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Anoikis and the Human Gut Epithelium in Health and Disease

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Anoikis

Abstract

Anoikis performs essential roles during organogenesis, as well as in the maintenance and repair of tissues. In this respect, the continuous renewal of the human gut epithelium is characterized by the exfoliation-by-anoikis of obsolete differentiated cells. Some progress has been made with regards to the functions of integrin- and E-cadherin-mediated signaling in the regulation of anoikis in human intestinal/colon epithelial cells (hIECs); however, much remains to be explored and understood. In the same vein, the extracellulare matrix (ECM)-, integrin- and E-cadherin-mediated mechanisms which underlie the emergence of anoikis resistance and its roles in the progression of colorectal cancer (CRC) remain largely to be elucidated, whereas tantilizing evidence has been rising with regards to anoikis being also implicated in inflammatory bowel disease (IBD). This chapter will review the main findings concerning the regulation of anoikis in hIECs, as well as those pertaining to anoikis deregulation in CRC and IBD—with a partiality geared towards integrins, E-cadherins and the signaling they enact to this effect.

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Acknowledgements

MB was supported by scholarships from the National Sciences and Engineering Research Council (NSERC) and the Fonds de la Recherche du Québec – Santé (FRQS). Original work was supported by a research grant from NSERC to PHV (RGPIN 227935-2013). PHV was a Researcher of the Canadian Foundation for Innovation (CFI) and a member of the FRQS-funded Centre de Recherche (CRC) du Centre Hospitalier Universitaire de Sherbrooke (CHUS), until his planned early (and happy) retirement in July 2019.

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  1. Gut Epithelial Anoikis Physiopathology Lab, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada

    Marco Beauséjour, Ariane Boutin & Pierre H. Vachon

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  1. Marco Beauséjour
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  2. Ariane Boutin
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  3. Pierre H. Vachon
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Correspondence to Pierre H. Vachon .

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  1. WVU Cancer Institute and Department of Biochemistry, West Virginia University, Morgantown, WV, USA

    Steven M. Frisch

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Beauséjour, M., Boutin, A., Vachon, P.H. (2021). Anoikis and the Human Gut Epithelium in Health and Disease. In: Frisch, S.M. (eds) Anoikis. Springer, Cham. https://doi.org/10.1007/978-3-030-73856-3_5

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