Abstract
Electrospinning is a highly used technique in the tissue engineering field, particularly for the development of tissue supportive scaffolds. Use of electrospun derived nano and microfibers is of crucial importance for extracellular matrix mimicking and cell adhesion and proliferation. This paper is focused on the electrospinning process and its ideal conditions for producing scaffolds for tissue engineering purpose. With use of a series of biocompatible polymers and solvents, solutions were tested in various electrospinning settings in order to produce microscale fibers. The production of these fibers is directly related to the electrospinning parameters in use, hence the importance of optimizing this process. A series of scaffold samples were built from various solutions in different parameter conditions. The scaffolds were analyzed with microscopy for fiber diameter measurement. Within this paper, we analyzed influence of input parameters on fiber output diameter which is of particular importance for cell adhesion. Input to the system are material properties of the tested solutions, needle electrode dimensions, the flow rate of the solution, the distance between electrodes and the applied voltage.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Vasita, R., Katti, D.S.: Nanofibers and their applications in tissue engineering. Int. J. Nanomed. 1(1), 15–30 (2006)
Bui, H.T., Chung, O.H., Dela Cruz, J., Park, J.S.: Fabrication and characterization of electrospun curcumin-loaded polycaprolactone-polyethylene glycol nanofibers for enhanced wound healing. Macromol. Res. 22, 1288–1296 (2014)
Liu, H., Ding, X., Zhou, G., Li, P., Wei, X., Fan, Y.: Electrospinning of nanofibers for tissue engineering applications. Biocompatibility and Toxicity of Nanobiomaterials, p. 495708 (2013)
Živanović, M.N.: Use of electrospinning to ehae the versatility of drug delivery. In: Lai, W.F. (eds) Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Healthy Ageing and Longevity, vol. 13. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-54490-4_14
Koupaei, N., Karkhaneh, A., Daliri, J.M.: Preparation and characterization of (PCL-crosslinked-PEG)/hydroxyapatite as bone tissue engineering scaffolds. J. Biomed. Mater. Res. Part A 103(12), 3919–3926 (2015)
Danafar, H.: Preparation and characterization of PCL-PEG-PCL copolymeric nanoparticles as polymersomes for delivery hydrophilic drugs. Iran. J. Pharm. Sci. 14(2), 21–32 (2018)
Acknowledgment
This research is supported by the European Uio’s Horizo 2020 research and innovation programme under grant agreement No 952603 (SGABU). This article reflects only the author’s view. The Commission is not responsible for any use that may be made of the information it contains. Also, the research is funded by Serbian Ministry of Education, Science, and Technological Development [451-03-68/202014/200378 (Institute for Information Technologies, University of Kragujevac)].
Author information
Authors and Affiliations
Contributions
The authors have no conflict of declaration.
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Virijević, K., Grujić, J., Kokanović, M., Nikolić, D., Živanović, M., Filipović, N. (2021). Electrospinning and Electrospun Nanofibrous Materials – Promising Scaffolds in Tissue Engineering. In: Badnjevic, A., Gurbeta Pokvić, L. (eds) CMBEBIH 2021. CMBEBIH 2021. IFMBE Proceedings, vol 84. Springer, Cham. https://doi.org/10.1007/978-3-030-73909-6_82
Download citation
DOI: https://doi.org/10.1007/978-3-030-73909-6_82
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-73908-9
Online ISBN: 978-3-030-73909-6
eBook Packages: EngineeringEngineering (R0)