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Targeting Pathogenic Inflammation for Therapeutic Intervention Against Colon Cancer

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Colon Cancer Diagnosis and Therapy Vol. 3

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Abstract

As the third most common cancer worldwide, colorectal cancer (CRC) is the concern of 14 billion dollars annually in healthcare costs and treatment. As the name insinuates, CRC is a multistep form of cancer that finds its origin in the colon and rectum. Most cases are associated with the development of adenomatous polyps, although lymphomas and gastrointestinal carcinoid tumors are also known to elicit the cancer. Following a common trend of cancer, CRC increases with age, adding 1.8 million new cases in 2018. A Western lifestyle cultivates a variety of risk factors to heighten the diagnosis, including the consumption of alcoholic drinks and obesity. Statistics on inflammatory bowel disease (IBD), including Crohn’s disease (CD), and ulcerative colitis (UC), show a strong correlation to CRC development as a result of increased inflammation. Taking a more in-depth look at histology, biomarkers, and other epigenetic patterns will provide insight into this rationale. CRC cases in the last 20 years have sharply declined as a result of early screening programs and the removal of precancerous polyps. This chapter gives a review of CRC types, prevalence, epidemiology, and pathophysiology, concluding with an account of targeted therapy to better understand preventative strategies for addressing one of the most extensive cancers of the modern day.

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Authors and Affiliations

  1. Department of Geriatrics, School of Medicine and Health Science, University of North Dakota, Grand Forks, ND, USA

    Julia Fleecs, Eden Abrham & Ramkumar Mathur

  2. Department of Biomedical Science, School of Medicine and Health Science, University of North Dakota, Grand Forks, ND, USA

    Mikale Kuntz & M. Nadeem Khan

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Correspondence to Ramkumar Mathur .

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  1. Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

    Dhananjay Shukla

  2. Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

    Naveen Kumar Vishvakarma

  3. Division of Hematology and Oncology, School of Medicine, University of Alabama, Birmingham, AL, USA

    Ganji Purnachandra Nagaraju

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Fleecs, J., Abrham, E., Kuntz, M., Khan, M.N., Mathur, R. (2022). Targeting Pathogenic Inflammation for Therapeutic Intervention Against Colon Cancer. In: Shukla, D., Vishvakarma, N.K., Nagaraju, G.P. (eds) Colon Cancer Diagnosis and Therapy Vol. 3. Springer, Cham. https://doi.org/10.1007/978-3-030-72702-4_9

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