Abstract
Inflammatory signaling is a major component in the development and progression of many lung diseases, including asthma, chronic obstructive pulmonary disorder (COPD), and pulmonary hypertension (PH). This chapter will provide a brief overview of asthma, COPD, and PH and how inflammation plays a vital role in these diseases. Specifically, we will discuss the role of reactive oxygen species (ROS) and Ca2+ signaling in inflammatory cellular responses and how these interactive signaling pathways mediate the development of asthma, COPD, and PH. We will also deliberate the key cellular responses of pulmonary arterial (PA) smooth muscle cells (SMCs) and airway SMCs (ASMCs) in these devastating lung diseases. The analysis of the importance of inflammation will shed light on the key questions remaining in this field and highlight molecular targets that are worth exploring. The crucial findings will not only demonstrate the novel roles of essential signaling molecules such as Rieske iron-sulfur protein and ryanodine receptor in the development and progress of asthma, COPD, and PH but also offer advanced insight for creating more effective and new therapeutic targets for these devastating inflammatory lung diseases.
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Abbreviations
- ASK1:
-
Apoptosis signal-regulating kinase 1
- ASMC:
-
Airway smooth muscle cell
- ATM:
-
Ataxia-telangiectasia mutated
- BALF:
-
Bronchoalveolar lavage fluid
- CaM:
-
Calmodulin
- CDK:
-
Cyclin-dependent kinase
- CICR:
-
Calcium-induced calcium release
- CIRG:
-
Calcium-induced ROS generation
- COPD:
-
Chronic obstructive pulmonary disease
- CS:
-
Cigarette smoke
- DAG:
-
Diacylglycerol
- DAMP:
-
Damage-associated molecular pattern
- ECM:
-
Extracellular matrix
- ETC:
-
Electron transport chain
- GPCR:
-
G protein-coupled receptor
- Gpx:
-
Glutathione peroxidase
- GSH:
-
Glutathione
- HIF-1α:
-
Hypoxia-inducible factor-1α
- HPV:
-
Hypoxic pulmonary vasoconstriction
- IKK:
-
IκB kinase
- IP3:
-
Inositol triphosphate
- IP3R:
-
Inositol-1,4,5-triphosphate receptor
- Kv:
-
Voltage-gated potassium
- LTCC:
-
L-type voltage-gated calcium channel
- MAPK:
-
Mitogen-activated protein kinase
- MLCK:
-
Myosin light chain kinase
- MMP:
-
Matrix metalloproteinases
- nAChR:
-
Nicotinic acetylcholine receptor
- NADPH:
-
Nicotinamide dinucleotide phosphate
- NEMO:
-
NF-κB essential modulator
- NF-κB:
-
Nuclear factor-κB
- NIK:
-
NF-κB-inducing kinase
- NLR:
-
NOD-like receptor
- NOS:
-
Nitric oxide synthase
- PA:
-
Pulmonary artery
- PAMP:
-
Pathogen-associated molecular pattern
- PH:
-
Pulmonary hypertension
- PKC:
-
Protein kinase C
- PPA:
-
Pulmonary arterial pressure
- PRR:
-
Pattern recognition receptor
- PVR:
-
Pulmonary vascular resistance
- RHD:
-
Rel homology domain
- RICR:
-
ROS-induced calcium release
- RISP:
-
Rieske iron-sulfur protein
- ROS:
-
Reactive oxygen species
- RyR:
-
Ryanodine receptor
- SMC:
-
Smooth muscle cells
- SR:
-
Sarcoplasmic reticulum
- TAK1:
-
TGF-β-activated kinase 1
- TLR:
-
Toll-like receptor
- TNF-α:
-
Tumor necrosis factor-α
- TRP:
-
Transient receptor potential
- TRPC:
-
Canonical TRP
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Truong, L., Zheng, YM., Kandhi, S., Wang, YX. (2021). Overview on Interactive Role of Inflammation, Reactive Oxygen Species, and Calcium Signaling in Asthma, COPD, and Pulmonary Hypertension. In: Wang, YX. (eds) Lung Inflammation in Health and Disease, Volume II. Advances in Experimental Medicine and Biology, vol 1304. Springer, Cham. https://doi.org/10.1007/978-3-030-68748-9_9
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