Abstract
Pharmaceutical processing includes several processes that are based on a multiphase system, particularly, gas/solid flow and fluidization. These processes are devoted to making particles, modifying their properties, and then turning them into structured products and may include crystallization, mixing, granulation, pulverization, drying, and tableting. Drying is one of the major unit operations in the manufacturing of solid pharmaceuticals. Optimum design of the drying process will significantly enhance the rate and reliability of the production and, in turn, decrease the cost of the pharmaceutical products. The focus of this chapter is on the computational fluid dynamics (CFD) approach for design, scale-up, and performance optimization of a pharmaceutical bubbling fluidized bed dryer. Gas/solid flow patterns, mixing, and drying of pharmaceutical particles in bubbling fluidized bed dryers of three different scales are simulated.
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Arastoopour, H., Gidaspow, D., Lyczkowski, R.W. (2022). Application of Multiphase Flow Simulation in Pharmaceutical Processes. In: Transport Phenomena in Multiphase Systems. Mechanical Engineering Series. Springer, Cham. https://doi.org/10.1007/978-3-030-68578-2_12
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DOI: https://doi.org/10.1007/978-3-030-68578-2_12
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