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Persistent Organic Pollutants (Part II): The New POPs – Sources and Adverse Effects

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Organic Pollutants

Abstract

Persistent organic pollutants (POPs) are organic pollutants that exist for extended periods of time in our environment. Due to their ubiquitous presence in the environment (water, air, soil, and living beings), both natural and man-made forms of POPs are of global concern. They can be considered as “forever chemicals” due to their resistance to degradation in the ecosystem via photolytically, biologically, or chemically to diversified degrees. They have the potential to biomagnify via the food chain, and due to their high lipid solubility they can bioaccumulate in the various organisms in the ecosystem. They are transported beyond international borders by water and wind and are detected in places far from their sources. The comprehensive contamination of the living organisms and environment by POPs has resulted in acute as well as chronic toxic effects in many living species. Under the leadership of United Nations Environment Programme (UNEP), 12 classes of organic compounds (or the “dirty dozen”) were initially identified as persistent organic pollutants in the Stockholm Convention of Persistent Organic Pollutants held in 2001. In the subsequent Stockholm Conventions held biennially from 2009 to 2019, additional chemicals were considered as new POPs. In this chapter, the source, structure, general characteristics, and uses of the intentionally produced and unintentionally generated new persistent organic pollutants introduced from 2009 will be described. The major adverse effects caused by these new persistent organic pollutants on human health and the environment will be also summarized.

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References

  • Ahmad, A., & Ahmad, M. (2017). Deciphering the toxic effects of organochlorine pesticide, dicofol on human RBCs and lymphocytes. Pesticide Biochemistry and Physiology, 143, 127–134.

    Article  CAS  Google Scholar 

  • Alexander, B. H., & Olsen, G. W. (2007). Bladder cancer in perfluorooctanesulfonyl fluoride manufacturing workers. Annals of Epidemiology, 17, 471–478.

    Article  Google Scholar 

  • Alexander, B. H., Olsen, G. W., Burris, J. M., Mandel, J. H., & Mandel, J. S. (2003). Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility. Occupational and Environmental Medicine, 60, 722–729.

    Article  CAS  Google Scholar 

  • Alharbi, O. M. L., Basheer, A. A., Khattab, R. A., & Ali, I. (2018). Health and environmental effects of persistent organic pollutants. Journal of Molecular Liquids, 263, 442–453.

    Article  CAS  Google Scholar 

  • Ali, H. A. A., & Azhar, A. S. (2013). Methoxychlor induced biochemical alterations and disruption of spermatogenesis in adult rats. Reproductive Toxicology, 40, 8–15.

    Article  Google Scholar 

  • Álvarez-Pedrerol, M., Ribas-Fitó, N., Torrent, M., Carrizo, D., Garcia-Esteban, R., Grimalt, J. O., & Sunyer, J. (2008). Thyroid disruption at birth due to prenatal exposure to β-hexachlorocyclohexane. Environment International, 34, 737–740.

    Article  Google Scholar 

  • Austin, M. E., Kasturi, B. S., Barber, M., Kannan, K., MohanKumar, P. S., & MohanKumar, S. M. J. (2003). Neuroendocrine effects of perfluorooctane sulfonate in rats. Environmental Health Perspectives, 111, 1485–1489.

    Article  CAS  Google Scholar 

  • Bahn, A. K., Mills, J. L., Snyder, P. J., Gann, P. H., Houten, L., Bialik, O., Hollmann, L., & Utiger, R. D. (1980). Hypothyroidism in workers exposed to polybrominated biphenyls. The New England Journal of Medicine, 302, 31–33.

    Article  CAS  Google Scholar 

  • Bailey, R. E., van Wijk, D., & Thomas, P. C. (2009). Sources and prevalence of pentachlorobenzene in the environment. Chemosphere, 75, 555–564.

    Article  CAS  Google Scholar 

  • Beesoon, S., Genuis, S. J., Benskin, J. P., & Martin, J. W. (2012). Exceptionally high serum concentrations of perfluorohexanesulfonate in a Canadian family are linked to home carpet treatment applications. Environmental Science & Technology, 46, 12960–12967.

    Article  CAS  Google Scholar 

  • Bekesi, J. G., Holland, J. F., Anderson, H. A., Fischbein, A. S., Rom, W., Wolff, M. S., & Selikoff, I. J. (1978). Lymphocyte function of Michigan dairy farmers exposed to polybrominated biphenyls. Science, 199, 1207–1209.

    Article  CAS  Google Scholar 

  • Ben, Y.-J., Li, X.-H., Yang, Y.-L., Li, L., Zheng, M.-Y., Wang, W.-Y., & Xu, X.-B. (2014). Placental transfer of dechlorane plus in mother−infant pairs in an E-waste recycling area (Wenling, China). Environmental Science & Technology, 48, 5187–5193.

    Article  CAS  Google Scholar 

  • Berthiaume, J., & Wallace, K. B. (2002). Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol; peroxisome proliferation and mitochondrial biogenesis. Toxicology Letters, 129, 23–32.

    Article  CAS  Google Scholar 

  • Bezchlebová, J., Cernohlávková, J., Kobeticová, K., Lána, J., Sochová, I., & Hofman, J. (2007). Effects of short-chain chlorinated paraffins on soil organisms. Ecotoxicology and Environmental Safety, 67, 206–211.

    Article  Google Scholar 

  • Bidleman, T. F., Kylin, H., Jantunen, L. M., Helm, P. A., & Macdonald, R. W. (2007). Hexachlorocyclohexanes in the Canadian archipelago. 1. Spatial distribution and pathways of α-, β-, and γ-HCHs in surface water. Environmental Science & Technology, 41, 2688–2695.

    Article  CAS  Google Scholar 

  • Blakley, B. R., Yole, M. J., Brousseau, P., Boermans, H., & Fournier, M. (1998). Effect of pentachlorophenol on immune function. Toxicology, 125, 141–148.

    Article  CAS  Google Scholar 

  • Blanck, H. M., Marcus, M., Tolbert, P. E., Rubin, C., Henderson, A. K., Hertzberg, V. S., Zhang, R. H., & Cameron, L. (2000). Age at menarche and tanner stage in girls exposed in utero and postnatally to polybrominated biphenyl. Epidemiology, 11, 641–647.

    Article  CAS  Google Scholar 

  • Boucher, O., Simard, M.-N., Muckle, G., Rouget, F., Kadhel, P., Bataille, H., Chajès, V., Dallaire, R., Monfort, C., Thomé, J.-P., Multigner, L., & Cordier, S. (2013). Exposure to an organochlorine pesticide (chlordecone) and development of 18-month-old infants. Neurotoxicology, 35, 162–168.

    Article  CAS  Google Scholar 

  • Brüschweiler, B. J., Märki, W., & Wülser, R. (2010). In vitro genotoxicity of polychlorinated butadienes (Cl4–Cl6). Mutation Research – Genetic Toxicology and Environmental, 699, 47–54.

    Article  Google Scholar 

  • Burgoyne, T. W., & Hites, R. A. (1993). Effects of temperature and wind direction on atmospheric concentrations of R-endosulfan. Environmental Science & Technology, 27, 910–914.

    Article  CAS  Google Scholar 

  • Cabidoche, Y. M., Achard, R., Cattan, P., Clermont-Dauphin, C., Massat, F., & Sansoulet, J. (2009). Long-term pollution by chlordecone of tropical volcanic soils in the French West Indies: A simple leaching model accounts for current residue. Environmental Pollution, 157, 1697–1705.

    Article  CAS  Google Scholar 

  • Cao, X., Lu, Y., Zhang, Y., Khan, K., Wang, C., & Baninla, Y. (2018). An overview of hexabromocyclododecane (HBCDs) in environmental media with focus on their potential risk and management in China. Environmental Pollution, 236, 283–295.

    Article  CAS  Google Scholar 

  • Carter, L. J. (1976). Michigan’s PBB incident: Chemical mix-up leads to disaster. Science, 192, 240–243.

    Article  CAS  Google Scholar 

  • Chan, C. H., & Perkins, L. H. (1989). Monitoring of trace organic contaminants in atmospheric precipitation. Journal of Great Lakes Research, 15, 465–475.

    Article  CAS  Google Scholar 

  • Chang, W.-C., Jeng, J.-H., Shieh, C.-C., Tsai, Y.-C., Ho, Y.-S., Guo, H.-R., Liu, H.-I., Lee, C.-C., Ho, S.-Y., & Wang, Y.-J. (2003). Skin tumor–promoting potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone in CD-1 Mice. Molecular Carcinogenesis, 36, 161–170.

    Article  CAS  Google Scholar 

  • Chen, X., Dong, Q., Chen, Y., Zhang, Z., Huang, C., Zhu, Y., & Zhang, Y. (2017). Effects of Dechlorane Plus exposure on axonal growth, musculature and motor behavior in embryo-larval zebrafish. Environmental Pollution, 224, 7–15.

    Article  CAS  Google Scholar 

  • Cheng, P., Zhang, Q., Shan, X., Shen, D., Wang, B., Tang, Z., Jin, Y., Zhang, C., & Huang, F. (2015). Cancer risks and long-term community-level exposure to pentachlorophenol in contaminated areas, China. Environmental Science and Pollution Research, 22, 1309–1317.

    Article  CAS  Google Scholar 

  • Chiusolo, A., Defazio, R., Casartelli, A., Bocchini, N., Mongillo, M., Zanetti, E., Cristofori, P., & Trevisan, A. (2008). Regucalcin down-regulation in rat kidney tissue after treatment with nephrotoxicants. Toxicology Letters, 182, 84–90.

    Article  CAS  Google Scholar 

  • Chiusolo, A., Defazio, R., Zanetti, E., Mongillo, M., Mori, N., Cristofori, P., & Trevisan, A. (2010). Kidney injury molecule-1 expression in rat proximal tubule after treatment with segment-specific nephrotoxicants: A tool for early screening of potential kidney toxicity. Toxicologic Pathology, 38, 338–345.

    Article  CAS  Google Scholar 

  • Choudhary, G. (1995). Human health perspectives on environmental exposure to hexachlorobutadiene: A review. Journal of Environmental Science and Health Part C, 13, 179–203.

    Article  Google Scholar 

  • Conder, J. M., Hoke, R. A., De Wolf, W., Russell, M. H., & Buck, R. C. (2008). Are PFCAs bioaccumulative? A critical review and comparison with regulatory criteria and persistent lipophilic compounds. Environmental Science & Technology, 42, 995–1003.

    Article  CAS  Google Scholar 

  • Costa, L. G., & Giordano, G. (2007). Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants. Neurotoxicology, 28, 1047–1067.

    Article  CAS  Google Scholar 

  • Covaci, A., Gerecke, A. C., Law, R. J., Voorspoels, S., Kohler, M., Heeb, N. V., Leslie, H., Allchin, C. R., & de Boer, J. (2006). Hexabromocyclododecanes (HBCDs) in the environment and humans: A review. Environmental Science & Technology, 40, 3679–3688.

    Article  CAS  Google Scholar 

  • Curran, C. P., Miller, K. A., Dalton, T. P., Vorhees, C. V., Miller, M. L., Shertzer, H. G., & Nebert, D. W. (2006). Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicological Sciences, 89, 454–464.

    Article  CAS  Google Scholar 

  • Dallaire, R., Muckle, G., Rouget, F., Kadhel, P., Bataille, H., Guldner, L., Seurin, S., Chajès, V., Monfort, C., Boucher, O., Thomé, J. P., Jacobson, S. W., Multigner, L., & Cordier, S. (2012). Cognitive, visual, and motor development of 7-month-old Guadeloupean infants exposed to chlordecone. Environmental Research, 118, 79–85.

    Article  CAS  Google Scholar 

  • Demers, P. A., Davies, H. W., Friesen, M. C., Hertzman, C., Ostry, A., Hershler, R., & Teschke, K. (2006). Cancer and occupational exposure to pentachlorophenol and tetrachlorophenol (Canada). Cancer Causes & Control, 17, 749.

    Article  Google Scholar 

  • Du, M., Zhang, D., Yan, C., & Zhang, X. (2012). Developmental toxicity evaluation of three hexabromocyclododecane diastereoisomers on zebrafish embryos. Aquatic Toxicology, 112, 1–10.

    Article  Google Scholar 

  • Du, X., Yuan, B., Zhou, Y., Zheng, Z., Wu, Y., Qiu, Y., Zhao, J., & Yin, G. (2019). Tissue-specific accumulation, sexual difference, and maternal transfer of chlorinated Paraffins in black-spotted frogs. Environmental Science & Technology, 53, 4739–4746.

    Article  CAS  Google Scholar 

  • Dubuisson, C., Héraud, F., Leblanc, J.-C., Gallotti, S., Flamand, C., Blateau, A., Quenel, P., & Volatier, J.-L. (2007). Impact of subsistence production on the management options to reduce the food exposure of the Martinican population to chlordecone. Regulatory Toxicology and Pharmacology, 49, 5–16.

    Article  CAS  Google Scholar 

  • El-Shahawi, M. S., Hamza, A., Bashammakh, A. S., & Al-Saggaf, W. T. (2010). An overview on the accumulation, distribution, transformations, toxicity and analytical methods for the monitoring of persistent organic pollutants. Talanta, 80, 1587–1597.

    Article  CAS  Google Scholar 

  • Faroon, O., Kueberuwa, S., Smith, L., & DeRosa, C. (1995). ATSDR evaluation of health effects of chemicals. II. Mirex and chlordecone: Health effects, toxicokinetics, human exposure, and environmental fate. Toxicology and Industrial Health, 11, 1–203.

    Article  CAS  Google Scholar 

  • Fei, C., McLaughlin, J. K., Tarone, R. E., & Olsen, J. (2007). Perfluorinated chemicals and fetal growth: A study within the Danish National Birth Cohort. Environmental Health Perspectives, 115, 1677–1682.

    Article  CAS  Google Scholar 

  • Fei, C., & Olsen, J. (2010). Prenatal exposure to perfluorinated chemicals and behavioral or coordination problems at age 7. Environmental Health Perspectives, 119, 573–578.

    Article  Google Scholar 

  • Fernandes, A., Mortimer, D., Gem, M., Smith, F., Rose, M., Panton, S., & Carr, M. (2010). Polychlorinated naphthalenes (PCNs): Congener specific analysis, occurrence in food, and dietary exposure in the UK. Environmental Science & Technology, 44, 3533–3538.

    Article  CAS  Google Scholar 

  • Fernandes, A., Rose, M., & Falandysz, J. (2017). Polychlorinated naphthalenes (PCNs) in food and humans. Environment International, 104, 1–13.

    Article  CAS  Google Scholar 

  • Fernandes, A. R., Mortimer, D., Rose, M., Smith, F., Steel, Z., & Panton, S. (2019). Recently listed Stockholm convention POPs: Analytical methodology, occurrence in food and dietary exposure. Science of the Total Environment, 678, 793–800.

    Article  CAS  Google Scholar 

  • Fiege, H., Voges, H.-M., Hamamoto, T., Umemura, S., Iwata, T., Miki, H., Fujita, Y., Buysch, H.-J., Garbe, D., & Paulus, W. (2000). Phenol derivatives. In Ullmann's encyclopedia of industrial chemistry. Weinheim: Wiley-VCH.

    Google Scholar 

  • Fraser, D. L., Stander, B. A., & Steenkamp, V. (2019). Cytotoxic activity of pentachlorophenol and its active metabolites in SH-SY5Y neuroblastoma cells. Toxicology In Vitro, 58, 118–125.

    Article  CAS  Google Scholar 

  • Frederiksen, M., Vorkamp, K., Thomsen, M., & Knudsen, L. E. (2009). Human internal and external exposure to PBDEs – A review of levels and sources. International Journal of Hygiene and Environmental Health, 212, 109–134.

    Article  CAS  Google Scholar 

  • Gagné, P.-L., Fortier, M., Fraser, M., Parent, L., Vaillancourt, C., & Verreault, J. (2017). Dechlorane Plus induces oxidative stress and decreases cyclooxygenase activity in the blue mussel. Aquatic Toxicology, 188, 26–32.

    Article  Google Scholar 

  • Gannon, A. M., Moreau, M., Farmahin, R., Thomas, R. S., Barton-Maclaren, T. S., Nong, A., Curran, I., & Yauk, C. L. (2019). Hexabromocyclododecane (HBCD): A case study applying tiered testing for human health risk assessment. Food and Chemical Toxicology, 131, 110581.

    Article  CAS  Google Scholar 

  • Garcia, J. G., Fronczek, F. R., & McLaughlin, M. L. (1991). Tandem reverse-electron-demand diels-alder reactions of 1,5-cyclooctadiene. Tetrahedron Letters, 32, 3289–3292.

    Article  CAS  Google Scholar 

  • Geng, N., Zhang, H., Zhang, B., Wu, P., Wang, F., Yu, Z., & Chen, J. (2015). Effects of short-chain chlorinated paraffins exposure on the viability and metabolism of human hepatoma HepG2 cells. Environmental Science & Technology, 49, 3076–3083.

    Article  CAS  Google Scholar 

  • Giddings, M., Meek, M. E., & Gomes, R. (1994). Pentachlorobenzene: Evaluation of risks to health from environmental exposure in Canada. Journal of Environmental Science and Health, Part C, 12, 435–441.

    Article  Google Scholar 

  • Girolami, G. S., Rauchfuss, T. B., & Angelici, R. J. (1999). Synthesis and technique in inorganic chemistry (3rd ed.). Sausalito, CA: University Science Books.

    Google Scholar 

  • Gong, N., Shao, K., Han, X., Zhang, Y., & Sun, Y. (2018). Enrichment and physiological responses of dechlorane plus on juvenile marine macroalgae (Ulva pertusa). Chemosphere, 205, 594–600.

    Article  CAS  Google Scholar 

  • Grasty, R. C., Grey, B. E., Lau, C. S., & Rogers, J. M. (2003). Prenatal window of susceptibility to perfluorooctane sulfonate-induced neonatal mortality in the Sprague–Dawley rat. Birth Defects Research. Part B, Developmental and Reproductive Toxicology, 68, 465–471.

    Article  CAS  Google Scholar 

  • Green, T., Lee, R., Farrar, D., & Hill, J. (2003). Assessing the health risks following environmental exposure to hexachlorobutadiene. Toxicology Letters, 138, 63–73.

    Article  CAS  Google Scholar 

  • Gregoraszczuk, E., Barc, J., & Falandysz, J. (2016). Differences in the action of lower and higher chlorinated polychlorinated naphthalene (PCN) congeners on estrogen dependent breast cancer cell line viability and apoptosis, and its correlation with Ahr and CYP1A1 expression. Toxicology, 366–367, 53–59.

    Article  Google Scholar 

  • Gregoraszczuk, E. L., Ptak, A., Karpeta, A., Fiedor, E., Wróbel, A., Milewics, T., & Falandysz, J. (2014). Hexachlorobenzene and pentachlorobenzene accumulation, metabolism and effect on steroid secretion and on CYP11A1 and CYP19 expression in cultured human placental tissue. Reproductive Toxicology, 43, 102–110.

    Article  CAS  Google Scholar 

  • Gregoraszczuk, E. L., Ptak, A., Rak-Mardyła, A., & Falandysz, J. (2011). Differential accumulation of HCBz and PeCBz in porcine ovarian follicles and their opposing actions on steroid secretion and CYP11, CYP17, 17β-HSD and CYP19 protein expression. A tissue culture approach. Reproductive Toxicology, 31, 494–499.

    Article  CAS  Google Scholar 

  • Guo, J.-Y., Wu, F.-C., Mai, B.-X., Luo, X.-J., & Zeng, E. Y. (2007). Polybrominated Diphenyl ethers in seafood products of South China. Journal of Agricultural and Food Chemistry, 55, 9152–9158.

    Article  CAS  Google Scholar 

  • Guo, Y., & Zhou, B. (2013). Thyroid endocrine system disruption by pentachlorophenol: An in vitro and in vivo assay. Aquatic Toxicology, 142–143, 138–145.

    Article  Google Scholar 

  • Haeba, M. H., Hilscherová, K., Mazurová, E., & Bláha, L. (2008). Selected endocrine disrupting compounds (Vinclozolin, Flutamide, Ketoconazole and Dicofol): Effects on survival, occurrence of males, growth, molting and reproduction of Daphnia magna. Environmental Science and Pollution Research, 15, 222.

    Article  CAS  Google Scholar 

  • Hall, R. C., & Hall, R. C. (1999). Long-term psychological and neurological complications of lindane poisoning. Psychosomatics, 40, 513–517.

    Article  CAS  Google Scholar 

  • Harrad, S. J., Abdallah, M. A.-E., Rose, N. L., Turner, S. D., & Davidson, T. A. (2009). Current-use brominated flame retardants in water, sediment, and fish from English Lakes. Environmental Science & Technology, 43, 9077–9083.

    Article  CAS  Google Scholar 

  • Harrison, R. M., & Harrad, S. (2001). The environmental behaviour of persistent organic pollutants. In R. M. Harrison (Ed.), Pollution: Causes, effects and control (4th ed., pp. 445–473). Cambridge, UK: RSC Publishing.

    Google Scholar 

  • Hebert, G. N., Odom, M. A., Craig, P. S., Dick, D. L., & Strauss, S. H. (2002). Method for the determination of sub-ppm concentrations of perfluoroalkylsulfonate anions in water. Journal of Environmental Monitoring, 4, 90–95.

    Article  CAS  Google Scholar 

  • Hoffman, K., Webster, T. F., Weisskopf, M. G., Weinberg, J., & Vieira, V. M. (2010). Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12–15 years of age. Environmental Health Perspectives, 118, 1762–1767.

    Article  CAS  Google Scholar 

  • Hu, W., Jones, P. D., Upham, B. L., Trosko, J. E., Lau, C., & Giesy, J. P. (2002). Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo. Toxicological Sciences, 68, 429–436.

    Article  CAS  Google Scholar 

  • Jacquet, N., Maire, M. A., Rast, C., Bonnard, M., & Vasseru, P. (2012). Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells. Environmental Science and Pollution Research, 19, 2537–2549.

    Article  CAS  Google Scholar 

  • Jadaramkunti, U. C., & Kaliwal, B. B. (2002). Dicofol formulation induced toxicity on testes and accessory reproductive organs in albino rats. Bulletin of Environmental Contamination and Toxicology, 69, 0741–0748.

    Article  CAS  Google Scholar 

  • Jin, J., Wang, S., Hu, J., Wu, J., Li, M., Wang, Y., & Jin, J. (2019). Polychlorinated naphthalenes in human serum samples from an industrial city in Eastern China: Levels, sources, and sex differences. Ecotoxicology and Environmental Safety, 177, 86–92.

    Article  CAS  Google Scholar 

  • Jo, H., Son, M.-H., Seo, S.-H., & Chang, Y.-S. (2017). Matrix-specific distribution and diastereomeric profiles of hexabromocyclododecane (HBCD) in a multimedia environment: Air, soil, sludge, sediment, and fish. Environmental Pollution, 226, 515–522.

    Article  CAS  Google Scholar 

  • Joensen, U. N., Bossi, R., Leffers, H., Jensen, A. A., Skakkebæk, N. E., & Jørgensen, N. (2009). Do perfluoroalkyl compounds impair human semen quality? Environmental Health Perspectives, 117, 923–927.

    Article  CAS  Google Scholar 

  • Jorens, P. G., & Schepens, P. J. C. (1993). Human pentachlorophenol poisoning. Human & Experimental Toxicology, 12, 479–495.

    Article  CAS  Google Scholar 

  • Kadhel, P., Monfort, C., Costet, N., Rouget, F., Thomé, J. P., Multigner, L., & Cordier, S. (2014). Chlordecone exposure, length of gestation, and risk of preterm birth. American Journal of Epidemiology, 179, 536–544.

    Article  Google Scholar 

  • Kamata, R., Shiraishi, F., Nakajima, D., Takahashi, S., & Shimizu, A. (2010). Evaluation of the impact of in-ovo exposure to dicofol on avian reproduction. Environmental Toxicology and Chemistry, 29, 2316–2322.

    Article  CAS  Google Scholar 

  • Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seecat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004). The toxicology of perfluorooctanoate. Critical Reviews in Toxicology, 34, 351–384.

    Article  CAS  Google Scholar 

  • Kilanowicz, A., Sitarek, K., Skrzypinska-Gawrysiak, M., & Sapota, A. (2011). Prenatal developmental toxicity of polychlorinated naphthalenes (PCNs) in the rat. Ecotoxicology and Environmental Safety, 74, 504–512.

    Article  CAS  Google Scholar 

  • Kilanowicz, A., & Skrzypinska-Gawrysiak, N. (2010). Toxicity of hexachloronaphthalene (HxCN) and induction of CYP 1A in rats. Ecotoxicology and Environmental Safety, 73, 196–205.

    Article  CAS  Google Scholar 

  • Koren, G., Carnevale, A., Ling, J., Ozsarfati, J., Kapur, B., & Bagli, D. (2019). Fetal exposure to polybrominated diphenyl ethers and the risk of hypospadias: Focus on the congeners involved. Journal of Pediatric Urology, 15, 405.e1–405.e6.

    Article  CAS  Google Scholar 

  • Kumari, B., & Duhan, A. (2011). Persistence of dicofol residues in cotton lint seed, and soil. Environmental Monitoring and Assessment, 182, 129–132.

    Article  CAS  Google Scholar 

  • Laessig, S. A., Auger, A. P., McCarthy, M. M., & Silbergeld, E. K. (2007). Effects of prenatal chlordecone on sexually differentiated behavior in adult rats. Neurotoxicology and Teratology, 29, 255–263.

    Article  CAS  Google Scholar 

  • Lafuente, A., Cabeleiro, T., Caride, A., Gutiérrez, A., & Esquifino, A. I. (2007). Toxic effects of methoxychlor in rat striatum: Modifications in several neurotransmitters. Journal of Physiology and Biochemistry, 63, 171–177.

    Article  CAS  Google Scholar 

  • Lallas, P. L. (2001). The Stockholm convention of persistent organic pollutants. American Journal of International Law, 95, 692–708.

    Article  Google Scholar 

  • Landrum, P. F., Steevens, J. A., Gossiaux, D. C., McElroy, M., Robinson, S., Begnoche, L., Chernyak, S., & Hickey, J. (2004). Time-dependent lethal body residues for the toxicity of pentachlorobenzene to Hyalella azteca. Environmental Toxicology and Chemistry, 23, 1335–1343.

    Article  CAS  Google Scholar 

  • Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007). Perfluoroalkyl acids: A review of monitoring and toxicological findings. Toxicological Sciences, 99, 366–394.

    Article  CAS  Google Scholar 

  • Lau, C., Butenhoff, J. L., & Rogers, J. M. (2004). The developmental toxicity of perfluoroalkyl acids and their derivatives. Toxicology and Applied Pharmacology, 198, 231–241.

    Article  CAS  Google Scholar 

  • Law, R. J., Kohler, M., Heeb, N. V., Gerecke, A. C., Schmid, P., Voorspoels, S., Covaci, A., Becher, G., Janák, K., & Thomsen, C. (2005). Hexabromocyclododecane challenges scientists and regulators. Environmental Science & Technology, 39, 281A–287A.

    Article  CAS  Google Scholar 

  • Lee, I., & Viberg, H. (2013). A single neonatal exposure to perfluorohexane sulfonate (PFHxS) affects the levels of important neuroproteins in the developing mouse brain. Neurotoxicology, 37, 190–196.

    Article  CAS  Google Scholar 

  • Lee, S., Choo, G., Ekpe, O. D., Kin, J., & Oh, J.-E. (2020). Short-chain chlorinated paraffins in various foods from Republic of Korea: Levels, congener patterns, and human dietary exposure. Environmental Pollution, 263, 114520.

    Article  CAS  Google Scholar 

  • Lee, Y. J., Choi, S. Y., & Yang, J. H. (2014). NMDA receptor-mediated ERK 1/2 pathway is involved in PFHxS-induced apoptosis of PC12 cells. Science of the Total Environment, 491–492, 227–234.

    Article  Google Scholar 

  • Lehmler, H.-J. (2005). Synthesis of environmentally relevant fluorinated surfactants—A review. Chemosphere, 58, 1471–1496.

    Article  CAS  Google Scholar 

  • Li, H., Fu, J., Zhang, A., Zhang, Q., & Wang, Y. (2016). Occurrence, bioaccumulation and long-range transport of short-chain chlorinated paraffins on the Fildes Peninsula at King George Island, Antarctica. Environment International, 94, 408–414.

    Article  CAS  Google Scholar 

  • Li, J., Ma, W., Zhao, Y., Jin, Y., Xiao, X., Ge, W., Shi, H., & Zhang, Y. (2020). Lactational exposure of polybrominated diphenyl ethers and its association with infant developmental measurements. Journal of Hazardous Materials, 388, 122031.

    Article  CAS  Google Scholar 

  • Li, L., Liu, J., & Hu, J. (2015). Global inventory, long-range transport and environmental distribution of Dicofol. Environmental Science & Technology, 49, 212–222.

    Article  CAS  Google Scholar 

  • Li, T., Wan, Y., Gao, S., Wang, B., & Hu, J. (2017). High-throughput determination and characterization of short-, medium-, and long-chain chlorinated Paraffins in human blood. Environmental Science & Technology, 51, 3346–3354.

    Article  CAS  Google Scholar 

  • Lindstrom, A. B., Strynar, M. J., & Libelo, E. L. (2011). Polyfluorinated compounds: Past, present, and future. Environmental Science & Technology, 45, 7954–7961.

    Article  CAS  Google Scholar 

  • Loomis, D., Guyton, K., Grosse, Y., El Ghissasi, F., Bouvard, V., Benbrahim-Tallaa, L., Guha, N., Mattock, H., & Straif, K. (2015). Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid. The Lancet Oncology, 16, 891–892.

    Article  CAS  Google Scholar 

  • Luebker, D. J., Hansen, K. J., Bass, N. M., Butenhoff, J. L., & Seacat, A. M. (2002). Interactions of fluorochemicals with rat liver fatty acid-binding protein. Toxicology, 176, 175–185.

    Article  CAS  Google Scholar 

  • Luellen, D. R., Vadas, G. C., & Unger, M. A. (2006). Kepone in James River fish: 1976–2002. Science of the Total Environment, 358, 286–297.

    Article  CAS  Google Scholar 

  • Ma, X., Zhang, H., Wang, Z., Yao, Z., Chen, J., Chen, J., & Chen, J. (2014). Bioaccumulation and trophic transfer of short chain chlorinated Paraffins in a marine food web from Liaodong Bay, North China. Environmental Science & Technology, 48, 5964–5971.

    Article  CAS  Google Scholar 

  • Mallinckrodt, M. G.-V., & Machbert, G. (1997). Pesticides. In H. Brandenberger & R. A. A. Maes (Eds.), Analytical toxicology: For clinical, forensic, and pharmaceutical chemists (Clinical biochemistry) (Vol. 5, pp. 215–264). Berlin, Germany: De Gruyter Publishing.

    Chapter  Google Scholar 

  • Marshall, K. A., & Pottenger, L. H. (2016). Chlorocarbons and chlorohydrocarbons. In Kirk-Othmer (Ed.), Encyclopedia of chemical technology. Wiley.

    Google Scholar 

  • Marvin, C. H., Tomy, G. T., Armitage, J. M., Arnot, J. A., McCarty, L., Covaci, A., & Palace, V. (2011). Hexabromocyclododecane: Current understanding of chemistry, environmental fate and toxicology and implications for global management. Environmental Science & Technology, 45, 8613–8623.

    Article  CAS  Google Scholar 

  • McCarthy, J. S., Kemp, D. J., Walton, S. F., & Currie, B. J. (2004). Scabies: More than just an irritation. Postgraduate Medical Journal, 80, 382–387.

    Article  CAS  Google Scholar 

  • Melzer, D., Rice, N., Depledge, M. H., Henley, W. E., & Galloway, T. S. (2010). Association between serum perfluoroctanoic acid (PFOA) and thyroid disease in the NHANES study. Environmental Health Perspectives, 118, 686–692.

    Article  CAS  Google Scholar 

  • Menezes, R. G., Qadir, T. F., Moin, A., Fatima, H., Hussain, S. A., Madadin, M., Pasha, S. B., Rubaish, F. A. A., & Senthilkumaran, S. (2017). Endosulfan poisoning: An overview. Journal of Forensic and Legal Medicine, 51, 27–33.

    Article  Google Scholar 

  • Miller, K. P., Gupta, R. K., & Flaws, J. A. (2006). Methoxychlor metabolites may cause ovarian toxicity through Estrogen-regulated pathways. Toxicological Sciences, 93, 180–188.

    Article  CAS  Google Scholar 

  • Möller, A., Xie, Z., Cai, M., Zhong, G., Huang, P., Cai, M., Sturm, R., He, J., & Ebinghaus, R. (2011). Polybrominated diphenyl ethers vs alternate brominated flame retardants and Dechloranes from East Asia to the Arctic. Environmental Science & Technology, 45, 6793–6799.

    Article  Google Scholar 

  • Mondal, D., Weldon, R. H., Armstrong, B. G., Gibson, L. J., Lopez-Espinosa, M. J., Shin, H. M., & Fletcher, T. (2014). Breastfeeding: A potential excretion route for mothers and implications for infant exposure to perfluoroalkyl acids. Environmental Health Perspectives, 122, 187–192.

    Article  Google Scholar 

  • Monroy, R., Morrison, K., Teo, K., Atkinson, S., Kubwabo, C., Stewart, B., & Foster, W. G. (2008). Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples. Environmental Research, 108, 56–62.

    Article  CAS  Google Scholar 

  • Moreau, M., & Nong, A. (2019). Evaluating hexabromocyclododecane (HBCD) toxicokinetics in humans and rodents by physiologically based pharmacokinetic modeling. Food and Chemical Toxicology, 133, 110785.

    Article  CAS  Google Scholar 

  • Multigner, L., Kadhel, P., Rouget, F., Blanchet, P., & Cordier, S. (2016). Chlordecone exposure and adverse effects in French West Indies populations. Environmental Science and Pollution Research International, 23, 3–8.

    Article  CAS  Google Scholar 

  • Multigner, L., Ndong, J. R., Giusti, A., Romana, M., Delacroix-Maillard, H., Cordier, S., Jégou, B., Thome, J. P., & Blanchet, P. (2010). Chlordecone exposure and risk of prostate cancer. Journal of Clinical Oncology, 28, 3457–3462.

    Article  CAS  Google Scholar 

  • Nelson, J. W., Hatch, E. E., & Webster, T. F. (2009). Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population. Environmental Health Perspectives, 118, 197–202.

    Article  Google Scholar 

  • Niu, L., Xu, C., Uao, Y., Liu, K., Yang, F., Tang, M., & Liu, W. (2013). Status, influences and risk assessment of hexachlorocyclohexanes in agricultural soils across China. Environmental Science & Technology, 47, 12140–12147.

    Article  CAS  Google Scholar 

  • Nolan, K., Kamrath, J., & Levitt, J. (2012). Lindane toxicity: A comprehensive review of the medical literature. Pediatric Dermatology, 29, 141–146.

    Article  Google Scholar 

  • Olsen, G. W., Burris, J. M., Burlew, M. M., & Mandel, J. H. (2003). Epidemiologic assessment of worker serum perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations and medical surveillance examinations. Journal of Occupational and Environmental Medicine, 45, 260–270.

    Article  CAS  Google Scholar 

  • Om, U., Erikson, L., Jacobsson, E., & Bergman, A. (1996). Synthesis and characterisation of polybrominated diphenyl ethers: Unlabelled and radiolabelled tetra-, penta- and hexabrominated diphenyl ethers. Acta Chemica Scandinavica, 50, 802–807.

    Article  Google Scholar 

  • Paul, A. G., Jones, K. C., & Sweetman, A. J. (2009). A first global production, emission, and environmental inventory for perfluorooctane sulfonate. Environmental Science & Technology, 43, 386–392.

    Article  CAS  Google Scholar 

  • Pavlostathis, S. G., & Prytula, M. T. (2000). Kinetics of the sequential microbial reductive dechlorination of hexachlorobenzene. Environmental Science & Technology, 34, 4001–4009.

    Article  CAS  Google Scholar 

  • Peshdary, V., Calzadilla, G., Landry, A., Sorisky, A., & Atlas, E. (2019). Dechlorane Plus increases adipogenesis in 3T3-L1 and human primary preadipocytes independent of peroxisome proliferatoractivated receptor γ transcriptional activity. International Journal of Obesity, 43, 545–555.

    Article  CAS  Google Scholar 

  • Pierozan, P., Jerneren, F., & Karlsson, O. (2018). Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells. Archives of Toxicology, 92, 1729–1739.

    Article  CAS  Google Scholar 

  • Porta, M., & Zumeta, E. (2002). Implementing the Stockholm treaty on persistent organic pollutants. Occupational and Environmental Medicine, 59, 651–652.

    Article  CAS  Google Scholar 

  • Power, M. C., Webster, T. F., Baccarelli, A. A., & Weisskopf, M. G. (2013). Cross-sectional association between polyfluoroalkyl chemicals and cognitive limitation in the National Health and Nutrition Examination Survey. Neuroepidemiology, 40, 125–132.

    Article  Google Scholar 

  • Prevedouros, K., Cousins, I. T., Buck, R. C., & Korzeniowski, S. H. (2006). Sources, fate and transport of perfluorocarboxylates. Environmental Science & Technology, 40, 32–44.

    Article  CAS  Google Scholar 

  • Qiao, L., Gao, L., Zheng, M., Xia, D., Li, J., Zhang, L., Wu, Y., Wang, R., Cui, L., & Xu, C. (2018). Mass fractions, congener group patterns, and placental transfer of short- and medium-chain chlorinated paraffins in paired maternal and cord serum. Environmental Science & Technology, 52, 10097–10103.

    Article  CAS  Google Scholar 

  • Qui, X., Zhu, T., Yao, B., Hu, J., & Hu, S. (2005). Contribution of dicofol to the current DDT pollution in China. Environmental Science & Technology, 39, 4385–4390.

    Article  Google Scholar 

  • Rahman, F., Langford, K. H., Scrimshaw, M. D., & Lester, J. N. (2001). Polybrominated diphenyl ether (PBDE) flame retardants. Science of the Total Environment, 275, 1–17.

    Article  CAS  Google Scholar 

  • Ren, X., Zhang, H., Geng, N., Xing, L., Zhao, Y., Wang, F., & Chen, J. (2018). Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure. Science of the Total Environment, 622–623, 214–221.

    Article  Google Scholar 

  • Reuber, M. D. (1980). Carcinogenicity and toxicity of methoxychlor. Environmental Health Perspectives, 35, 205–219.

    Article  Google Scholar 

  • Rosenberg, C., Hämeilä, M., Tornaeus, J., Säkkinen, K., Puttonen, K., Korpi, A., Linnainmaa, M., & Hesso, A. (2011). Exposure to flame retardants in electronics recycling sites. The Annals of Occupational Hygiene, 55, 658–665.

    CAS  Google Scholar 

  • Rossberg, M., Lendle, W., Pfleiderer, G., Tögel, A., Dreher, E.-L., Langer, E., Rassaerts, H., Kleinschmidt, P., Strack, H., Cook, R., Beck, U., Lipper, K.-A., Torkelson, T. R., Löser, E., Beutel, K. K., & Mann, T. (2006). Chlorinated hydrocarbons. In Ullmann's encyclopedia of industrial chemistry. Weinheim: Wiley-VCH.

    Google Scholar 

  • Sadeghnia, H. R., Yousefsani, B. S., Rashidfar, M., Boroushaki, M. T., Asadpour, E., & Ghorbani, A. (2013). Protective effect of rutin on hexachlorobutadiene-induced nephrotoxicity. Renal Failure, 35, 1151–1155.

    Article  CAS  Google Scholar 

  • Safe, S., Kohli, J., & Crawford, A. (1978). FireMaster BP-6: Fractionation, metabolic and enzyme induction studies. Environmental Health Perspectives, 23, 147–152.

    Article  CAS  Google Scholar 

  • Saiyed, H., Dewan, A., Bhatnagar, V., Shenoy, U., Shenoy, R., Rajmohan, H., Patel, K., Kashyap, R., Kulkarni, P., Rajan, B., & Lakkad, B. (2003). Effect of endosulfan on male reproductive development. Environmental Health Perspectives, 111, 1958–1962.

    Article  CAS  Google Scholar 

  • Savu, P. M. (2000). Fluorinated higher carboxylic acids. In Kirk-Othmer (Ed.), Encyclopedia of chemical technology. Wiley.

    Google Scholar 

  • Schecter, A., Johnson-Welch, S., Tung, K. C., Harris, T. R., Päpke, O., & Rosen, R. (2006). Polybrominated Diphenyl Ether (PBDE) levels in livers of U.S. human fetuses and newborns. Journal of Toxicology and Environmental Health. Part A, 70, 1–6.

    Article  Google Scholar 

  • Schmidt, W. F., Bilboulian, S., Rice, C. P., Fettinger, J. C., McConnell, L. L., & Hapeman, C. J. (2001). Thermodynamic, spectroscopic, and computational evidence for the irreversible conversion of β- to α-endosulfan. Journal of Agricultural and Food Chemistry, 49, 5372–5376.

    Article  CAS  Google Scholar 

  • Schmidt, W. F., Hapeman, C. J., Fettinger, J. C., Rice, C. P., & Bilboulian, S. (1997). Structure and asymmetry in the isomeric conversion of β- to α-endosulfan. Journal of Agricultural and Food Chemistry, 45, 1023–1102.

    Article  CAS  Google Scholar 

  • Schwarzbach, S. E. (1991). The role of dicofol metabolites in the eggshell thinning response of Ring Neck Doves. Archives of Environmental Contamination and Toxicology, 20, 200–205.

    Article  CAS  Google Scholar 

  • Sebastian, R., & Raghavan, S. C. (2016). Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan. Carcinogenesis, 37, 929–940.

    Article  CAS  Google Scholar 

  • Shane, H. L., Baur, R., Lukomska, E., Weatherly, L., & Anderson, S. E. (2020). Immunotoxicity and allergenic potential induced by topical application of perfluorooctanoic acid (PFOA) in a murine model. Food and Chemical Toxicology, 136, 111114.

    Article  CAS  Google Scholar 

  • Shi, X., Zha, J., Wen, B., & Zhang, S. (2019). Diastereoisomer-specific neurotoxicity of hexabromocyclododecane in human SH-SY5Y neuroblastoma cells. Science of the Total Environment, 686, 893–902.

    Article  CAS  Google Scholar 

  • Shipley, J. M., Hurst, C. H., Tanaka, S. S., DeRoos, F. L., Butenhoff, J. L., Seacat, A. M., & Waxman, D. J. (2004). Trans-activation of PPARa and induction of PPARa target genes by perfluorooctane-based chemicals. Toxicological Sciences, 80, 151–160.

    Article  CAS  Google Scholar 

  • Silva, M. H., & Gammon, D. (2009). An assessment of the developmental, reproductive, and neurotoxicity of endosulfan. Birth Defects Research. Part B, Developmental and Reproductive Toxicology, 86, 1–28.

    Article  CAS  Google Scholar 

  • Singh, N. D., Sharma, A. K., Dwivedi, P., Patil, R. D., & Kumar, M. (2007). Citrinin and endosulfan induced teratogenic effects in Wistar rats. Journal of Applied Toxicology, 27, 143–151.

    Article  CAS  Google Scholar 

  • Soto, A. M., Chung, K. L., & Sonnenschein, C. (1994). The pesticides endosulfan, toxaphene and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environmental Health Perspectives, 102, 380–383.

    Article  CAS  Google Scholar 

  • Starkov, A. A., & Wallace, K. B. (2002). Structural determinants of fluorochemical-induced mitochondrial dysfunction. Toxicological Sciences, 66, 244–252.

    Article  CAS  Google Scholar 

  • Steenland, K., Fletcher, T., & Savitz, D. A. (2010). Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA). Environmental Health Perspectives, 118, 1100–1108.

    Article  CAS  Google Scholar 

  • Stein, C. R., Savitz, D. A., Elston, B., Thorpe, P. G., & Cilboa, S. M. (2014). Perfluorooctanoate exposure and major birth defects. Reproductive Toxicology, 47, 15–20.

    Article  CAS  Google Scholar 

  • Su, Y., Hung, H., Blanchard, P., Patton, G. W., Kallenborn, R., Konoplev, A., Fellin, P., Li, H., Geen, C., Stern, G., Rosenberg, B., & Barrie, L. A. (2006). Spatial and seasonal variations of hexachlorocyclohexanes (HCHs) and hexachlorobenzene (HCB) in the arctic atmosphere. Environmental Science & Technology, 40, 6601–6607.

    Article  CAS  Google Scholar 

  • Sujatha, R., Chitra, K. C., Latchoumycandane, C., & Mathur, P. P. (2001). Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats. Asian Journal of Andrology, 3, 135–138.

    CAS  Google Scholar 

  • Sun, W., Jia, Y., Ding, X., Dai, L., Liu, C., Wang, J., Zhao, G., Zhou, H., & Yu, L. (2019). Combined effects of pentachlorophenol and its byproduct hexachlorobenzene on endocrine and reproduction in zebrafish. Chemosphere, 220, 216–226.

    Article  CAS  Google Scholar 

  • Szabo, D. T., Diliberto, J. J., Hakk, H., Huwe, J. K., & Birnbaum, L. S. (2010). Toxicokinetics of the flame retardant hexabromocyclododecane gamma: Effect of dose, timing, route, repeated exposure, and metabolism. Toxicological Sciences, 117, 282–293.

    Article  CAS  Google Scholar 

  • Tang, H. P.-O. (2013). Recent development in analysis of persistent organic pollutants under the Stockholm Convention. TrAC Trends in Analytical Chemistry, 45, 48–66.

    Article  CAS  Google Scholar 

  • Thomas, D. R., McCarroll, L., Roberts, R., Karunaratne, P., Roberts, C., Casey, D., Morgan, S., Touhig, K., Morgan, J., Collins, F., & Hemingway, J. (2006). Surveillance of insecticide resistance in head lice using biochemical and molecular methods. Archives of Disease in Childhood, 91, 777–778.

    Article  Google Scholar 

  • Toms, L.-M. L., Hearn, L., Kennady, K., Harden, F., Bartkow, M., Temme, C., & Mueller, J. F. (2009). Concentrations of polybrominated diphenyl ethers (PBDEs) in matched samples of human milk, dust and indoor air. Environment International, 35, 864–869.

    Article  CAS  Google Scholar 

  • Tomy, G. T., Fisk, A. T., Westmore, J. B., & Muir, D. C. G. (1998). Environmental chemistry and toxicology of polychlorinated n-alkanes. In G. W. Ware (Ed.), Reviews of environmental contamination and toxicology (pp. 53–128). New York: Springer.

    Chapter  Google Scholar 

  • Tseng, L.-H., Lee, C.-W., Pan, M.-H., Tsan, S.-S., Li, M.-H., Chen, J.-R., Lay, J.-J., & Hsu, P.-C. (2006). Postnatal exposure of the male mouse to 2,2′,3,3′,4,4′,5,5′,6,6′-decabrominated diphenyl ether: Decreased epididymal sperm functions without alterations in DNA content and histology in testis. Toxicology, 224, 33–43.

    Article  CAS  Google Scholar 

  • Tseng, L.-H., Li, M.-H., Tsai, S.-S., Lee, C.-W., Pan, M.-H., Yao, W.-J., & Hsu, P.-C. (2008). Developmental exposure to decabromodiphenyl ether (PBDE 209): Effects on thyroid hormone and hepatic enzyme activity in male mouse offspring. Chemosphere, 70, 640–647.

    Article  CAS  Google Scholar 

  • Tumburu, L., Shepard, E. F., Strand, A. E., & Browdy, C. L. (2011). Effects of endosulfan exposure and Taura Syndrome Virus infection on the survival and molting of the marine penaeid shrimp, Litopenaeus vannamei. Chemosphere, 86, 912–918.

    Article  Google Scholar 

  • van Dyke, T. G. (1963). The chemistry of fluorocarbon sulfonic acids. I. Preparation of anhydrides and sulfonyl halides. The Journal of Organic Chemistry, 28, 1244–1246.

    Article  Google Scholar 

  • Varayoud, J., Monje, L., Bernhardt, T., Muñoz-de-Toro, M., Luque, E. H., & Ramos, J. G. (2008). Endosulfan modulates estrogen-dependent genes like a non-uterotrophic dose of 17β-estradiol. Reproductive Toxicology, 26, 138–145.

    Article  CAS  Google Scholar 

  • Vilberg, H., Fredriksson, A., & Eriksson, P. (2007). Changes in spontaneous behaviour and altered response to nicotine in the adult rat, after neonatal exposure to the brominated flame retardant, decabrominated diphenyl ether (PBDE 209). Neurotoxicology, 28, 136–142.

    Article  Google Scholar 

  • Villeneuve, D. L., Khim, J. S., Kannan, K., Falandysz, J., Blankenship, A. L., Nikiforov, V., & Giesy, J. P. (2000). Relative potencies of individual polychlorinated naphthalenes to induce dioxin-like response in fish and mammalian in vitro bioassays. Archives of Environmental Contamination and Toxicology, 39, 273–281.

    Article  CAS  Google Scholar 

  • Wang, X., Zhu, J., Xue, Z., Jin, X., Jin, Y., & Fu, Z. (2019). The environmental distribution and toxicity of short-chain chlorinated paraffins and underlying mechanisms: Implications for further toxicological investigation. Science of the Total Environment, 695, 133834.

    Article  CAS  Google Scholar 

  • Washino, N., Saijo, Y., Sasaki, S., Kato, S., Ban, S., Konishi, K., Ito, R., Nakata, A., Iwasaki, Y., Saito, K., Nakazawa, H., & Kishi, R. (2009). Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth. Environmental Health Perspectives, 117, 660–667.

    Article  CAS  Google Scholar 

  • Webster, G. M., Venners, S. A., Mattman, A., & Martin, J. W. (2014). Associations between perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: A population-based cohort study. Environmental Research, 133, 338–347.

    Article  CAS  Google Scholar 

  • Willett, K. L., Ulrich, E. M., & Hites, R. A. (1998). Differential toxicity and environmental fates of hexachlorocyclohexane isomers. Environmental Science Toxicology, 32, 2197–2207.

    CAS  Google Scholar 

  • Wilson, V. S., & LeBlanc, G. A. (1998). Endosulfan elevates testosterone biotransformation and clearance in CD-1 mice. Toxicology and Applied Pharmacology, 148, 158–168.

    Article  CAS  Google Scholar 

  • Xian, Q., Siddhique, S., Li, T., Y-l, F., Takser, L., & Zhu, J. (2011). Sources and environmental behavior of dechlorane plus — A review. Environment International, 37, 1273–1284.

    Article  CAS  Google Scholar 

  • Xu, C., Gao, L., Zheng, M., Qiao, L., Cui, L., Wang, K., & Huang, D. (2019). Short- and medium-chain chlorinated paraffins in commercial rubber track products and raw materials. Journal of Hazardous Materials, 380, 120854.

    Article  CAS  Google Scholar 

  • Xu, X.-P., Xi, Y.-L., & Wang, X.-M. (2020). Effects of DDT and dicofol on life table demography of the freshwater rotifer Brachionus calyciflorus Pallas. Polish Journal of Environmental Studies, 29, 1945–1951.

    Article  CAS  Google Scholar 

  • Yu, L.-Q., Zhao, G.-F., Feng, M., Wen, W., Li, K., Zhang, P.-W., Peng, X., Huo, W.-J., & Zhou, H.-D. (2013). Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish. Environmental Toxicology and Chemistry, 33, 170–176.

    Article  Google Scholar 

  • Yu, Y., Tao, S., Liu, W., Lu, X., Wang, X., & Wong, M. (2009). Dietary intake and human milk residues of hexachlorocyclohexane isomers in two Chinese cities. Environmental Science & Technology, 43, 4830–4835.

    Article  CAS  Google Scholar 

  • Zhan, M., Wang, H., Hao, R., & Li, Y. (2019). A review of sample preparation and analysis methods for the hexabromocyclododecanes (HBCDS) in the environment. Journal of Environmental & Analytical Toxicology, 9, 594.

    Google Scholar 

  • Zhang, H., Shen, Y., Liu, W., He, Z., Fu, J., Cai, Z., & Jiang, G. (2019). A review of sources, environmental occurrences and human exposure risks of hexachlorobutadiene and its association with some other chlorinated organics. Environmental Pollution, 253, 831–840.

    Article  CAS  Google Scholar 

  • Zhang, L., Dolbier, W. R., Sheeller, B., & Ingold, K. U. (2002). Absolute rate constants of alkene addition reactions of a fluorinated radical in water. Journal of the American Chemical Society, 124, 6362–6366.

    Article  CAS  Google Scholar 

  • Zhang, Q., Wang, J., Zhu, J., Liu, J., Zhang, J., & Zhao, M. (2016). Assessment of the endocrine-disrupting effects of short-chain chlorinated paraffins in in vitro models. Environment International, 94, 43–50.

    Article  CAS  Google Scholar 

  • Zhang, Q., Xia, Z., Wu, M., Wang, L., & Yang, H. (2017). Human health risk assessment of DDTs and HCHs through dietary exposure in Nanjing, China. Chemosphere, 117, 211–216.

    Article  Google Scholar 

  • Zheng, J., Wang, J., Luo, X.-J., Tian, M., He, L.-Y., Yuan, J.-G., Mai, B.-X., & Yang, Z.-Y. (2010). Dechlorane Plus in human hair from an e-waste recycling area in South China: Comparison with dust. Environmental Science & Technology, 44, 9298–9303.

    Article  CAS  Google Scholar 

  • Zheng, W., Yu, H., Wang, X., & Qu, W. (2012). Systematic review of pentachlorophenol occurrence in the environment and in humans in China: Not a negligible health risk due to the re-emergence of schistosomiasis. Environment International, 42, 105–116.

    Article  CAS  Google Scholar 

  • Zheng, X., Sun, Q., Wang, S., Li, X., Liu, P., Yan, Z., Kong, X., & Fan, J. (2020). Advances in studies on toxic effects of short-chain chlorinated paraffins (SCCPs) and characterization of environmental pollution in China. Archives of Environmental Contamination and Toxicology, 78, 501–512.

    Article  CAS  Google Scholar 

  • Zhong, Y., Shen, L., Ye, X., Zhou, D., He, Y., & Zhang, H. (2020). Mechanism of immunosuppression in zebrafish (Danio rerio) spleen induced by environmentally relevant concentrations of perfluorooctanoic acid. Chemosphere, 249, 126200.

    Article  CAS  Google Scholar 

  • Zhou, T., Taylor, M. M., DeVito, M. J., & Crofton, K. M. (2002). Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicological Sciences, 66, 105–116.

    Article  CAS  Google Scholar 

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Prabhu, R.N., Lakshmipraba, J. (2022). Persistent Organic Pollutants (Part II): The New POPs – Sources and Adverse Effects. In: Vasanthy, M., Sivasankar, V., Sunitha, T.G. (eds) Organic Pollutants. Emerging Contaminants and Associated Treatment Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-72441-2_2

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