Abstract
The cornea is a transparent tissue at the front of the eye that acts as both an important structural barrier and a crucial refractive medium. Its clarity is essential for the eye to perform its function. Many trials have studied how to best protect the cornea from infections, prevent progression of ectasias, ensure optimal ocular surface conditions, and keep the tissue optically clear through transplantation. Key landmark trials are summarized in the following chapter.
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References
Wilhelmus KR, Gee L, Hauck WW, Kurinij N, Dawson CR, Jones DB, et al. Herpetic Eye Disease Study. A controlled trial of topical corticosteroids for herpes simplex stromal keratitis. Ophthalmology. 1994;101:1883–95; discussion 1895–1896.
Barron BA, Gee L, Hauck WW, Kurinij N, Dawson CR, Jones DB, et al. Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. Ophthalmology. 1994;101:1871–82.
The Herpetic Eye Disease Study Group. A controlled trial of Oral acyclovir for Iridocyclitis caused by herpes simplex virus. Arch Ophthalmol. 1996;114:1065–72.
The Herpetic Eye Disease Study Group. A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis: the epithelial keratitis trial. Arch Ophthalmol. 1997;115:703–12.
Wilhelmus KR, Beck RW, Moke PS, Dawson CR, Barron BA, Jones DB, et al. Acyclovir for the prevention of recurrent herpes simplex virus eye disease. N Engl J Med. 1998;339:300–6.
The Herpetic Eye Disease Study Group. Predictors of recurrent herpes simplex virus keratitis. Cornea. 2001;20:123–8.
Prajna NV, Krishnan T, Mascarenhas J, Rajaraman R, Prajna L, Srinivasan M, et al. The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole. JAMA Ophthalmol. 2013;131:422–9.
Prajna NV, Krishnan T, Rajaraman R, Patel S, Srinivasan M, Das M, et al. Effect of oral voriconazole on fungal keratitis in the mycotic ulcer treatment trial II (MUTT II): a randomized clinical trial. JAMA Ophthalmol. 2016;134:1365–72.
Srinivasan M, Mascarenhas J, Rajaraman R, Ravindran M, Lalitha P, Glidden DV, et al. Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). Arch Ophthalmol Chic Ill 1960. 2012;130:143–50.
The Collaborative Corneal Transplantation Studies Research Group. The collaborative corneal transplantation studies (CCTS): effectiveness of histocompatibility matching in high-risk corneal transplantation. Arch Ophthalmol. 1992;110:1392–403.
Maguire MG, Stark WJ, Gottsch JD, Stulting RD, Sugar A, Fink NE, et al. Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies. Ophthalmology. 1994;101:1536–47.
Writing Committee for the Cornea Donor Study Research Group, Mannis MJ, Holland EJ, Gal RL, Dontchev M, Kollman C, et al. The effect of donor age on penetrating keratoplasty for endothelial disease: graft survival after 10 years in the Cornea Donor Study. Ophthalmology. 2013;120:2419–27.
Rosenwasser GO, Szczotka-Flynn LB, Ayala AR, Liang W, Aldave AJ, Dunn SP, et al. Effect of cornea preservation time on success of descemet stripping automated endothelial keratoplasty: a randomized clinical trial. JAMA Ophthalmol. American Medical Association. 2017;135:1401–9.
Hersh PS, Stulting RD, Muller D, Durrie DS, Rajpal RK, Binder PS, et al. United States multicenter clinical trial of corneal collagen crosslinking for keratoconus treatment. Ophthalmology. 2017;124:1259–70.
Dry Eye Assessment and Management Study Research Group, Asbell PA, Maguire MG, Pistilli M, Ying G, Szczotka-Flynn LB, et al. n-3 fatty acid supplementation for the treatment of dry eye disease. N Engl J Med. 2018;378:1681–90.
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Ma, K.K., Yin, J. (2021). Cornea. In: Dohlman, J.C., Lorch, A.C. (eds) Pivotal Trials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-030-63978-5_2
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DOI: https://doi.org/10.1007/978-3-030-63978-5_2
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