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Acute Coronary Syndromes in Pregnancy

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Obstetric Catastrophes

Abstract

Coronary artery disease is relatively uncommon during pregnancy, and it is not surprising that its prevalence is increasing due to changing lifestyle patterns. Physiological changes in pregnancy and the postpartum period can put a strain on the heart, especially in the presence of recognized risk factors for myocardial infarction. Diagnosis of acute coronary syndromes (ACS) in pregnancy may be challenging because its presentation mimics the normal manifestations of pregnancy and consequently low index of suspicion is mandatory. Knowledge of the pathophysiology of ACS in pregnant patients and the challenges in diagnosis and treatment is of pivotal importance. Acute coronary syndrome during pregnancy is associated with high maternal and neonatal mortality and morbidity. Thus, appropriate investigations and treatment must not be delayed because of foetal concerns and multidisciplinary team management and early involvement of the cardiologist are vital for a good outcome.

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References

  1. Elkayam U, Jalnapurkar S, Barakkat MN, Khatri N, Kealey AJ, Mehra A, Roth A. Pregnancy-associated acute myocardial infarction: a review of contemporary experience in 150 cases between 2006 and 2011. Circulation. 2014;129:1695–702.

    Article  PubMed  Google Scholar 

  2. Bush N, Nelson-Piercy C, Spark P, Kurinczuk JJ, Brocklehurst P, Knight M. Myocardial infarction in pregnancy and postpartum in the UK. Eur J Prev Cardiol. 2013;20:12–20.

    Article  CAS  PubMed  Google Scholar 

  3. Ismail S, Wong C, Rajan P, Vidovich MI. ST-elevation acute myocardial infarction in pregnancy: 2016 update. Clin Cardiol. 2017;40(6):399–406.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Nelson-Piercy C, Adamson D, Knight M. Acute coronary syndrome in pregnancy: time to act. Heart. 2012;98:760–1.

    Article  PubMed  Google Scholar 

  5. Poh CL, Lee CH. Acute myocardial infarction in pregnant women. Ann Acad Med Singap. 2010;39:247–53.

    PubMed  Google Scholar 

  6. Savu O, Jurcut R, Giusca S, Van Mieghem T, Gussi I, Popescu BA, Ginghină C, Rademakers F, Deprest J, Voigt JU. Morphological and functional adaptation of the maternal heart during pregnancy. Circ Cardiovasc Imaging. 2012;5(3):289–97.

    Article  PubMed  Google Scholar 

  7. Söhnchen N, Melzer K, Martinez de Tejada B, Jastrow-Meyer N, Othenin-Girard V, Irion O, Boulvain M, Kayser B. Maternal heart rate changes during labour. Eur J Obst Gynecol Reprod Biol. 2011;158:173–8.

    Article  Google Scholar 

  8. Wuntakal R, Shetty N, Ioannou E, Sharma S, Kurian J. Myocardial infarction and pregnancy. Obstet Gynaecol. 2013;15:247–55.

    Google Scholar 

  9. Roth A, Elkayam U. Acute myocardial infarction associated with pregnancy. J Am Coll Cardiol. 2008;52:171–80.

    Article  PubMed  Google Scholar 

  10. James AH, Jamison MG, Biswas MS, Brancazio LR, Swamy GK, Myers ER. Acute myocardial infarction in pregnancy: a United States population-based study. Circulation. 2006;113:1564–71.

    Article  PubMed  Google Scholar 

  11. Janion-Sadowska A, Sadowski M, Kurzawski J, Zandecki L, Janion M. Pregnancy after acute coronary syndrome: a proposal for patients’ management and a literature review. BioMed Res Int. 2013;2013, Article ID 957027:7 pages.

    Google Scholar 

  12. Tweet MS, Hayes SN, Gulati R, Rose CH, Best PJ. Pregnancy after spontaneous coronary artery dissection: a case series. Ann Intern Med. 2015;162:598–600.

    Article  PubMed  Google Scholar 

  13. Vijayaraghavan R, Verma S, Gupta N, Saw J. Pregnancy-related spontaneous coronary artery dissection. Circulation. 2014;130:1915–20.

    Article  PubMed  Google Scholar 

  14. Goland S, Elkayam U. Anticoagulation in pregnancy. Cardiol Clin. 2012;30:395–405.

    Article  PubMed  Google Scholar 

  15. Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio AL, De Caterina R, Zimarino M, Roffi M, Kjeldsen K, Atar D, Kaski JC, Sechtem U, Tornvall P. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart J. 2017;38:143–53.

    PubMed  Google Scholar 

  16. Gordon CT, Jimenez-Fernandez S, Daniels LB, Kahn AM, Tarsa M, Matsubara T, Shimizu C, Burns JC, Gordon JB. Pregnancy in women with a history of Kawasaki disease: management and outcomes. BJOG. 2014;121:1431–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Practice Bulletin No ACOG. 212: pregnancy and heart disease. Obstet Gynecol. 2019;133(5):e320–56. https://doi.org/10.1097/AOG.0000000000003243.

    Article  Google Scholar 

  18. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimský P, ESC Scientific Document Group. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39:119–77.

    Article  PubMed  Google Scholar 

  19. Joyal D, Leya F, Koh M, Besinger R, Ramana R, Kahn S, Jeske W, Lewis B, Steen L, Mestril R, Arab D. Troponin I levels in patients with preeclampsia. Am J Med. 2007;120:819.e13–4.

    Google Scholar 

  20. Lancellotti P, Price S, Edvardsen T, Cosyns B, Neskovic AN, Dulgheru R, Flachskampf FA, Hassager C, Pasquet A, Gargani L, Galderisi M, Cardim N, Haugaa KH, Ancion A, Zamorano JL, Donal E, Bueno H, Habib G. The use of echocardiography in acute cardiovascular care: recommendations of the European Association of Cardiovascular Imaging and the Acute Cardiovascular Care Association. Eur Heart J Acute Cardiovasc Care. 2015;4(1):3–5.

    Article  PubMed  Google Scholar 

  21. Cornette J, Ruys TP, Rossi A, Rizopoulos D, Takkenberg JJ, Karamermer Y, Opic P, Van den Bosch AE, Geleijnse ML, Duvekot JJ, Steegers EA, Roos-Hesselink JW. Hemodynamic adaptation to pregnancy in women with structural heart disease. Int J Cardiol. 2013;168:825–31.

    Article  CAS  PubMed  Google Scholar 

  22. Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomström-Lundqvist C, Cífková R, De Bonis M, Iung B, Johnson MR, Kintscher U, Kranke P, Lang IM, Morais J, Pieper PG, Presbitero P, Price S, Rosano GMC, Seeland U, Simoncini T, Swan L, Warnes CA, ESC Scientific Document Group. 2018 ESC guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. 2018;39(34):3165–241.

    Article  PubMed  Google Scholar 

  23. Thomsen HS. European Society of Urogenital Radiology (ESUR) guidelines on the safe use of iodinated contrast media. Eur J Radiol. 2006;60:307–13.

    Article  PubMed  Google Scholar 

  24. Colletti PM, Lee KH, Elkayam U. Cardiovascular imaging of the pregnant patient. AJR Am J Roentgenol. 2013;200:515–21.

    Article  PubMed  Google Scholar 

  25. Yilmaz S, Sahinkus S, Kilic H, Gunduz H, Akdemir R. Acute coronary syndrome during pregnancy: a case report and literature review. Turk J Emerg Med. 2016;14(3):135–8.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Havakuk O, Goland S, Mehra A, Elkayam U. Pregnancy and the risk of spontaneous coronary artery dissection: an analysis of 120 contemporary cases. Circ Cardiovasc Interv. 2017;10:e004941.

    Article  PubMed  Google Scholar 

  27. Frishman WH, Elkayam U, Aronow WS. Cardiovascular drugs in pregnancy. Cardiol Clin. 2012;30:463–91.

    Article  PubMed  Google Scholar 

  28. Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Ganiats TG, Holmes DR, Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN, Liebson PR, Mukherjee D, Peterson ED, Sabatine MS, Smalling RW, Zieman SJ. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;130:e344–426.

    PubMed  Google Scholar 

  29. Bates SM, Greer IA, Hirsh J, Ginsberg JS. Use of antithrombotic agents during pregnancy: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3):627S–44S.

    Article  CAS  PubMed  Google Scholar 

  30. Stone GW, White HD, Ohman EM, Bertrand ME, Lincoff AM, McLaurin BT, Cox DA, Pocock SJ, Ware JH, Feit F, Colombo A, Manoukian SV, Lansky AJ, Mehran R, Moses JW, Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial investigators. Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial. Lancet. 2007;369:907–19.

    Article  CAS  PubMed  Google Scholar 

  31. Ekbatani A, Asaro LR, Malinow AM. Anticoagulation with argatroban in a parturient with heparin-induced thrombocytopenia. Int J Obstet Anesth. 2010;19:82–7.

    Article  CAS  PubMed  Google Scholar 

  32. White HD, Kleiman NS, Mahaffey KW, Lokhnygina Y, Pieper KS, Chiswell K, Cohen M, Harrington RA, Chew DP, Petersen JL, Berdan LG, Aylward PE, Nessel CC, Ferguson JJ 3rd, Califf RM. Efficacy and safety of enoxaparin compared with unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention in the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial. Am Heart J. 2006;152:1042–50.

    Article  CAS  PubMed  Google Scholar 

  33. Gibson CM, Ten Y, Murphy SA, Ciaglo LN, Southard MC, Lincoff AM, Waksman R. Association of prerandomization anticoagulant switching with bleeding in the setting of percutaneous coronary intervention (A REPLACE-2 analysis). Am J Cardiol. 2007;99:1687–90.

    Article  PubMed  Google Scholar 

  34. Tawfik MM, Taman ME, Motawea AA, Abdel-Hady E. Thrombolysis for the management of massive pulmonary embolism in pregnancy. Int J Obstet Anesth. 2013;22:149–52.

    Article  CAS  PubMed  Google Scholar 

  35. Ntusi NA, Samuels P, Moosa S, Mocumbi AO. Diagnosing cardiac disease during pregnancy: Imaging modalities. Cardiovasc J Afr. 2016;27:95–103.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, Granger CB, Lange RA, Mack MJ, Mauri L, Mehran R, Mukherjee D, Newby LK, O’Gara PT, Sabatine MS, Smith PK, Smith SC Jr. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2016;68:1082–115.

    Article  PubMed  Google Scholar 

  37. Kapoor MC. Cardiopulmonary bypass in pregnancy. Ann Card Anaesth. 2014;17:33–9.

    Article  PubMed  Google Scholar 

  38. Hosseini S, Kashfi F, Samiei N, Khamoushi A, Ghavidel AA, Yazdanian F, Mirmesdagh Y, Mestres CA. Feto-maternal outcomes of urgent open-heart surgery during pregnancy. J Heart Valve Dis. 2015;24:253–9.

    PubMed  Google Scholar 

  39. John AS, Gurley F, Schaff HV, Warnes CA, Phillips SD, Arendt KW, Abel MD, Rose CH, Connolly HM. Cardiopulmonary bypass during pregnancy. Ann Thorac Surg. 2011;91:1191–6.

    Article  PubMed  Google Scholar 

  40. Ruys TP, Roos-Hesselink JW, Pijuan-Domenech A, Vasario E, Gaisin IR, Iung B, Freeman LJ, Gordon EP, Pieper PG, Hall R, Boersma E, Johnson MR. Is a planned caesarean section in women with cardiac disease beneficial? Heart. 2015;101:530–6.

    Article  PubMed  Google Scholar 

  41. Ramsey PS, Hogg BB, Savage KG, Winkler DD, Owen J. Cardiovascular effects of intravaginal misoprostol in the mid trimester of pregnancy. Am J Obstet Gynecol. 2000;183:1100–2.

    Article  CAS  PubMed  Google Scholar 

  42. Kilpatrick AW, Thorburn J. Severe hypotension due to intramyometrial injection of prostaglandin E2. Anaesthesia. 1990;45:848–9.

    Article  CAS  PubMed  Google Scholar 

  43. Cauldwell M, Steer PJ, Swan L, Uebing A, Gatzoulis MA, Johnson MR. The management of the third stage of labour in women with heart disease. Heart. 2017;103:945–51.

    Article  CAS  PubMed  Google Scholar 

  44. Van Veen JJ, Maclean RM, Hampton KK, Laidlaw S, Kitchen S, Toth P, Makris M. Protamine reversal of low molecular weight heparin: clinically effective? Blood Coagul Fibrinolysis. 2011;22:565–70.

    Article  PubMed  CAS  Google Scholar 

  45. Horlocker TT, Vandermeuelen E, Kopp SL, Gogarten W, Leffert LR, Benzon HT. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy American Society of Regional Anesthesia and Pain Medicine evidence-based guidelines (fourth edition). Reg Anesth Pain Med. 2018;43:263–309.

    Article  PubMed  Google Scholar 

  46. Burchill LJ, Lameijer H, Roos-Hesselink JW, Grewal J, Ruys TP, Kulikowski JD, Burchill LA, Oudijk MA, Wald RM, Colman JM, Siu SC, Pieper PG, Silversides CK. Pregnancy risks in women with pre-existing coronary artery disease, or following acute coronary syndrome. Heart. 2015;101:525–9.

    Article  CAS  PubMed  Google Scholar 

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Ali, R.M., Hassan, B.ED.E., Mahmoud, N.M.Y. (2021). Acute Coronary Syndromes in Pregnancy. In: Montufar, C., Hidalgo, J., Gei, A.F. (eds) Obstetric Catastrophes. Springer, Cham. https://doi.org/10.1007/978-3-030-70034-8_34

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  • DOI: https://doi.org/10.1007/978-3-030-70034-8_34

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