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Pain Associated with Head and Neck Cancers

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Early Detection and Treatment of Head & Neck Cancers

Abstract

Cancerous lesions in the head and neck are destructive and have significant morbidity and mortality rates. Pain, as the foremost morbidity of these types of cancers, is multifactorial and not necessarily related to tumor burden or metastatic spread. The treatments of such lesions are often aggressive and disfiguring as well as lead to extended convalescence and alteration in function. Paramount to helping survivors is a better understanding of the etiology, progression, and treatment of pain. In this chapter, we concisely review the current understanding of neuropathic pain, mechanisms, and drug treatment of pain associated with head and neck cancer.

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References

  1. Macfarlane TV, Wirth T, Ranasinghe S, et al. Head and neck cancer pain: systematic review of prevalence and associated factors. J Oral Maxillofac Res. 2012;3(1):e1.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Schmidt BL. The neurobiology of cancer pain. J Oral Maxillofac Surg. 2015;73(12 Suppl):S132–5.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Connelly ST, Schmidt BL. Evaluation of pain in patients with oral squamous cell carcinoma. J Pain. 2004;5(9):505–10.

    Article  PubMed  Google Scholar 

  4. Schmidt BL. The neurobiology of cancer pain. Neuroscientist. 2014;20(5):546–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Marshall JA, Mahanna GK. Cancer in the differential diagnosis of orofacial pain. Dent Clin North Am. 1997;41(2):355–65.

    CAS  PubMed  Google Scholar 

  6. Lam DK, Dang D, Zhang J, Dolan JC, Schmidt BL. Novel animal models of acute and chronic cancer pain: a pivotal role for PAR2. J Neurosci. 2012;32:14178.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Nelson J, Bagnato A, Battistini B, Nisen P. The endothelin axis: emerging role in cancer. Nat Rev Cancer. 2003;3:110–6.

    Article  CAS  PubMed  Google Scholar 

  8. Pickering V, Jay Gupta R, Quang P, et al. Effect of peripheral endothelin-1 concentration on carcinoma-induced pain in mice. Eur J Pain. 2008;12:293.

    Article  CAS  PubMed  Google Scholar 

  9. Quang PN, Schmidt BL. Endothelin-A receptor antagonism attenuates carcinoma-induced pain through opioids in mice. J Pain. 2010;11(7):663–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L, Leon A. Nerve growth factor: from neurotrophin to neurokine. Trends Neurosci. 1996;19(11):514–20.

    Article  CAS  PubMed  Google Scholar 

  11. Schmidt BL, Hamamoto DT, Simone DA, Wilcox GL. Mechanism of cancer pain. Mol Interv. 2010;10(3):164–78.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Nico B, Mangieri D, Benagiano V, Crivellato E, Ribatti D. Nerve growth factor as an angiogenic factor. Microvasc Res. 2008;75:135–41.

    Article  CAS  PubMed  Google Scholar 

  13. Yang Y, Zhang P, Li W. Comparison of orofacial pain of patients with different stages of precancer and oral cancer. Sci Rep. 2017;7(1):203.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Hardt M, Lam DK, Dolan JC, Schmidt BL. Surveying proteolytic processes in human cancer microenvironments by microdialysis and activity-based mass spectrometry. Proteomics Clin Appl. 2011;5(11–12):636–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gellrich NC, Schimming R, Schramm A, Schmalohr D, Bremerich A, Kugler J. Pain, function, and psychologic outcome before, during, and after intraoral tumor resection. J Oral Maxillofac Surg. 2002;60(7):772–7.

    Article  PubMed  Google Scholar 

  16. Fornasari D. Pharmacotherapy for neuropathic pain: a review. Pain Ther. 2017;6(1):25–33.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Colloca L, Ludman T, Bouhassira D, et al. Neuropathic pain. Nat Rev Dis Primers. 2017;3:17002.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: systematic review, meta-analysis and updated NeuPSIG recommendations. Lancet Neurol. 2015;14(2):162–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Binder A, Baron R. The pharmacological therapy of chronic neuropathic pain. Dtsch Arztebl Int. 2016;113(37):616–25.

    PubMed  PubMed Central  Google Scholar 

  20. Rose M. Neck pain in adults. NetCE course reference material #94130.

    Google Scholar 

  21. Baron R, Hans G, Dickenson AH. Peripheral input and its importance for central sensitization. Ann Neurol. 2013;74(5):630–6.

    Article  PubMed  Google Scholar 

  22. Bannister K, Dickenson AH. What the brain tells the spinal cord. Pain. 2016;157(10):2148–51.

    Article  PubMed  Google Scholar 

  23. Simone DA, Nolano M, Johnson T, Wendelschafer-Crabb G, Kennedy WR. Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function. J Neurosci. 1998;18(21):8947–59.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Yarnitsky D. Role of endogenous pain modulation in chronic pain mechanisms and treatment. Pain. 2015;156(Suppl 1):S24–31. Fornasari D. Pain mechanisms in patients with chronic pain. Clin Drug Investig. 2012;32(1):45–52.

    Article  PubMed  Google Scholar 

  25. Worley SL. New directions in the treatment of chronic pain. PT. 2016;41(2):107–14.

    Google Scholar 

  26. Spahr N, Hodkinson D, Jolly K, Williams S, Howard M, Thacker M. Distinguishing between nociceptive and neuropathic components in chronic low back pain using behavioral evaluation and sensory examination. Musculoskelet Sci Pract. 2017;27:40–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Fornasari D. Pain mechanisms in patients with chronic pain. Clin Drug Investig. 2012;32(1):45–52.

    Article  CAS  PubMed  Google Scholar 

  28. Förster M, Mahn F, Gockel U, et al. Axial low back pain: one painful area—many perceptions and mechanisms. PLoS One. 2013;8(7):e68273.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Woolf CJ, American College of Physicians, American Physiological Society. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med. 2004;140(6):441–51.

    Article  PubMed  Google Scholar 

  30. Slatkin NE, Rhiner M. Topical ketamine in the treatment of mucositis pain. Pain Med. 2003;4(3):298–303.

    Article  PubMed  Google Scholar 

  31. Knezevic NN, Tverdohleb T, Nikibin F, Knezevic I, Candido KD. Management of chronic neuropathic pain with single and compounded topical analgesics. Pain Manag. 2017;7(6):537–58.

    Article  PubMed  Google Scholar 

  32. Derry S, Conaghan P, Da Silva JA, et al. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev. 2016;4:CD007400.

    PubMed  Google Scholar 

  33. Hesselink JMK. Topical analgesics: critical issues related to formulation and concentration. J Pain Relief. 2016;5:274.

    Google Scholar 

  34. Manion J, Waller MA, Clark T, Massingham JN, Gregory Neely G. Developing modern pain therapies. Front Neurosci. 2019;13:1370.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Baron R, Eberhart L, Kern KU, et al. Tapentadol prolonged release for chronic pain: a review of clinical trials and 5 years of routine clinical practice data. Pain Pract. 2017;17(5):678–700.

    Article  PubMed  Google Scholar 

  36. Sánchez Del Águila MJ, Schenk M, Kern KU, Drost T, Steigerwald I. Practical considerations for the use of tapentadol prolonged release for the management of severe chronic pain. Clin Ther. 2015;37(1):94–113.

    Article  PubMed  Google Scholar 

  37. Tramullas M, Francés R, de la Fuente R, Velategui S, Carcelén M, García R, Llorca J, Hurlé MA. MicroRNA-30c-5p modulates neuropathic pain in rodents. Sci Transl Med. 2018;10(453):eaao6299.

    Article  PubMed  Google Scholar 

  38. Christoph A, Eerdekens MH, Kok M, Volkers G, Freynhagen R. Cebranopadol, a novel first-in-class analgesic drug candidate: first experience in patients with chronic low back pain in a randomized clinical trial. Pain. 2017;158(9):1813–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Miyazaki T, Choi IY, Rubas W, et al. NKTR-181: a novel mu-opioid analgesic with inherently low abuse potential. J Pharmacol Exp Ther. 2017;363(1):104–13.

    Article  CAS  PubMed  Google Scholar 

  40. Stover JD, Farhang N, Berrett KC, Gertz J, Lawrence B, Bowles RD. CRISPR epigenome editing of AKAP150 in DRG neurons abolishes degenerative IVD-induced neuronal activation. Mol Ther. 2017;25:2014–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Young, J.M., Connelly, S.T. (2021). Pain Associated with Head and Neck Cancers. In: El Assal, R., Gaudilliere, D., Connelly, S.T. (eds) Early Detection and Treatment of Head & Neck Cancers. Springer, Cham. https://doi.org/10.1007/978-3-030-69852-2_8

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  • DOI: https://doi.org/10.1007/978-3-030-69852-2_8

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