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Pathophysiology and Clinical Evaluation of Chronic Pelvic Pain

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Female Genitourinary and Pelvic Floor Reconstruction

Abstract

Chronic pelvic pain is a prevalent problem among the female and male population worldwide. This disorder is commonly multifactorial and although diagnosis and management can prove difficult for even the most experienced clinician, it is often straightforward and satisfying to treat. In more complex cases, a multidisciplinary team is best equipped to manage, as pelvic pain can result from any pelvic organ or system. Initial signs and symptoms that will aid in the diagnosis of a specific etiology and treatment can be tailored to underlying diagnosis, if found. In cases with no established diagnosis, symptoms can still be managed effectively based on information from the workup. Psychological referral can be especially important in these cases, but must be introduced as a holistic component care, clearly validating that the pain is physiologic. Mind-based approaches can not only address the loss associated with chronic pain but known techniques can reduce pain severity and impact. This chapter presents etiologies for chronic pelvic pain in a pragmatic, useable manner, including the signs and symptoms pointing to each organ system and causes of systemic pain, as well as treatment strategies to help patients cope with this disorder when idiopathic.

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References

  1. American College of Obstetricians and Gynecologists. Chronic Pelvic Pain. 2011. Available at: https://www.acog.org/womens-health/faqs/chronic-pelvic-pain#:~:text=Chronic%20pelvic%20pain%20is%20pain,it%20may%20occur%20during%20menstruation. Last updated 2020. Accessed 6 June 2021.

  2. Ahangari A. Prevalence of chronic pelvic pain among women: an updated review. Pain Physician. 2014;17(2):E141–7. PMID: 24658485.

    Article  PubMed  Google Scholar 

  3. Mathias SD, Kuppermann M, Liberman RF, Lipschutz RC, Steege JF. Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol. 1996;87(3):321–7. https://doi.org/10.1016/0029-7844(95)00458-0. PMID: 8598948.

    Article  CAS  PubMed  Google Scholar 

  4. Smith CP. Male chronic pelvic pain: an update. Indian J Urol. 2016;32(1):34–9. https://doi.org/10.4103/0970-1591.173105.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Honorio B. Essentials of pain medicine. 4th ed. Elsevier; The Netherlands, Europe, 2018. p. 262.

    Google Scholar 

  6. Bryant C, Cockburn R, Plante A-F, Chia A. The psychological profile of women presenting to a multidisciplinary clinic for chronic pelvic pain: high levels of psychological dysfunction and implications for practice. J Pain Res. 2016;9:1049–56.

    Article  PubMed  PubMed Central  Google Scholar 

  7. EAU Guidelines. Edn. Presented at the EAU Annual Congress, Milan; 2021. ISBN 978-94-92671-13-4.

    Google Scholar 

  8. Meissner MH, Gloviczki P. Atlas of endovascular venous surgery (Second Edition) Chapter 21 – Pelvic venous disorders. 2019, p. 567–599. https://doi.org/10.1016/B978-0-323-51139-1.00021-8.

  9. Zondervan KT, Yudkin PL, Vessey MP. Chronic pelvic pain in the community – symptoms, investigations, and diagnoses. Am J Obstet Gynecol. 2001;184(6):1149–55.

    Article  CAS  PubMed  Google Scholar 

  10. Grace VM, Zondervan KR. Chronic pelvic pain in New Zealand: prevalence, pain severity, diagnoses and use of the health services. Aust NZ J Public Health. 2004;28(4):369–75.

    Article  Google Scholar 

  11. Chronic Pelvic Pain: ACOG practice bulletin, Number 218. Obstet Gynecol. 2020;135(3):e98–e109. https://doi.org/10.1097/AOG.0000000000003716. PMID: 32080051.

  12. Chen A, De E, Argoff C. Small fiber polyneuropathy is prevalent in patients experiencing complex chronic pelvic pain. Pain Med. 2018;20(3):521–7. https://doi.org/10.1093/pm/pny001. PMID 29447372.

    Article  Google Scholar 

  13. Albrecht PJ, Hou Q, Argoff CE, et al. Excessive peptidergic sensory innervation of cutaneous arteriole-venule shunts (AVS) in the palmar glabrous skin of fibromyalgia patients: implications for widespread deep tissue pain and fatigue. Pain Med. 2013;14(6):895–915.

    Article  PubMed  Google Scholar 

  14. Giannoccaro MP, Donadio V, Incensi A, Avoni P, Liguori R. Small nerve fiber involvement in patients referred for fibromyalgia. Muscle Nerve. 2014;49(5):757–9.

    Article  PubMed  Google Scholar 

  15. Caro XJ, Winter EF. The role and importance of small fiber neuropathy in fibromyalgia pain. Curr Pain Headache Rep. 2015;19(12):55.

    Article  PubMed  Google Scholar 

  16. De E, Stern TA. Facing pelvic pain: a guide for patients and their family members. Due for publication September 2020; Massachusetts General Hospital Psychiatry Academy (via Amazon).

    Google Scholar 

  17. International Pelvic Pain Society. Pelvic Pain Assessment Form. Documents and forms: history and physical. 2008. Available at: https://www.pelvicpain.org/IPPS/Professional/Documents-Forms/IPPS/Content/Professional/Documents_and_Forms.aspx. Retrieved 23 September 2019. (Level III).

  18. Clemens JQ, Calhoun EA, Litwin MS, et al. Validation of a modified National Institutes of Health chronic prostatitis symptom index to assess genitourinary pain in both men and women. Urology. 2009;74(5):983–987.e9873. https://doi.org/10.1016/j.urology.2009.06.078.

    Article  PubMed  Google Scholar 

  19. Brookes ST, Donovan JL, Wright M, Jackson S, Abrams P. A scored form of the Bristol Female Lower Urinary Tract Symptoms questionnaire: data from a randomized controlled trial of surgery for women with stress incontinence. Am J Obstet Gynecol. 2004;191:73–82.

    Article  PubMed  Google Scholar 

  20. Barry MJ, Fowler FJ Jr, O’Leary MP, Bruskewitz RC, Holtgrewe HL, Mebust WK, Cockett AT. The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J Urol. 1992;148(5):1549–57. https://doi.org/10.1016/s0022-5347(17)36966-5. discussion 1564. PMID: 1279218.

    Article  CAS  PubMed  Google Scholar 

  21. Barber MD, Walters MD, Bump RC. Short forms of two condition-specific quality-of-life questionnaires for women with pelvic floor disorders (PFDI-20 adn PFIQ-7). Am J Obstet Gynecol. 2005;193:103–13.

    Article  CAS  PubMed  Google Scholar 

  22. Bordeianou LG, Anger J, Boutros M, et al. Measuring pelvic floor disorder symptoms using patient-reported instruments: proceedings of the consensus meeting of the pelvic floor consortium of the American Society of Colon and Rectal Surgeons, the International Continence Society, the American Urogynecologic Society, and the Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction. Tech Coloproctol. 2020;24:5–22. https://doi.org/10.1007/s10151-019-02125-4.

    Article  CAS  PubMed  Google Scholar 

  23. Yosef A, Allaire C, Williams C, Ahmed AG, Al-Hussaini T, Abdellah MS, et al. Multifactorial contributors to the severity of chronic pelvic pain in women. Am J Obstet Gynecol. 2016;215(760):e1–14. (Level II-3)

    Google Scholar 

  24. Speer LM, Mushkbar S, Erbele T. Chronic pelvic pain in women. Am Fam Physician. 2016;93(5):380–7. PMID: 26926975.

    PubMed  Google Scholar 

  25. Hovaguimian A, Gibbons CH. Diagnosis and treatment of pain in small-fiber neuropathy. Curr Pain Headache Rep. 2011;15(3):193–200. https://doi.org/10.1007/s11916-011-0181-7.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Centers for Disease Control and Prevention. Infographic: 6 guiding principles to a trauma-informed approach. September 17, 2020. Available at: https://www.cdc.gov/cpr/infographics/6_principles_trauma_info.htm

  27. Carrubba AR, et al. How to perform the physical examination in the female chronic pelvic pain patient: the pre-exam evaluation. J Minimally Invasive Gynecol. 25(7):S161–2.

    Google Scholar 

  28. Johns Hopkins Medicine. Pelvic ultrasound. [Internet] 2021 [cited 7 July 2021]. Available from: https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/pelvic-ultrasound#:~:text=A%20pelvic%20ultrasound%20is%20a,vagina%2C%20fallopian%20tubes%20and%20ovaries.

  29. Rigor BM. Pelvic cancer pain. J Surg Oncol. 2000;75(4):280–300. https://doi.org/10.1002/1096-9098(200012)75:4<280::aid-jso13>3.0.co;2-q.

  30. ACOG Practice Bulletin July 2010 Farquhar, C. endometriosis: clinical review. BMJ. 2007;334:249–253.

    Google Scholar 

  31. Bishop LA. Management of chronic pelvic pain. Clin Obstet Gynecol. 2017;60(3):524–30. https://doi.org/10.1097/GRF.0000000000000299.

    Article  PubMed  Google Scholar 

  32. Kuhn A. Chronischer Beckenschmerz [Chronic pelvic pain]. Ther Umsch. 2019;73(9):573–5. https://doi.org/10.1024/0040-5930/a001039.

    Article  PubMed  Google Scholar 

  33. O’Brien MT, Gillespie DL. Diagnosis and treatment of the pelvic congestion syndrome. J Vasc Surg Venous Lymphatic Disord. 2015;3:96–106.

    Article  Google Scholar 

  34. Erben Y, Gloviczki P, Kalra M, et al. Treatment of nutcracker syndrome with open and endovascular interventions. J Vasc Surg Venous Lymphatic Disord. 2015;3:389–96.

    Article  Google Scholar 

  35. Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus definition and classification of prostatitis. JAMA. 1999;282:236.

    Article  CAS  PubMed  Google Scholar 

  36. Litwin MS, McNaughton-Collins M, Fowler FJ, et al. The National Institutes of Health chronic prostatitis symptom index: development and validation of a new outcome measure. J Urol. 1999;162:369.

    Article  CAS  PubMed  Google Scholar 

  37. Polackwich AS, Shoskes DA. Chronic prostatitis/chronic pelvic pain syndrome: a review of evaluation and therapy. Prostate Cancer Prostatic Dis. 2016;19(2):132–8. https://doi.org/10.1038/pcan.2016.8. Epub 2016 Mar 8. PMID: 26951713.

    Article  CAS  PubMed  Google Scholar 

  38. Moses S. Expressed prostatic secretion. Family Practice Notebook 2007. Available online at: https://fpnotebook.com/uro/Lab/ExprsdPrstcScrtn.htm

  39. Sigalos JT, Pastuszak AW. Chronic orchialgia: epidemiology, diagnosis and evaluation. Transl Androl Urol. 2017;6(Suppl 1):S37–43.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Parekattil SJ, Ergun O, Gudeloglu A. Management of chronic Orchialgia: challenges and solutions – the current standard of care. Res Rep Urol. 2020;12:199–210. https://doi.org/10.2147/RRU.S198785. PMID: 32754451; PMCID: PMC7351977.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Hanno P, Dmochowski R. Status of international consensus on interstitial cystitis/bladder pain syndrome/painful bladder syndrome: 2008 snapshot. Neurourol Urodyn. 2009;28:274.

    Article  PubMed  Google Scholar 

  42. Hanno PM, Erickson D, Moldwin R, Faraday MM. Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment. J Urol. 2015;193:1545–53. https://doi.org/10.1016/j.juro.2015.01.086. ® © 2015 by American Urological Association Education and Research, Inc.

    Article  PubMed  Google Scholar 

  43. Metts JF. Interstitial cystitis: urgency and frequency syndrome. Am Fam Physician. 2001;64(7):1199–206. PMID: 11601802.

    CAS  PubMed  Google Scholar 

  44. Young A, Toncar A, Wray AA. Urethritis. [Updated 2020 Dec 14]. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2021. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537282/

  45. Ulmer WD, Gilbert JL, De EJB. Urethritis in women – considerations beyond urinary tract infection. Curr Bladder Dysfunct Rep. 2014;9:181–7. https://doi.org/10.1007/s11884-014-0246-7.

    Article  Google Scholar 

  46. Bedaiwy MA, Patterson B, Mahajan S. Prevalence of myofascial chronic pelvic pain and the effectiveness of pelvic floor physical therapy. J Reprod Med. 2013;58(11–12):504–10.

    PubMed  Google Scholar 

  47. Rogalski MJ, Kellogg-Spadt S, Hoffmann AR, Fariello JY, Whitmore KE. Retrospective chart review of vaginal diazepam suppository use in high-tone pelvic floor dysfunction. Int Urogynecol J Pelvic Floor Dysfunct. 2010;21(7):895–9.

    Article  Google Scholar 

  48. Faubion SS, Shuster LT, Bharucha AE. Recognition and management of nonrelaxing pelvic floor dysfunction. Mayo Clin Proc. 2012;87(2):187–93. https://doi.org/10.1016/j.mayocp.2011.09.004.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Frawley H, Shelly B, Morin M, Bernard S, Bø K, Digesu GA, Dickinson T, Goonewardene S, McClurg D, Rahnama'i MS, Schizas A, Slieker-Ten Hove M, Takahashi S, Voelkl Guevara J. An International Continence Society (ICS) report on the terminology for pelvic floor muscle assessment. Neurourol Urodyn. 2021;40(5):1217–60. https://doi.org/10.1002/nau.24658. Epub 2021 Apr 12. PMID: 33844342.

    Article  PubMed  Google Scholar 

  50. Spettel S, Frawley HC, Blais DR, De EJB. Biofeedback treatment for overactive bladder. Curr Bladder Dysfunct Rep. 2012;7:7–13.

    Article  Google Scholar 

  51. Ford AC, Lacy BE, Talley NJ. Irritable Bowel syndrome. N Engl J Med. 2017;376(26):2566–78. https://doi.org/10.1056/nejmra1607547.

    Article  CAS  PubMed  Google Scholar 

  52. Schmulson MJ, Drossman DA. What is new in Rome IV. J Neurogastroenterol Motil. 2017;23(2):151–63. https://doi.org/10.5056/jnm16214.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Sairenji T, Collins KL, Evans DV. An update on inflammatory Bowel disease. Prim Care. 2017;44(4):673–92. https://doi.org/10.1016/j.pop.2017.07.010. Epub 2017 Oct 5. PMID: 29132528.

    Article  PubMed  Google Scholar 

  54. Simren M, Palsson OS, Whitehead WE. Update on Rome IV criteria for colorectal disorders: implications for clinical practice. Curr Gastroenterol Rep. 2017;19(4):15. https://doi.org/10.1007/s11894-017-0554-0. PMID: 28374308; PMCID: PMC5378729.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Durham JD, Machan L. Pelvic congestion syndrome. Semin Intervent Radiol. 2013;30(4):372–80. https://doi.org/10.1055/s-0033-1359731.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Meissner MH, Gibson K. Clinical outcome after treatment of pelvic congestion syndrome: sense and nonsense. Phlebology. 2015;30(1 Suppl):73–80.

    Article  CAS  PubMed  Google Scholar 

  57. Beard RW, Highman JH, Pearce S, Reginald PW. Diagnosis of pelvic pain varicosities in women with chronic pelvic pain. Lancet. 1984;2:946–69.

    Article  CAS  PubMed  Google Scholar 

  58. Gonzalez-Gay MA, Barros S, Lopez-Diaz MJ, Garcia-Porrua C, Sanchez-Andrade A. Giant cell arteritis: disease patterns of clinical presentation in a series of 240 patients. Llorca J Med (Baltimore). 2005;84(5):269–76.

    Article  Google Scholar 

  59. Labat JJ, Riant T, Robert R, Amarenco G, Lefaucheur JP, Rigaud J. Diagnostic criteria for pudendal neuralgia by pudendal nerve entrapment (Nantes criteria). Neurourol Urodyn. 2008;27(4):306–10. https://doi.org/10.1002/nau.20505.

    Article  PubMed  Google Scholar 

  60. Alexander CE, Varacallo M. Lumbosacral radiculopathy. [Updated 2021 May 4]. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2021. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430837/

  61. Modirian E, Pirouzi P, Soroush MR, Karbalaei-Esmaeili S, Shojaei H. Physical medicine and rehabilitation, HamidReza Zamani, General Surgeon, chronic pain after spinal cord injury: results of a long-term study. Pain Med. 2010;11(7):1037–43.

    Article  PubMed  Google Scholar 

  62. Li W, Xiong Z, Dong C, Song J, Zhang L, Zhou J, Wang Y, Yi P, Yang F, Tang X, Tan M. Distribution and imaging characteristics of spina bifida occulta in young people with low back pain: a retrospective cross-sectional study. J Orthop Surg Res. 2021;16(1):151. https://doi.org/10.1186/s13018-021-02285-w. PMID: 33618758; PMCID: PMC7898417.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Menezes AH, Seaman SC, Iii MAH, Hitchon PW, Takacs EB. Tethered spinal cord syndrome in adults in the MRI era: recognition, pathology, and long-term objective outcomes. J Neurosurg Spine. 2021:1–13. https://doi.org/10.3171/2020.9.SPINE201453. Epub ahead of print. PMID: 33740756.

  64. Kumar B, Kalita J, Kumar G, Misra UK. Central poststroke pain: a review of pathophysiology and treatment. Anesth Analg. 2009;108:1645–57.

    Article  PubMed  Google Scholar 

  65. Bermejo PE, Oreja-Guevara C, Diez-Tejedor E. Pain in multiple sclerosis: prevalence, mechanisms, types and treatment. Rev Neurol. 2010;50:101–8.

    PubMed  Google Scholar 

  66. Fukunishi S, Fukui T, Nishio S, Imamura F, Yoshiya S. Multiple pelvic insufficiency fractures in rheumatoid patients with mutilating changes. Orthop Rev (Pavia). 2009;1(2):e23. https://doi.org/10.4081/or.2009.e23.

    Article  PubMed  Google Scholar 

  67. Engeler D, Baranowski AP, Borovicka J, et al. European Association of Urology. Guidelines on chronic pelvic pain. 2021. Available at: https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Chronic-Pelvic-Pain-2020.pdf

  68. Sator-Katzenschlager SM, Scharbert G, Kress HG, et al. Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. Wien Klin Wochenschr. 2005;117(21–22):761–8.

    Article  CAS  PubMed  Google Scholar 

  69. Haugstad GK, Kirste U, Leganger S, Haakonsen E, Haugstad TS. Somatocognitive therapy in the management of chronic gynaecological pain. A review of the historical background and results of a current approach. Scand J Pain. 2011;2(3):124–9.

    Article  Google Scholar 

  70. Pak DJ, Yong RJ, Kaye AD, Urman RD. Chronification of pain: mechanisms, current understanding, and clinical implications. Curr Pain Headache Rep. 2018;22(2) https://doi.org/10.1007/s11916-018-0666-8.

  71. Voscopoulos C, Lema M. When does acute pain become chronic? Br J Anaesth. 2010;105(Suppl 1):i69–85. https://doi.org/10.1093/bja/aeq323.

    Article  PubMed  Google Scholar 

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De, E.J.B., Paredes Mogica, J.A. (2023). Pathophysiology and Clinical Evaluation of Chronic Pelvic Pain. In: Martins, F.E., Holm, H.V., Sandhu, J., McCammon, K.A. (eds) Female Genitourinary and Pelvic Floor Reconstruction. Springer, Cham. https://doi.org/10.1007/978-3-030-71112-2_53-1

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