Skip to main content
SpringerLink
Log in

Cultivation and Utilization of Valeriana jatamansi Jones for Conservation Planning and Management

  • Chapter
  • First Online:
Medicinal Plants

Part of the book series: Sustainable Development and Biodiversity ((SDEB,volume 28))

  • 2115 Accesses

Abstract

Valeriana jatamansi is a medicinal herb generally known as Indian Valerian belongs to family Caprifoliaceae. This is an herbal plant blended with many medicinal properties such as stimulant, carminative, antispasmodic, cytotoxic and aromatic property. The herb is used in custom and advanced medicine system for curing various ailments and in flavor and perfume industries. In this study, brief phytochemical, traditional and pharmacological studies of species and prospects of the species in future are envisaged. This study also evaluated domestication and cultivation practices available on V. jatamansi. Six major groups of active constituents, namely valepotriates (145), lignans compound (18), flavones or its glycosides (18), sesquiterpenoids or its glycoside (12), bakkenolide-type sesquiterpenoids (6), phenolic constituents (6), miscellaneous compounds (12) and major oil constituents (294) have been listed from V. jatamansi. Several therapeutic properties, e.g., neurotoxic, cytotoxic, sedative, anti-inflammation, antidepressant, antidiarrheal, anti-HCV, adaptogenic, analgesic, antioxidant and antimicrobial effects and key compounds responsible for these properties have been described. The present study clearly indicated that this plant comprises huge potential for future research and drug development. Numerous active constituents discussed in the present study can be vital for further in vivo and in vitro experimentation. The study suggested the need to promote research on identification of active component from the species and their mechanism of action. Methods available for cultivation and domestication of V. jatamansi will be applicable for multiplication of this valuable species to meet out domestic and industrial demand. Findings from the study will be useful for conservation planning and sustainable uses of this valuable species.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

2,4-D:

2, 4-dichlorophenoxyacetic acid

Azoto:

Azotobacter

BA:

Benzyl adenine

DW:

Dry weight

IHR:

Indian Himalayan Region

FYM:

Farm yard manure

GABA:

Gamma Aminobutaric Acid

IAA:

Indole-acetic acid

IBA:

Indole-3-butyric acid

MAPs:

Medicinal and Aromatic Plant

NAA:

α-naphthalene acetic acid

PSB:

Phosphate Solubilizing Bacteria

VAM:

Vesicular-Arbuscular Mycorrhiza

References

  • Abraham J, Cheruvathur MK, Mani B, Thomas TD (2010) A rapid in vitro multiplication system for commercial propagation of pharmaceutically important Cycleapeltata (Lam) Hook & Thoms. based on enhanced axillary branching. Ind Crop Prod 31(1):92–98

    Google Scholar 

  • Agnihotri S, Wakode S, Ali M (2011) Chemical composition, antimicrobial and topical anti-inflammatory activity of Valeriana jatamansi Jones. essential oil. J Essent Oil Bear Plant 14:417–422

    Article  CAS  Google Scholar 

  • Arora RB, Arora CK (1963) Hypotensive and tranquillizing activity of jatamansone (valeranone) a sesquiterpene from Nardostachys jatamansi DC. In: Chen KK, Mukerji B (eds) Pharmacology of oriental plants. Pergamon Press, Oxford, pp 51–60

    Google Scholar 

  • Awan HMH (1990) Kitabulmufradat. GA Printers, Lahore, pp 178–179

    Google Scholar 

  • Babu P, Verma SK, Mathur A (2015) Screening of solvent extracts of valeriana jatamansi for isolation of antimicrobial compound. Int J Pharm Sci Res 6:2641–2648

    CAS  Google Scholar 

  • Baibado JT, Cheung HY (2011) Mini-Review on neuropsychiatric properties of the root extract of Valerian (Valeriana officinalis L.) Hong Kong Physiol J 18:70–81

    Google Scholar 

  • Baquar SR (1989) Medicinal and poisonous plants of Pakistan. Karachi, Printas, p 461

    Google Scholar 

  • Becker H, Chavadeoi S (1985) Valepotriate production of normal and colchicine-treated cell suspension cultures of Valeriana wallichii. J Nat Prod 48:17–21

    Article  CAS  PubMed  Google Scholar 

  • Bhatt ID, Dauthal P, Rawat S, Gaira KS, Jugran A, Rawal RS, Dhar U (2012) Characterization of essential oil composition, phenolic content, and antioxidant properties in wild and planted individuals of Valeriana jatamansi Jones. Sci Horticult 136:61–68

    Article  CAS  Google Scholar 

  • Bhattacharjee SK (2008) Handbook of medicinal plants. Pointer Publisher, Jaipur, pp 364–365

    Google Scholar 

  • Bhattacharya D, Jana U, Debnath PK, Sur TK (2007) Initial exploratory observational pharmacology of Valeriana wallichii on stress management: a clinical report. Indian J Exp Biol 45:764–769

    Google Scholar 

  • Bos R, Hendriks H, Scheffer JJC, Woerdenbas HJ (1998) Cytotoxic potential of valerian constituents and valerian tinctures. Phytomedicine 5(3):219–225

    Article  CAS  PubMed  Google Scholar 

  • Bos R, Woerdenbag HJ, Hendriks H, Smit HF, Wikström HV, Scheffer JJ (1997) Composition of essential oil from roots and rhizomes of valeriana wallichii DC. Flav Frag J 12(2):123–132

    Google Scholar 

  • Bos R, Woerdenbag HJ, Hendriks H, Zwaving JH, De Smet PAGM, Tittel G, Wikstrom HV, Scheffer JJC (1996) Analytical aspects of phytotherapeutic valerian preparations. Phytochem Anal 7:143–151

    Article  CAS  Google Scholar 

  • Bos R, Woerdenbag HJ, Pras N (2002) Determination of valepotriates. J chromatograph A 967(1):131–146

    Article  CAS  Google Scholar 

  • Bounthanh C, Bergmann C, Beck JP, Hagg-Berrurier M, Anton R (1981) Valepotriates, a new class of cytotoxic and antitumor agents. Plant Med 41:21–28

    Article  CAS  Google Scholar 

  • Chen R, Zhang M, Lu J, Zhang X, Teixeira da Silva JA Ma, G (2014) Shoot organogenesis and somatic embryogenesis from leaf explants of Valeriana jatamansi Jones. Sci Horticult 165:392–397

    Google Scholar 

  • Chevallier A (1996) The encyclopaedia of medicinal plants. Dorling Kindersley, London (seen at http://www.himalayahealthcare.com/aboutayurveda/cahv.html)

  • Chevallier A (1999) The encyclopedia of medicinal plants. Dorling Kindersley London (seen at http://www.diet-and-healthnet/neuropathy/valerian.html)

  • Cionga E (1961) Considerations on the root of valerian. Pharmazie1 6: 43–44

    Google Scholar 

  • Das J, Mao AA, Handique PJ (2013) Callus-mediated organogenesis and effect of growth regulators on production of different valepotriates in Indian valerian (Valeriana jatamansi Jones.). Acta Physiol Plant 35(1):55–63

    Article  CAS  Google Scholar 

  • Denee R, Bos R, Hazelhoff B (1979) Isolation and structure elucidation of isovaltral, a decomposition product of isovaltrate. Planta Med 37(9):45–48

    Article  CAS  Google Scholar 

  • Dhiman B, Sharma P, Shivani, PK Pal (2020) Biology, chemical diversity, agronomy, conservation and industrial importance of Valeriana jatamansi: a natural sedative JARMAP 16:100243

    Google Scholar 

  • Dinda B, Chowdhury DR, Mohanta BC (2009) Naturally occurring iridoids, secoiridoids and their bioactivity. An updated review, part 3. Chem Pharm Bull (Tokyo) 57:765–796

    Article  CAS  Google Scholar 

  • Dong FW, Yang L, Wu ZK, Wei-Gao Zi CT, Yang D, Luo HR, Zhou J, Hu JM (2015) Iridoids and sesquiterpenoids from the roots of Valeriana jatamansi Jones. Fitoterapia 102:27–34

    Article  CAS  PubMed  Google Scholar 

  • Dunaev VV, Trzhetsinskii SD, Tishkin VS, Fursa NS, Linenko VI. (1987) Biological activity of the sum of the valepotriates isolated from Valeriana alliariifolia. Biologicheskaiaaktivnost’ summy valepotriatov, vydelennykhi zvaleriany chesno chnikolistnoi. Farmakol Toksikol 50:33–37 (Published in Russian)

    Google Scholar 

  • Fernandez S, Wasowski C, Paladini AC, Marder M (2004) Sedative and sleep enhancing properties of linarin, a flavonoids isolated from Valeriana officinalis. Pharmacol Biochem Behav 77:399–404

    Article  CAS  PubMed  Google Scholar 

  • Ganta KK, Mandal A, Debnath S, Hazra B, Chaubey B (2017) Anti-HCV activity from semi-purified methanolic root extracts of Valeriana wallichii. Phyto Res 31:433–440

    Article  CAS  Google Scholar 

  • Gilani AH, Khan AU, Jabeena Q, Subhan F, Ghafar R (2005) Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation. J Ethnopharmacol 100:347–352

    Article  PubMed  Google Scholar 

  • Girgune JB, Jain NK, Garg BD (1980) Antimicorbial activity of the essential oil from Valeriana wallichii DC (Valerianaceae). Indian J Microbiol 20:142–143

    CAS  Google Scholar 

  • He X, Wang S, Shi J, Sun Z, Lei Z, Yin Z, Qian Z, Tang H, Xie H (2018) Genotypic and environmental effects on the volatile Chemotype of Valeriana jatamansi Jones. Front Plant Sci 9:1003. https://doi.org/10.3389/fpls.2018.01003

    Article  PubMed  PubMed Central  Google Scholar 

  • Hendricks H, Geertsma HJ, Malingre TM (1981) The occurrence of valeranone and crypto-fauronol in the essential oil of Valeriana offcinalis L. s. l. collected in the northern part of The Netherlands. Pharmaceutisch Weekblad Sci Ed 116:1316–1320

    Article  Google Scholar 

  • Hobbs C (1989) Valerian: a literature review. Herbal Gram 21:19–34

    Google Scholar 

  • Holzl J (1975) Signification of chemical races, origins, cultivars and species of the in vivo preparation of radioactively marked natural substances illustrated by valeriana. Planta Medica 28:301–314

    Google Scholar 

  • Houghton PJ (1999) The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 51:505–512

    Article  CAS  PubMed  Google Scholar 

  • Irshad M, Aziz S, Habib-ur-Rehman Hussain H (2012) GC-MS analysis and antifungal activity of essential oils of Angelica glauca, Plectranthus rugosus and Valeriana wallichii. J Essent Oil Bear Plant 15:15–21

    Article  CAS  Google Scholar 

  • IUCN (1993) Guidelines on the conservation of medicinal plants. The International Union for Conservation of Nature and Natural Resources (IUCN), Gland, Switzerland, p 38

    Google Scholar 

  • Joseph L, Puthallath RE, Rao SN (2016) Acute and chronic toxicity study of Valeriana wallichii rhizome hydro-ethanolic extract in Swiss albino mice. Asian J Med Sci 7:49–54. https://doi.org/10.3126/ajms.v7i2.13326

    Article  Google Scholar 

  • Jugran A, Rawat S, Dauthal P, Mondal S, Bhatt ID, Rawal RS (2013a) Association of ISSR markers with some biochemical traits of Valeriana jatamansi Jones. Ind Crop Prod 44:671–676

    Article  CAS  Google Scholar 

  • Jugran AK, Rawat S, Bhatt ID, Rawal RS (2021) Essential oil composition, phenolics and antioxidant activities of Valeriana jatamansi at different phenological stages. Plant Biosyst 155:891–8981

    Google Scholar 

  • Jugran AK, Bahukhandi A, Dhyani P, Bhatt ID, Rawal RS, Nandi SK (2016a) Impact of altitudes and habitats on valerenic acid, total phenolics, flavonoids, tannins, and antioxidant activity of Valeriana jatamansi. J Appl Biochem Biotechnol 179:911–926

    Article  CAS  Google Scholar 

  • Jugran AK, Bhatt ID, Mondal S, Rawal RS, Nandi SK (2015a) Genetic diversity of Valeriana jatamansi across habitat types and altitudinal range using nuclear and chloroplast microsatellite markers. Curr Sci 109:1273–1282

    Article  Google Scholar 

  • Jugran AK, Bhatt ID, Rawal RS (2015b) Identification of ISSR markers associated with valerenic acid and antioxidant activity in Valeriana jatamansi Jones in Western Himalaya. Mol Breed 35:1–14

    Article  CAS  Google Scholar 

  • Jugran AK, Bahukhandi A, Bhatt ID, Rawal RS, Nandi SK (2015c) H2O2 induced DNA damage preventive activity of selected Valeriana species from West Himalaya. Proc Natl Acad Sci India, Sect B Biol Sci. 10.1007/s40011-015-0559-0

    Google Scholar 

  • Jugran AK, Bahukhandi A, Dhyani P, Bhatt ID, Rawal RS, Nandi SK, Palni LMS (2015d) The effect of inoculation with mycorrhiza: AM on growth, phenolics, tannins, phenolic composition and antioxidant activity in Valeriana jatamansi Jones. J Soil Sci Plant Nutri 15:1036–1049

    CAS  Google Scholar 

  • Jugran AK, Bhatt ID, Rawal RS (2016b) Integrated approaches for conservation and effective utilization of V. jatamansi in Uttarakhand. Asia Pacific J Biodivers 9:152–159

    Article  Google Scholar 

  • Jugran AK, Bhatt ID, Rawal RS, Nandi SK, Pande V (2013b) Patterns of morphological and genetic diversity of Valeriana jatamansi Jones in different habitats and altitudinal range of West Himalaya, India. Flora 208:13–21

    Article  Google Scholar 

  • Jugran AK, Joshi RK, Bhatt ID, Rawal RS, Palni LMS (2018) The relationship of visiting insect diversity and density of Valeriana jatamansi with increasing altitude in Western Himalaya. Proc Natl Acad Sci India Sect B Biol Sci. https://doi.org/10.1007/s40011-017-0954-9

    Article  Google Scholar 

  • Jugran AK, Rawat S, Bhatt ID, Rawal RS (2019) Valeriana jatamansi: an herbaceous plant with multiple medicinal uses. Phytother Res. https://doi.org/10.1002/ptr.6245

    Article  PubMed  Google Scholar 

  • Kalim MD, Bhattacharya D, Banerjee A, Chattopadhyay S (2010) Oxidative DNA damage preventive activity and antioxidant potential of plants used in Unani system of medicine. BMC Compl Alt Med 10:77. http://www.biomedcentral.com/1472-6882/10/77

  • Kapoor LD (1990) CRC Handbook of ayurvedic medicinal plants. CRC Press, Boca Raton, p 330

    Google Scholar 

  • Karnwal MK, Rai R, Singh VP (2012) Effect of sex form and environment on biomass yield in Valeriana jatamansi Jones. Progressive Horticult 44(1):55–59

    Google Scholar 

  • Katoch O, Kaushik S, Kumar MSY, Agrawal PK, Misra K (2012) Radioprotective property of an aqueous extract from Valeriana wallichii. J Pharm Bioall Sci 4:327–332

    Article  Google Scholar 

  • Kaur R, Sood M, Chander S, Mahajan R, Kumar V, Sharma DR (1999) In vitro propagation of Valeriana jatamansi. Plant Cell, Tissue Organ Cult 59(3):227–229

    Article  Google Scholar 

  • Keochanthala-Bounthanh C, Haag- Berrurier M, Beck JP, Anton R (1993) Effects of two monoterpene esters, valtrate and didrovaltrate, isolated from Valeriana wallichi, on the ultrastructure of hepatoma cells in culture. Phyto Res 7:124–127

    Article  CAS  Google Scholar 

  • Khajuria A, Verma S, Sharma P (2011) Stylar movement in Valeriana wallichii DC.—A contrivance for reproductive assurance and species survival. Curr Sci 100:1143–1144

    Google Scholar 

  • Khan AU, Gilani AH (2011) Pharmacological basis for the medicinal use of Valeriana wallichii in Constipation. Latin Am J Pharm 30:186–188

    CAS  Google Scholar 

  • Khuda F, Iqbal Z, Khan A, Zakiullah Nasir F, Shah Y (2013) Anti-inflammatory activity of the topical preparation of Valeriana wallichii and Achyranthes aspera leaves. Pak J Pharm Sci 26:451–454

    CAS  PubMed  Google Scholar 

  • Khuda F, Iqbal Z, Khan A, Zakiullah Shah Y, Khan A (2014) Screening of selected medicinal plants for their enzyme inhibitory potential—a validation of their ethnopharmacological uses. Pak J Pharm Sci 27:593–596

    PubMed  Google Scholar 

  • Khuda F, Iqbal Z, Zakiullah KA, Nasir F (2012) Antimicrobial and anti-inflammatory activities of leaf extract of Valeriana wallichii DC. Pak J Pharm Sci 25:715–719

    PubMed  Google Scholar 

  • Leathwood PD, Chauffard F (1983) Quantifying the effects of mild sedatives. J Psychiatric Res 17:115–122

    Article  CAS  Google Scholar 

  • Leuschner J, Müller J, Rudman M (1993) Characterization of the central nervous depressant activity of a commercially available Valerian root extract. Arzneim Forschung 43:638–641

    CAS  Google Scholar 

  • Li YD, Wu ZY, Li HM, Li HZ, Li RT (2013) Iridoids from the Roots of Valeriana jatamansi. Helve Chim Acta 96:424–430

    Article  CAS  Google Scholar 

  • Lin S, Chen T, Fu P, Ye J, Yang XW, Shan L, Li HL, Liu RH, Shen YH, Xu XK, Zhang WD (2015a) Three decomposition products of valepotriates from Valeriana jatamansi and their cytotoxic activity. J Asian Nat Prod Res 17:455–461

    Article  CAS  PubMed  Google Scholar 

  • Lin S, Chen T, Liu XH, Shen YH, Li HL, Shan L, Liu RH, Xu XK, Zhang WD, Wang HJ (2010) Iridoids and lignans from Valeriana jatamansi. J Nat Prod 73:632–638

    Article  CAS  PubMed  Google Scholar 

  • Lin S, Fu P, Chen T, Ye J, Su YQ, Yang XW, Zhang ZX, Zhang WD (2015b) Minor valepotriates from Valeriana jatamansi and their cytotoxicity against metastatic prostate cancer cells. Plant Med 81:56–61

    CAS  Google Scholar 

  • Lin S, Shen YH, Li HL, Yang XW, Chen T, Lu LH, Huang ZS, Liu RH, Xu XK, Zhang WD, Wang H (2009) Acylated iridoids with cytotoxicity from Valeriana jatamansi. J Nat Prod 72:650–655

    Article  CAS  PubMed  Google Scholar 

  • Lin S, Zhang ZX, Chen T, Ye J, Dai WX, Shan L, Su J, Shen YH, Li HL, Liu RH, Xu XK, Wang H, Zhang WD (2013) Characterization of chlorinated valepotriates from Valeriana jatamansi. Phytochemistry 85:185–193

    Article  CAS  PubMed  Google Scholar 

  • Lin S, Fu P, Chen T, Ye J, Yang XW, Zhang WD (2017) Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity. J Asian Nat Prod Res 19:15–21. https://doi.org/10.1080/10286020.2016.1258065

    Article  CAS  PubMed  Google Scholar 

  • Liu XC, Zhou L, Liu ZL (2013) Identification of insecticidal constituents from the essential oil of Valeriana jatamansi Jones against Liposcelis bostrychophila Badonnel. J Chem Article ID 853912, http://dx.doi.org/10.1155/2013/853912

    Google Scholar 

  • Marder M, Viola H, Wasowski C, Fernandez S, Medina JH, Paladini AC (2003) 6-methylapigenin and hesperidins: new Valeriana flavonoids with activity on the CNS. Pharmacol Biochem Behav 75:537–545

    Article  CAS  PubMed  Google Scholar 

  • Mathela CS, Tiwari M, Sammal SS, Chanotiya CS (2005) Valeriana wallichii DC, a new chemotype from North-Western Himalaya. J Essent Oil Res 17(6):672–675

    Article  CAS  Google Scholar 

  • Mathur J, Ahuja PS (1991) Plant regeneration from callus cultures of Valeriana wallichii DC. Plant Cell Rep 9:523–526

    Article  CAS  PubMed  Google Scholar 

  • Mathur J, Ahuja PS, Mathur A, Kukreja AK, Shah NC (1988) In vitro propagation of Valeriana wallichii. Plant Med 54(1):82–83

    Article  CAS  Google Scholar 

  • Morazzoni P, Bombardelli E (1995) Valeriana officinalis traditional use and recent evaluation of activity. Fitoterapia 66:99–112

    CAS  Google Scholar 

  • Mukherjee D (2015) Studies on seed germination pattern and effect of sowing date with planting prototype on Valeriana jatamansi (Jones): a rare medicinal plant of Eastern Himalaya. J Crop Weed 11(2):9–13

    Google Scholar 

  • Mukherjee D (2018) Effect of different seed priming treatments on germination and seedling establishment of two threatened endangered medicinal plants of Darjeeling Himalaya. In: Rakshit A, Singh HB (eds) Advances in seed priming. Springer Nature Singapore Pte Ltd., Singapore, p 241. https://doi.org/10.1007/978-981-13-0032-5_13

    Chapter  Google Scholar 

  • Mukherjee D, Chakraborty S (2014) Studies on ecology, habitats diversification and seed germination behavior of Valeriana jatamansi Jones: a critical endangered plant. Int J Agric Sci Res 4(5):203–209

    Google Scholar 

  • Nadkarni KM (1976) Indian Medica, III edn. Popular Prakashan, Mumbai, pp 1260–1262

    Google Scholar 

  • National Medicinal Plant Board (NMPB) (2008) Agro-techniques of selected medicinal plants. National Medicinal Plants Board Volume-I Department of AYUSH, Ministry of Health and Family Welfare, Government of India, New Delhi, 110001

    Google Scholar 

  • Navarrete A, Avula B, Choi YW (2006) Chemical fingerprinting of Valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection. J AOAC Int 89:8–15

    Article  CAS  PubMed  Google Scholar 

  • Pal PK, Sharma RK, Kumar D, Kumar S (2020). Indian Valerian (Valeriana jatamansi) variety Him Surbhit (CSIR-IHBT-VJ-05). Technical Folder: March, 2020

    Google Scholar 

  • Pande A, Shukla YN (1993) Naphthoic acid derivative from Valeriana wallichii. Phytochemistry 32:1350–1351

    Article  CAS  Google Scholar 

  • Pandian DS, Nagarajan NS (2015) Comparison of chemical composition and antioxidant potential of hydrodistilled oil and supercritical fluid CO2 extract of Valeriana wallichi DC. J Nat Prod Res J Nat Prod Res 1:25–30

    Google Scholar 

  • Paquette A, Bouchard A, Cogliastro A (2006) Survival and growth of under-planted trees: a meta-analysis across four biomes. Ecol Appl 16(4):1575–1589

    Article  PubMed  Google Scholar 

  • Phondani PC, Bhatt ID, Negi VS, Kothyari BP, Bhatt A, Maikhuri RK (2016) Promoting medicinal plants cultivation as a tool for biodiversity conservation and livelihood enhancement in Indian Himalaya. J Asia-Pacific Biodiver 9:39e46

    Google Scholar 

  • Polunin O, Stainton A (1987) Concise flowers of the Himalaya. Oxford University Press, London

    Google Scholar 

  • Prakash V (1999) Indian Valerianaceae: a monograph on medicinally important family. Scientific Publishers, Jodhpur, India, p 70

    Google Scholar 

  • Prasad R, Naime M, Routray I, Mahmood A, Khan F, Ali S (2010) Valeriana jatamansi partially reverses liver cirrhosis and tissue hyperproliferative response in rat. Method Finding Exper Clin Pharm 32:713–719

    Article  CAS  Google Scholar 

  • Purohit S, Rawat V, Jugran AK, Singh RV, Bhatt ID, Nandi SK (2015) Micropropagation and genetic fidelity analysis in Valeriana jatamansi Jones. JARMAP 2(1):15–20

    Google Scholar 

  • Raina AP, Negi KS (2015) Essential oil composition of Valeriana jatamansi Jones from Himalayan regions of India. Indian J Pharm Sci 77:218–222

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rajkumar S, Singh SK, Nag A, Ahuja PS (2011) Genetic structure of Indian valerian (Valeriana jatamansi) populations in Western Himalaya revealed by AFLP. Biochem Genet 49(9–10):674–681

    Article  CAS  PubMed  Google Scholar 

  • Rather AM, Nawchoo IA, Wani AA, Ganie AH (2011) Effect of habitat diversification and temperature on Valeriana jatamansi. New York Sci J 4:57–59

    Google Scholar 

  • Rehni AK, Pantlya HS, Rich S, Singh M (2007) Effect of chlorophyll and aqueous extracts of Bacopa monniera and Valeriana wallichii on ischaemia and reperfusion-induced cerebral injury in mice. Indian J Experim Biol 45:764–769

    Google Scholar 

  • Ravichandran G, Bhardwaz VS, Kolhapure SA (2005) Evaluation of the efficacy and safety of antiwrinkle cream in the treatment of facial skin wrinkle: a prospective open phase II clinical trial. The Antiseptic 102:65–70

    Google Scholar 

  • Rawat S, Jugran AK, Bhatt ID, Rawal RS, Andola HC, Dhar U (2017) Essential oil composition and antioxidant activity in Valeriana jatamansi Jones: Influence of seasons and growing sources. J Essent Oil Res 29:101–107

    Article  CAS  Google Scholar 

  • Riedel E, Hänsel R, Ehrke G (1982) Inhibition of γ-aminobutyric acid catabolism by valerenic acid derivatives. Plant Med 46:219–4220

    Article  CAS  Google Scholar 

  • Ron BH, Willis CV, Bone K, Morgan M (2000) Herbal products: active constituents, mode of action and quality control. Nutr Res Rev 13:47–77

    Article  Google Scholar 

  • Sah SP, Mathela CS, Chopra K (2010a) Valeriana wallichii: a phyto-pharmacological review. J Pharm Res 3:2337–2339

    CAS  Google Scholar 

  • Sah SP, Mathela CS, Chopra K (2010b) Elucidation of possible mechanism of analgesic action of Valeriana wallichii DC chemotype(patchouli alcohol) in experimental animal models. Indian J Experim Bio 48:289–293

    Google Scholar 

  • Sah SP, Mathela CS, Chopra K (2011) Antidepressant effect of Valeriana wallichii patchouli alcohol chemotype in mice: behavbiochem evid. J Ethnopharmacol 135:197–200

    Article  PubMed  Google Scholar 

  • Sahu S, Ray K, Kumar YMS, Gupta S, Kauser H, Kumar S, Mishra K, Panjwani U (2012) Valeriana wallichii root extract improves sleep quality and modulates brain monoamine level in rats. Phytomedicine 19:924–929

    Article  PubMed  Google Scholar 

  • Said HM (1970) Hamdard pharmacopoeia of eastern medicine. Times Press, Karachi, p 53

    Google Scholar 

  • Samant SS, Dhar U, Palni LMS (1998) Medicinal Plants of Himalaya: Diversity, distribution Potential Values. Gyanodaya Prakashan, Nainital, India

    Google Scholar 

  • Santos MS, Ferreira F, Faro C, Pires E, Carvalho AP, Cunha AP, Macedo T (1994) The amount of GABA present in aqueous extracts of Valerian is sufficient to account for [3H] GABA release in synaptosomes. Plant Med 60:475–476

    Article  CAS  Google Scholar 

  • Sati S, Chanotiya CS, Mathela CS (2005) Comparative investigations on the leaf and root oils of Valeriana wallichii DC. from Northwestern Himalaya. J Essent Oil Res 17:408–409

    Article  CAS  Google Scholar 

  • Sati SC, Khulbe K, Joshi S (2011) Antimicrobial evaluation of the Himalayan medicinal plant Valeriana wallichii. Res J Microbiol 6:289–296

    Article  Google Scholar 

  • Schmidt B, Ribnicky DM, Poulev A, Logendra S, Cafalu WT, Raskin I (2008) A natural history of botanical therapeutics. Metabolism Clini Exper 57:3–9

    Article  CAS  Google Scholar 

  • Schneider G, Willems M (1982) Weitere Erkenntnisseuber die abbauprodukte der valepotriateaus Kentranthusruber (L.) DC (Further observations on the byproducts of Kentranthusruber valepotriates). Archive der Pharmazie 315:691–697

    Article  CAS  Google Scholar 

  • Sharma P, Kirar V, Meena DK, Suryakumar G, Misra K (2012a) Adaptogenic activity of Valeriana wallichii using cold, hypoxia and restraint multiple stress animal model. Biomed Aging Pathol 2:198–205

    Article  Google Scholar 

  • Sharma R (2003) Medicinal plants of India: An encyclopaedia. Daya Publishing House, New Delhi pp 253–254

    Google Scholar 

  • Sharma S, Negi PS, Singh J (2012b) Vegetative propagation of Picrorhiza kurrooa Royle ex Benth and Valeriana jatamansi Jones through macroproliferation technique for large scale nursery production. Int J Farm Sci 2:91–97

    Google Scholar 

  • Shi SN, Shi JL, Liu Y, Wang YL, Wang CG, Hou WH, Guo JY (2014) The anxiolytic effects of valtrate in rats involves changes of corticosterone levels. eCAM 325948. https://doi.org/10.1155/2014/325948

  • Singh N, Gupta AP, Singh B, Kaul VK (2006) Quantification of valerenic acid in Valeriana jatamansi and Valeriana officinalis by HPTLC. Chromatographia 63:209–213

    Article  CAS  Google Scholar 

  • Singh RD (2007) Evaluation of different variants of Muskbala (Valeriana jatamansi) for enhanced productivity and quality under mid hills of U.P. Final Technical Report, IHBT Palampur, Himanchal Pradesh, India

    Google Scholar 

  • Singh RD, Ahuja PS, Nagar PK, Kaul VK, Singh B, Lal B, Vats SK, Yadav P, Mishra S (2000) Effect of manuring and shade on yield and quality of Valeriana wallichii. J Med Aroma Plant Sci 22(1B):669–670

    CAS  Google Scholar 

  • Singh RD, Gopichand MRL, Sharma B, Bikram S, Kaul VK, Ahuja PS (2010) Seasonal variation of bioactive components in Valeriana jatamansi from Himachal Pradesh, India. Ind Crop Prod 32:292–296

    Article  CAS  Google Scholar 

  • Singh VK, Ali ZA (1998) Herbal drugs of Himalaya: medicinal plants of Garhwal and Kumaon regions of India. Today and Tomorrow’s Printers and Publishers, New Delhi, pp 214

    Google Scholar 

  • Slathia VS (2005) Studies on organic cultivation of Valeriana jatamansi Jones. Doctoral Dissertation, DYSP UHF Solan

    Google Scholar 

  • Steinegger E, Hansel R (1992) Pharmakognosie, 5th edn. Springer, Berlin, pp 162–666

    Book  Google Scholar 

  • Subhan F, Karim N, Gilani AH, Sewell RDE (2010) Terpenoid content of Valeriana wallichii extracts and antidepressant-like response profiles. Photother Res 24:686–691

    Article  CAS  Google Scholar 

  • Subhan F, Karim N, Ibrar M (2007) Anti- inflammatory activity of methanolic and aqueous extracts of Valeriana wallichi DC rhizome. Pak J Plant Sci 13:103–108

    Google Scholar 

  • Suri S, Thind TS (1978) Antibacterial activity of some essential oils. Indian Drug Pharm Ind 13:25–28

    CAS  Google Scholar 

  • Tan YZ, Yong Y, Dong YH, Wang RJ, Li HX, Zhang H, Guo DL, Zhang SJ, Dong XP, Xie XF (2016) A new secoiridoid glycoside and a new sesquiterpenoid glycoside from Valeriana jatamansi with neuroprotective activity. Phytochem Lett 17:177–180

    Article  CAS  Google Scholar 

  • Thies PW (1968) Linarin-isovalerianate, a currently unknown flavonoid from Valeriana wallichii. Plant Med 16:363–371

    Article  CAS  Google Scholar 

  • Thies PW, Funke S (1966) On the active ingredients in baldrian 1. Detection and isolation of isovalerian acid esters with sedative effect from roots and rhizomes of various valerian and kentranthus species. Tetrahed Lett 11:1155–1162

    Article  CAS  Google Scholar 

  • Thind TS, Suri RK (1979) In vitro antifungal efficacy of four essential oils. Indian Perfum 23:138–140

    CAS  Google Scholar 

  • Thusoo S, Gupta S, Sudan R, Kour J, Bhagat S, Hussain R, Bhagat M (2014) Antioxidant activity of essential oil and extracts of Valeriana jatamansi roots. BioMed Res Inter Article ID 614187. https://doi.org/10.1155/2014/614187

  • Turek C, Stintzing FC (2013) Stability of essential oils: a review. Comprehensive Rev Food Sci Saf 12:40–53. https://doi.org/10.1111/1541-4337.12006

    Article  CAS  Google Scholar 

  • Vats SK, Pandey S, Nagar PK (2002) Photosynthetic response to irradiance in Valeriana jatamansi Jones, a threatened understorey medicinal herb of Western Himalaya. Photosynthetica 40(4):625–628

    Article  CAS  Google Scholar 

  • Veith J, Schneider G, Lemmer B, Willems M (1986) The influence of some degradation products of valepotriates on the motor activity of light-dark synchronized mice (in German). Planta Med 52:179–183

    Article  Google Scholar 

  • Verma RS, Padalia RC, Chauhan A (2013) Chemical differentiation of rhizome and root essential oils of Indian Valerian (Valeriana jatamansi Jones). J Essent Oil Bear Plant 16:835–840

    Article  CAS  Google Scholar 

  • Vinegar R, Schreiber W, Hugo R (1969) Biphasic development of carrageenan oedema in rats. J Pharmacol Experim Therap 166:96–103

    CAS  Google Scholar 

  • Vishwakarma S, Goyal R, Gupta V, Dhar KL (2016) GABAergic effect of valeric acid from Valeriana wallichii in amelioration of ICV STZ induced dementia in rats. Revista Brasileira de Farmacognosia 26:484–489

    Article  CAS  Google Scholar 

  • Wagner H, Jurcic K, Schaette R (1980) Comparative studies on the sedative action of Valeriana extracts, valepotriates and their degradation products. Plant Med 39:358–365

    Article  CAS  Google Scholar 

  • Wasowski C, Marder M, Viola H, Medina JH, Paladini AC (2002) Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA (A) receptors, from Valerianawallichii. Plant Med 68:934–936

    Article  CAS  Google Scholar 

  • Xu J, Guo P, Guo Y, Fang L, Li Y, Sun Z, Gui L (2012a) Iridoids from the roots of Valeriana jatamansi and their biological activities. Nat Prod Res 26:1996–2001

    Article  CAS  PubMed  Google Scholar 

  • Xu J, Guo Y, Xie C, Jin DQ, Gao J, Gui L (2012b) Isolation and neuroprotective activities of acylated iridoids from Valeriana jatamansi. Chem Biodivers 9:1382–1388

    Article  CAS  PubMed  Google Scholar 

  • Xu J, Li Y, Guo Y, Guo P, Yamakuni T, Ohizumi Y (2012c) Isolation, structural elucidation, and neuroprotective effects of iridoids from Valeriana jatamansi. Biosci Biotechnol Biochem 76:1401–1403

    Article  CAS  PubMed  Google Scholar 

  • Xu J, Yang B, Guo Y, Jin D, Guo P, Liu C, Hou W, Zhang T, Gui L, Sun Z (2011a) Neuroprotective bakkenolides from the roots of V. jatamansi. Fitoterapia 82:849–853

    Article  CAS  PubMed  Google Scholar 

  • Xu J, Zhao P, Guo Y, Xie C, Jin DQ, Ma Y, Hou W, Zhang T (2011b) Iridoids from the roots of Valeriana jatamansi and their neuroprotective effects. Fitoterapia 82:1133–1136

    Article  CAS  PubMed  Google Scholar 

  • Xu J, Guo P, Fang LZ, Li YS, Guo YQ (2012d) Iridoids from the roots of Valeriana jatamansi. J Asian Nat Prod Res 14:1–6

    Article  PubMed  CAS  Google Scholar 

  • Yahia EM (2006) Postharvest handling of aromatic and medicinal plants

    Google Scholar 

  • Yan ZY, Zhang TE, Pan LZ, Zuo CY (2011) Action of Valeriana jatamansi Jones on the apoptosis-related genes expression in the anxiety model of Rat. Proced Environ Sci 8:744–750

    Article  CAS  Google Scholar 

  • Yang B, Zhu R, Tian S, Wang Y, Lou S, Zhao H (2017) Jatamanvaltrate P induces cell cycle arrest, apoptosis and autophagy in human breast cancer cells in vitro and in vivo. Biomed Pharmacother 10:1027–1036

    Article  CAS  Google Scholar 

  • Zhang T, Chen C, Chen, C, Li S, Zuo C, Yan ZY (2012) Effect on TGF-beta signaling pathway of the total flavonoids from Valeriana jatamansi Jones in hepatocarcinoma 22-bearing mice. In: 2012 International conference on biomedical engineering and biotechnology. 10.1109/iCBEB.2012.172

    Google Scholar 

  • Zhu J, Xu K, Zhang X, Cao J, Jia Z, Yang R, Ma C, Chen C, Zhang T, Yan Z (2016) Studies on the regulation of lipid metabolism and its mechanism of the iridoids rich fraction in Valeriana jatamansi Jones. Biomed Pharmacother 84:1891–1898

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We would like to thank Director G.B. Pant ‘National Institute of Himalayan Environment’ (NIHE) for providing the facilities and encouragement. AKJ is thankful to National Medicinal Plant Board (NMPB), New Delhi (File No. Z.18017/187/CSS/R&D/UK-01/2019-20-NMPB-IV A), and IDB is thankful to National Mission on Himalayan Studies (NMHS) for project grant (Project ID NMHS_ID_MG_34) for partial support of this work. All authors declare no conflicts of interest in publishing this manuscript.

Author information

Authors and Affiliations

  1. G.B. Pant, National Institute of Himalayan Environment, Garhwal Regional Centre, Srinagar, Uttarakhand, 246174, India

    Arun Kumar Jugran

  2. Center for Biodiversity Conservation and Management, G.B. Pant National Institute of Himalayan Environment, Kosi-Katarmal, Almora, Uttarakhand, 263643, India

    Indra D. Bhatt & Ranbeer S. Rawal

Authors
  1. Arun Kumar Jugran
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Indra D. Bhatt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ranbeer S. Rawal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arun Kumar Jugran .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Kraków, Poland

    Halina Maria Ekiert

  2. Department of Botany, Mohanlal Sukhadia University, Udaipur, Rajasthan, India

    Kishan Gopal Ramawat

  3. Department of Botany, Mohanlal Sukhadia University, Udaipur, Rajasthan, India

    Jaya Arora

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Jugran, A.K., Bhatt, I.D., Rawal, R.S. (2021). Cultivation and Utilization of Valeriana jatamansi Jones for Conservation Planning and Management. In: Ekiert, H.M., Ramawat, K.G., Arora, J. (eds) Medicinal Plants. Sustainable Development and Biodiversity, vol 28. Springer, Cham. https://doi.org/10.1007/978-3-030-74779-4_5

Download citation

Publish with us

Policies and ethics

Search

Navigation