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Renoprotective Roles of Curcumin

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Natural Products and Human Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1328))

Abstract

The use of herb-based therapies is increasing over the past decades. These agents have been reported to provide many beneficial effects in many experimental and clinical studies. Curcumin is one of these agents which has potent pharmacological effects enabling it for the prevent and treatment of many diseases and pathologies such as renal disorders, hyperglycemia, oxidative stress, hypertension, and dyslipidemia. However, the exact molecular mechanisms mediating these renoprotective effects of curcumin are not well established. So, in the current study, we surveyed for possible renoprotective roles of curcumin and concluded how curcumin protects against renal injuries.

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Notes

  1. 1.

    Protein kinase C.

  2. 2.

    Advanced glycation end products.

  3. 3.

    Receptors for advanced glycation end products.

  4. 4.

    Autonomic nervous system.

  5. 5.

    Renin-angiotensin system.

  6. 6.

    Nuclear factor erythroid 2-related factor 2.

  7. 7.

    Sirtuin.

  8. 8.

    Interleukin.

  9. 9.

    Monocyte chemoattractant protein 1.

  10. 10.

    Tumor necrosis factor-alpha.

  11. 11.

    Peroxisome proliferator-activated receptor.

  12. 12.

    Nuclear factor kappa b.

  13. 13.

    Interferon gamma.

  14. 14.

    Kidney injury molecule 1.

  15. 15.

    Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.

  16. 16.

    Cathepsine.

  17. 17.

    Heme oxygenase 1.

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Acknowledgments

The authors are thankful to the “Research Center of Physiology, Semnan University of Medical Sciences (Semnan, Iran)” for providing technical supports.

Conflict of Interests

Muhammed Majeed is the founder of Sabinsa Corp. and Sami Labs Ltd. Other authors declare no competing interests.

Author information

Authors and Affiliations

  1. Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran

    Habib Yaribeygi

  2. Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mina Maleki

  3. Sabinsa Corporation, East Windsor, NJ, USA

    Muhammed Majeed

  4. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran

    Tannaz Jamialahmadi

  5. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Tannaz Jamialahmadi

  6. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  7. Biotechnology Research Center, Pharmaceutical technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  8. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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  1. Habib Yaribeygi
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  2. Mina Maleki
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  3. Muhammed Majeed
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  4. Tannaz Jamialahmadi
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  5. Amirhossein Sahebkar
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Editor information

Editors and Affiliations

  1. Pharmacy, Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  2. Diabetes, Endocrinology & Metabolism, The University of Hull, Brough, UK

    Thozhukat Sathyapalan

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Yaribeygi, H., Maleki, M., Majeed, M., Jamialahmadi, T., Sahebkar, A. (2021). Renoprotective Roles of Curcumin. In: Sahebkar, A., Sathyapalan, T. (eds) Natural Products and Human Diseases. Advances in Experimental Medicine and Biology(), vol 1328. Springer, Cham. https://doi.org/10.1007/978-3-030-73234-9_38

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