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Immunotherapy and Radiotherapy: New Strategies

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Lung Cancer

Part of the book series: Current Cancer Research ((CUCR))

Abstract

Ionizing radiation is a local therapeutic intervention that plays a role in the multipronged approach to the treatment of non-small cell lung cancer. Case reports of excellent clinical responses in patients treated with both checkpoint inhibition and radiation point to a synergy between these two modalities that may extend the reach of radiotherapy from a local to a systemic treatment. Radiotherapy has been referred to as an in situ vaccine, given that its application has the potential to liberate tumor antigen in the context of pro-inflammatory cell death. This chapter describes interactions between radiotherapy and the immune system, with a particular focus on an emerging mechanistic understanding of how radiation can materially contribute to an anti-tumor immune response.

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Authors and Affiliations

  1. Department of Therapeutic Radiology, Yale School of Medicine/Yale Cancer Center, New Haven, CT, USA

    Allison M. Campbell & Roy H. Decker

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  1. Allison M. Campbell
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  2. Roy H. Decker
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Correspondence to Allison M. Campbell .

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  1. Yale Comprehensive Cancer Center, Yale University, New Haevn, CT, USA

    Anne C. Chiang

  2. Yale Comprehensive Cancer Center, Yale University, New Haevn, CT, USA

    Roy S. Herbst

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Campbell, A.M., Decker, R.H. (2021). Immunotherapy and Radiotherapy: New Strategies. In: Chiang, A.C., Herbst, R.S. (eds) Lung Cancer. Current Cancer Research. Humana, Cham. https://doi.org/10.1007/978-3-030-74028-3_10

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  • DOI: https://doi.org/10.1007/978-3-030-74028-3_10

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