Abstract
Chondrosarcoma, Ewing sarcoma, osteosarcoma, multiple melanoma/plasma cell myeloma, metastases, undifferentiated high-grade pleomorphic sarcoma, fibrosarcoma, chondroma/enchondroma, Langerhans cell histiocytosis/eosinophilic granuloma, desmoplastic fibroma, aneurysmal bone cyst, giant cell tumor, fibrous dysplasia, and osteoid osteoma are the most common histological type of pelvic bone tumors. This chapter will illustrate the gross and histological features of these tumors; highlight the ancillary testing of diagnostic, prognostic, and predictive markers, and the collaborative opportunities between pathologists and orthopedic surgeons to improve the quality, safety, and value of patient care.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bloem JL, Reidsma II. Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 2012;81:3793–801.
Jeffrey S, et al. Chapter 38. Bone. In: Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, et al., editors. AJCC cancer staging manual. 8th ed. New York: Sprinter International Publishing; 2017.
Dodd L, Bui MM. Chapter 16.6. Chondrosarcoma. In: Dodd L, Bui MM, editors. Atlas of soft tissue and bone pathology: with histologic, cytologic and radiologic correlations. New York: Demos Medical Publishing; 2015. ISBN 9781620700372.
Rozeman LB, Hogendoorn PC, Bovee JV. Diagnosis and prognosis of chondrosarcoma of bone. Expert Rev Mol Diagn. 2002;2(5):461–72.
Henderson-Jackson EB, Bui MM. Molecular pathology of soft-tissue neoplasms and its role in clinical practice. Cancer Control. 2015;22(2):186–92.
Taylor BS, et al. Advances in sarcoma genomics and new therapeutic targets. Nat Rev Cancer. 2011;11(8):541–57.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescul CR. BCOR-CCNB3-fusion positive sarcomas: a clinicopathologic and molecular analysis of 36 cases with comparison to morphologic spectrum and clinical behavior of other round cell sarcomas. Am J Surg Pathol. 2018;42(5):604–15. https://doi.org/10.1097/PAS.0000000000000965.
Yoshimoto T, Tanaka M, Homme M, Yamazaki Y, Takazawa Y, Antonescu CR, Nakamura T. CIC-DUX4 induces small round cell sarcomas distinct from Ewing sarcoma. Cancer Res. 2017;77(11):2927–37. https://doi.org/10.1158/0008-5472.CAN-16-3351.
Wei S, Henderson-Jackson E, Qian X, Bui MM. Soft tissue tumor immunohistochemistry update: illustrative examples of diagnostic pearls to avoid pitfalls. Arch Pathol Lab Med. 2017;141(8):1072–91.
Bui MM, Smith P, Agresta S, Cheong D, Letson D. Practical issues of intraoperative frozen section diagnosis of bone and soft tissue lesions. Cancer Control. 2008;15(1):7–12.
Anninga JK, Gelderblom H, Fiocco M, Kroep JR, Taminiau AH, Hogendoorn PC, et al. Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand? Eur J Cancer. 2011;47(16):2431–45.
Egas-Bejar D, et al. Theranostic profiling for actionable aberrations in advanced high risk osteosarcoma with aggressive biology reveals high molecular diversity: the human fingerprint hypothesis. Onco Targets Ther. 2014;1(2):167–79.
Gibbs J, Henderson-Jackson E, Bui MM. Bone and soft tissue pathology: diagnostic and prognostic implications. Surg Clin N Am. 2016;96(5):915–62.
Rosenberg AE, et al. Conventional osteosarcoma. In: Fletcher CDM, et al., editors. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press; 2013. 288p.
Lorsbach R, Kluin PM. Plasma cell myeloma. In: Fletcher CDM, et al., editors. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press; 2013. 314p.
Picci P, Manfrini M, Fabbri N, Gambarotti M, Vanel D. Atlas of musculoskeletal tumors and tumor-like lesions. Berlin: Springer; 2014.
Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi BL, et al. USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol. 2004;165(5):1773–80.
Huang L, Xu J, Wood DJ, Zheng MH. Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kappaB in giant cell tumor of bone: possible involvement in tumor cell-induced osteoclast-like cell formation. Am J Pathol. 2000;156(3):761–7.
Yamamoto H, Iwasaki T, Yamada Y, et al. Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone. Hum Pathol. 2018;73:41–50.
Bianco P, Riminucci M, Majolagbe A, et al. Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic change in non-McCune-Albright fibrous dysplasia of bone. J Bone Miner Res. 2000;15:120128.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Bui, M.M., Rosenberg, A.E. (2021). Most Common Histological Type of Pelvic Bone Tumors. In: Ruggieri, P., Angelini, A. (eds) Surgery of Pelvic Bone Tumors. Springer, Cham. https://doi.org/10.1007/978-3-030-77007-5_4
Download citation
DOI: https://doi.org/10.1007/978-3-030-77007-5_4
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-77006-8
Online ISBN: 978-3-030-77007-5
eBook Packages: MedicineMedicine (R0)