F, Joshi V, et al. Optical coherence tomography in gastroenterology: a review and future outlook. J Biomed Opt. 2017;22(12):1–17.
Waldner MJ, Knieling F, Egger C, Morscher S, Claussen J, Vetter M, et al. Multispectral optoacoustic tomography in crohn’s disease: noninvasive imaging of disease activity. Gastroenterology. 2016;151(2):238–40.
Wisotzky EL, Uecker FC, Arens P, Dommerich S, Hilsmann A, Eisert P. Intraoperative hyperspectral determination of human tissue properties. J Biomed Opt. 2018;23(9):1–8.
Xu M, Wang LV. Photoacoustic imaging in biomedicine. Rev Sci Instrum. 2006;77(4):41101.
Zhao T, Desjardins AE, Ourselin S, Vercauteren T, Xia W. Minimally invasive photoacoustic imaging: current status and future perspectives. Photo-Dermatology. 2019;16:100146.
Acknowledgments
Part of this work was funded by the Federal Ministry of Education and Research of Germany (grant number: 13GW0248B). The authors thank the colleagues of the companies Diaspective Vision GmbH and KARL STORZ SE & Co. KG for their contribution to the development of the projects. Thomas Neumuth (ICCAS) acquired funding and supported the research projects.
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Chalopin, C. et al. (2021). Intraoperative Imaging for Procedures of the Gastrointestinal Tract. In: Horgan, S., Fuchs, KH. (eds) Innovative Endoscopic and Surgical Technology in the GI Tract . Springer, Cham. https://doi.org/10.1007/978-3-030-78217-7_32
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DOI: https://doi.org/10.1007/978-3-030-78217-7_32
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