Abstract
Extensive research has been carried out to find associations between arterial stiffness markers and blood levels of low-density lipoprotein cholesterol (LDL-Chol), triglycerides (TG), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-Chol) relating to assessment of cardiovascular diseases’ (CVD) risk factors and early detection of atherosclerosis. However, data on levels of atherogenic lipoproteins as apolipoprotein B (apoB), low-density lipoprotein(a) (Lp(a)) and high-density apolipoprotein A (apoA) related to arterial biomechanical properties are scarce.
The aim of this study was to investigate whether stratification of the population according to serum levels of atherogenic lipoproteins (apoB, Lp(a), TG, TC, LDL-Chol) and high-density lipoproteins (HDL-Chol, apoA) are related to arterial biomechanical properties for early and non-invasive cardiovascular risk diagnosis.
The investigation was conducted on 44 healthy subjects with familial hypercholesterolemia in their anamnesis. A SphygmoCor device for the aortic pulse wave velocity (PWVao) and augmentation index estimation, and an ultrasound device for carotid intima-media thickness, the radial artery, and the femoral artery wall thickness and lumen diameter measurements, were utilized.
An association between the serum apoB values and the radial artery wall thickness (p = 0.03) and the radial artery wall thickness to lumen diameter ratio was found (p = 0.05), indicating that the apoB level may be related to the arterial remodeling process. Also, a dependence between TG levels and age-related PWVao (p = 0.02) was discovered, which needs further investigation.
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The research was funded partly by the Estonian Ministry of Education and Research under institutional research financing IUT 19-2 and by Estonian Centre of Excellence in IT (EXCITE) funded by the European Regional Development Fund.
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Kööts, K. et al. (2021). Assessment of Associations Between Arterial Mechanical Properties and Biochemical Blood Markers for Early Detection of Atherosclerosis. In: Jarm, T., Cvetkoska, A., Mahnič-Kalamiza, S., Miklavcic, D. (eds) 8th European Medical and Biological Engineering Conference. EMBEC 2020. IFMBE Proceedings, vol 80. Springer, Cham. https://doi.org/10.1007/978-3-030-64610-3_15
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