Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the novel coronavirus disease 2019 (COVID-19) pandemic, which spread throughout the world. Acute hypoxemic respiratory failure is the most dangerous complication of COVID-19 pneumonia. To date, no specific therapeutic drugs or vaccines have been proven efficacious. Ventilatory support is still a significant challenge for physicians facing COVID-19. The mechanisms underlying hypoxemia in those patients are not fully understood, but a new physiopathology model has been proposed. Oxygen therapy should be delivered to patients with mild to moderate hypoxemia. More severe patients could benefit from other treatments (high-flow nasal cannula, noninvasive ventilation or intubation, and invasive ventilation). Given the rapid evolution of COVID-19, there has been a paucity of the high-quality data that typically inform clinical practice guidelines from professional societies, and a worldwide consensus is still lacking. This chapter aims to illustrate the potentials of ventilatory support as therapeutic options for adult and pediatric patients affected by COVID-19 pneumonia.
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Acknowledgments
The authors would like to sincerely thank the entire Columbus COVID Team (Fabiana Baldi, Andrea Bellieni, Vincenzo Brandi, Angelo Calabrese, Maria Rosaria Calvello, Arturo Ciccullo, Antonella Cingolani, Camilla Cipriani, Giuseppe Maria Corbo, Cinzia Falsiroli, Massimo Fantoni, Enrica Intini, Giovanni Landi, Paolo Maria Leone, Rosa Liperoti, Francesco Macagno, Ilaria Martis, Giuliano Montemurro, Davide Moschese, Rita Murri, Cristina Pais, Giuliana Pasciuto, Annalisa Potenza, Sara Salini, Matteo Siciliano, Jacopo Simonetti, Eleonora Taddei, Matteo Tosato, Anita Tummolo, Francesco Varone, Giulio Ventura) for facing daily COVID-19 side by side on a multidisciplinary basis, and a special thanks goes to the Alpha Team.
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Leone, P.M. et al. (2021). Ventilatory Support in Patients with COVID-19. In: Rezaei, N. (eds) Coronavirus Disease - COVID-19. Advances in Experimental Medicine and Biology, vol 1318. Springer, Cham. https://doi.org/10.1007/978-3-030-63761-3_27
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DOI: https://doi.org/10.1007/978-3-030-63761-3_27
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