Abstract
Wound repair is a complicated and firmly synchronized physiological process, entailing the activation of various cell types throughout each succeeding step (homeostasis, inflammation, proliferation, and tissue remodeling). Any impairment within the correct sequence of the healing events could prompt incessant injuries, with probable denouement on the patients’ quality of life, and consequential failures on wound care management. Contemporary wound healing treatments like gauzes and bandages primarily are pivoted on passively cushioning the wound and do not proffer properties that escalate the rate of wound healing. Even though these strategies are resilient at safeguarding any infection after application, they are futile at healing a heretofore infected wound or spurring tissue regeneration. The burgeoning of next-generation wound healing treatments aid in enhancing patient care pathways and clinical outcomes. Natural polymers play a significant role in wound care. They deliver a versatile and tunable platform to design the germane extracellular matrix competent to succor tissue regeneration, while contrasting the onset of adverse events. Our goal is to scrutinize the evolution of natural polymers in wound dressing from traditional to modern-day treatment methods. The chief characteristics and properties of a natural polymer, which is widely utilized as biomaterial, are presented. Properties of composite material with peculiar heed on their applications in the skin tissue repair field are discussed. Finally, the unmet needs and developmental perspectives of the new generations of environmentally friendly, naturally derived, smart wound dressings are addressed in light of future research.
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References
Naik S (2018) Wound, heal thyself. Nature Med 24(9):1311–1312
Hamdan S, Pastar I, Drakulich S, Dikici E, Tomic-Canic M, Deo S, Daunert S (2017) Nanotechnology-driven therapeutic interventions in wound healing: potential uses and applications. ACS Central Sci 3(3):163–175
Shah JB (2011) The history of wound care. J Amer College Certified Wound Specialists 3(3):65–66
Gaspar-Pintiliescu A, Stanciuc AM, Craciunescu O (2019) Natural composite dressings based on collagen, gelatin and plant bioactive compounds for wound healing: a review. Int J Biolog Macromolecules 1(138):854–865
Mogoşanu GD, Grumezescu AM (2014) Natural and synthetic polymers for wounds and burns dressing. Int J Pharmaceutics 463(2):127–136
Dabiri G, Damstetter E, Phillips T (2016) Choosing a wound dressing based on common wound characteristics. Adv Wound Care 5(1):32–41
Evans ND, Oreffo RO, Healy E, Thurner PJ, Man YH (2013) Epithelial mechanobiology, skin wound healing, and the stem cell niche. J Mech Behav Biomed Mater 1(28):397–409
De Jong LA (1995) Pre-tension and anisotropy in skin: modelling and experiments. Master of Science Thesis, Eindhoven University of Technology. Available on institution repository at (http://alexandria.tue.nl/repository/books/633250.pdf.1995)
Diridollou S, Patat F, Gens F, Vaillant L, Black D, Lagarde JM, Gall Y, Berson M (2000) In vivo model of the mechanical properties of the human skin under suction. Skin Res Technol 6(4):214–221
Atkinson JA, McKenna KT, Barnett AG, McGrath DJ, Rudd M (2005) A randomized, controlled trial to determine the efficacy of paper tape in preventing hypertrophic scar formation in surgical incisions that traverse Langer’s skin tension lines. Plastic Reconstruct Surgery 116(6):1648–1656
Gurtner GC, Dauskardt RH, Wong VW, Bhatt KA, Wu K, Vial IN, Padois K, Korman JM, Longaker MT (2011) Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies. Annals Surgery 254(2):217–225
Sarrazy V, Billet F, Micallef L, Coulomb B, Desmoulière A (2011) Mechanisms of pathological scarring: role of myofibroblasts and current developments. Wound Repair Regener 19:s10–5
Webb K, Hitchcock RW, Smeal RM, Li W, Gray SD, Tresco PA (2006) Cyclic strain increases fibroblast proliferation, matrix accumulation, and elastic modulus of fibroblast-seeded polyurethane constructs. J Biomech 39(6):1136–1144
Aarabi S, Bhatt KA, Shi Y, Paterno J, Chang EI, Loh SA, Holmes JW, Longaker MT, Yee H, Gurtner GC (2007) Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. The FASEB J 21(12):3250–3261
Vowden K, Vowden P (2017) Wound dressings: principles and practice. Surgery (Oxford) 35(9):489–494
Weller CD, Team V, Sussman G (2020) First-line interactive wound dressing update: a comprehensive review of the evidence. Front Pharmacol 28(11):155
Weir D (2020) Wound dressings. In: Local wound care for dermatologists, Springer, Cham, pp 25–34
Shi C, Wang C, Liu H, Li Q, Li R, Zhang Y, Liu Y, Shao Y, Wang J (2020) Selection of appropriate wound dressing for various wounds. Front Bioeng Biotechnol 8
Stern D, Cui H (2019) Crafting polymeric and peptidic hydrogels for improved wound healing. Adv Healthcare Mater 8(9):1900104
Suarato G, Bertorelli R, Athanassiou A (2018) Borrowing from nature: biopolymers and biocomposites as smart wound care materials. Front Bioeng Biotechnol 2(6):137
Das A, Abas M, Biswas N, Banerjee P, Ghosh N, Rawat A, Khanna S, Roy S, Sen CK (2019) A modified collagen dressing induces transition of inflammatory to reparative phenotype of wound macrophages. Sci Reports 9(1):1
Ding C, Yang Q, Tian M, Guo C, Deng F, Dang Y, Zhang M (2020) Novel collagen‐based hydrogels with injectable, self‐healing, wound‐healing properties via a dynamic crosslinking interaction. Polym Int
Xu C, Akakuru OU, Ma X, Zheng J, Zheng J, Wu A (2020) Nanoparticle-based wound dressing: recent progress in the detection and therapy of bacterial infections. Bioconjugate Chem 31(7):1708–1723
Alvarez GS, Hélary C, Mebert AM, Wang X, Coradin T, Desimone MF (2014) Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention. J Mater Chem B 2(29):4660–4670
Ghorbani M, Nezhad-Mokhtari P, Ramazani S (2020) Aloe vera-loaded nanofibrous scaffold based on Zein/Polycaprolactone/Collagen for wound healing. Int J Biolog Macromolecules
Zare-Gachi M, Daemi H, Mohammadi J, Baei P, Bazgir F, Hosseini-Salekdeh S, Baharvand H (2020) Improving anti-hemolytic, antibacterial and wound healing properties of alginate fibrous wound dressings by exchanging counter-cation for infected full-thickness skin wounds. Mater Sci Eng C 1(107):110321
Singh B, Varshney L, Francis S (2017) Designing sterile biocompatible moxifloxacin loaded trgacanth-PVA-alginate wound dressing by radiation crosslinking method. Wound Med 1(17):11–17
Li H, Yang J, Hu X, Liang J, Fan Y, Zhang X (2011) Superabsorbent polysaccharide hydrogels based on pullulan derivate as antibacterial release wound dressing. J Biomed Mater Res, Part A 98(1):31–39
Abdel-Mohsen AM, Abdel-Rahman RM, Kubena I, Kobera L, Spotz Z, Zboncak M, Prikryl R, Brus J, Jancar J (2020) Chitosan-glucan complex hollow fibers reinforced collagen wound dressing embedded with aloe vera. part I: preparation and characterization. Carbohydrate Polym 230:115708
Lehtovaara BC, Gu FX (2011) Pharmacological, structural, and drug delivery properties and applications of 1, 3-β-glucans. J Agri Food Chem 59(13):6813–6828
Hosary RE, El-Mancy SM, El Deeb KS, Eid HH, Tantawy ME, Shams MM, Samir R, Assar NH, Sleem AA (2020) Efficient wound healing composite hydrogel using Egyptian Avena sativa L. polysaccharide containing β-glucan. Int J Biolog Macromolecules 149:1331–1338
Gharibi R, Kazemi S, Yeganeh H, Tafakori V (2019) Utilizing dextran to improve hemocompatibility of antimicrobial wound dressings with embedded quaternary ammonium salts. Int J Biolog Macromolecules 15(131):1044–1056
Mansuroğlu B, Kızılbey K, ŞayanPoyraz F, Yurttaş Z, Fuerkaiti SN, Abaoğlu İY, Başat HN (2020) Chitosan/dextran sulphate sodium hydrogels for wound healing material: preparation, characterisation and in vitro evaluation. Mater Technol 4:1–8
Turner PR, Murray E, McAdam CJ, McConnell MA, Cabral JD (2020) Peptide chitosan/dextran core/shell vascularized 3D constructs for wound healing. ACS Appl Mater Interfaces 12(29):32328–32339
Savitskaya IS, Shokatayeva DH, Kistaubayeva AS, Ignatova LV, Digel IE (2019) Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells. Heliyon 5(10):e02592
Fürsatz M, Skog M, Sivlér P, Palm E, Aronsson C, Skallberg A, Greczynski G, Khalaf H, Bengtsson T, Aili D (2018) Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-Lysine. Biomed Mater 13(2):025014
Pinho E, Soares G (2018) Functionalization of cotton cellulose for improved wound healing. J Mater Chem B 6(13):1887–1898
Ali Khan Z, Jamil S, Akhtar A, Mustehsan Bashir M, Yar M (2020) Chitosan based hybrid materials used for wound healing applications-a short review. Int J Polym Mater Polym Biomater 69(7):419–436
Li Q, Lu F, Zhou G, Yu K, Lu B, Xiao Y, Dai F, Wu D, Lan G (2017) Silver inlaid with gold nanoparticle/chitosan wound dressing enhances antibacterial activity and porosity, and promotes wound healing. Biomacromol 18(11):3766–3775
Liang D, Lu Z, Yang H, Gao J, Chen R (2016) Novel asymmetric wettableAgNPs/chitosan wound dressing: in vitro and in vivo evaluation. ACS Appl Mater Interfaces 8(6):3958–3968
Adeli H, Khorasani MT, Parvazinia M (2019) Wound dressing based on electrospun PVA/chitosan/starch nanofibrous mats: fabrication, antibacterial and cytocompatibility evaluation and in vitro healing assay. Int J Biol Macromolecules 1(122):238–254
Long J, Etxeberria AE, Nand AV, Bunt CR, Ray S, Seyfoddin A (2019) A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery. Mater Sci Eng C 1(104):109873
El-Aassar MR, Ibrahim OM, Fouda MM, El-Beheri NG, Agwa MM (2020) Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies. Carbohydrate Polym 15(238):116175
Zhang S, Hou J, Yuan Q, Xin P, Cheng H, Gu Z, Wu J (2020) Arginine derivatives assist dopamine-hyaluronic acid hybrid hydrogels to have enhanced antioxidant activity for wound healing. Chem Eng J 15(392):123775
Duan Y, Li K, Wang H, Wu T, Zhao Y, Li H, Tang H, Yang W (2020) Preparation and evaluation of curcumin grafted hyaluronic acid modified pullulan polymers as a functional wound dressing material. Carbohydrate Polym 19:
Duan Y, Li K, Wang H, Wu T, Zhao Y, Li H, Tang H, Yang W (2020) Preparation and evaluation of curcumin grafted hyaluronic acid modified pullulan polymers as a functional wound dressing material. Carbohydrate Polym 19:116195
Graça MF, Miguel SP, Cabral CS, Correia IJ (2020) Hyaluronic acid-based wound dressings: a review. Carbohydrate Polym 27:116364
Eskandarinia A, Kefayat A, Agheb M, Rafienia M, Baghbadorani MA, Navid S, Ebrahimpour K, Khodabakhshi D, Ghahremani F (2020) A novel bilayer wound dressing composed of a dense polyurethane/propolis membrane and a biodegradable polycaprolactone/gelatin nanofibrous scaffold. Sci Report 10(1):1–5
Hubner P, Donati N, de MenezesQuines LK, Tessaro IC, Marcilio NR (2020) Gelatin-based films containing clinoptilolite-Ag for application as wound dressing. Mater Sci Eng C 1(107):110215
ForoutanKoudehi M, Zibaseresht R (2020) Synthesis of molecularly imprinted polymer nanoparticles containing gentamicin drug as wound dressing based polyvinyl alcohol/gelatin nanofiber. Mater Technol 35(1):21–30
Batzer AT, Marsh C, Kirsner RS (2016) The use of keratin-based wound products on refractory wounds. Int Wound J 13(1):110–115
Sadeghi S, Nourmohammadi J, Ghaee A, Soleimani N (2020) Carboxymethyl cellulose-human hair keratin hydrogel with controlled clindamycin release as antibacterial wound dressing. Int J Biol Macromolecules 15(147):1239–1247
Navarro J, Clohessy RM, Holder RC, Gabard AR, Herendeen GJ, Christy RJ, Burnett LR, Fisher JP (2020) In Vivo evaluation of three-dimensional printed, keratin-based hydrogels in a porcine thermal burn model. Tissue Eng Part A 26(5–6):265–278
Patil PP, Reagan MR, Bohara RA (2020) Silk fibroin and silk-based biomaterial derivatives for ideal wound dressings. Int J Biol Macromolecules
Nourmohammadi J, Hadidi M, Nazarpak MH, Mansouri M, Hasannasab M (2020) Physicochemical and antibacterial characterization of nanofibrous wound dressing from silk fibroin-polyvinyl alcohol-elaeagnusangustifolia extract. Fibers Polym 21(3):456–464
Zhang Y, Lu L, Chen Y, Wang J, Chen Y, Mao C, Yang M (2019) Polydopamine modification of silk fibroin membranes significantly promotes their wound healing effect. Biomater Sci 7(12):5232–5237
Hashimoto T, Kojima K, Tamada Y (2020) Gene expression advances skin reconstruction and wound repair better on silk fibroin-based materials than on collagen-based materials. Materialia 1(9):100519
Hadisi Z, Farokhi M, Bakhsheshi-Rad HR, Jahanshahi M, Hasanpour S, Pagan E, Dolatshahi-Pirouz A, Zhang YS, Kundu SC, Akbari M (2020) Hyaluronic Acid (HA)-Based Silk Fibroin/Zinc Oxide core-shell electrospun dressing for burn wound management. Macromolecular Biosci 20(4):1900328
Feng Y, Li X, Zhang Q, Yan S, Guo Y, Li M, You R (2019) Mechanically robust and flexible silk protein/polysaccharide composite sponges for wound dressing. Carbohydrate Polym 15(216):17–24
Bakhsheshi-Rad HR, Hadisi Z, Ismail AF, Aziz M, Akbari M, Berto F, Chen XB (2020) In vitro and in vivo evaluation of chitosan-alginate/gentamicin wound dressing nanofibrous with high antibacterial performance. Polym Test 1(82):106298
Ehterami A, Salehi M, Farzamfar S, Samadian H, Vaez A, Sahrapeyma H, Ghorbani S (2020) A promising wound dressing based on alginate hydrogels containing vitamin D3 cross-linked by calcium carbonate/d-glucono-δ-lactone. Biomed Eng Lett 19:1–1
Samadian H, Zamiri S, Ehterami A, Farzamfar S, Vaez A, Khastar H, Alam M, Ai A, Derakhshankhah H, Allahyari Z, Goodarzi A (2020) Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies. Sci Rep 10
Das A, Uppaluri R, Das C (2019) Feasibility of poly-vinyl alcohol/starch/glycerol/citric acid composite films for wound dressing applications. Int J Biol Macromolecules 15(131):998–1007
Zhao X, Wang L, Gao J, Chen X, Wang K (2020) Hyaluronic acid/lysozyme self-assembled coacervate to promote cutaneous wound healing. Biomater Sci 8(6):1702–1710
Konop M, Czuwara J, Kłodzińska E, Laskowska AK, Sulejczak D, Damps T, Zielenkiewicz U, Brzozowska I, Sureda A, Kowalkowski T, Schwartz RA (2020) Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full-thickness skin wound model in diabetic mice. J Tissue Eng Regener Med 14(2):334–346
Homaeigohar S, Tsai TY, Zarie ES, Elbahri M, Young TH, Boccaccini AR (2020) Bovine serum albumin (BSA)/polyacrylonitrile (PAN) biohybridnanofibers coated with a biomineralized calcium deficient hydroxyapatite (HA) shell for wound dressing. Mater Sci Eng: C. 111248
Akrami M, Tayebi L, Ghorbani M (2020) Curcumin-loaded naturally-based nanofibers as active wound dressing mats: morphology, drug release, cell proliferation and cell adhesion studies. New J Chem
Peng J, Zhao H, Tu C, Xu Z, Ye L, Zhao L, Gu Z, Zhao D, Zhang J, Feng Z (2020) In situ hydrogel dressing loaded with heparin and basic fibroblast growth factor for accelerating wound healing in rat. Mater Sci Eng C 6:111169
Hodel KV, Fonseca LM, Santos IM, Cerqueira JC, Santos-Júnior RE, Nunes SB, Barbosa JD, Machado BA (2020) Evaluation of different methods for cultivating gluconacetobacterhansenii for bacterial cellulose and montmorillonitebiocomposite production: wound-dressing applications. Polymers 12(2):267
Zhu F, Wang C, Yang S, Wang Q, Liang F, Liu C, Qiu D, Qu X, Hu Z, Yang Z (2017) Injectable tissue adhesive composite hydrogel with fibroblasts for treating skin defects. J Mater Chem B 5(13):2416–2424
Raja IS, Fathima NN (2018) Gelatin–cerium oxide nanocomposite for enhanced excisional wound healing. ACS Appl Bio Mater 1(2):487–495
Yadav C, Chhajed M, Choudhury P, Sahu RP, Patel A, Chawla S, Goswami L, Goswami C, Li X, Agrawal AK, Saini A (2020) Bio-extract amalgamated sodium alginate-cellulose nanofibres based 3D-sponges with interpenetrating BioPU coating as potential wound care scaffolds. Mater Sci Eng C 11:111348
Bergonzi C, d’Ayala GG, Elviri L, Laurienzo P, Bandiera A, Catanzano O (2020) Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application. Int J Biol Macromolecules
Păunica-Panea G, Ficai A, Marin MM, Marin Ș, Albu MG, Constantin VD, Dinu-Pîrvu C, Vuluga Z, Corobea MC, Ghica MV (2016) New collagen-dextran-zinc oxide composites for wound dressing. J Nanomater 1
Kossyvaki D, Suarato G, Summa M, Gennari A, Francini N, Gounaki I, Venieri D, Tirelli N, Bertorelli R, Athanassiou A, Papadopoulou EL (2020) Keratin–cinnamon essential oil biocomposite fibrous patches for skin burn care. Mater Adv
Huang Y, Dan N, Dan W, Zhao W (2019) Reinforcement of polycaprolactone/chitosan with nanoclay and controlled release of curcumin for wound dressing. ACS Omega 4(27):22292–22301
Ahn S, Chantre CO, Gannon AR, Lind JU, Campbell PH, Grevesse T, O’Connor BB, Parker KK (2018) Soy protein/cellulose nanofiber scaffolds mimicking skin extracellular matrix for enhanced wound healing. Adv Healthcare Mater 7(9):1701175
Kocaaga B, Kurkcuoglu O, Tatlier M, Batirel S, Guner FS (2019) Low-methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healing. J Appl Polym Sci 136(24):47640
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Authors would like to pay gratitude toward the Department of Chemistry and Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Delhi, India.
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Sharma, S., Sharma, B., Shekhar, S., Jain, P. (2022). Natural Polymer-Based Composite Wound Dressings. In: Hasnain, M.S., Nayak, A.K., Alkahtani, S. (eds) Polymeric and Natural Composites. Advances in Material Research and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-70266-3_13
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