Skip to main content

Contraceptives and Mood

  • Chapter
  • First Online:
Female and Male Contraception

Part of the book series: Trends in Andrology and Sexual Medicine ((TASM))

Abstract

The interest in how, and if, hormonal contraceptives influence mood has increased over the past years. Mood symptoms, such as depressive symptoms, irritability, anxiety, and mood swings, are becoming a clinical problem for many hormonal contraceptive users and are often a reason for discontinuation. While the great majority of hormonal contraceptive users, including those using combined methods as well as progesterone-only methods, should not expect to experience negative mood, a smaller percentage of women are hormone sensitive and at risk of experiencing a worsening of their mood. High-quality evidence suggests that use of combined hormonal contraceptives is associated with minor mood changes, like increased irritability, increased anxiety and mood swings, and lowered general well-being, whereas depressive symptoms seem less affected. For some women, these modest changes in mood may be clinically relevant and the final push to a mental health problem in need of psychotropic treatment. Overall, modern contraceptive counselling should include a discussion about the potential risk of minor mood disturbances while on treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mojtabai R, Olfson M, Han B. National trends in the prevalence and treatment of depression in adolescents and young adults. Pediatrics. 2016;138(6):e20161878.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Balazs J, Miklosi M, Kereszteny A, Hoven CW, Carli V, Wasserman C, Apter A, Bobes J, Brunner R, Cosman D, Cotter P, Haring C, Iosue M, Kaess M, Kahn JP, Keeley H, Marusic D, Postuvan V, Resch F, Saiz PA, Sisask M, Snir A, Tubiana A, Varnik A, Sarchiapone M, Wasserman D. Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk. J Child Psychol Psychiatry. 2013;54(6):670–7.

    Article  PubMed  Google Scholar 

  3. Eaton WW, Shao H, Nestadt G, Lee HB, Bienvenu OJ, Zandi P. Population-based study of first onset and chronicity in major depressive disorder. Arch Gen Psychiatry. 2008;65(5):513–20.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Marcus SM, Young EA, Kerber KB, Kornstein S, Farabaugh AH, Mitchell J, Wisniewski SR, Balasubramani GK, Trivedi MH, Rush AJ. Gender differences in depression: findings from the STAR*D study. J Affect Disord. 2005;87(2–3):141–50.

    Article  PubMed  Google Scholar 

  5. Mattisson C, Bogren M, Horstmann V, Munk-Jorgensen P, Nettelbladt P. The long-term course of depressive disorders in the Lundby Study. Psychol Med. 2007;37(6):883–91.

    Article  PubMed  Google Scholar 

  6. Bitzer J. Hormonal contraception and depression: another Pill scandal? Eur J Contracept Reprod Health Care. 2017;22(1):1–2.

    Article  PubMed  Google Scholar 

  7. Lindh I, Hognert H, Milsom I. The changing pattern of contraceptive use and pregnancies in four generations of young women. Acta Obstet Gynecol Scand. 2016;95(11):1264–72.

    Article  CAS  PubMed  Google Scholar 

  8. Rosenberg MJ, Waugh MS. Oral contraceptive discontinuation: a prospective evaluation of frequency and reasons. Am J Obstet Gynecol. 1998;179(3 Pt 1):577–82.

    Article  CAS  Google Scholar 

  9. Segebladh B, Borgstrom A, Odlind V, Bixo M, Sundstrom-Poromaa I. Prevalence of psychiatric disorders and premenstrual dysphoric symptoms in patients with experience of adverse mood during treatment with combined oral contraceptives. Contraception. 2009;79(1):50–5.

    Article  CAS  PubMed  Google Scholar 

  10. Skouby SO. Contraceptive use and behavior in the 21st century: a comprehensive study across five European countries. Eur J Contracept Reprod Health Care. 2010;15(Suppl 2):S42–53.

    Article  PubMed  Google Scholar 

  11. Poromaa IS, Segebladh B. Adverse mood symptoms with oral contraceptives. Acta Obstet Gynecol Scand. 2012;91(4):420–7.

    Article  CAS  PubMed  Google Scholar 

  12. Schaffir J, Worly BL, Gur TL. Combined hormonal contraception and its effects on mood: a critical review. Eur J Contracept Reprod Health Care. 2016;21(5):347–55.

    Article  CAS  PubMed  Google Scholar 

  13. Worly BL, Gur TL, Schaffir J. The relationship between progestin hormonal contraception and depression: a systematic review. Contraception. 2018;97(6):478–89.

    Article  CAS  PubMed  Google Scholar 

  14. Lundin C, Danielsson KG, Bixo M, Moby L, Bengtsdotter H, Jawad I, Marions L, Brynhildsen J, Malmborg A, Lindh I, Sundstrom Poromaa I. Combined oral contraceptive use is associated with both improvement and worsening of mood in the different phases of the treatment cycle-A double-blind, placebo-controlled randomized trial. Psychoneuroendocrinology. 2017;76:135–43.

    Article  CAS  PubMed  Google Scholar 

  15. Zethraeus N, Dreber A, Ranehill E, Blomberg L, Labrie F, von Schoultz B, Johannesson M, Hirschberg AL. A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2017;107(5):1238–45.

    Article  CAS  PubMed  Google Scholar 

  16. Zettermark S, Perez Vicente R, Merlo J. Hormonal contraception increases the risk of psychotropic drug use in adolescent girls but not in adults: a pharmacoepidemiological study on 800,000 Swedish women. PLoS One. 2018;13(3):e0194773.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Skovlund CW, Morch LS, Kessing LV, Lidegaard O. Association of hormonal contraception with depression. JAMA Psychiat. 2016;

    Google Scholar 

  18. Slattery J, Morales D, Pinheiro L, Kurz X. Cohort study of psychiatric adverse events following exposure to levonorgestrel-containing intrauterine devices in UK general practice. Drug Saf. 2018;41(10):951–8.

    Article  CAS  PubMed  Google Scholar 

  19. Graham CA, Ramos R, Bancroft J, Maglaya C, Farley TM. The effects of steroidal contraceptives on the well-being and sexuality of women: a double-blind, placebo-controlled, two-centre study of combined and progestogen-only methods. Contraception. 1995;52(6):363–9.

    Article  CAS  Google Scholar 

  20. O’Connell K, Davis AR, Kerns J. Oral contraceptives: side effects and depression in adolescent girls. Contraception. 2007;75(4):299–304.

    Article  CAS  PubMed  Google Scholar 

  21. Pearlstein TB, Bachmann GA, Zacur HA, Yonkers KA. Treatment of premenstrual dysphoric disorder with a new drospirenone-containing oral contraceptive formulation. Contraception. 2005;72(6):414–21.

    Article  CAS  Google Scholar 

  22. Yonkers KA, Brown C, Pearlstein TB, Foegh M, Sampson-Landers C, Rapkin A. Efficacy of a new low-dose oral contraceptive with drospirenone in premenstrual dysphoric disorder. Obstet Gynecol. 2005;106(3):492–501.

    Article  CAS  Google Scholar 

  23. Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB. Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence. J Affect Disord. 1993;29(2–3):85–96.

    Article  CAS  Google Scholar 

  24. Oinonen KA, Mazmanian D. To what extent do oral contraceptives influence mood and affect? J Affect Disord. 2002;70(3):229–40.

    Article  CAS  Google Scholar 

  25. Skovlund C. Depression, Suicide and Hormonal Contraception. Copenhagen: University Copenhagen; 2017.

    Google Scholar 

  26. Sahin N, Kasap B, Kirli U, Yeniceri N, Topal Y. Assessment of anxiety-depression levels and perceptions of quality of life in adolescents with dysmenorrhea. Reprod Health. 2018;15(1):13.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Balik G, Ustuner I, Kagitci M, Sahin FK. Is there a relationship between mood disorders and dysmenorrhea? J Pediatr Adolesc Gynecol. 2014;27(6):371–4.

    Article  PubMed  Google Scholar 

  28. Gambadauro P, Carli V, Hadlaczky G. Depressive symptoms among women with endometriosis: a systematic review and meta-analysis. Am J Obstet Gynecol. 2019;220(3):230–41.

    Article  PubMed  Google Scholar 

  29. Pope CJ, Sharma V, Sharma S, Mazmanian D. A systematic review of the association between psychiatric disturbances and endometriosis. J Obstet Gynaecol Can. 2015;37(11):1006–15.

    Article  Google Scholar 

  30. Brutocao C, Zaiem F, Alsawas M, Morrow AS, Murad MH, Javed A. Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine. 2018;62(2):318–25.

    Article  CAS  PubMed  Google Scholar 

  31. Lukaviciute L, Navickas P, Navickas A, Grigaitiene J, Ganceviciene R, Zouboulis CC. Quality of life, anxiety prevalence, depression symptomatology and suicidal ideation among acne patients in Lithuania. J Eur Acad Dermatol Venereol. 2017;31(11):1900–6.

    Article  CAS  PubMed  Google Scholar 

  32. Huang YC, Cheng YC. Isotretinoin treatment for acne and risk of depression: a systematic review and meta-analysis. J Am Acad Dermatol. 2017;76(6):1068–1076.e1069.

    Article  CAS  Google Scholar 

  33. Strine TW, Chapman DP, Ahluwalia IB. Menstrual-related problems and psychological distress among women in the United States. J Women’s Health (Larchmt). 2005;14(4):316–23.

    Article  Google Scholar 

  34. de Carvalho AB, Cardoso TA, Mondin TC, da Silva RA, Souza LDM, Magalhaes P, Jansen K. Prevalence and factors associated with premenstrual dysphoric disorder: a community sample of young adult women. Psychiatry Res. 2018;268:42–5.

    Article  PubMed  Google Scholar 

  35. Kerns J, Darney P. Vaginal ring contraception. Contraception. 2011;83(2):107–15.

    Article  CAS  PubMed  Google Scholar 

  36. Duke JM, Sibbritt DW, Young AF. Is there an association between the use of oral contraception and depressive symptoms in young Australian women? Contraception. 2007;75(1):27–31.

    Article  CAS  PubMed  Google Scholar 

  37. Urdl W, Apter D, Alperstein A, Koll P, Schonian S, Bringer J, Fisher AC, Preik M. Contraceptive efficacy, compliance and beyond: factors related to satisfaction with once-weekly transdermal compared with oral contraception. Eur J Obstet Gynecol Reprod Biol. 2005;121(2):202–10.

    Article  PubMed  Google Scholar 

  38. Sucato GS, Land SR, Murray PJ, Cecchini R, Gold MA. Adolescents’ experiences using the contraceptive patch versus pills. J Pediatr Adolesc Gynecol. 2011;24(4):197–203.

    Article  PubMed  Google Scholar 

  39. De Sanctis V, Soliman AT, Elsedfy H, Soliman NA, Soliman R, El Kholy M. Dysmenorrhea in adolescents and young adults: a review in different country. Acta Biomed. 2017;87(3):233–46.

    Google Scholar 

  40. Kristjansdottir J, Sundelin C, Naessen T. Health-related quality of life in young women starting hormonal contraception: a pilot study. Eur J Contracept Reprod Health Care. 2018;23(3):171–8.

    Article  PubMed  Google Scholar 

  41. Ott MA, Shew ML, Ofner S, Tu W, Fortenberry JD. The influence of hormonal contraception on mood and sexual interest among adolescents. Arch Sex Behav. 2008;37(4):605–13.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Skovlund CW, Morch LS, Kessing LV, Lidegaard O. Association of hormonal contraception with depression. JAMA Psychiatry. 2016;73(11):1154–62.

    Article  PubMed  Google Scholar 

  43. Borgstrom A, Odlind V, Ekselius L, Sundstrom-Poromaa I. Adverse mood effects of combined oral contraceptives in relation to personality traits. Eur J Obstet Gynecol Reprod Biol. 2008;141(2):127–30.

    Article  CAS  PubMed  Google Scholar 

  44. Fedor-Freybergh P, Hjelmqvist M, Zador G. Psychodiagnostic follow-up of Neovletta—a new low dose oral contraceptive. Acta Obstet Gynecol Scand Suppl. 1976;54:77–82.

    Article  CAS  Google Scholar 

  45. Gingnell M, Engman J, Frick A, Moby L, Wikstrom J, Fredrikson M, Sundstrom-Poromaa I. Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill—a double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive. Psychoneuroendocrinology. 2013;38(7):1133–44.

    Article  CAS  PubMed  Google Scholar 

  46. Joffe H, Cohen LS, Harlow BL. Impact of oral contraceptive pill use on premenstrual mood: predictors of improvement and deterioration. Am J Obstet Gynecol. 2003;189(6):1523–30.

    Article  CAS  Google Scholar 

  47. Hall KS, White KO, Rickert VI, Reame N, Westhoff C. Influence of depressed mood and psychological stress symptoms on perceived oral contraceptive side effects and discontinuation in young minority women. Contraception. 2012;86(5):518–25.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Ernst U, Baumgartner L, Bauer U, Janssen G. Improvement of quality of life in women using a low-dose desogestrel-containing contraceptive: results of an observational clinical evaluation. Eur J Contracept Reprod Health Care. 2002;7(4):238–43.

    Article  CAS  Google Scholar 

  49. Huber JC, Heskamp ML, Schramm GA. Effect of an oral contraceptive with chlormadinone acetate on depressive mood: analysis of data from four observational studies. Clin Drug Investig. 2008;28(12):783–91.

    Article  CAS  Google Scholar 

  50. Bengtsdotter H, Lundin C, Gemzell Danielsson K, Bixo M, Baumgart J, Marions L, Brynhildsen J, Malmborg A, Lindh I, Sundstrom Poromaa I. Ongoing or previous mental disorders predispose to adverse mood reporting during combined oral contraceptive use. Eur J Contracept Reprod Health Care. 2018;23(1):45–51.

    Article  CAS  PubMed  Google Scholar 

  51. Sundstrom Poromaa I, Gingnell M. Menstrual cycle influence on cognitive function and emotion processing-from a reproductive perspective. Front Neurosci. 2014;8:380.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Toffoletto S, Lanzenberger R, Gingnell M, Sundstrom-Poromaa I, Comasco E. Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain: a systematic review. Psychoneuroendocrinology. 2014;50:28–52.

    Article  CAS  PubMed  Google Scholar 

  53. Backstrom T, Andreen L, Birzniece V, Bjorn I, Johansson IM, Nordenstam-Haghjo M, Nyberg S, Sundstrom-Poromaa I, Wahlstrom G, Wang M, Zhu D. The role of hormones and hormonal treatments in premenstrual syndrome. CNS Drugs. 2003;17(5):325–42.

    Article  CAS  Google Scholar 

  54. Kelly S, Davies E, Fearns S, McKinnon C, Carter R, Gerlinger C, Smithers A. Effects of oral contraceptives containing ethinylestradiol with either drospirenone or levonorgestrel on various parameters associated with well-being in healthy women: a randomized, single-blind, parallel-group, multicentre study. Clin Drug Investig. 2010;30(5):325–36.

    Article  CAS  PubMed  Google Scholar 

  55. Sangthawan M, Taneepanichskul S. A comparative study of monophasic oral contraceptives containing either drospirenone 3 mg or levonorgestrel 150 microg on premenstrual symptoms. Contraception. 2005;71(1):1–7.

    Article  CAS  PubMed  Google Scholar 

  56. Bruni V, Croxatto H, De La Cruz J, Dhont M, Durlot F, Fernandes MT, Andrade RP, Weisberg E, Rhoa M. A comparison of cycle control and effect on well-being of monophasic gestodene-, triphasic gestodene- and monophasic desogestrel-containing oral contraceptives. Gestodene Study Group. Gynecol Endocrinol. 2000;14(2):90–8.

    Article  CAS  PubMed  Google Scholar 

  57. Winkler UH, Ferguson H, Mulders JA. Cycle control, quality of life and acne with two low-dose oral contraceptives containing 20 microg ethinylestradiol. Contraception. 2004;69(6):469–76.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Inger Sundström-Poromaa .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sundström-Poromaa, I. (2021). Contraceptives and Mood. In: Meriggiola, M.C., Gemzell-Danielsson, K. (eds) Female and Male Contraception. Trends in Andrology and Sexual Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-70932-7_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-70932-7_5

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-70931-0

  • Online ISBN: 978-3-030-70932-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics