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Management of Radiotherapy-Induced Acute Toxicities

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Nasopharyngeal Cancer

Part of the book series: Practical Guides in Radiation Oncology ((PGRO))

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Abstract

Radiation therapy is the backbone of nasopharyngeal cancer treatments. Despite advances and innovations in the planning and delivery technologies, radiotherapy-induced acute toxicities remain substantial. The most commonly observed acute toxicities include oral mucositis, dysphagia, dermatitis, dysgeusia, otological symptoms, and rhinosinusitis, with sequelae of pain, dehydration, weight loss, and infection. These adverse effects not only contribute to decreased quality of life but may also cause treatment interruptions, hospitalization, thereby compromised treatment outcomes. This chapter discusses the mechanism, presentation, assessment, and evidence-based prevention/management of these acute toxicities in detail. The interventions recommended are refined from well-recognized guidelines, such as The National Comprehensive Cancer Network (NCCN) Guidelines for Head and Neck Cancers (Version 1.2020) and guidelines from Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO).

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Authors and Affiliations

  1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Yingzhi Wu

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Editors and Affiliations

  1. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China

    Jun Ma

  2. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA

    Nancy Y. Lee

  3. Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China

    Jiade J. Lu

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Wu, Y. (2021). Management of Radiotherapy-Induced Acute Toxicities. In: Ma, J., Lee, N.Y., Lu, J.J. (eds) Nasopharyngeal Cancer. Practical Guides in Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-65037-7_10

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