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Intensity Dependent Long-Term Potentiation and Inhibition in Paired Associated Stimulation by Transcranial Magnetic Stimulation: A Pilot Study

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Converging Clinical and Engineering Research on Neurorehabilitation IV (ICNR 2020)

Part of the book series: Biosystems & Biorobotics ((BIOSYSROB,volume 28))

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Abstract

The Paired Associated Stimulation (PAS) protocol has been probed to successfully induce motor cortico-spinal plasticity. However, there is not an official consensus for the optimal Transcranial Magnetic Stimulation (TMS) intensity in PAS applications. The aim of this pilot study is to research the implication of intensity factor during the plasticity induction by PAS in later excitability assessment through each measurable intensity (90, 100, 110, 120 and 130% of the rMT). The results point to a conditioning of the intensity on the Motor Evoked Potentials (MEPs) towards a polarized outcome between high and low frequencies. Regardless, a complete research would be necessary to determine the impact extent of the PAS intensity factor.

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Acknowledgment

This work was supported by the Neuro Rehabilitation Group (NRG) from the Cajal Institute of the Spanish National Research Council, Madrid, Spain.

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Authors and Affiliations

  1. Neural Rehabilitation Group of the Spanish National Research Council, Madrid, Spain

    A. San Agustín, D. Crevillén & J. C. Moreno

  2. School of Medicine, Universidad Autónoma de Madrid (UAM), Madrid, Spain

    A. San Agustín

  3. FENNSI Group, National Hospital of Paraplegics, Toledo, Spain

    A. Oliviero

  4. Legs & Walking AbilityLab, Shirley Ryan AbilityLab, Chicago, IL, USA

    José L. Pons

Authors
  1. A. San Agustín
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  2. D. Crevillén
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  3. A. Oliviero
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  4. José L. Pons
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  5. J. C. Moreno
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Corresponding author

Correspondence to A. San Agustín .

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Editors and Affiliations

  1. Neural Rehabilitation Group, Cajal Institute, Madrid, Spain

    Diego Torricelli

  2. Department of Biomedical Engineering, University of Houston, Houston, TX, USA

    Metin Akay

  3. Department of Biomedical Engineering, Shirley Ryan AbilityLab, Chicago, IL, USA

    Jose L. Pons

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Agustín, A.S., Crevillén, D., Oliviero, A., Pons, J.L., Moreno, J.C. (2022). Intensity Dependent Long-Term Potentiation and Inhibition in Paired Associated Stimulation by Transcranial Magnetic Stimulation: A Pilot Study. In: Torricelli, D., Akay, M., Pons, J.L. (eds) Converging Clinical and Engineering Research on Neurorehabilitation IV. ICNR 2020. Biosystems & Biorobotics, vol 28. Springer, Cham. https://doi.org/10.1007/978-3-030-70316-5_123

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  • DOI: https://doi.org/10.1007/978-3-030-70316-5_123

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-70315-8

  • Online ISBN: 978-3-030-70316-5

  • eBook Packages: EngineeringEngineering (R0)

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