Abstract
Status epilepticus (SE) is a neurological emergency and is defined by a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms, which leads to abnormally prolonged seizures. Neuronal death, neuronal injury, and alteration of neuronal networks are consequences of this condition. Operational definitions have been established to conduct the treatment appropriately in each phase. Stage I (pre-SE or imminent SE) seizures last for more than 10 minutes and less than 30 minutes. Stage II or established SE seizures last for 30 minutes or more and less than 60 minutes. Stage III or refractory SE seizures last longer than 60 minutes and Stage IV is super-refractory SE epileptic seizures that last for more than 24 hours despite the use of anesthetic drugs. It’s important to follow specific guideline for treatment and investigation of etiology as well to recognize and to treat complications.
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References
Gastaut H. Classification of status epilepticus. In: Delgado-Escueta AV, Wasterlain CG, Treiman DM, Porter RJ, editors. Status epilepticus: mechanisms of brain damage and treatment, Advances in neurology, vol. 34. New York: Raven Press; 1983. p. 15–35.
Commission on Classification and Terminology of the International League Against Epilepsy. A proposed international classification of epileptic seizures. Epilepsia. 1964;5:297–306.
Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia. 1981;22:489–501.
Lowenstein DH, Bleck T, Macdonald RL. It’s time to revise the definition of status epilepticus. Epilepsia. 1999;40(1):120–2.
DeLorenzo RJ, Garnett LK, Towne AR, Waterhouse EJ, Boggs JG, Morton L, AfzalChoudhry M, Barnes T, Ko D. Comparison of status epilepticus with prolonged seizure episodes lasting from 10 to 29 minutes. Epilepsia. 1999;40(2):164–9.
Trinka E, Cock H, Hesdorffer D, Rossetti AO, Scheffer IE, Shinnar S, Shorvon S, Lowenstein DH. A definition and classification of status epilepticus. Report of the ILAE task force on classification of status epilepticus. Epilepsia. 2015;56(10):1515–23.
Blume WT, Lüders HO, Mizrahi E, Tassinari C, van Emde BW, Engel J Jr. Glossary of descriptive terminology for ictal semiology : report of the ILAE task force on classification and terminology. Epilepsia. 2001;42(9):1212–8.
Rona S, Rosenow F, Arnold S, Carreño M, Diehl B, Ebner A, Fritsch B, Hamer HM, Holthausen H, Knake S, Kruse B, Noachtar S, Pieper T, Tuxhorn I, Lüders HO. A semiological classification of status epilepticus. Epileptic Disord. 2005;7(1):5–12.
Shorvon SD. Definition, classification and frequency of status epilepticus. In: Shorvon SD, editor. Status epilepticus: its clinical features and treatment in children and adults. Cambridge: Cambridge University Press; 1994a. p. 21–33.
Treiman DM, DeGiorgio CM, Salisbury S, Wickboldt C. Subtle generalized convulsive status epilepticus (Abstract). Epilepsia. 1984;25:653.
DeLorenzo RJ, Pellock JM, Towne AR, Boggs JG. Epidemiology of status epilepticus. J Clin Neurophysiol. 1995;12(4):316–25.
Hauser WA. Status epilepticus: epidemiologic considerations. Neurology. 1990;40(suppl 2):9–13.
Garzon E, Fernandes RMF, Sakamoto AC. Analysis of clinical characteristics and risk factors for mortality in human status epilepticus. Seizure. 2003;12:337–45.
Kapur J, MacDonald RL. Status epilepticus: a proposed pathophysiology. In: Shorvon SD, Dreifuss F, Fish D, Thomas D, editors. The treatment of epilepsy. Oxford: Blackwell Science; 1996. p. 258–68.
Brown JK, Hussain IHMI. Status epilepticus I: pathogenesis. Dev Med Child Neurol. 1991;33:3–17.
Fountain NB, Lothman EW. Pathophysiology of status epilepticus. J Clin Neurophysiol. 1995;12(4):326–42.
Trinka E, Kälviäinen R. 25 years of advances in the definition, classification and treatment of status epilepticus. Seizure. 2017;44:65–73.
Garzon E, Fernandes RM, Sakamoto AC. Serial EEG during human status epilepticus: evidence for PLED as an ictal pattern. Neurology. 2001;57(7):1175–83.
Liberalesso PBN, Yacubian EMT, Sakamoto AC, Garzon E. Nonconvulsive status epilepticus: clinical and electrographic aspects. J Epilepsy Clin Neurophysiol. 2004;10(4):191–200.
De Paola L, Palmini A, Yacubian EM, Castro LHM, Sakamoto A, Guerreiro C, Marques L, Arruda F. Non-epileptic seizures (NES) in Brazil: results on a national survey. J Epilepsy Clin Neurophysiol. 2004;10(2):109–12.
Crawshawa AA, Cockb HR. Medical management of status epilepticus: emergency room to intensive care unit. Seizure. 2020;75:145–52.
Working Group on Status Epilepticus. Epilepsy Foudation of America. Treatment of convulsive status epilepticus. JAMA. 1993;270:854–9.
Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011;134(Pt 10):2802–018.
Sutter R, Dittrich T, Semmlack S, Rüegg S, Marsch S, Kaplan PW. Acute systemic complications of convulsive status epilepticus – a systematic review. Crit Care Med. 2018;6(1):138–45.
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Cobas, C., Garzon, E. (2021). Status Epilepticus. In: Figueiredo, E.G., Welling, L.C., Rabelo, N.N. (eds) Neurocritical Care for Neurosurgeons. Springer, Cham. https://doi.org/10.1007/978-3-030-66572-2_31
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