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Proteome in Leukemic vs. Differentiated Leukemia Cells

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Epigenetics and Proteomics of Leukemia

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Abstract

We exploited the proteomic approach to identify proteins whose expression changed during leukemia cell differentiation. The determination of protein expression differences in leukemia and normal blood cells can help identify novel cancer signaling mechanisms. In Chap. 4 are presented proteomic studies in order to identify proteins characteristic for AML cells and significantly altered during granulocytic differentiation and/or its leading apoptosis. Computational comparative proteome analysis of CD34+, mature neutrophils, leukemia cells and cells induced to differentiation or apoptosis is presented and identified proteins likelihood important to a potential therapeutic target for AML.

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Authors and Affiliations

  1. Department of Molecular Cell Biology Institute of Biochemistry Life Sciences Center, Vilnius University, Vilnius, Lithuania

    Rūta Navakauskienė & Veronika Borutinskaitė

  2. Department of Electronic Systems Faculty of Electronics, Vilnius Gediminas Technical University, Vilnius, Lithuania

    Dalius Navakauskas & Dalius Matuzevičius

Authors
  1. Rūta Navakauskienė
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  2. Dalius Navakauskas
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  3. Veronika Borutinskaitė
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  4. Dalius Matuzevičius
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Navakauskienė, R., Navakauskas, D., Borutinskaitė, V., Matuzevičius, D. (2021). Proteome in Leukemic vs. Differentiated Leukemia Cells. In: Epigenetics and Proteomics of Leukemia. Springer, Cham. https://doi.org/10.1007/978-3-030-68708-3_4

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