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Applications of IgY in Veterinary Medicine

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IgY-Technology: Production and Application of Egg Yolk Antibodies

Abstract

Animal health and welfare is under constant threat from pathogenic organisms and there is need to move from the use of antibiotics as a first line of defence. The oral administration of IgY antibodies constitutes a powerful passive immune strategy and has been used in terrestrial and aquatic animals. The prevention and treatment of gastrointestinal diseases, particularly diarrhoea from different infectious agents in livestock and dogs, is one of the most studied uses of IgY for passive protection. The use of IgY for the treatment of calves, adult cattle, pigs and poultry is described. One of the major factors impacting on the productivity of aquaculture is the outbreak of disease and there is a need for development of treatments suitable for an aqueous environment. IgY used in the treatment of dogs is also expanding. Finally, the use of IgY in the detection of disease is outlined.

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Change history

  • 16 September 2021

    The original version of the book was inadvertently published with only one of the three affiliations of the volume editor and chapter author Xiao-Ying Zhang.

References

  • Aghamohammadi M, Haine D, Kelton DF, Barkema HW, Hogeveen H, Keefe GP, Dufour S (2018) Herd-level mastitis-associated costs on Canadian dairy Farms. Front Vet Sci 5:100

    Article  PubMed  PubMed Central  Google Scholar 

  • Akila S, Jyothi VP, Selvan MK, Naidu H, Raghunathan S, Kota S, Sundaram RC, Rana SK, Raj GD, Srinivasan VA, Mohana Subramanian B (2016) Direct typing of canine parvovirus (CPV) from infected dog faeces by rapid mini sequencing technique. J Virol Methods 238:66–69

    Article  CAS  Google Scholar 

  • Alcorn SW, Pascho RJ (2002) Antibody responses by Chinook salmon (Oncorhynchus tshawytscha) and rainbow trout (Oncorhynchus mykiss) to various protein antigens. Fish Shellfish Immunol 13(4):327–333

    Article  CAS  PubMed  Google Scholar 

  • Alustiza F, Bellingeri R, Picco N, Motta C, Grosso MC, Barbero CA, Acevedo DF, Vivas A (2016) IgY against enterotoxigenic Escherichia coli administered by hydrogel-carbon nanotubes composites to prevent neonatal diarrhoea in experimentally challenged piglets. Vaccine 34(28):3291–3297

    Article  CAS  PubMed  Google Scholar 

  • Appel MJ, Scott FW, Carmichael LE (1979) Isolation and immunisation studies of a canine parco-like virus from dogs with haemorrhagic enteritis. Vet Rec 105(8):156–159

    Article  CAS  PubMed  Google Scholar 

  • Arasteh N, Aminirissehei AH, Yousif AN, Albright LJ, Durance TD (2004) Passive immunization of rainbow trout (Oncorhynchus mykiss) with chicken egg yolk immunoglobulins (IgY). Aquaculture 231(1):23–36

    Article  CAS  Google Scholar 

  • Badaracco A, Garaicoechea L, Rodríguez D, Uriarte EL, Odeón A, Bilbao G, Galarza R, Abdala A, Fernandez F, Parreño V (2012) Bovine rotavirus strains circulating in beef and dairy herds in Argentina from 2004 to 2010. Vet Microbiol 158(3–4):394–399

    Article  CAS  PubMed  Google Scholar 

  • Baloch A, Zhang XY, Schade R (2014) IgY technology in aquaculture–a review. Rev Aquac 6:1–8

    Google Scholar 

  • Barnes JH, Vaillancourt JP, Gross WB (2003) Colibacillosis. In: Diseases of poultry, 11th edn. Iowa State University Press, Ames, pp 631–652

    Google Scholar 

  • Bartels CJ, Holzhauer M, Jorritsma R, Swart WA, Lam TJ (2010) Prevalence, prediction and risk factors of enteropathogens in normal and non-normal faeces of young Dutch dairy calves. Prev Vet Med 93(2–3):162–169

    Article  PubMed  Google Scholar 

  • Barton MD (2000) Antibiotic use in animal feed and its impact on human healt. Nutr Res Rev 13(2):279–299

    Article  CAS  PubMed  Google Scholar 

  • Bayles KW, Wesson CA, Liou LE, Fox LK, Bohach GA, Trumble WR (1998) Intracellular Staphylococcus aureus escapes the endosome and induces apoptosis in epithelial cells. Infect Immun 66(1):336–342

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bok M, Miño S, Rodriguez D, Badaracco A, Nuñes I, Souza SP, Bilbao G, Louge Uriarte E, Galarza R, Vega C, Odeon A, Saif LJ, Parreño V (2015) Molecular and antigenic characterization of bovine coronavirus circulating in Argentinean cattle during 1994-2010. Vet Microbiol 181(3–4):221–229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bollini M, Leal ES, Adler NS, Aucar MG, Fernández GA, Pascual MJ, Merwaiss F, Alvarez DE, Cavasotto CN (2018) Discovery of novel bovine viral diarrhea inhibitors using structure-based virtual screening on the envelope protein E2. Front Chem 6:79

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bostock J (2011) The application of science and technology development in shaping current and future aquaculture production systems. J Agric Sci 149(S1):133–141

    Article  Google Scholar 

  • Brooks HL, Rushton K, Lovell K, Bee P, Walker L, Grant L, Rogers A (2018) The power of support from companion animals for people living with mental health problems: a systematic review and narrative synthesis of the evidence. BMC Psychiatry 18(1):1–12

    Article  Google Scholar 

  • Buonavoglia C, Martella V, Pratelli A, Tempesta M, Cavalli A, Buonavoglia D, Bozzo G, Elia G, Decaro N, Carmichael L (2001) Evidence for evolution of canine parvovirus type 2 in Italy. J Gen Virol 82(Pt 12):3021–3025

    Article  CAS  PubMed  Google Scholar 

  • Burtonboy G, Coignoul F, Delferriere N, Pastoret PP (1979) Canine hemorrhagic enteritis: detection of viral particles by electron microscopy. Arch Virol 61(1–2):1–11

    Article  CAS  PubMed  Google Scholar 

  • Campora CE, Hokama Y, Yabusaki K, Isobe M (2008) Development of an enzyme-linked immunosorbent assay for the detection of ciguatoxin in fish tissue using chicken immunoglobulin Y. J Clin Lab Anal 22(4):239–245

    Article  CAS  Google Scholar 

  • Chalghoumi R, Marcq C, Théwis A, Portetelle D, Beckers Y (2009) Effects of feed supplementation with specific hen egg yolk antibody (immunoglobin Y) on salmonella species cecal colonization and growth performances of challenged broiler chickens. Poult Sci 88(10):2081–2092

    Article  CAS  PubMed  Google Scholar 

  • Chinchkar SR, Mohana Subramanian B, Hanumantha Rao N, Rangarajan PN, Thiagarajan D, Srinivasan VA (2006) Analysis of VP2 gene sequences of canine parvovirus isolates in India. Arch Virol 151(9):1881–1887

    Article  CAS  PubMed  Google Scholar 

  • Chinchkar S, Subramanian B, Naidu H, Dorairajan T, Srinivasan VA (2014) Canine parvovirus isolates of India and the relevance of canine parvovirus Type-2 vaccines. J Adv Vet Res 4(1):34–41

    Google Scholar 

  • Cho YI, Han JI, Wang C, Cooper V, Schwartz K, Engelken T, Yoon KJ (2013) Case-control study of microbiological etiology associated with calf diarrhea. Vet Microbiol 166(3–4):375–385

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cho YI, Yoon KJ (2014) An overview of calf diarrhea - infectious etiology, diagnosis, and intervention. J Vet Sci 15(1):1–17

    Article  PubMed  PubMed Central  Google Scholar 

  • Costa VGD, Saivish MV, Rodrigues RL, Lima Silva RF, Moreli ML, Krüger RH (2019) Molecular and serological surveys of canine distemper virus: a meta-analysis of cross-sectional studies. PLoS One 14(5):e0217594

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Crute IR, Muir JF (2011) Improving the productivity and sustainability of terrestrial and aquatic food production systems: future perspectives. J Agric Sci 149(S1):1–7

    Article  Google Scholar 

  • Davis TC, White RR (2020) Breeding animals to feed people: the many roles of animal reproduction in ensuring global food security. Theriogenology 150:27–33

    Article  CAS  PubMed  Google Scholar 

  • Decaro N, Desario C, Lucente MS, Amorisco F, Campolo M, Elia G, Cavalli A, Martella V, Buonavoglia C (2008) Specific identification of feline panleukopenia virus and its rapid differentiation from canine parvoviruses using minor groove binder probes. J Virol Methods 147(1):67–71

    Article  CAS  PubMed  Google Scholar 

  • Dey S, Pathak DC, Ramamurthy N, Maity HK, Chellappa MM (2019) Infectious bursal disease virus in chickens: prevalence, impact, and management strategies. Vet Med (Auckland, NZ) 10(2019):85–97

    Google Scholar 

  • DiLorenzo N, Diez-Gonzalez F, DiCostanzo A (2006) Effects of feeding polyclonal antibody preparations on ruminal bacterial populations and ruminal pH of steers fed high-grain diets. J Anim Sci 84(8):2178–2185

    Article  CAS  PubMed  Google Scholar 

  • Diraviyam T, Zhao B, Wang Y, Schade R, Michael A, Zhang X (2014) Effect of chicken egg yolk antibodies (IgY) against diarrhea in domesticated animals: a systematic review and meta-analysis. PLoS One 9(5):e97716

    Article  PubMed  CAS  Google Scholar 

  • El-Ghany WA (2011) Comparison between immunoglobulins IgY and the vaccine for prevention of infectious bursal disease in chickens. Global Vet 6:16–24

    Google Scholar 

  • FAO (2009) The state of food and agriculture. http://www.fao.org/3/i0680e/i0680e.pdf

  • FAO (2016) Economic analysis of animal diseases. http://www.fao.org/3/a-i5512e.pdf

  • FAO (2020) The state of world fisheries and aquaculture 2020. http://www.fao.org/publications/sofia/2020/en/

  • FAO, OECD (2020) Dairy and dairy products. In: OECD-FAO Agricultural Outlook 2020–2029, pp 174–183

    Chapter  Google Scholar 

  • FAOSTAT (2012) Food and agricultural organization statistical da-tabase. . http://faostat3.fao.org/faostatgateway/go/to/download/Q/QL/E

  • Farms T (2017) What are the three biggest challenges facing the pork industry? https://toshfarms.net/what-are-the-three-biggest-challenges-facing-the-pork-industry/#:~:text=Bill%20Even%2C%20CEO%20of%20theand%20consumers'%20fear%20of%20science.&text=A%20foreign%20animal%20disease%20outbreak%20would%20be%20devastating

  • Farooq A, Rabbani M, Khushi M, Akram Z, Ahad A, Fatima Z, Khurram T, Anwar Z (2012) Passive immunization in infectious bursal disease virus infected birds using chemically purified immune yolk immunoglobulins (IgY). Afr J Microbiol Res 6(12):2993–2998

    CAS  Google Scholar 

  • Ferragut F, Vega CG, Mauroy A, Conceição-Neto N, Zeller M, Heylen E, Uriarte EL, Bilbao G, Bok M, Matthijnssens J, Thiry E, Badaracco A, Parreño V (2016) Molecular detection of bovine noroviruses in Argentinean dairy calves: circulation of a tentative new genotype. Infect Genet Evol 40:144–150

    Article  CAS  PubMed  Google Scholar 

  • Foster DM, Smith GW (2009) Pathophysiology of diarrhea in calves. Veterinary clinics of North America. Food Anim Pract 25(1):13–36

    Article  CAS  Google Scholar 

  • Fulton RM, Nersessian BN, Reed WM (2002) Prevention of Salmonella enteritidis infection in commercial ducklings by oral chicken egg-derived antibody alone or in combination with probiotics. Poult Sci 81(1):34–40

    Article  CAS  PubMed  Google Scholar 

  • Gadde U, Rathinam T, Lillehoj HS (2015) Passive immunization with hyperimmune egg-yolk IgY as prophylaxis and therapy for poultry diseases--a review. Anim Health Res Rev 16(2):163–176

    Article  CAS  PubMed  Google Scholar 

  • Gao J, Barkema HW, Zhang L, Liu G, Deng Z, Cai L, Shan R, Zhang S, Zou J, Kastelic JP, Han B (2017) Incidence of clinical mastitis and distribution of pathogens on large Chinese dairy farms. J Dairy Sci 100(6):4797–4806

    Article  CAS  PubMed  Google Scholar 

  • Gao X, Zhang X, Lin L, Yao D, Sun J, Du X, Li X, Zhang Y (2016) Passive immune-protection of Litopenaeus vannamei against Vibrio harveyi and Vibrio parahaemolyticus infections with anti-vibrio egg yolk (IgY)-encapsulated feed. Int J Mol Sci 17(5):723

    Article  CAS  Google Scholar 

  • Garaicoechea L, Bok K, Jones LR, Combessies G, Odeón A, Fernandez F, Parreño V (2006) Molecular characterization of bovine rotavirus circulating in beef and dairy herds in Argentina during a 10-year period (1994-2003). Vet Microbiol 118(1–2):1–11

    Article  CAS  PubMed  Google Scholar 

  • Gasparyan VK (2005) Hen egg immunoglobulin Y in colloidal gold agglutination assay: comparison with rabbit immunoglobulin G. J Clin Lab Anal 19(3):124–127

    Article  CAS  PubMed  Google Scholar 

  • Ge S, Xu L, Li B, Zhong F, Liu X, Zhang X (2020) Canine parvovirus is diagnosed and neutralized by chicken IgY-scFv generated against the virus capsid protein. Vet Res 51(1):110

    Article  CAS  PubMed  Google Scholar 

  • Gerlach M, Proksch AL, Dörfelt R, Unterer S, Hartmann K (2020) Therapy of canine parvovirus infection - review and current insights. Tierarztliche praxis. Ausgabe K, Kleintiere/Heimtiere 48(1):26–37

    Google Scholar 

  • González-Figueredo J, Rajme-Manzur D, Negrin-Thomson G, Dopico-Paz JR (2015) Obtención de anticuerpos policlonales IgY antiparvovirus canino y evaluación en un sistema de aglutinación con látex. VacciMonitor 25(4):451–463

    Google Scholar 

  • Grünberg W (2014) Diarrhoea in neonatal ruminants. https://www.msdvetmanual.com/digestive-system/intestinal-diseases-in-ruminants/diarrhea-in-neonatal-ruminants

  • Guimaraes MCC, Amaral LG, Borges FV, Vieira HPL, Matta CGF, Matta MFDR (2009) Characterization of an IgY polyclonal antibodies directed against the canine distemper virus. J Med Biol Sci 8(1):18–25

    CAS  Google Scholar 

  • Guimaraes MCC, Amaral LG, Borges FV, Vieira HPL, Shimoya A, Gomes C, Matta F, Matta R (2008) Production and use of egg-yolk antibody for detection of canine parvovirus in feces. J Med Biol Sci 7(3):241–248

    CAS  Google Scholar 

  • Gui-rong Z, Yun-ying Z (2011) Development of yolk antibodies against young duck viral hepatitis. China Anim Hus Vet Med 38(10):142–144

    Google Scholar 

  • Gürtler M, Methner U, Kobilke H, Fehlhaber K (2004) Effect of orally administered egg yolk antibodies on Salmonella enteritidis contamination of hen's eggs. J Vet Med 51(3):129–134

    Article  Google Scholar 

  • Hafez H (2011) Enteric diseases of poultry with special attention to Clostridium perfringens. Pak Vet J 31:175–184

    Google Scholar 

  • Han S, Zhang XY, Zhao J (2012) Production of egg yolk antibody (IgY) against recombinant canine parvovirus VP2 protein. Acta Sci Vet 40(2):1029

    Google Scholar 

  • Hatamzade IN, Rahimi S, Rasaee MJ, Karimi Torshizi MA, Zahraei Salehi T, Grimes JL (2020) The effect of capsulated and noncapsulated egg-yolk-specific antibody to reduce colonization in the intestine of Salmonella enterica ssp. enterica serovar Infantis-challenged broiler chickens. Poult Sci 99(3):1387–1394

    Article  Google Scholar 

  • He J, Wang Y, Sun S, Zhang X (2015) Evaluation of chicken IgY generated against canine parvovirus viral-like particles and development of enzyme-linked immunosorbent assay and Immunochromatographic assay for canine parvovirus detection. Viral Immunol 28(9):489–494

    Article  CAS  PubMed  Google Scholar 

  • Hedegaard CJ, Heegaard PM (2016) Passive immunisation, an old idea revisited: basic principles and application to modern animal production systems. Vet Immunol Immunopathol 174:50–63

    Article  PubMed  PubMed Central  Google Scholar 

  • Heller MC, Chigerwe M (2018) Diagnosis and treatment of infectious enteritis in neonatal and juvenile ruminants. Veterinary clinics of North America. Food Anim Pract 34(1):101–117

    Article  Google Scholar 

  • Hermans D, Van Steendam K, Verbrugghe E, Verlinden M, Martel A, Seliwiorstow T, Heyndrickx M, Haesebrouck F, De Zutter L, Deforce D, Pasmans F (2014) Passive immunization to reduce campylobacter jejuni colonization and transmission in broiler chickens. Vet Res 45(1):27

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hoelzer K, Parrish CR (2008) Evolution and variation of the parvoviruses. In: Domingo E, Parrish CR, Holland JJ (eds) Origin and evolution of viruses, 2nd edn. Academic

    Google Scholar 

  • Hoet AE, Smiley J, Thomas C, Nielsen PR, Wittum TE, Saif LJ (2003) Association of enteric shedding of bovine torovirus (Breda virus) and other enteropathogens with diarrhea in veal calves. Am J Vet Res 64(4):485–490

    Article  PubMed  Google Scholar 

  • Hoskins JD, Breitschwerdt EB, Gaunt SD, French TW, Burgdorfer W (1988) Antibodies to Ehrlichia canis, Ehrlichia platys, and spotted fever group rickettsiae in Louisiana dogs. J Vet Intern Med 2(2):55–59

    Article  CAS  PubMed  Google Scholar 

  • Houe H (2003) Economic impact of BVDV infection in dairies. Biologicals 31(2):137–143

    Article  PubMed  Google Scholar 

  • Igwaran A, Okoh AI (2019) Human campylobacteriosis: a public health concern of global importance. Heliyon 5(11):e02814

    Article  PubMed  Google Scholar 

  • Ismail ZB (2017) Mastitis vaccines in dairy cows: recent developments and recommendations of application. Veterinary World 10(9):1057–1062

    Article  CAS  PubMed  Google Scholar 

  • Izzo MM, Kirkland PD, Mohler VL, Perkins NR, Gunn AA, House JK (2011) Prevalence of major enteric pathogens in Australian dairy calves with diarrhoea. Aust Vet J 89(5):167–173

    Article  CAS  PubMed  Google Scholar 

  • Jámbor A, Czine P, Balogh PJS (2020) The impact of the coronavirus on agriculture: first evidence based on global newspapers. Sustainability 12(11):4535

    Article  CAS  Google Scholar 

  • Jiang Z, Jiang X, Li C, Xue H, Zhang X (2016) Development of an IgY antibody-based immunoassay for the screening of the CYP2E1 inhibitor/enhancer from herbal medicines. Front Pharmacol 7:502

    Article  PubMed  PubMed Central  Google Scholar 

  • Jin LZ, Baidoo SK, Marquardt RR, Frohlich AA (1998) In vitro inhibition of adhesion of enterotoxigenic Escherichia coli K88 to piglet intestinal mucus by egg-yolk antibodies. FEMS Immunol Med Microbiol 21(4):313–321

    Article  CAS  PubMed  Google Scholar 

  • Kapil S, Cooper E, Lamm C, Murray B, Rezabek G, Johnston L 3rd, Campbell G, Johnson B (2007) Canine parvovirus types 2c and 2b circulating in north American dogs in 2006 and 2007. J Clin Microbiol 45(12):4044–4047

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kariyawasam S, Wilkie BN, Gyles CL (2004) Resistance of broiler chickens to Escherichia coli respiratory tract infection induced by passively transferred egg-yolk antibodies. Vet Microbiol 98(3–4):273–284

    Article  CAS  PubMed  Google Scholar 

  • Kelman M, Barrs VR, Norris JM, Ward MP (2020) Canine parvovirus prevention and prevalence: veterinarian perceptions and behaviors. Prev Vet Med 174:104817

    Article  CAS  PubMed  Google Scholar 

  • Kim DK, Jang IK, Seo HC, Shin SO, Yang SY, Kim JW (2004) Shrimp protected from WSSV disease by treatment with egg yolk antibodies (IgY) against a truncated fusion protein derived from WSSV. Aquaculture 237(1):21–30

    Article  CAS  Google Scholar 

  • Kongsted H, Toft N, Nielsen JP (2014) Risk factors and epidemiological characteristics of new neonatal porcine diarrhoea syndrome in four Danish herds. BMC Vet Res 10:151

    Article  PubMed  PubMed Central  Google Scholar 

  • Kovacs-Nolan J, Mine Y (2012) Egg yolk antibodies for passive immunity. Annu Rev Food Sci Technol 3:163–182

    Article  CAS  PubMed  Google Scholar 

  • Kumaran T, Michaelbab M, Thangaswamy S, Albindhas S, Citarasu T (2010) Production of anti WSSV IgY edible antibody using herbal Immunoadjuvant Asparagus racemosus and its immunological influence against WSSV infection in Penaeus monodon. J Aquac Feed Sci Nutr 2(1):1–5

    Article  Google Scholar 

  • Kuroki M, Ohta M, Ikemori Y, Icatlo FC, Kobayashi C, Yokoyama H, Kodama Y (1997) Field evaluation of chicken egg yolk immunoglobulins specific for bovine rotavirus in neonatal calves. Arch Virol 142(4):843–851

    Article  CAS  PubMed  Google Scholar 

  • Kuroki M, Ohta M, Ikemori Y, Peralta RC, Yokoyama H, Kodama Y (1994) Passive protection against bovine rotavirus in calves by specific immunoglobulins from chicken egg yolk. Arch Virol 138(1–2):143–148

    Article  CAS  PubMed  Google Scholar 

  • Kweon CH, Kwon BJ, Woo SR, Kim JM, Woo GH, Son DH, Hur W, Lee YS (2000) Immunoprophylactic effect of chicken egg yolk immunoglobulin (Ig Y) against porcine epidemic diarrhea virus (PEDV) in piglets. J Vet Med Sci 62(9):961–964

    Article  CAS  PubMed  Google Scholar 

  • Langel SN, Paim FC, Lager KM, Vlasova AN, Saif LJ (2016) Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): historical and current concepts. Virus Res 226:93–107

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Larsson A, Bålöw RM, Lindahl TL, Forsberg PO (1993) Chicken antibodies: taking advantage of evolution--a review. Poult Sci 72(10):1807–1812

    Article  CAS  PubMed  Google Scholar 

  • Lee DH, Jeon YS, Park CK, Kim S, Lee DS, Lee C (2015) Immunoprophylactic effect of chicken egg yolk antibody (IgY) against a recombinant S1 domain of the porcine epidemic diarrhea virus spike protein in piglets. Arch Virol 160(9):2197–2207

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee SH, Lillehoj HS, Park DW, Jang SI, Morales A, García D, Lucio E, Larios R, Victoria G, Marrufo D, Lillehoj EP (2009a) Induction of passive immunity in broiler chickens against Eimeria acervulina by hyperimmune egg yolk immunoglobulin Y. Poult Sci 88(3):562–566

    Article  CAS  PubMed  Google Scholar 

  • Lee SH, Lillehoj HS, Park DW, Jang SI, Morales A, García D, Lucio E, Larios R, Victoria G, Marrufo D, Lillehoj EP (2009b) Protective effect of hyperimmune egg yolk IgY antibodies against Eimeria tenella and Eimeria maxima infections. Vet Parasitol 163(1–2):123–126

    Article  CAS  PubMed  Google Scholar 

  • Lee SB, Mine Y, Stevenson RM (2000) Effects of hen egg yolk immunoglobulin in passive protection of rainbow trout against Yersinia ruckeri. J Agric Food Chem 48(1):110–115

    Article  CAS  PubMed  Google Scholar 

  • Leu JH, Yang F, Zhang X, Xu X, Kou G, Lo CF (2009) Whispovirus. book: lesser known large DsDNA viruses, current topics. In: Microbiolo-gy and immunology, vol 328. Springer, Berlin, Heidelberg, pp 197–227

    Google Scholar 

  • Li C, He J, Ren H, Zhang X, Du E, Li X (2016) Preparation of a chicken scFv to analyze gentamicin residue in animal derived food products. Anal Chem 88(7):4092–4098

    Article  CAS  PubMed  Google Scholar 

  • Li ZX, Hu WD, Li BC, Li TY, Zhou XY, Zhang Z (2014) Egg yolk IgY against RHDV capsid protein VP60 promotes rabbit defense against RHDV infection. Vet Immunol Immunopathol 157(1–2):97–104

    Article  CAS  PubMed  Google Scholar 

  • Li XY, Jin LJ, McAllister TA, Stanford K, Xu JY, Lu YN, Zhen YH, Sun YX, Xu YP (2007) Chitosan-alginate microcapsules for oral delivery of egg yolk immunoglobulin (IgY). J Agric Food Chem 55(8):2911–2917

    Article  CAS  PubMed  Google Scholar 

  • Li X, Wang L, Zhen Y, Li S, Xu Y (2015) Chicken egg yolk antibodies (IgY) as non-antibiotic production enhancers for use in swine production: a review. J Anim Sci Biotechnol 6(1):40

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lu Y, Liu J, Jin L, Li X, Zhen Y, Xue H, Lin Q, Xu Y (2009) Passive immunization of crayfish (Procambius clarkiaii) with chicken egg yolk immunoglobulin (IgY) against white spot syndrome virus (WSSV). Appl Biochem Biotechnol 159(3):750–758

    Article  CAS  PubMed  Google Scholar 

  • Lu Y, Liu J, Jin L, Li X, Zhen Y, Xue H, You J, Xu Y (2008) Passive protection of shrimp against white spot syndrome virus (WSSV) using specific antibody from egg yolk of chickens immunized with inactivated virus or a WSSV-DNA vaccine. Fish Shellfish Immunol 25(5):604–610

    Article  CAS  PubMed  Google Scholar 

  • Łupicka-Słowik A, Grzywa R, Leporowska E, Procyk D, Oleksyszyn J, Sieńczyk M (2019) Development and evaluation of an immunoglobulin Y-based ELISA for measuring prostate specific antigen in human serum. Ann Lab Med 39(4):373–380

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ma J, Cocchiaro J, Lee JC (2004) Evaluation of serotypes of Staphylococcus aureus strains used in the production of a bovine mastitis bacterin. J Dairy Sci 87(1):178–182

    Article  CAS  PubMed  Google Scholar 

  • Mahdavi A, Rahmani H, Nili N, Samie A, Soleimania S (2010a) Chicken egg yolk antibody (IgY) powder against Escherichia coli O78:K80. J Anim Vet Adv 9(2):366–373

    Article  CAS  Google Scholar 

  • Mahdavi AH, Rahmani HR, Nili N, Samie AH, Soleimanian-Zad S, Jahanian R (2010b) Effects of dietary egg yolk antibody powder on growth performance, intestinal Escherichia coli colonization, and immunocompetence of challenged broiler chicks. Poult Sci 89(3):484–494

    Article  CAS  PubMed  Google Scholar 

  • Malik MW, Ayub N, Qureshi IZ (2006) Passive immunization using purified IgYs against infectious bursal disease of chickens in Pakistan. J Vet Sci 7(1):43–46

    Article  PubMed  PubMed Central  Google Scholar 

  • Marquardt RR, Jin LZ, Kim JW, Fang L, Frohlich AA, Baidoo SK (1999) Passive protective effect of egg-yolk antibodies against enterotoxigenic Escherichia coli K88+ infection in neonatal and early-weaned piglets. FEMS Immunol Med Microbiol 23(4):283–288

    Article  CAS  PubMed  Google Scholar 

  • Meenatchisundaram S, Michael A, Subbraj T, Diraviam T, Shanmugam V (2011) Isolation, purification and neutralizing potential of chicken egg yolk immunoglobulin (IgY) against mastitis causing Escherichia coli in dairy cows in Coimbatore District. Int J Drug Develop Res 3(2):147–153

    Google Scholar 

  • Mesonero-Escuredo S, Strutzberg-Minder K, Casanovas C, Segalés J (2018) Viral and bacterial investigations on the aetiology of recurrent pig neonatal diarrhoea cases in Spain. Porcine Health Manag 4:5

    Article  PubMed  PubMed Central  Google Scholar 

  • Mine Y, Kovacs-Nolan J (2002) Chicken egg yolk antibodies as therapeutics in enteric infectious disease: a review. J Med Food 5(3):159–169

    Article  CAS  PubMed  Google Scholar 

  • Monistero V, Graber HU, Pollera C, Cremonesi P, Castiglioni B, Bottini E, Ceballos-Marquez A, Lasso-Rojas L, Kroemker V, Wente N, Petzer IM, Santisteban C, Runyan J, Veiga Dos Santos M, Alves BG, Piccinini R, Bronzo V, Abbassi MS, Said MB, Moroni P (2018) Staphylococcus aureus isolates from bovine mastitis in eight countries: genotypes, detection of genes encoding different toxins and other virulence genes. Toxins (Basel) 10(6):247

    Article  CAS  Google Scholar 

  • Mudili V, Makam SS, Sundararaj N, Siddaiah C, Gupta VK, Rao PVL (2015) A novel IgY-aptamer hybrid system for cost-effective detection of SEB and its evaluation on food and clinical samples. Sci Rep 5:15151

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muhammad K, Rabbi F, Hussain I, Riaz A, Saeed K, Hussain T (2001) Passive immunization against infectious bursal disease in chicks. Int J Agric Biol 3:413–415

    Google Scholar 

  • Nair MK, Joy J, Vasudevan P, Hinckley L, Hoagland TA, Venkitanarayanan KS (2005) Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens. J Dairy Sci 88(10):3488–3495

    Article  CAS  PubMed  Google Scholar 

  • Nakamura R, Pedrosa-Gerasmio IR, Alenton RRR, Nozaki R, Kondo H, Hirono I (2019) Anti-PirA-like toxin immunoglobulin (IgY) in feeds passively immunizes shrimp against acute hepatopancreatic necrosis disease. J Fish Dis 42(8):1125–1132

    Article  CAS  PubMed  Google Scholar 

  • Nakamura M, Tohya Y, Miyazawa T, Mochizuki M, Phung HT, Nguyen NH, Huynh LM, Nguyen LT, Nguyen PN, Nguyen PV, Nguyen NP, Akashi H (2004) A novel antigenic variant of canine parvovirus from a Vietnamese dog. Arch Virol 149(11):2261–2269

    Article  CAS  PubMed  Google Scholar 

  • Nandi S, Kumar M (2010) Canine parvovirus: current perspective. Ind J Virol 21(1):31–44

    Article  CAS  Google Scholar 

  • Newcomer BW, Chamorro MF, Walz PH (2017) Vaccination of cattle against bovine viral diarrhea virus. Vet Microbiol 206:78–83

    Article  CAS  PubMed  Google Scholar 

  • Oliva JL, Johnston KL (2020) Puppy love in the time of Corona: dog ownership protects against loneliness for those living alone during the COVID-19 lockdown. Int J Soc Psychiatry 23:1–11

    Google Scholar 

  • Oliver C, Valenzuela K, Silva H, Haro RE, Cortés M, Sandoval R, Pontigo JP, Álvarez C, Figueroa JE, Avendaño-Herrera R, Troncoso JM, Yáñez AJ (2015) Effectiveness of egg yolk immunoglobulin against the intracellular salmonid pathogen Piscirickettsia salmonis. J Appl Microbiol 119(2):365–376

    Article  CAS  PubMed  Google Scholar 

  • Otto PH, Clarke IN, Lambden PR, Salim O, Reetz J, Liebler-Tenorio EM (2011) Infection of calves with bovine norovirus GIII.1 strain Jena virus: an experimental model to study the pathogenesis of norovirus infection. J Virol 85(22):12013–12021

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ozkan B, Budama-Kilinc Y, Cakir-Koc R, Mese S, Badur S (2019) Application of an immunoglobulin Y-alkaline phosphatase bioconjugate as a diagnostic tool for influenza a virus. Bioengineered 10(1):33–42

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Park SB, Aoki T, Jung TS (2012) Pathogenesis of and strategies for preventing Edwardsiella tarda infection in fish. Vet Res 43(1):67

    Article  PubMed  PubMed Central  Google Scholar 

  • Park HS, Park KI, Nagappan A, Lee DH, Kang SR, Kim JA, Kim EH, Han DY, Kim GS (2011) Proteomic analysis of effects on natural herb additive containing immunoglobulin Yolksac (IgY) in pigs. Am J Chin Med 39(3):477–488

    Article  PubMed  Google Scholar 

  • Parreño V, Béjar C, Vagnozzi A, Barrandeguy M, Costantini V, Craig MI, Yuan L, Hodgins D, Saif L, Fernández F (2004) Modulation by colostrum-acquired maternal antibodies of systemic and mucosal antibody responses to rotavirus in calves experimentally challenged with bovine rotavirus. Vet Immunol Immunopathol 100(1–2):7–24

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Parreño V, Marcoppido G, Vega C, Garaicoechea L, Rodriguez D, Saif L, Fernández F (2010) Milk supplemented with immune colostrum: protection against rotavirus diarrhea and modulatory effect on the systemic and mucosal antibody responses in calves experimentally challenged with bovine rotavirus. Vet Immunol Immunopathol 136(1–2):12–27

    Article  PubMed  CAS  Google Scholar 

  • Parrish CR, Aquadro CF, Strassheim ML, Evermann JF, Sgro JY, Mohammed HO (1991) Rapid antigenic-type replacement and DNA sequence evolution of canine parvovirus. J Virol 65(12):6544–6552

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patra MK, Begum S, Deka B (2014) Problems and prospects of traditional pig farming for tribal livelihood in Nagaland. Ind Res J Exten Edu 14(4):6–11

    Google Scholar 

  • Pereira EPV, van Tilburg MF, Florean E, Guedes MIF (2019) Egg yolk antibodies (IgY) and their applications in human and veterinary health: a review. Int Immunopharmacol 73:293–303

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Prasad K, Sukumaran JK (2013) Advances in aquatic animal health manage-ment. Int J Bio-Tech Res 3:35–44

    Google Scholar 

  • Pratelli A (2011) Canine distemper virus: the emergence of new variants. Vet J (London, England: 1997) 187(3):290–291

    Article  Google Scholar 

  • Qi S, Zhao J, Guo D, Sun D (2020) A mini-review on the epidemiology of canine parvovirus in China. Front Vet Sci 7:5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Quintero-Gil C, Rendon-Marin S, Martinez-Gutierrez M, Ruiz-Saenz J (2019) Origin of canine distemper virus: consolidating evidence to understand potential Zoonoses. Front Microbiol 10:1982

    Article  PubMed  PubMed Central  Google Scholar 

  • Rahimi S, Shiraz Z, Salehi T, Karimi Torshizi MA, Grimes J (2007) Prevention of salmonella infection in poultry by specific egg-derived antibody. Int J Poult Sci 6(4):230–235

    Article  Google Scholar 

  • Rahman S, Van Nguyen S, Icatlo FC Jr, Umeda K, Kodama Y (2013) Oral passive IgY-based immunotherapeutics: a novel solution for prevention and treatment of alimentary tract diseases. Human Vaccines and Immunotherapeutics 9(5):1039–1048

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Raj JM, Mukhopadhyay HK, Thanislass J, Antony PX, Pillai RM (2010) Isolation, molecular characterization and phylogenetic analysis of canine parvovirus. Infect Genet Evol 10(8):1237–1241

    Article  CAS  Google Scholar 

  • Rajan B, Løkka G, Koppang EO, Austbø L (2017) Passive immunization of farmed fish. J Immunol. (Baltimore, Md. : 1950) 198(11):4195–4202

    Article  CAS  PubMed  Google Scholar 

  • Rhouma M, Fairbrother JM, Beaudry F, Letellier A (2017) Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies. Acta Vet Scand 59(1):31

    Article  PubMed  CAS  Google Scholar 

  • Riffon R, Sayasith K, Khalil H, Dubreuil P, Drolet M, Lagacé J (2001) Development of a rapid and sensitive test for identification of major pathogens in bovine mastitis by PCR. J Clin Microbiol 39(7):2584–2589

    Article  CAS  PubMed  Google Scholar 

  • Ritchie H (2017) Meat and dairy production. Published online at OurWorldInData.org. https://ourworldindata.org/meat-production

  • Rodríguez-Tovar LE, Becker JA, Markham RJ, Speare DJ (2006) Induction time for resistance to microsporidial gill disease caused by Loma salmonae following vaccination of rainbow trout (Oncorhynchus mykiss) with a spore-based vaccine. Fish Shellfish Immunol 21(2):170–175

    Article  PubMed  CAS  Google Scholar 

  • Ruegg PL (2017) A 100-year review: mastitis detection, management, and prevention. J Dairy Sci 100(12):10381–10397

    Article  CAS  PubMed  Google Scholar 

  • Saif LJ, Thiel K (1990) Viral diarrheas of man and animals. CRC Press, Boca Raton, Florida

    Google Scholar 

  • Saleh M, Soliman H, El-Matbouli M (2008) Loop-mediated isothermal amplification as an emerging technology for detection of Yersinia ruckeri the causative agent of enteric red mouth disease in fish. BMC Vet Res 4:31

    Article  PubMed  CAS  Google Scholar 

  • Satyaraj E, Wedner HJ, Bousquet J (2019) Keep the cat, change the care pathway: a transformational approach to managing Fel d 1, the major cat allergen. Allergy 74(107):5–17

    Article  PubMed  Google Scholar 

  • Shahbandeh M (2020) Egg production worldwide 1990–2018. https://www.statista.com/statistics/263972/egg-production-worldwide-since-1990/

  • Shimizu M, Watanabe A, Tanaka A (1995) Detection of high-molecular weight mucin-like glycoprotein-a (HMGP-A) of human milk by chicken egg yolk antibody. Biosci Biotechnol Biochem 59(1):138–139

    Article  CAS  PubMed  Google Scholar 

  • Skottrup PD, López R, Ksiazek M, Højrup P, Baelum V, Potempa J, Kaczmarek JZ (2019) An IgY-based immunoassay to evaluate the biomarker potential of the Tannerella forsythia virulence factor karilysin in human saliva. J Immunol Methods 469:26–32

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Spibey N, Greenwood NM, Sutton D, Chalmers WS, Tarpey I (2008) Canine parvovirus type 2 vaccine protects against virulent challenge with type 2c virus. Vet Microbiol 128(1–2):48–55

    Article  CAS  PubMed  Google Scholar 

  • Spillner E, Braren I, Greunke K, Seismann H, Blank S, du Plessis D (2012) Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy. Biologicals 40(5):313–322

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stefaniak T (2006) Chapter 8 control of intestinal diseases by dietary supplementation with antibodies. In: Mosenthin R, Zentek J, Żebrowska T (eds) Biology of growing animals, vol 4. Elsevier, pp 285–309

    Google Scholar 

  • Stefaniak T, Rzasa A, Jawor P, Zyzak A, Niemczuk W, Kuczaj M, Popławski M, Borkowski J (2014) Field application of egg yolk immunoglobulin as the feed additive in prophylaxis of diseases in weaned piglets. Med Weter 70(9):553–557

    Google Scholar 

  • Stevens MP, Humphrey TJ, Maskell DJ (2009) Molecular insights into farm animal and zoonotic salmonella infections. Philosophical transactions of the Royal Society of London. Series B, Biol Sci 364(1530):2709–2723

    Article  CAS  Google Scholar 

  • Suartini IGAA, Sendow I, Agustini NLP, Suprayogi A, Wibawan IWT, Mahardika IGNK (2016) Kinetika Immunoglobulin Kuning Telur Antiparvovirus Anjing Pada Anjing (KINETICS OF ANTICANINE PARVOVIRUS YOLK IMMUNOGLOBULIN IN DOGS). Jurnal Veteriner 17(2):292–299

    Article  Google Scholar 

  • Suartini GAA, Suprayogi A, Wibawan WT, Sendow I, Mahardika G (2014) Intravenous administration of chicken immunoglobulin has a curative effect in experimental infection of canine parvovirus. Global Vet 13:801–808

    Google Scholar 

  • Sunyer JO (2013) Fishing for mammalian paradigms in the teleost immune system. Nat Immunol 14(4):320–326

    Article  CAS  PubMed  Google Scholar 

  • Tamilzarasan KB, Dinakaran AM, Selvaraju G, Dorairajan N (2009) Efficacy of egg yolk immunoglobulins (IgY) against enteric pathogens in poultry. Tamilnadu J Vet Sci 5(6):264–268

    Google Scholar 

  • Tenhagen BA, Köster G, Wallmann J, Heuwieser W (2006) Prevalence of mastitis pathogens and their resistance against antimicrobial agents in dairy cows in Brandenburg, Germany. J Dairy Sci 89(7):2542–2551

    Article  CAS  PubMed  Google Scholar 

  • Thirumalai D, Visaga Ambi S, Vieira-Pires RS, Xiaoying Z, Sekaran S, Krishnan U (2019) Chicken egg yolk antibody (IgY) as diagnostics and therapeutics in parasitic infections - a review. Int J Biol Macromol 136:755–763

    Article  CAS  PubMed  Google Scholar 

  • Thu HM, Myat TW, Win MM, Thant KZ, Rahman S, Umeda K, Nguyen SV, Icatlo FC Jr, Higo-Moriguchi K, Taniguchi K, Tsuji T, Oguma K, Kim SJ, Bae HS, Choi HJ (2017) Chicken egg yolk antibodies (IgY) for prophylaxis and treatment of rotavirus diarrhea in human and animal neonates: a concise review. Korean J Food Sci Anim Resour 37(1):1–9

    Article  PubMed  Google Scholar 

  • Tran TV, Do BN, Nguyen TPT, Tran TT, Tran SC, Nguyen BV, Nguyen CV, Le HQ (2019) Development of an IgY-based lateral flow immunoassay for detection of fumonisin B in maize. F1000Research 8:1042

    Article  CAS  PubMed  Google Scholar 

  • Tsubokura K, Berndtson E, Bogstedt A, Kaijser B, Kim M, Ozeki M, Hammarström L (1997) Oral administration of antibodies as prophylaxis and therapy in campylobacter jejuni-infected chickens. Clin Exp Immunol 108(3):451–455

    Article  CAS  PubMed  Google Scholar 

  • USDA (2019) What is the most consumed meat in the world? https://ask.usda.gov/s/article/What-is-the-most-consumed-meat-in-the-world#:~:text=Information&text=According%20to%20the%20United%20Nationsgoats%2Fsheep%20(5%25)

  • USDA, APHIS (2014) Veterinary Services, Health and management practices on U.S dairy operations. In. Fort Collins, CO, USA

    Google Scholar 

  • Van Nguyen S, Umeda K, Yokoyama H, Tohya Y, Kodama Y (2006) Passive protection of dogs against clinical disease due to canine parvovirus-2 by specific antibody from chicken egg yolk. Canadian J Vet Res 70(1):62–64

    Google Scholar 

  • Vandeputte J, Martel A, Canessa S, Van Rysselberghe N, De Zutter L, Heyndrickx M, Haesebrouck F, Pasmans F, Garmyn A (2019) Reducing campylobacter jejuni colonization in broiler chickens by in-feed supplementation with hyperimmune egg yolk antibodies. Sci Rep 9(1):8931

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vazquez L, Alpuche J, Maldonado G, Agundis C, Pereyra-Morales A, Zenteno E (2009) Review: immunity mechanisms in crustaceans. Innate Immun 15(3):179–188

    Article  CAS  PubMed  Google Scholar 

  • Vega C, Bok M, Chacana P, Saif L, Fernandez F, Parreño V (2011) Egg yolk IgY: protection against rotavirus induced diarrhea and modulatory effect on the systemic and mucosal antibody responses in newborn calves. Vet Immunol Immunopathol 142(3–4):156–169

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vega C, Bok M, Saif L, Fernandez F, Parreño V (2015) Egg yolk IgY antibodies: a therapeutic intervention against group a rotavirus in calves. Res Vet Sci 103:1–10

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vega CG, Bok M, Vlasova AN, Chattha KS, Fernández FM, Wigdorovitz A, Parreño VG, Saif LJ (2012) IgY antibodies protect against human rotavirus induced diarrhea in the neonatal gnotobiotic piglet disease model. PLoS One 7(8):e42788

    Article  CAS  PubMed  Google Scholar 

  • Verma AK, Gupta S, Verma S, Mishra A, Nagpure NS, Singh SP, Pathak AK, Sarkar UK, Singh SP, Singh M, Seth PK (2013) Interaction between shrimp and white spot syndrome virus through PmRab7-VP28 complex: an insight using simulation and docking studies. J Mol Model 19(3):1285–1294

    Article  CAS  PubMed  Google Scholar 

  • Wang LH, Li XY, Jin LJ, You JS, Zhou Y, Li SY, Xu YP (2011) Characterization of chicken egg yolk immunoglobulins (IgYs) specific for the most prevalent capsular serotypes of mastitis-causing Staphylococcus aureus. Vet Microbiol 149(3–4):415–421

    Article  CAS  PubMed  Google Scholar 

  • Winkelbach A, Günzel D, Schulz C, Wuertz S (2015a) Differences in IgY gut absorption in gastric rainbow trout (Oncorhynchus mykiss) and agastric common carp (Cyprinus carpio) assessed in vivo and in vitro. Comp Biochem Physiol C Toxicol Pharmacol 167:58–64

    Article  CAS  PubMed  Google Scholar 

  • Winkelbach A, Schade R, Schulz C, Wuertz S (2015b) Comparison of oral, rectal and intraperitoneal administration of IgY antibodies in passive immunization of rainbow trout (Oncorhynchus mykiss). Aquaculture Int 23(2):427–438

    Article  CAS  Google Scholar 

  • Wu CJ, Wang H, Chan YL, Li TL (2011) Passive immune-protection of small abalone against vibrio alginolyticus infection by anti-vibrio IgY-encapsulated feed. Fish Shellfish Immunol 30(4–5):1042–1048

    Article  CAS  PubMed  Google Scholar 

  • Xiao Y, Gao X, Gannot G, Emmert-Buck MR, Srivastava S, Wagner PD, Amos MD, Barker PE (2008) Quantitation of HER2 and telomerase biomarkers in solid tumors with IgY antibodies and nanocrystal detection. Int J Cancer 122(10):2178–2186

    Article  CAS  PubMed  Google Scholar 

  • Xu L, Che J, Xu Y, Chen Y, Li Y, Murtaza B, Wang L, Zhang M, Li X (2020) Oral administration of microencapsulated egg yolk immunoglobulin (IgY) in turbot (Scophthalmus maximus) to combat against Edwardsiella tarda 2CDM001 infections. Fish Shellfish Immunol 106:609–620

    Article  CAS  PubMed  Google Scholar 

  • Xu J, Ren C, Wang S, Liu D, Cao L, Tao J (2013) Protection efficacy of multivalent egg yolk immunoglobulin against Eimeria tenella infection in chickens. Iran J Parasitol 8(3):449–458

    PubMed  Google Scholar 

  • Xu J, Tan X, Zhang X, Xia X, Sun H (2015) The diversities of staphylococcal species, virulence and antibiotic resistance genes in the subclinical mastitis milk from a single Chinese cow herd. Microb Pathog 88:29–38

    Article  CAS  PubMed  Google Scholar 

  • Xu L, Xu Y, He L, Zhang M, Wang L, Li Z, Li X (2019) Immunomodulatory effects of chicken egg yolk antibodies (IgY) against experimental Shewanella marisflavi AP629 infections in sea cucumbers (Apostichopus japonicus). Fish Shellfish Immunol 84:108–119

    Article  CAS  PubMed  Google Scholar 

  • Yokoyama H, Peralta RC, Diaz R, Sendo S, Ikemori Y, Kodama Y (1992) Passive protective effect of chicken egg yolk immunoglobulins against experimental enterotoxigenic Escherichia coli infection in neonatal piglets. Infect Immun 60(3):998–1007

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang X, Calvert RA, Sutton BJ, Doré KA (2017) IgY: a key isotype in antibody evolution. Biol Rev Camb Philos Soc 92(4):2144–2156

    Article  PubMed  Google Scholar 

  • Zhang X, Diraviyam T, Li X, Yao G, Michael A (2016) Preparation of chicken IgY against recombinant E2 protein of bovine viral diarrhea virus (BVDV) and development of ELISA and ICA for BVDV detection. Biosci Biotech Bioch 80(12):2467–2472

    Article  CAS  Google Scholar 

  • Zhang JJ, Kang TY, Kwon T, Koh H, Chandimali N, Wang XZ, Kim N, Jeong DK (2019) Specific chicken egg yolk antibody improves the protective response against Gallibacterium anatis infection. Infection Immunity 87(3):e00618–e00619

    Article  Google Scholar 

  • Zhen YH, Jin LJ, Guo J, Li XY, Lu YN, Chen J, Xu YP (2008) Characterization of specific egg yolk immunoglobulin (IgY) against mastitis-causing Escherichia coli. Vet Microbiol 130(1–2):126–133

    Article  CAS  PubMed  Google Scholar 

  • Zhen YH, Jin LJ, Li XY, Guo J, Li Z, Zhang BJ, Fang R, Xu YP (2009) Efficacy of specific egg yolk immunoglobulin (IgY) to bovine mastitis caused by Staphylococcus aureus. Vet Microbiol 133(4):317–322

    Article  CAS  PubMed  Google Scholar 

  • Zhong F, Li N, Huang X, Guo Y, Chen H, Wang X, Shi C, Zhang X (2011) Genetic typing and epidemiologic observation of bovine viral diarrhea virus in Western China. Virus Genes 42(2):204–207

    Article  CAS  PubMed  Google Scholar 

  • Zuo Y, Fan J, Fan H, Li T, Zhang X (2009) Prophylactic and therapeutic effects of egg yolk immunoglobulin against porcine transmissible gastroenteritis virus in piglets. Front Agric China 3(1):104–108

    Article  PubMed  Google Scholar 

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Chelliappan, B., Michael, A., Vega, C.G., Zhong, F., Zhang, X., Morgan, P.M. (2021). Applications of IgY in Veterinary Medicine. In: Zhang, XY., Vieira-Pires, R.S., Morgan, P.M., Schade, R. (eds) IgY-Technology: Production and Application of Egg Yolk Antibodies. Springer, Cham. https://doi.org/10.1007/978-3-030-72688-1_15

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