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Production and Characterization of Antibiotic Containing Nano Calcium Phosphates

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Nanotechnology Applications in Health and Environmental Sciences

Part of the book series: Nanotechnology in the Life Sciences ((NALIS))

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Abstract

Implant-related infections constitute a large percentage of hospital-acquired infections and may result in implant failure and bone degradation. Such occurrences stem from either the colonization of bacteria around the host tissue or the formation of biofilm on the implant surface. In clinical treatment, antibiotics may be administered systemically or locally. The latter is expected to be much more effective due to the local intensified antibacterial activity with minimal systemic toxicity. In order to achieve such an outcome, suitable carriers need to be developed. Among many biodegradable carriers, calcium phosphates have attracted specific interest owing to their osteoconductive and bioactive characteristics. This chapter aims to bring together the results reported in the current relevant literature about the applications of calcium phosphates used for local delivery of a variety of antibiotics. Specifically, the influence of the delivery system properties both on drug-releasing profile and antibacterial activity are discussed.

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Authors and Affiliations

  1. SUNUM Sabancı University Nanotechnology Research and Application Center, Istanbul, Turkey

    Feray Bakan

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  1. Feray Bakan
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Correspondence to Feray Bakan .

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Editors and Affiliations

  1. Department of Nanotechnology and Nanomedicine, Graduate School of Science and Engineering, Hacettepe University, Ankara, Turkey

    Necdet Saglam

  2. Department of Sports Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Feza Korkusuz

  3. Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar, India

    Ram Prasad

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Bakan, F. (2021). Production and Characterization of Antibiotic Containing Nano Calcium Phosphates. In: Saglam, N., Korkusuz, F., Prasad, R. (eds) Nanotechnology Applications in Health and Environmental Sciences. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-64410-9_16

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