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The Role of Ribonucleases in RNA Damage, Inactivation and Degradation

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RNA Damage and Repair

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Abstract

Nucleic acids are universally present in all forms of life on earth. Since their discovery more than 150 years ago, knowledge on the roles of nucleic acids, both DNA and RNA, has been gradually evolving. RNA, the less stable of the two, is a molecule capable of a wide range of functions, such as transmission of information, catalysis and regulation of gene expression among many others. The prevalence and diverse functions of RNA underlie the need for its regulation. As such, cells possess an arsenal of regulatory tools which modulate RNA. In this review, we focus on the role of ribonucleases acting specifically against damaged host RNA, pro-inflammatory messenger RNA and foreign RNA as part of defence mechanisms employed by mammalian cells against invading viruses.

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Acknowledgements

The authors thank all members of our laboratory for discussions. This work is supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers JP18H05278 and 20F20115 and by AMED under Grant Number JP19gm4010002.

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  1. Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Fabian Hia & Osamu Takeuchi

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  1. Fabian Hia
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Correspondence to Osamu Takeuchi .

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    Ioly Kotta-Loizou

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Hia, F., Takeuchi, O. (2021). The Role of Ribonucleases in RNA Damage, Inactivation and Degradation. In: Kotta-Loizou, I. (eds) RNA Damage and Repair. Springer, Cham. https://doi.org/10.1007/978-3-030-76571-2_5

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