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Development of Elemental Technologies for Magnetic Hyperthermia in Cancer Treatment

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11th Asian-Pacific Conference on Medical and Biological Engineering (APCMBE 2020)

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Abstract

Hyperthermia utilizing magnetic particles has been widely studied as a possible method for cancer treatment in recent years. This method induces apoptosis (cell death) using heat generation from magnetic particles which are injected into a tumor region and subjected to an external high-frequency magnetic field. In previous studies, we succeeded in developing microsize thermosensitive ferromagnetic particles with a low Curie temperature of around 40–45 °C as a self-controlled heating element that possibly prevents the local overheating surrounding healthy tissues. Further, by utilizing the change of its permeability around its Curie temperature resulting in the change in the magnetic flux density around tumor region, we also developed a wireless temperature measurement. In addition, to localize magnetic particles which cannot be seen from the body surface, we also developed an automatic localization system by using a robot arm equipped with three detection coils symmetrically installed in heating coil. To make our proposed elemental technologies feasible in clinical settings, we have also been developing a magnetic hyperthermia system that can treat deep-seated tumors up to 5 cm. In this paper, we report our elemental technologies which have been developed so far such as heating elements, temperature and position monitoring technologies.

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Acknowledgment

This work was supported by Grant-in-Aid for Scientific Research (KAKENHI) under Grant 19K23597 and 18H03545, all from Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Tohoku University, Sendai, 980-8579, Japan

    Loi Tonthat & Shin Yabukami

  2. Tokai University, Tokyo, 151-8677, Japan

    Fumitaka Aki

  3. Akita University, Akita, 010-8502, Japan

    Kazutaka Mitobe & Yoshiyuki Yamamoto

Authors
  1. Loi Tonthat
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  2. Fumitaka Aki
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  3. Kazutaka Mitobe
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  4. Shin Yabukami
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  5. Yoshiyuki Yamamoto
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Corresponding author

Correspondence to Loi Tonthat .

Editor information

Editors and Affiliations

  1. Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Yasuyuki Shiraishi

  2. School of Engineering, The University of Tokyo, Tokyo, Japan

    Ichiro Sakuma

  3. Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

    Keiji Naruse

  4. School of Engineering, Tokyo Denki University, Tokyo, Japan

    Akinori Ueno

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Tonthat, L., Aki, F., Mitobe, K., Yabukami, S., Yamamoto, Y. (2021). Development of Elemental Technologies for Magnetic Hyperthermia in Cancer Treatment. In: Shiraishi, Y., Sakuma, I., Naruse, K., Ueno, A. (eds) 11th Asian-Pacific Conference on Medical and Biological Engineering. APCMBE 2020. IFMBE Proceedings, vol 82. Springer, Cham. https://doi.org/10.1007/978-3-030-66169-4_33

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  • DOI: https://doi.org/10.1007/978-3-030-66169-4_33

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-66168-7

  • Online ISBN: 978-3-030-66169-4

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